A decade ago, leptin (from the greek lepto meaning ‘thin’) was identified as the product of the ob gene.1 This adipocyte‐derived hormone was found to suppress feeding and stimulate thermogenesis, and was thus proposed as a mediator in a negative feedback loop that controls body adiposity. This discovery led to a rapid revolution in the understanding of neurobiological mechanisms regulating obesity. However, while leptin's first life was as an adipostat, it is now known to have a wide range of additional (...) neuroendocrine, metabolic and behavioural functions in the CNS and periphery. Remarkably, the pleiotropic nature of the hormone continues to be extended with the recent publication of two papers that expand on leptin's neurobiological actions in the CNS.2,3 They indicate novel regulatory roles for the hormone in both synaptic plasticity and axon guidance. Crucially, in light of the rising incidence of obesity in modern society, both of the studies reveal leptin‐mediated links between nutrition and neurodevelopment, findings that have further implications for leptin's role in the regulation of energy homeostasis. BioEssays 26:1043–1045, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

A central question in neuroscience and psychology is how the mammalian brain represents the outside world and enables interaction with it. Significant progress on this question has been made in the domain of spatial cognition, where a consistent network of brain regions that represent external space has been identified in both humans and rodents. In rodents, much of the work to date has been done in situations where the animal is free to move about naturally. By contrast, the majority of (...) work carried out to date in humans is static, due to limitations imposed by traditional laboratory based imaging techniques. In recent years, significant progress has been made in bridging the gap between animal and human work by employing Virtual Reality (VR) technology to simulate aspects of real-world navigation. Despite this progress, the VR studies often fail to fully simulate important aspects of real-world navigation, where information derived from self-motion is integrated with representations of environmental features and task goals. In the current review, we provide a brief overview of animal and human imaging work to date, focusing on commonalties and differences in findings across species. Following on from this we discuss VR studies of spatial cognition, outlining limitations and developments, before introducing mobile brain imaging techniques and describe technical challenges and solutions for real-world recording. Finally, we discuss how these advances in mobile brain imaging technology, provide an unprecedented opportunity to illuminate how the brain represents complex multifaceted information during naturalistic navigation. (shrink)

It is often assumed that pet ownership improves peoples’ wellbeing, but evidence of this pet effect has been mixed. We extended past research on pet personality, the pet effect, and value congruence to examine whether people perceive their pets to have humanlike values and if owner-pet values similarity has a positive effect on owners’ life satisfaction. In a large and diverse sample of Australian dog and cat owners, we find that people imbue their dogs and cats with humanlike values in (...) a way that reflects the theoretical circular structure of values. Importantly, perceptions of the values of dogs and cats differed in that dogs were perceived to prioritize more social-focus values, whereas cats were perceived to prioritize more personal-focus values. Additionally, we find that similarity in the values profile of dog owners and their dogs is positively associated with life satisfaction, but this was not the case for cats. However, when we examined associations between individual values similarity and life satisfaction, our results suggest a more complex and nuanced picture of both direct and indirect similarity effects. (shrink)

For the successful achievement of evidence-based practice, clinicians, managers and purchasers need evidence on whether a particular intervention works and ways to judge the appropriateness of the outcome criteria and measures used. Guidance is needed on what outcome measure to use, especially within routine clinical care settings. Beginning with a re-clarification of the difference between a health status and an outcome measure, the paper presents an evaluative checklist for use by clinical audit and research staff to review outcome measures for (...) use in routine care settings. Central features include the user-centredness of the measure, its psychometric properties, feasibility of use and utility. The applicability of the checklist is illustrated for outcome measurement in diabetes and stroke care. A modified form of the checklist is proposed for use by the busy clinician as an aid to the critical review of research papers within the context of evidence-based practice and to aid health care practitioners' choice of which outcome measure(s) to use within routine clinical care. (shrink)

The issues involved in deciding whether to use artificial methods of delivering hydration and nutrition are often very difficult for patients, families, and health care providers. Once private and personal matters, these decisions now frequently involve the judicial system. Five years ago, Hospice of Washington recognized the need for a written policy and wrote the one published here. Its goal is to respect individual preferences and family concerns while addressing the nutrition and hydration needs of dying patients. The policy sets (...) parameters on the issue, provides basic information, and encourages crafting the most fitting resolution to each situation. (shrink)

We develop a novel argument scheme tailored to debates surrounding public votes on a state action. It can be used to propose reasons for voting “yes” or “no” and allows for natural reconstructions of such debates. These reconstructions are of particular use to voters trying to weigh the pros and cons of the proposed state action. The scheme for proposing reasons helps answering two questions: What changes will the proposed state action bring with it? And are these changes good or (...) not? Using the scheme, we derive a three-layered structure of public debates surrounding votes that aides in constructing systematic and comprehensive overviews. The scheme for proposing reasons also lends itself to concise summaries for voter information and can be incorporated into more general deliberation dialogues. (shrink)

This volume illuminates the processes of self maintenance and change.

A leading idea of cultural evolutionary theory is that for human cultures to undergo evolutionary change, cultural transmission must generally serve as a high-fidelity copying process. In analogy to genetic inheritance, the high fidelity of human cultural transmission would act as a safeguard against the transformation and loss of cultural information, thus ensuring both the stability and longevity of cultural traditions. Cultural fidelity would also serve as the key difference-maker between human cumulative cultures and non-human non-cumulative traditions, explaining why only (...) us humans, with our uniquely high-fidelity transmission capabilities, are capable of evolving and sustaining complex traditions. But what does it mean for cultural transmission to be more or less faithful? This article has two objectives. The first is to clarify the meaning and uses of the concept of cultural fidelity and to evaluate their explanatory import. I argue that cultural evolutionists use several fidelity concepts (episodic, propensity, and generalized fidelity), concepts that I will define and clarify. The second objective is to challenge the explanatory significance of a general notion of fidelity (generalized fidelity) as being both explanatorily meaningful and operationalizable. I conclude that if fidelity is to serve as an explanation of the key differences between human cumulative cultures and non-human non-cumulative traditions, then the concept will have to be redesigned and rely on different assumptions. 1Introduction 2Generalized Fidelity 2.1The need for an explanatory concept of fidelity 2.2Three conditions for a general notion of cultural fidelity 3Episodic Fidelity 3.1Measuring episodic fidelity 3.2The relevance problem 3.3Explanatory pluralism 3.4The incommensurability of fidelity metrics 4Propensity Fidelity 5Fidelity as an Explanatory Concept 5.1Explaining cultural stability 5.2Explaining human distinctiveness 6Conclusion. (shrink)

High-fidelity cultural transmission, rather than brute intelligence, is the secret of our species’ success, or so many cultural evolutionists claim. It has been selected because it ensures the spread, stability and longevity of beneficial cultural traditions, and it supports cumulative cultural change. To play these roles, however, fidelity must be a causally-efficient property of cultural transmission. This is where the grain problem comes in and challenges the explanatory potency of fidelity. Assessing the degree of fidelity of any episode or mechanism (...) of cultural transmission always depends upon an investigator’s choice of grain of description at which cultural traditions are being studied. The fidelity of cultural transmission then appears to be relative to the granularity at which one approaches cultural variation, and since there is a multiplicity of grains of description by which the same tradition can be studied, there results a multiplicity of measures of fidelity for a same event or mechanism of cultural transmission. If this is correct, because fidelity is always relative to the grain of description dictated by the local and specific research interests of the investigator, then there seems to be no fact of the matter as to whether cultural transmission is faithful or not, independently from a researcher’s framework of analysis. The aims of this paper are to offer a conceptual clarification of the grain problem in cultural evolution, to assess its causes, to unpack its epistemological implications, and to examine its reach and consequences for a science of cultural evolution. (shrink)

There is an emerging consensus that we are experiencing radical change in the way that science is organized and performed. Frequently described as a shift from Mode 1 to Mode 2, this view emphasizes application, transdisciplinarity, collaboration, and accountability. This article examines the ways in which U.K. public sector scientists make sense of scientific endeavor. The data reveal that the extent to which science is being constructed varied both across and between institutions. Data highlight how individual scientists weave their own (...) paths through the changing discourses of science, constructing new understandings that do not fit neatly into any binary framework for understanding. (shrink)

There is little empirical evidence showing a direct link between a capacity for statistical learning (SL) and proficiency with natural language. Moreover, discussion of the role of SL in language acquisition has seldom focused on literacy development. Our study addressed these issues by investigating the relationship between SL and reading ability in typically developing children and healthy adults. We tested SL using visually presented stimuli within a triplet learning paradigm and examined reading ability by administering the Wide Range Achievement Test (...) (WRAT-4; Wilkinson & Robertson, 2006). A total of 38 typically developing children (mean age of 9;5 years, range 6;4–12;5) and 37 healthy adults (mean age of 21 years, range 18–34) were assessed. In children, SL was significantly related to reading ability. Importantly, this relationship was independent of grade and also age. The adult data, too, revealed that SL was significantly related to reading ability. A regression analysis of the combined child and adult data revealed that SL accounted for a unique amount of variance in reading ability, after age and attention had been taken into consideration. For the first time, this study provides empirical evidence that a capacity for more effective SL is related to higher reading ability in the general population. (shrink)

Volume 20, Issue 8, August 2020, Page W12-W13.

For a population to undergo evolution by natural selection, it is assumed that the constituents of the population form parent-offspring lineages, that is, that they must reproduce. I challenge this assumption by dividing the notion of reproduction into two subprocesses, that is, multiplication and inheritance, that produce parent-offspring lineages between the parts of a population, and I show that their population-level roles, generation and memory, respectively, can be effected by processes that do not rely on such local-level lineages. I further (...) argue that these two population-level processes, not local parent-offspring lineages, are necessary conditions for a population to undergo Darwinian evolution. (shrink)

What is wrong with participating in a democratic decision-making process, and then doing something other than the outcome of the decision? It is often thought that collective decision-making entails being prima facie bound to the outcome of that decision, although little analysis has been done on why that is the case. Conventional perspectives are inadequate to explain its wrongness. I offer a new and more robust analysis on the nature of voting: voting when you will accept the outcome only if (...) the decision goes your way is an act of bad faith: you are not taking part in a ‘process that decides what we will do’. This analysis sheds light on understanding the intrinsic nature of voting and what we are doing when we make decisions collectively. (shrink)

This study examines how authentic leadership influences team performance via the mediating mechanism of team reflexivity. Adopting a self-regulatory perspective, we propose that authentic leadership will predict the specific team regulatory process of reflexivity, which in turn will be associated with two outcomes of team performance, effectiveness and productivity. Using survey data from 53 teams in three organizations in the United Kingdom and Greece and controlling for collective trust, we found support for our stated hypotheses with the results indicating a (...) significant fully mediated relationship. As predicted the self-regulatory behaviors inherent in the process of authentic leadership served to collectively shape team behavior, manifesting in the process of team reflexivity, which, in turn, positively predicted team performance. We conclude with a discussion of how this study extends theoretical understanding of authentic leadership in relation to teamwork and delineate several practical implications for leaders and organizations. (shrink)

Designed for Pilates and yoga teachers, health and rehabilitation professionals, The Power and the Grace demystifies functional movement and integrates the science of movement with the art of teaching it. It aims to help the holistically minded movement professional achieve rewarding results in neuromuscular function. From brain science to physics, fascia to emotion, this book distils a seemingly complex field into a practical and instantly usable approach that will resonate with movement teachers at all levels of experience. Find the color (...) in your language; learn the difference between talking to the brain or to the mind; and discover how to communicate the intention and sense of a movement with ease! (shrink)

Social transmission is at the core of cultural evolutionary theory. It occurs when a demonstrator uses mental representations to produce some public displays which in turn allow a learner to acquire similar mental representations. Although cultural evolutionists do not dispute this view of social transmission, they typically abstract away from the multistep nature of the process when they speak of cultural variants at large, thereby referring both to variation and evolutionary change in mental representations as well as in their corresponding (...) public displays. This conflation suggests that differentiating each step of the transmission process is redundant. In this paper, I examine different forms of interplay between the multistep nature of social transmission and the metric spaces used by cultural evolutionists to measure cultural variation and to model cultural change. I offer a conceptual analysis of what assumptions seem to be at work when cultural evolutionists conflate the complex causal sequence of social transmission as a single space of variation in which populations evolve. To this aim, I use the framework of variation spaces, a formal framework commonly used in evolutionary biology, and I develop two theoretical concepts, ‘technique’ and ‘technical space’, for addressing cases where the complexity of social transmission defies the handy assumption of a single variation space for cultural change. (shrink)

We contribute to the literature on ethics in the professions by theorizing how global mobility precipitates professional insecurity and constrained moral agency. We present our findings of a study of accountants migrating to Canada. Using postcolonial theory and relational/poststructuralist theories of identity and ethics, we contrast the experiences of marginalized and privileged migrant accountants to show how those with “diverse” social identities are not recognized by professionals in Canada and must seek recognition from Canadian colleagues, employers, and clients to reconstitute (...) their professional identities and moral agency. We discuss the implications of the exclusion and marginalization of professionals for migrants, the profession, and society more generally. (shrink)

In today's business world, ethics is not simply a peripheral concern of executive boards or a set of supposed constraints on free enterprise. Ethics stands at the very core of our working lives and of society as a whole, defining the public image of the business community and the ways in which individual companies and people behave. What people do at work--and how they think about work--determines their attitudes and aspirations, affecting and even structuring their personal lives and habits. Working (...) from this premise, Honest Work: A Business Ethics Reader provides a practical overview of business ethics that concentrates on the ethical problems and dilemmas students are most likely to face in their prospective work environments. Classic and recent articles and cases cover a broad spectrum of issues and concerns--from private ethical dilemmas to larger considerations of corporate values--and propose guidelines for thinking about the business world in a moral context. Each reading and case is followed by lively questions for discussion. Offering a welcome alternative to the impersonal tone of most business ethics texts, the editors address students in an appealing and conversational manner. They provide engaging chapter introductions that include personal narratives and also present the ideas of great philosophers in a unique way--as emails. Ideal for introductory undergraduate and MBA courses in business ethics, Honest Work: A Business Ethics Reader can be read as a coherent narrative but also offers instructors great flexibility, as its various chapters, readings, and cases can be pursued in almost any order. A Companion Website featuring chapter objectives and summaries, study questions, self-tests, and off-site links of interest will soon be available. An Instructor's Manual with Test Bank is available to adopters. (shrink)

Published to coincide with an exhibition at Open Eye Gallery in Liverpool, Women on the Waterfront combines essays, first-person accounts, and stunning photographic images to tell the story of the twentieth-century women who worked, and continue to work, in and around the city’s waterfront—or who abandoned urban life to earn a living at sea. At the heart of the project are Michelle Sank’s remarkable and vibrant portraits of the women she has photographed, alongside their own words—alternately chillingly real in their (...) gritty depictions of life on the waterfront and remarkably confident, vulnerable, and even otherworldly. Enhancing these already extraordinary stories is Joanne Lacey’s rich essay, “Journey to the Water’s Edge,” which examines the story behind this fascinating archive and its origins in Lacey’s own family history. (shrink)

The cumulative open-endedness of human cultures represents a major break with the social traditions of nonhuman species. As traditions are altered and the modifications retained along the cultural lineage, human populations are capable of producing complex traits that no individual could have figured out on its own. For cultures to produce increasingly complex traditions, improvements and modifications must be kept for the next generations to build upon. High-fidelity transmission would thus act as a ratchet, retaining modifications and allowing the historical (...) buildup of complex traditions. Mechanisms acting against slippage are important, of course, but cultures also need to move forward for the ratchet to retain anything important. In this article, I argue that studies of modification-generating processes and the many ways they shape cumulative culture have been overlooked. Key to a better understanding of cultural modification processes is taking seriously that cultural traditions consist of complex, hierarchically structured recipes. Taking such structures seriously and assessing the different ways they can vary in cultural design space, a novel picture for the onset of cumulative cultural evolution emerges. I argue that a possible impediment for cumulative culture in nonhuman animals may in fact reside not so much in the fidelity of their social transmission but rather in the constraints, internal and external, on their capacity to modify complex, hierarchically structured cultural recipes. (shrink)

Chapters in this outstanding text are grouped into sections focusing on major themes. Each features an overview, a debate chapter, and several viewpoint chapters. This format gives students the opportunity fo analyze conflicting viewpoints and encourages critical thinking. The text boasts a well-known and well-respected author group, allowing students to learn from recognized leaders in the field. (Includes a FREE MERLIN website. at:www.harcourthealth.com/merlin/Dochterman/current/).

There is a plurality of theoretical approaches, methodological tools, and explanatory strategies in the social sciences. Different fields rely on different methods and explanatory tools even when they study the very same phenomena. We illustrate this plurality of the social sciences with the studies of crowds. We show how three different takes on crowd phenomena—psychology, rational choice theory, and network theory—can complement one another. We conclude that social scientists are better described as researchers endowed with explanatory toolkits than specialists of (...) some specific social domain. Social scientists’ toolkits are adapted for identifying and specifying the role of specific causal factors among the multiple factors that produce social phenomena. These factors can be, in a nonexclusive way, economic incentives, psychological processes, the ecology, or aspects of the social and cultural environment. The plurality of methods and theories in the social sciences flies in the face of the project to unify the sciences associated with the positivists of the nineteenth and twentieth centuries. Yet, the compatibility and consilience of theories and practices still have epistemic value: they enable the development of more powerful and robust theories and they allow the advent of interdisciplinary studies. We present the integrative stance as the will to improve compatibility and consilience across fields, yet recognize that the plurality of causes of social phenomena invite a diversity of methodological and theoretical tools. We conclude by characterizing naturalism as an integrative stance applied to fields that belong to the social science and to the natural sciences. (shrink)

Understanding the nature of science has long been a desired outcome of science education, despite ongoing disagreements about the content, structure, and focus of NOS expectations. Addressing the concern that teachers likely focus only on student learning expectations appearing in standards documents, this study examines the current state of NOS in science education standards documents from nine diverse countries to determine the overt NOS learning expectations that appeared, NOS statements provided near those learning expectations, but not identified as learning outcomes, (...) and NOS statements found in ancillary text. Findings indicate that NOS ideas rarely occur as expectations for student learning and are far more commonly found in ancillary material. Moreover, consensus was not apparent in the overt learning outcomes for students. Given the well-documented poor state of NOS instruction and the consistent lack of NOS appearing in published curriculum materials, the NOS standards appearing in nearly all documents analyzed are unlikely to provide sufficient conceptual or pedagogical support for NOS to be accurately interpreted or translated into meaningful experiences for students. (shrink)

This paper explores the rhetoric of obstetric ultrasound technology as it relates to the abortion debate, specifically the interpretation given to ultrasound images by opponents of abortion. The tenor of the anti-abortion approach is precisely captured in the videotape, Ultrasound:A Window to the Womb. Aspects of this videotape are analyzed in order to tease out the assumptions about the (female) body and about the access to truth yielded by scientific technology (ultrasound) held by militant opponents of abortion. It is argued (...) that the ultrasound images do not offer transparent confirmation of the ontological status of the embryo and fetus. Rather, the window of ultrasound is constructed through a complex combination of visual and verbal devices: ultrasound images, photographic images, verbal argument, and emotional appeal. (shrink)

The A to Z of the Lesbian Liberation Movement: Still the Rage is a comprehensive overview and resource guide for one of the most invisible social political movements: the Lesbian Liberation Movement. This book helps to make the still-active movement visible—the history, successes, setbacks, controversies, and issues. This book is a good resource for those studying this social political movement, containing a chronology, contextual overview, dictionary entries that cover persons, laws, terminology, issues, and countries, and an extensive bibliography of primary (...) resources and current work. (shrink)

The question of whether cultural transmission is faithful has attracted significant debate over the last 30 years. The degree of fidelity with which an object is transmitted depends on 1) the features chosen to be relevant, and 2) the quantity of details given about those features. Once these choices have been made, an object is described at a particular grain. In the absence of conventions between different researchers and across different fields about which grain to use, transmission fidelity cannot be (...) evaluated because it is relative to the choice of grain. In biology, because a genotype-to-phenotype mapping exists and transmission occurs from genotype to genotype, a privileged grain of description exists that circumvents this ‘grain problem.’ In contrast, in cultural evolution, the genotype–phenotype distinction cannot be drawn, rendering claims about fidelity dependent upon researchers’ choices. Thus, due to a lack of unified conventions, claims about fidelity transmission are difficult to evaluate. (shrink)

Grainger, Joanne This article explores the proposed Victorian Medical Treatment (Physician Assisted Dying) Bill from a nursing perspective. Public trust of the nursing profession will be lessened with the introduction of any law that permits euthanasia or assisted suicide. In Australian society, care of the dying is a compelling social duty and responsibility. In health and social terms, this is known as palliative care, whereby the provision of physical, psychological, spiritual and emotional support to terminally ill people and their (...) families ensures that suffering at life's end is lessened and minimised. (shrink)