The Dutch microbiologist/biochemist Albert Jan Kluyver was an early proponent of the idea of biochemical unity, and how that concept might be demonstrated through the careful study of microbial life. The fundamental relatedness of living systems is an obvious correlate of the theory of evolution, and modern attempts to construct phylogenetic schemes support this relatedness through comparison of genomes. The approach of Kluyver and his scientific descendants predated the tools of modern molecular biology by decades. Kluyver himself is poorly recognized (...) today, yet his influence at the time was profound. Through lens of today however, it has been argued that the focus by Kluyver and others to create taxonomic and phylogenetic schemes using morphology and biochemistry distorted and hindered progress of the discipline of microbiology, because of a perception that the older approaches focused too much on a reductionist worldview. This essay argues that in contrast the careful characterization of fundamental microbial metabolism and physiology by Kluyver made many of the advances of the latter part of the twentieth century possible, by offering a framework which in many respects anticipated our current view of phylogeny, and by directly and indirectly training a generation of scientists who became leaders in the explosive growth of biotechnology. (shrink)

This essay explores connections between bacteriology and the disciplinary evolution of biochemistry in this country during the 1930s. Many features of intermediary metabolism, a central component of biochemistry, originated as attempts to answer fundamental bacteriological questions. Thus, many bacteriologists altered their research programs to answer these questions. In so doing they changed their disciplinary focus from bacteriology to biochemistry. Chester Hamlin Werkman's (1893-1962) Iowa State career illustrates the research perspective that many bacteriologists adopted. As a junior faculty member in the (...) Bacteriology Department in the late 1920s, Werkman faced a powerful professional dilemma: establishing a research identity that distinguished him from his colleagues with flourishing national and international reputations. His solution was to radically alter his research program from traditional bacteriology to a biochemistry program, which reflected the influence of the Dutch microbiologist/biochemist, Albert Jan Kluyver (1888-1956). Werkman was extremely successful in this career change. His laboratory made significant contributions to biochemistry, and Werkman achieved a notable degree of personal success. His career began in the shadow of his departmental bacteriological colleagues; within a decade he became the department's dominant research figure, as a biochemist. Werkman's personal success, however, had profound consequences for the disciplinary future of bacteriology at Iowa State. (shrink)

As the first of its kind this collection draws together cutting edge scholarship in the field, focusing on the theory and practice of yoga in contemporary times ...

This article presents a review of the literature, summarizes current initiatives, and provides a heuristic for assessing the effectiveness of a range of institutional review board collaborative strategies that can reduce the regulatory burden of ethics review while ensuring protection of human subjects, with a particular focus on international research. Broad adoption of IRB collaborative strategies will reduce regulatory burdens posed by overlapping oversight mechanisms and has the potential to enhance human subjects protections.

Yoga is hugely popular around the world today, yet until now little has been known of its roots. This book collects, for the first time, core teachings of yoga in their original form, translated and edited by two of the world's foremost scholars of the subject. It includes a wide range of texts from different schools of yoga, languages and eras: among others, key passages from the early Upanisads and the Mahabharata, and from the Tantric, Buddhist and Jaina traditions, with (...) many pieces in scholarly translation for the first time. Covering yoga's varying definitions across systems, models of the esoteric and physical bodies, and its most important practices, such as posture, breath control, sensory withdrawal and meditation, Roots of Yoga is a unique and essential source of knowledge. (shrink)

New Approaches to Monetary Economics brings together presentations of innovative research in the field of monetary economics. Much of this research develops and applies approaches to modelling financial intermediation, aggregate fluctuations, monetary aggregation and transactions-motivated monetary equilibrium. The contents of this volume comprise the proceedings of the second in a conference series entitled International Symposia in Economic Theory and Econometrics. This conference was held in 1985 at the IC2 Institute at the University of Texas at Austin. The symposia in this (...) series are sponsored by the IC2 Institute and the RGK Foundation. New Approaches to Monetary Economics, edited by Professors William A. Barnett and Kenneth J. Singleton, consists of five parts. Part I examines transactions-motivated monetary holding in general equilibrium; Part II, financial intermediation; Part III, monetary aggregation theory, Part IV, issues in aggregate fluctuation; and Part V, theoretical issues in the foundations of monetary economics and macroeconomics. (shrink)

A useful guide to best practice including reviews of the latest and most helpful tests available. In Part One, contributors discuss the theory of reading assessment including issues such as screening, legal aspects, memory and visual problems, computer based assessment and the dyslexias. Part Two contains the review section where experts give comprehensive reviews of named tests.

It is currently estimated that more than 1 billion animals are killed for the fur industry every year. This industry is estimated to be valued in the region of $40 billion. This indicates both that there is a moral imperative and an economic opportunity to explore alternatives to conventional fur. While faux fur is currently available on the market, its production is associated with environmentally destructive practices. The development of stem cell technologies provides an exciting new avenue to explore. Specifically, (...) the use of induced pluripotent stem cells may provide a means of growing fur in a laboratory setting. Here we outline the proposed technology and methods. We consider and respond to a number of potential moral objections against pursuing this innovative possibility, arguing that the benefits such technology could bring to animals in the fur industry are too great to be ignored. (shrink)

In this contribution to the Common Knowledge symposium “Fuzzy Studies,” the authors, all of whom work in the field of science, technology, and society, begin from the assumption that, as Bruno Latour has put it, “we have never been modern.” They accept the STS thesis that, while modern practices purport to be entirely rational and coherent, on closer inspection they turn out to be as much noncoherent as coherent. This article poses the question of what forms “noncoherences” take and how (...) they are managed. The basic argument is that there is a range of styles of noncoherence or “modes of syncretism.” In small case studies, the authors identify six such modes or styles, which they term denial, domestication, separation, care, conflict, and collapse. Given that consistency and coherence seem less important now than they were once taken to be — and given that the conditions of possibility for purity are, in any case, in decline — this list and its supporting case studies, while not meant to be definitive, are offered as a way of understanding how practices that do not cohere may still function and fit together admirably. (shrink)

Joseph Priestley, the eighteenth-century scientist who discovered oxygen, was one of the most remarkable thinkers of his time. This collection of essays by a team of experts covers the full range of his work in the fields of education, politics, philosophy, and theology, and firmly re-establishes him as a major intellectual figure.

Put briefly: perhaps the entire evolution of the spirit is a question of the body; it is the history of the development of a higher body that emerges into our sensibility. The organic is rising to yet higher levels. Our lust for knowledge of nature is a means through which the body desires to perfect itself. Or rather: hundreds of thousands of experiments are made to change the nourishment, the mode of living and of dwelling in the body; consciousness and (...) evaluations in the body, all kinds of pleasure and displeasure, are signs of these changes and experiments. In the long run, it is not a question of man at all: he is to be overcome (Nietzsche 1967: 358). (shrink)

Contemporary theories of Virtue Ethics are often presented as being in opposition to Kantian Ethics and Consequentialism. It is argued that Virtue Ethics takes as fundamental the question, “What sort of character would a virtuous person have?” and that Kantian Ethics and Consequentialism take as fundamental the question, “What makes an action right?” I argue that this opposition is misconceived. The opposition is rather between Virtue Ethics and Kantian Ethics on the one hand and Consequentialism on the other. The former (...) two are concerned with, respectively, the development of a virtuous character and a good will, whereas Consequentialism is essentially a doctrine that just provides a justification of the right option without specifying how this is to be achieved. Furthermore, I show that Consequentialism, interpreted as a justificatory doctrine, is both an impoverished doctrine and one that cannot be enriched by taking a “pick and mix” approach to other ethical theories in the way that Consequentialists advocate. I argue that there is at least one reason to prefer Kantian Ethics: Kantian Ethics necessarily avoids the objection of selfcenteredness, whereas the avoidance of this objection is only contingent in the case of Virtue Ethics. (shrink)

Contemporary theories of Virtue Ethics are often presented as being in opposition to Kantian Ethics and Consequentialism. It is argued that Virtue Ethics takes as fundamental the question, “What sort of character would a virtuous person have?” and that Kantian Ethics and Consequentialism take as fundamental the question, “What makes an action right?” I argue that this opposition is misconceived. The opposition is rather between Virtue Ethics and Kantian Ethics on the one hand and Consequentialism on the other. The former (...) two are concerned with, respectively, the development of a virtuous character and a good will, whereas Consequentialism is essentially a doctrine that just provides a justification of the right option without specifying how this is to be achieved. Furthermore, I show that Consequentialism, interpreted as a justificatory doctrine, is both an impoverished doctrine and one that cannot be enriched by taking a “pick and mix” approach to other ethical theories in the way that Consequentialists advocate. I argue that there is at least one reason to prefer Kantian Ethics: Kantian Ethics necessarily avoids the objection of selfcenteredness, whereas the avoidance of this objection is only contingent in the case of Virtue Ethics. (shrink)

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

Background: Randomized controlled trials have been criticized for their inability to identify and differentiate the causal mechanisms that generate the outcomes they measure. One solution is the development of realist trials that combine the empirical precision of trials' outcome data with realism's theoretical capacity to identify the powers that generate outcomes. Main Body: We review arguments for and against this position and conclude that critical realist trials are viable. Using the example of an evaluation of the educational effectiveness of virtual (...) reality simulation, we explore whether Partial Least Squares Structural Equation Modelling can move statistical analysis beyond correlational analysis to support realist identification of the mechanisms that generate correlations. Conclusion: We tentatively conclude that PLS-SEM, with its ability to identify ‘points of action’, has the potential to provide direction for researchers and practitioners in terms of how, for whom, when, where and in what circumstances an intervention has worked. (shrink)

This book details the underlining philosophical approaches to ethical theories and how these can be used to structure an approach to day-to-day ethical issues, and thereby resolve them. It provides an understanding of the ethical theories which underpin decisions in health care by first laying the foundation with a philosophical framework and then going on to develop this into an examination of contemporary health care dilemmas and professional issues. Not available in the U.S.

In this article I shall be supporting two main claims. The first is that the essence of the difference between particularism and generalism lies in where they locate ethical correctness. The second is that generalism, although to be preferred to particularism, is not the final resting place for ethical correctness. Ultimately, ethical correctness resides in ethical theories that provide the rationale for generalism. Particularism is presented as a theory that allows attention to be paid to specific cases and shows a (...) sensitivity to the particular case. Generalism, with its appeal to moral principles, is supposed to lack this sensitivity to specific cases. I argue that although this might be true of subsumptive generalism, it is not true of what I call judgmental generalism. This latter type of generalism retains an appeal to moral principles while requiring sensitivity to the particular case. I consider Kantian ethics as an example of this sort of generalism. Furthermore, I support the claim that this judgmental generalism is to be preferred to particularism. I argue against a prominent form of particularism, put forward by Jonathan Dancy, based on an appeal to the holism of reasons. This doctrine involves the claim that the value of a complex whole is not necessarily identical with the value of its parts. I show that Dancy’s discussion of this involves inconsistencies and also appears to incorporate subsumptive generalism. This statement of particularism is ultimately incoherent. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Henry James—Aristotle's Ally, An Exclusive Pact?Jane SingletonIMany claims are advanced for the importance of narrative art works in philosophy. This paper will concentrate on one specific thesis put forward by Martha Nussbaum about the relationship between certain works of literature and moral philosophy. Although Nussbaum explores many roles for narrative artworks in philosophy,1 I shall concentrate on those works where she argues for a close connection between the novels (...) of Henry James and Aristotle's ethics. These are Love's Knowledge,2 where other authors other than James are also considered, and "Exactly and Responsibly: A Defense of Ethical Criticism," an article that formed part of a debate with Richard Posner and Wayne Booth in 1997 and 1998 in Philosophy and Literature.3 It is this latter work that provides the central thesis to be considered.I argue that there are least four possible attributes or combinations of them that Nussbaum might be suggesting are present in James's novels when she claims that James is an ally of Aristotle. My claim will be that James can only be regarded as an ally of Aristotle with respect to some of these attributes. It is a second question to determine precisely how the legitimate attributes isolated in James's novels are to be used to provide an ally for Aristotle's ethics. I shall claim that in any sense in which it is legitimate to regard James as an ally of Aristotle, he could also be regarded as an ally of a generalist theory. This is an important point to emphasise since Nussbaum explicitly enlists James as an ally of Aristotle because of the normative primacy that he gives to the particular. I shall use Kant's theory as an example of a generalist theory. Henry [End Page 61] James, I argue, can be an ally of both Aristotle and Kant but both can adopt an isolationist policy.IIThe specific thesis put forward by Nussbaum in 1998 is as follows:My claim is that in order to investigate this Aristotelian ethical view fully and fairly, we need to turn to texts in which the case for that sort of rationality is made out in a powerful and convincing way—and this cannot be done if we confine ourselves to works written in the abstract style characteristic of most contemporary theory... Aristotle's conception is much more dependent on "allies" who will make out the force of such obscure claims as the claim that "the discernment rests with perception," and that correct action "lies in a mean." Because Aristotle's conception leaves so much to particularized contextual judgment, one cannot well assess the conception without studying complex examples of such particularized judgment; and of course Aristotle's text does not supply such material. I claim that Henry James is a powerful ally of Aristotle, and one whom Aristotle badly needs if he is to convince us of his claims.("ER," pp. 347–48)It is the clarification and discussion of this that provides my point of departure. I shall then consider the four possible characteristics of James's novels that I have isolated. These are: exemplars of good choice, illustrations of the direction of thought to follow for the discernment of the particular, vehicles for developing imagination and sources that enable us to develop an understanding of and engagement of emotions. In each case I shall consider how, if at all, these characteristics enable James to be an ally of either Aristotle or Kant.IIINussbaum's thesis is limited to the late novels of James. "I assert that there is a distinctive type of ethical view... that requires literary works of a very specific type, primarily exemplified by the late novels of James, for its complete investigation" ("ER," p. 348). These include The Wings of the Dove (1902), The Ambassadors (1903), and The Golden Bowl (1904). I shall use examples from each of these although, as Posner notes, The Wings of The Dove, is one book that Nussbaum does not discuss in the article.4 [End Page 62]What attributes or characteristics do these late novels of James possess? They all have in common... (shrink)