This volume contains contributions on different aspects of practical conflicts by: Peter Baumann Monika Betzler Ruth Chang Jon Elster Barbara Guckes Christine M. Korsgaard Isaac Levi Alfred R. Mele Joseph Raz Henry S. Richardson Peter Schaber J. David Velleman Nicholas White.

I offer an account of how ideals motivate us. My account suggests that although emulating an ideal is often rational, it can lead us to do irrational things. * This is the third in a series of four papers on narrative self-conceptions and their role in moral motivation. In the first paper, “The Self as Narrator” (to appear in Autonomy and the Challenges to Liberalism: New Essays, ed. Joel Anderson and John Christman), I explore the motivational role of narrative self-conceptions, (...) drawing on Daniel Dennett’s notion of the self as a “center of narrative gravity”. In the second paper, “Willing the Law” (in Practical Conflicts, ed. Monika Betzler and Peter Baumann [Cambridge: Cambridge University Press, forthcoming]), I explore the role of selfconceptions in Kantian “conflicts in the will”, drawing on Christine Korsgaard’s notion of “practical identities”. In a fourth paper, “A Sense of Self” (ms), I explore the role of narrative self-con-ceptions in Kantian “conflicts in conception”, drawing on the work of Thomas Nagel and John Perry on the self. (shrink)

Obwohl Kants Tugendlehre bei ihrer Veröffentlichung weithin unbeachtet bleibt, entfaltet sie in den letzten Jahren eine zunehmende Wirkung: ein revolutionär neuer Tugend-Begriff, der mit Nachdruck vertretene Gedanke von Pflichten gegen andere und auch gegen sich selbst, eine Auseinandersetzung mit "Liebespflichten" sowie mit Achtung und Würde. Der von Fachleuten verfasste Kommentar, der anlässlich des 300. Jubiläums Immanuel Kants in einer 2. überarbeiteten erscheint, entschlüsselt damit das letzte wichtige Werk Kants zur Moral. Mit Beiträgen von Monika Betzler, Jochen Bojanowski, Dahan Fan, (...) Franz Hespe Moritz Hildt, Otfried Höffe, Dieter Hüning, Heiner F. Klemme, Karoline Reinhardt, Elke E. Schmidt, Dieter Schönecker, Oliver Sensen, Amelie Stuart. (shrink)

This Reply offers my answers to Cheshire Calhoun’s, Elizabeth Brake’s, and Monika Betzler’s wonderful contributions to the Criminal Law and Philosophy symposium on Being Sure of Each Other (2020). Their contributions focus respectively on the conceptual and normative foundations of my defence of our human rights to have adequate social inclusion, the harms that might flow from recognising such rights as human rights, and the impact such rights can have on our most intimate relations. My replies aim both to (...) clarify and solidify the argumentative basis for my account and to show that whatever harms and wrongs might dog the recognition of social human rights are nothing compared to the injustices that flow–and have long-flowed–from ignoring or attacking these rights. (shrink)

In the first half of the 15ᵗʰ century there was a coherent philosophical system of teaching at the Jagiellonian university, so-called ars vetus, concerning the interpretation of three treatises: Aristotle’s Categories and Hermeneutics and Porphyry’s Isagoge. The question-commentaries on the Categories that have been preserved in several manuscripts show astonishing similarity in solving individual problems – there are three copies of Benedict Hesse’s commentary and one copy of Paul of Pyskowice’s work, moreover, in BJ 1941 there is an anonymous commentary (...) on the Categories that is also very close to the ones mentioned before, to prove that fact. This paper, discussing the four-fold division of opposition in those Polish commentaries on Aristotle’s Categories, is part of the studies on the manuscript material that has not been critically edited yet. The main goal is to show the philosophical views on contraries, contradictories, relatives and possession and privation in a wider perspective, comparing the Polish commentaries’ doctrine with the authoritative text itself. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Evolution and Creation—A Response to Michael Chaberek's Critique of Theistic EvolutionMariusz Tabaczek O.P.Translated by Monika Metlerska-ColerickIntroductionMichael Chaberek's critique of my "Afterword" to the Polish edition of Thomistic Evolution: A Catholic Approach to Understanding Evolution in the Light of Faith is essentially focused on three points. First of all, Chaberek questions my thesis supporting the compatibility of evolutionary theory with the Christian faith in creation. Secondly he discounts the (...) possibility of reconciling evolution with the Aristotelian-Thomistic philosophical tradition. Finally he provides arguments undermining the theory of evolution as the best scientific explanation for the diversity of species observable in the world.1 Because I do not undertake an analysis [End Page 255] of strictly biological problems in the "Afterword," in the present response I will concentrate on the first two points only.2 I trust that engaging in a discussion with Chaberek's views in this respect provides an opportunity to broaden and clarify my position regarding the issue which is the subject of our dispute. To begin with, I would like to stress that, in exploring the topic from the perspective of the Aristotelian-Thomistic tradition of philosophy and theology, I am moving in the sphere of possible interpretations and new approaches. Therefore, I do not treat the aforementioned tradition in an inflexible and dogmatic manner.3 [End Page 256]The Definition of CreationI should start my response to Chaberek's critique by invoking the definition of creation as elaborated by Aquinas. After all, it seems that the disagreement referred to in the present article focuses, to a large extent, on the comprehension of the divine act of creation. My views on this matter are not, in my estimation, a significant alteration of the teaching of St. Thomas. Rather, they are an attempt at drawing conclusions from some of his intuitions regarding creation, which appear in various sections of the body of his work.4According to St. Thomas, the word "creation" (creatio) has two crucial and inextricably linked meanings: (I) creation in an active sense (divine action) and (II) creation in a passive sense (receiving divine action). Within the scope of the first meaning, St. Thomas distinguishes between: (Ia) the primary act of creation, defined as bringing the entirety of being into existence out of nothing (ex nihilo), without any prior existing matter, and (Ib) maintaining contingent beings in their existence and essence. The consequence of (Ia) and (Ib) is contingent beings' full dependence on God regarding what they are and the fact that they are (exist), which determines the essence of creation in the passive sense (II).Regarding (Ia), St. Thomas—in a neo-Platonic vein, in support of the claim that nothingness cannot be the object of God's action in the act of creation—states that "we must consider not only the emanation of a particular being from a particular agent, but also the emanation of all being from the universal cause, which is God; and this emanation we designate by the name of creation" (ST I, q 45, a. 1, corp.). It is worth adding here that, according to St. Thomas, the matter, which is the result of the act of creation, is not indefinite, as is assumed by Chaberek when he refers to creation as the bringing out of nothing "of a certain primordial matter of an indefinite form."5 On the contrary, Aquinas states explicitly that "primary matter was not created altogether formless, nor under any one common form, but under [End Page 257] distinct forms" (ST I, q. 66, a. 1, corp., ad 2), enumerating, at this point, the forms of the four elements: earth, water, air, and fire.In reference to (Ib), St. Thomas defines the divine act of maintaining contingent beings in existence and essence (in the fact that they are, as well as in what they are) as conservatio rerum. What is more, even though he emphasizes that "the preservation of things by God is a continuation of that action whereby He gives existence" (ST I, q. 104, a. 1, ad 4), Aquinas does not employ the currently popular concept of continual creation (creatio continua). It seems that... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Afterword to the Polish Edition of Thomistic EvolutionA Catholic Approach to Understanding Evolution in the Light of Faith by Nicanor Pier Giorgio Austriaco, O.P., James Brent, O.P., Thomas Davenport, O.P., and John Baptist Ku, O.P.*Mariusz Tabaczek O.P.Translated by Monika Metlerska-Colerick[End Page 225]Thomistic Evolution: A Catholic Approach to Understanding Evolution in the Light of Faith, by Nicanor Pier Giorgio Austriaco, O.P., James Brent, O.P., Thomas Davenport, O.P., and John (...) Baptist Ku, O.P., is an intriguing attempt at a comprehensive approach to the question of theistic evolutionism from the perspective of Thomistic tradition. The breadth of the approach offered by the authors, starting with the problem of the relationship between reason and faith and subsequently reaching to the foundations of the philosophy of nature, natural theology, and theology of creation, as well as biblical exegesis, provides an appropriate introduction and background for the analysis of a thesis suggesting that it is possible for God to create new species of living organisms (including the Homo sapiens sapiens species) through the processes of evolution. The comprehensible manner in which the discussed questions are presented renders the book accessible to a wide audience.Although one should agree with the main thesis formulated by the authors of Thomistic Evolution regarding the possibility of God expressing his creative power through the emergence of new species of living beings by way of evolution, it also has to be noticed that the arguments they present do not always take fully into consideration certain significant difficulties that arise along the way and the resulting necessity to broaden and adjust the ideas of the Aristotelian-Thomistic tradition to present-day standards in order for it to engage in a dialogue with contemporary science. In the absence of such broadening and adjusting, one might arrive at an overly simplified view of things in which St. Thomas himself would easily come to agree with the main assumptions of theistic evolutionism. Our aim, thus, is to reveal a more profound level of the complexity of the debate regarding the Thomistic view of creation and evolution.St. Thomas and EvolutionismOn the one hand, Brent's intuition seems justified that the Thomistic definition of creation as being dependent on God in existence (depicted in chapter 7) is compatible with both the image of the world in which various kinds of species are immutable and the image of the world in which they are subject to change. On the other hand, we cannot forget that St. Thomas himself perceived forms of species as permanently fixed in the moment of the first member of a given species coming into existence and—consequently—not being subject to any future alterations. Hence, reproduction, according to Aquinas, serves as a continuation of species without the introduction of any significant variations: "Nature produces like from like. Now the thing generated is like its generator in [End Page 226] species and form. Therefore the form is produced by the action of the generator and not by creation" (De pot., q. 3, a. 8, sc 4).This quotation from Questiones disputatae de potentia points us towards the theological question of creation. Here, we must emphasize that, according to St. Thomas, at its origin, the world was perfect as to the number of created species. Hence, "something can be added every day to the perfection of the universe, as to the number of individuals, but not as to the number of species" (ST I, q. 118, a. 3, ad 2).1 It is true that Aquinas allowed for the arising of new animal species through putrefaction caused by the power of the sun, as well as through the crossbreeding of already existing species (see ST I, q. 73, a. 1, ad 3, a portion of which is quoted by Austriaco in chapter 24). However, the emergence of new forms of animal organisms in this way by no means implies or anticipates the theory of their descent from a common ancestor by way of evolutionary transformation. Nor is it a manifestation or expression of the most basic rules governing nature, but rather an exception and a departure from their regularity... (shrink)

The concept of vulnerability is widely used in human rights policy documents, reports, and case law focusing on the impacts of climate change on human rights. In academic discussions, the concept, however, has also sparked a discussion on its benefits and challenges for the advancement of human rights, especially concerning the principles of equality and non-discrimination. This article aims at contributing to this debate from a frame-analytical perspective. In social sciences, frame-analysis is a form of discourse analysis which focuses on (...) the consequences of different concepts for legal, political, and social discussions and norms. With the example of selected UN documents on different human rights issues in the context of climate change, the article, firstly, analyzes whether and how the concept of vulnerability is defined in the documents and why it is used in the documents. Secondly, it is elaborated to which individuals and groups the concept is applied. Thirdly, it is discussed how vulnerability is conceptualized in relation to or in distinction to the concepts of inequality and discrimination. In a further section it is analyzed what narratives are mobilized by the frame of vulnerability. The article concludes that from a discourse-analytical perspective the frame of vulnerability mobilizes problematic narratives which has gendered and racialized implications for those labeled vulnerable. (shrink)

Recent trends in the debate about natural kinds tend towards increasingly permissive and practice-oriented views. I argue that while these accounts—which I characterize using Boyd’s ([1991]) term ‘enthusiasm’—offer several helpful insights, they often lack the normative force that they want to have; that is, they cannot provide an account of what makes something a good or bad, better or worse, kind for scientific pursuits. I argue that such accounts can regain a minimal sense of normativity in two ways. The first, (...) which has already been widely embraced by theorists, is to index the appropriateness of a scientific kind to the domain within which it is situated. While this is a good solution, it is not clear how it can be applied in interdisciplinary and cross-domain research pursuits, which are increasingly common. The second way of regaining normativity—which is especially, but not exclusively, effective for such cross-domain pursuits—is to attend to the stage at which scientific research is occurring. (shrink)

Many women are initially unable to contract the pelvic floor muscles (PFMs) properly, activating other muscle groups before, or instead of, PFM. Numerous authors have proved that biofeedback can be an ideal tool supporting learning of the PFM contraction. However, there is currently a lack of scientific data on how many biofeedback sessions are necessary in this educational process. In this study we aimed at assessing the effects of one-time electromyography (EMG) biofeedback session on the order in which PFM are (...) activated (so called firing order) during conscious contractions in relation to selected synergistic muscles in pregnant, continent women. A randomized controlled trial was conducted in 90 healthy nulliparous women with uncomplicated pregnancies and without diagnosed urinary incontinence. We divided the participants into a biofeedback group (50) and a control group (40). They were, respectively: 30 ± 4 and 30 ± 4 years old, at their 23 ± 5 or 25 ± 7 week of gestation and presented 23 ± 5 or 24 ± 5 kg/m2 BMI value (M + SD). Surface EMG with vaginal probes has been used to assess the PFM firing order in selected tasks: in five 3-s maximal contractions (quick flicks), five 10-s contractions, and in a 60-s contraction (static hold). We used the 1–5 scale, where “1” meant the best score, awarded when PFM was activated first in order. The most important finding of our study is that a single EMG biofeedback substantially improved the PFM contractions in pregnant women. First, when applying one-time biofeedback session, more women maintained correct technique or improved it in the second assessment, compared to the control group (73 vs. 65%). Secondly, using the quantitative and qualitative analysis with the Chi-square McNamara B/C test, in the biofeedback group we observed a statistically significant improvement of PFM firing order in four tasks: in the first quick flicks (p = 0.016), third quick flicks (p = 0.027), fifth quick flicks (p = 0.008), and in the first 10-s contractions (p = 0.046). In the control group we observed better outcome only in one motor task: in the fourth 10-s contraction (p = 0.009). Given the positive effects of a single session of EMG biofeedback on the firing order in the PFM contractions, it should be recommended for pregnant women without urinary incontinence to teach them how to perform PFM exercises correctly. (shrink)

The notion of empathy has been explicated in different ways in the current debate on how to understand others. Whereas defenders of simulation-based approaches claim that empathy involves some kind of isomorphism between the empathizer’s and the target’s mental state, defenders of the phenomenological account vehemently deny this and claim that empathy allows us to directly perceive someone else’s mental states. Although these views are typically presented as being opposed, I argue that at least one version of a simulation-based approach—the (...) account given by de Vignemont and Jacob—is compatible with the direct-perception view. My argument has two parts: My first step is to show that the conflict between these accounts is not—as it seems at first glance—a disagreement on the mechanism by which empathy comes about. Rather, it is due to the fact that their proponents attribute two very different roles to empathy in understanding others. My second step is to introduce Stein’s account of empathy. By not restricting empathy to either one of these two roles, her process model of empathy helps to see how the divergent intuitions that have been brought forward in the current debate could be integrated. (shrink)

The current study investigated age differences in the use of attentional deployment, positive reappraisal and suppression while regulating responses to sadness-eliciting content. We also tested to what extent these emotion regulation strategies were useful for each age group in managing response to age-relevant sad information. Forty-two young participants (Mage = 18.5, SE =.15) and 48 older participants (Mage = 71.42, SE = 1.15) watched four sadness-eliciting videos (about death/illness, four to five minutes long) under four conditions—no-regulation (no regulation instructions), attentional (...) deployment (divert attention away), positive reappraisal (focus on positive outcomes) and suppression (conceal emotional expressions). We assessed negative emotional experience, expression, skin conductance level (SCL) and visual fixation duration while participants watched the emotional clips and followed the instructions for each condition. Results suggest that older adults were more successful than younger adults at implementing both attentional deployment and positive reappraisal. Ability to suppress emotions appears to remain stable with age. Within age-group comparisons suggested that for the older adults, positive reappraisal was a more useful emotion regulation strategy than the others, while the pattern among younger adults was less conclusive. Age-relevant differences in motivation and successful emotion regulatory efforts based on theoretical and empirical literatures are discussed. (shrink)

What’s the basis for considering an egg donor a genetic parent but not a mitochondrial donor? I will argue that a closer look at the biological facts will not give us an answer to this question because the process by which one becomes a genetic parent, i.e., the process of reproduction, is not a concept that can be settled by looking. It is, rather, a concept in need of philosophical attention. The details of my argument will rest on recent developments (...) in biological technology, but the persuasiveness of my argument will turn on the history of another biological concept, death. Given some important similarities between the two concepts, the way in which ‘death’ evolved in the recent past can provide guidance on how we should think about ‘reproduction.’. (shrink)

The article is an attempt at interpreting two Jarosław Iwaszkiewicz’s texts: Brzezina and Sława i chwała. The authoress examines the presence in texts by Jarosław Iwaszkiewicz two interrelated elements: tuberculosis and music. This relationship resulted from the characteristic image of tuberculosis – the disease of the soul, which gave ill features artists. Music became a special language, which spoke of tuberculosis in Jarosław Iwaszkiewicz’s texts. This is particularly interesting falls in the story Brzezina and the novel Sława i chwała. Music (...) accompanies the heroes dying there in various forms: nature sounds, piano, radio, singing women. (shrink)

It has become increasingly common to talk about the second person in the theory of mind debate. While theory theory and simulation theory are described as third person and first person accounts respectively, a second person account suggests itself as a viable, though wrongfully neglected third option. In this paper I argue that this way of framing the debate is misleading. Although defenders of second person accounts make use of the vocabulary of the theory of mind debate, they understand some (...) of the core expressions in a different way. I will illustrate this claim by focusing on Reddy’s and Gallagher’s accounts and argue that these authors use the notions of knowing and of understanding other minds differently than traditionally assumed. As a consequence, second person accounts thus conceived do not directly address the questions that gave rise to the theory of mind debate. They invite us, however, to critically reflect upon the way the debate has been set up. (shrink)

Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...) implications drawn from comparative genomic studies largely unwarranted, if not completely mistaken. †To contact the author, please write to: Department of Philosophy, University of Utah, 215 South Central Campus Drive, Carolyn Tanner Irish Humanities Building, 4th Floor, Salt Lake City, UT 84112; e‐mail: monika[email protected]. (shrink)

The aim of this article is to point out the basic areas of judgment made by employees considering the ethical or unethical behaviour of employers in the workplace. The authors analyse this subject from three perspectives: The first one is labour legislation in Poland; the second is the perspective of employers, especially codes of ethical standards created by contemporary organizations, and the third perspective is the point of view of employees. The conclusions in this area have been made on the (...) basis of research in two Polish insurance companies. The authors attempted to create a ranking of ethical elements significant for employees. Such knowledge could be very useful for creating proper personnel policy in any organisation. (shrink)

In this essay, the reminiscences of Margaret Fuller, feminist activist and member of the American Transcendentalist movement, from her journey to the Great Lakes region, entitled Summer on the Lakes, are considered in the light of EcoGothic considerations. The essay shows how Fuller’s journey disillusioned her about progress and led to abandoning the serene vision of nature and landscapes reflected in the works of Transcendentalists. The destruction of nature and landscape verging on an ecological catastrophe is presented by Fuller in (...) the perspective of the Gothic, as a price for the technological development driven by the capitalist economy. The Gothic character of Summer on the Lakes derives from the mental condition of the writer and a pessimistic vision arising from the debunking of the myth of America as a virgin land. Fuller’s work constitutes an EcoGothic tribute to the indigenous inhabitants of America—but also a Gothic live burial of the Native Americans who do still live in the regions she visits—as well as to Mariana and Frederica, unusual and gothicized women excluded from society. By bringing together Fuller’s observations about nature, indigenous peoples and marginalized women, the essay shows how Fuller’s text prophetically announces the beginning of the end of the American environment. (shrink)

_Reinventing Film Studies_ Edited by Christine Gledhill and Linda Williams London: Arnold Publishers, 2000 ISBN 0-340-67723-6 464 pp.

Human–nonhuman chimeras have been the focus of ethical controversies for more than a decade, yet some related issues remain unaddressed. For example, little has been said about the relationship between the origin of transferred cells and the morally relevant capacities to which they may give rise. Consider, for example, a developing mouse fetus that receives a brain stem cell transplant from a human and another that receives a brain stem cell transplant from a dolphin. If both chimeras acquire morally relevant (...) capacities as a result of transplantation, and if those capacities are indistinguishable, should the difference in cell origin matter to how we classify these creatures? I argue that if morally relevant capacities are easy to detect, cell origin is irrelevant to how the chimera ought to be treated. However, if such capacities are hard to detect, cell origin should play a role in considerations about how to treat the chimera. (shrink)

In dieser Studie untersucht Monika Palowski das kontrovers diskutierte Phänomen der Klassenwiederholung erstmals aus Perspektive der Wissenssoziologischen Diskursanalyse. Anhand von insgesamt über 700 Texten aus Erziehungswissenschaft und Printmedien werden machtvolle Diskursstränge und -formationen rekonstruiert, die nicht nur die Wahrnehmung von Klassenwiederholung und schulischer Selektion, sondern auch der betroffenen Subjekte je spezifisch präfigurieren und dadurch Klassenwiederholung teils auch legitimieren. Die Ergebnisse der Analyse sind daher einerseits für die erziehungswissenschaftliche Auseinandersetzung mit schulischer Selektion und Bildungsungerechtigkeit relevant, andererseits aber auch für die (...) Diskurs- und Subjektivierungsforschung. (shrink)

This paper argues that critical realism is one of the main theoretical orientations of the social sciences in the twentieth and twenty-first centuries. Critical realism aims to study the transcende...

This book provides a detailed commentary on the classic monograph by Alfred Tarski, and offers a reinterpretation and retranslation of the work using the original Polish text and the English and German translations. In the original work, Tarski presents a method for constructing definitions of truth for classical, quantificational formal languages. Furthermore, using the defined notion of truth, he demonstrates that it is possible to provide intuitively adequate definitions of the semantic notions of definability and denotation and that the notion (...) in a structure can be defined in a way that is analogous to that used to define truth. Tarski’s piece is considered to be one of the major contributions to logic, semantics, and epistemology in the 20th century. However, the author points out that some mistakes were introduced into the text when it was translated into German in 1935. As the 1956 English version of the work was translated from the German text, those discrepancies were carried over in addition to new mistakes. The author has painstakingly compared the three texts, sentence-by-sentence, highlighting the inaccurate translations, offering explanations as to how they came about, and commenting on how they have influenced the content and suggesting a correct interpretation of certain passages. Furthermore, the author thoroughly examines Tarski’s article, offering interpretations and comments on the work. (shrink)

The concept of the dialogical soul proposed by Joseph Ratzinger is a contemporary attempt to describe the anthropology of humanity in terms of basic, fundamental theological concepts. Epistemological approach of the dialogic soul is not about the division, but co-existence in the concept of humanity significantly different anthropological concepts. Modern neuroscience, although following completely different paths of knowing is currently concerning an important issue "of the embodied mind". Such a holistic effort to discover the truth about the man, though carried (...) out on completely different epistemological platforms, however, have some points in common. The difficulty in finding a common language for the dialogue in this field can be overcome and lead to dialogue, which is extremely difficult but doable. We must, however, at the beginning formulate certain fundamental axioms that define class concepts used in different areas of scientific activity. The concept of dialogical soul of Ratzinger’s now exceeds the barrier of scientific paradigms axioms. It does not stop on the vision of human oneself, but recognition of one in the area of relationships and makes room for a substantial dialogue with the world of modern science. (shrink)

The relationship between teacher and student is an important element of school education and as such irreplaceable: If we want schools to be good places for those who teach and learn there, we must make sure that the educational relationships between teachers and students are good, too. In research about school education, surprisingly little attention is paid to the normative dimension of the relationship between teacher and student. This lacuna points to a desideratum in the philosophy of education: More should (...) be said about the normative structure of the teacher-student relationship, its role in teaching and learning, and its final value for teacher and student. Answering these fundamental philosophical questions is the core of this book. It offers a normatively rich concept of a good teacher-student relationship that is based on the analysis of two major relationship goods: trust and care. Moreover, the book explains the instrumental value of a good educational relationship for the student’s achievement of epistemic aims of school education as well as the final value of such a relationship for teacher and student. (shrink)

Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to their human counterparts to (...) simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)