This 1990 collection explores one recurrent theme connecting philosophy and politics: the relation between the nature of man and the structure of society. It does so by concentrating on the topical issue of the market economy as an attempt to resolve the clash between individual autonomy and collective action. Beginning with a historical and personal recollection by Enoch Powell and a response by Robert Skidelsky, the volume then provides a forum for political theorists and philosophers to take issue on the (...) fundamental topics of markets and morals; liberal man; and equality and libertarianism. It succeeds equally as a stimulating textbook and a book for the general reader who wishes to understand the philosophical issues arising in a market economy. (shrink)

When Wittgenstein moved from Manchester to Cambridge he was following a path from the study of the natural sciences to the study of philosophy which was then not unusual, and has since become increasingly common. Russell had preceded him in that intellectual emigration and many more were to follow. Of the three philosophy departments I have been in, two were headed by natural scientists . Both my research supervisors in philosophy were natural scientists . Less surprising, but still significant, a (...) considerable proportion of Presidents of the British Society for the Philosophy of Science were originally trained as natural scientists. Yet it is a subject still unrecognized by the Royal Society. The editors of both the British Journal for the Philosophy of Science and the journal Analysis were both originally natural scientists. Eminent scientists seem to feel impelled to discuss there own subjects in a wider context of philosophy. Bohr, Schrodinger, Kilmister, Hoyle, Hawking and Penrose, are but a few from a long list. (shrink)

When Wittgenstein moved from Manchester to Cambridge he was following a path from the study of the natural sciences to the study of philosophy which was then not unusual, and has since become increasingly common. Russell had preceded him in that intellectual emigration and many more were to follow. Of the three philosophy departments I have been in, two were headed by natural scientists. Both my research supervisors in philosophy were natural scientists. Less surprising, but still significant, a considerable proportion (...) of Presidents of the British Society for the Philosophy of Science were originally trained as natural scientists. Yet it is a subject still unrecognized by the Royal Society. The editors of both the British Journal for the Philosophy of Science and the journal Analysis were both originally natural scientists. Eminent scientists seem to feel impelled to discuss there own subjects in a wider context of philosophy. Bohr, Schrodinger, Kilmister, Hoyle, Hawking and Penrose, are but a few from a long list. (shrink)

Abstract It is argued that the problem of the necessity and projectability of laws may be solved by distinguishing between the fact of necessity and explanations of its nature. This reduces the problem of necessity to that of induction, which in consequences must be solved without reference to necessity using ?self?supporting? arguments. The consequences for the analysis of ?counterfactual conditionals and the problem of language dependence is discussed.

This is a collection of lectures and papers, written during the past ten years. They are all concerned with the logical properties of the Absolute and to this extent are a denial of the author's 1948 argument designed to disprove the existence of an Absolute Being. The first three lectures on Absolute-theory are a systematic account of the notion of a unique, necessary Existent and the repercussions such a notion has upon other philosophical problems such as space and time, substance (...) and causality, life and mind, value and evil, etc., and finally, the relation of logical necessity between this notion and a rational eschatology. The twelve remaining lectures cumulatively demonstrate the path toward a revisionary metaphysics which is logically founded upon Absolute-theory. Each is a complete essay in itself and the titles are largely descriptive of the contents. "The Teaching of Meaning" is an interchange between the author and other contemporary philosophers interested in the subject. "Some Reflections on Necessary Existence" concerns the propriety of affirming a categorically necessary existent and searches for a feasible ontological argument in the realm of value. "Freedom and Value" explores the relation between the two, while "Metaphysics and Affinity" explores the relation between thought and being, between the realities of our environment and our metaphysical approaches to them. "Hegel's Use of Teleology" is a thoroughgoing study of teleology in the works of Hegel. A description of our fragmentational approach to reality is contained in "The Diremptive Tendencies of Western Philosophy." The "Logic of Mysticism" is a refutation of Stace's account and a sketch of mysticism as a logical matter, i.e., as a frame of mind connected with some sort of absolute. "Essential Probabilities" is an attempt to formulate and connect the eidetic method in philosophy with modalities, especially probability, considering its role in an a priori framework. "The Logic of Ultimates" sets out the important theorems in an absolutist logic, refutes common candidates for absolute status, and finally proposes some sort of 'infinite' teleology as a viable form of absolutism. "The Systematic Unity of Value" is an analysis of the ways and means of asserting common values and of relating them to their logical keystone found in Absolute-theory. "Intentional Inexistence" establishes intentionality as categorical and defines its working mode which culminates in a picture of 'unitive logic'. The final paper, "Toward a Neo-Neo-Platonism," is the delineation of what a metaphysic ought to envisage through a unifying, living logic which embodies the absolute. All in all, this is a refreshing, meaty reconsideration of some very out-of-vogue topics.--G. M. K. (shrink)

This 1990 collection explores one recurrent theme connecting philosophy and politics: the relation between the nature of man and the structure of society. It does so by concentrating on the topical issue of the market economy as an attempt to resolve the clash between individual autonomy and collective action. Beginning with a historical and personal recollection by Enoch Powell and a response by Robert Skidelsky, the volume then provides a forum for political theorists and philosophers to take issue on the (...) fundamental topics of markets and morals; liberal man; and equality and libertarianism. It succeeds equally as a stimulating textbook and a book for the general reader who wishes to understand the philosophical issues arising in a market economy. (shrink)

Knowledge of the ethical and legal basis of medicine is as essential to clinical practice as an understanding of basic medical sciences. In the UK, the General Medical Council requires that medical graduates behave according to ethical and legal principles and must know about and comply with the GMC’s ethical guidance and standards. We suggest that these standards can only be achieved when the teaching and learning of medical ethics, law and professionalism are fundamental to, and thoroughly integrated both vertically (...) and horizontally throughout, the curricula of all medical schools as a shared obligation of all teachers. The GMC also requires that each medical school provides adequate teaching time and resources to achieve the above. We reiterate that the adequate provision and coordination of teaching and learning of ethics and law requires at least one full-time senior academic in ethics and law with relevant professional and academic expertise. In this paper we set out an updated indicative core content of learning for medical ethics and law in UK medical schools and describe its origins and the consultative process by which it was achieved. (shrink)

Exploratory behavior is considered under the following categories: (1) extrinsic exploration in which the animal seeks information about conventional reinforcers such as food, (2) intrinsic exploration which is directed toward stimuli which may have no biological significance, further divided into inspective and inquisitive exploration. In the former the animal inspects a particular object; in the latter, the animal performs behavior to make a change in its environment, rather than merely responding to a change. Extrinsic exploration is synonymous with the ethological (...) term, appetitive behavior. It is shown that much of the behavior indicative of frustration reported in intensively housed animals occurs when the appetitive component of a drive rather than the consummatory component, is prevented. Consideration of inspective exploration is necessary for good husbandry practice, for fear is an important competing response. Inquisitive exploration has not been widely investigated in infraprimate species, but the authors present several possible examples in the species of common agricultural animals. However, they suggest that the propensity to show this type of exploration may vary between closely related species. In environments barren to the extent of stifling exploration, animals may develop apathy, and its relevance to animal welfare is discussed. (shrink)

Exploratory behavior is considered under the following categories: (1) extrinsic exploration in which the animal seeks information about conventional reinforcers such as food, (2) intrinsic exploration which is directed toward stimuli which may have no biological significance, further divided into inspective and inquisitive exploration. In the former the animal inspects a particular object; in the latter, the animal performs behavior to make a change in its environment, rather than merely responding to a change. Extrinsic exploration is synonymous with the ethological (...) term, appetitive behavior. It is shown that much of the behavior indicative of frustration reported in intensively housed animals occurs when the appetitive component of a drive rather than the consummatory component, is prevented. Consideration of inspective exploration is necessary for good husbandry practice, for fear is an important competing response. Inquisitive exploration has not been widely investigated in infraprimate species, but the authors present several possible examples in the species of common agricultural animals. However, they suggest that the propensity to show this type of exploration may vary between closely related species. In environments barren to the extent of stifling exploration, animals may develop apathy, and its relevance to animal welfare is discussed. (shrink)

As contribution to a recent debate (James, 1998; Murphy etal., 1997, 1998) the proportion of twins following ovulation induction (OI) or assisted conception (AC) in 1994 in Oxfordshire and West Berkshire was estimated, and by extrapolation the natural twinning rate in England and Wales was judged to have maintained a plateau phase since the 1970s. Similar figures for 1995 and 1996 from the same study, and hence a more stable local estimate, are now provided. The proportions, as before, were estimated (...) from women's responses to a questionnaire within a case[hyphen]control study, with ascertainment from general practitioners' records or hospital case[hyphen]notes for non[hyphen]responders or for those excluded from the study originally. In 1994, 1995 and 1996 the proportion of twins following OI/AC was overall 27% (24%, 30% and 27% respectively). Restriction to the 87% locally resident made no difference. The national crude twinning rate for those years was overall 13·3 per 1000 maternities (12·8, 13·6 and 13·4 respectively). (shrink)

Co‐expression of two or more genes at the single‐cell level is usually associated with functional co‐regulation. While mRNA co‐expression—measured as the correlation in mRNA levels—can be influenced by both transcriptional and post‐transcriptional events, transcriptional regulation is typically considered dominant. We review and connect the literature describing transcriptional and post‐transcriptional regulation of co‐expression. To enhance our understanding, we integrate four datasets spanning single‐cell gene expression data, single‐cell promoter activity data and individual transcript half‐lives. Confirming expectations, we find that positive co‐expression necessitates (...) promoter coordination and similar mRNA half‐lives. Surprisingly, negative co‐expression is favored by differences in mRNA half‐lives, contrary to initial predictions from stochastic simulations. Notably, this association manifests specifically within clusters of genes. We further observe a striking compensation between promoter coordination and mRNA half‐lives, which additional stochastic simulations suggest might give rise to the observed co‐expression patterns. These findings raise intriguing questions about the functional advantages conferred by this compensation between distal kinetic steps. (shrink)

Subjects enrolled in studies testing high risk interventions for incurable or progressive brain diseases may be vulnerable to deficiencies in informed consent, such as the therapeutic misconception. However, the definition and measurement of the therapeutic misconception is a subject of continuing debate. Our qualitative pilot study of persons enrolled in a phase I trial of gene transfer for Parkinson disease suggests potential avenues for both measuring and preventing the therapeutic misconception. Building on earlier literature on the topic, we developed and (...) tested an interview guide that focuses on how the subjects decided to participate, emphasizing the integration of subjects’ various statements that are relevant to assessing the therapeutic misconception, rather than evaluating them as isolated statements. The results indicate that a subject’s understanding of the purpose of research is best explored in juxtaposition to the subject’s motivation for participating. (shrink)