Many scientists and philosophers of science are troubled by the relative isolation of developmental from evolutionary biology. Reconciling the science of development with the science of heredity preoccupied a minority of biologists for much of the twentieth century, but these efforts were not corporately successful. Mainly in the past fifteen years, however, these previously dispersed integrating programmes have been themselves synthesized and so reinvigorated. Two of these more recent synthesizing endeavours are evolutionary developmental biology and developmental systems theory. While the (...) former is a bourgeoning and scientifically well-respected biological discipline, the same cannot be said of DST, which is virtually unknown among biologists. In this review, we provide overviews of DST and EDB, summarize their key tenets, examine how they relate to one another and to the study of epigenetics, and survey the impact that DST and EDB have had on biological theory and practice. (shrink)

Conrad Hal Waddington integrated genetics with embryology and evolution by formulating and providing experimental evidence for the mechanisms of canalization and genetic assimilation in the context of stabilizing selection, and by fostering an epigenetic rather than the prevailing gene-centered view of embryonic development and of evolutionary change in development and adult form. Waddington saw phenotypes as processes, not static structures and behaviors. Trained in geology at Cambridge, Waddington turned to experimental studies on the chemical nature of the primary organizer and (...) developed the concepts of evocation and individuation as separable components of embryonic induction. A move after WW II to Edinburgh provided Waddington with his professional home for the rest of his career, during which he integrated genetics and development into an evolutionarily relevant discipline. Our conception of embryonic development as a highly integrated series of canalized pathways owes much to Waddington’s development of the concepts of canalization, chreods, epigenetics, and the epigenotype. The integrated, heritable, epigenetic organization of embryonic development is Waddington’s lasting legacy to development. He demonstrated organismal response to environmental change and hidden genetic variation, integrated environmental responsiveness into heritable change in response to selection, and coupled development, environment, and evolution. (shrink)

Modularity has become a central and remarkably useful concept in evolutionary developmental biology, offering an explanation of how independent, interacting units make possible developmental events and evolutionary changes. These modules exist at several different levels of organization, from genes to signal transduction pathways to cell populations. Cell populations, which are multicellular modules, provide an opportunity both to clarify our notion of modularity and to reexamine such central concepts as cell-to-cell communication. Rosine Chandebois’s work on “cell sociology” is reframed in the (...) language of modularity in order to show how groups of cells maintain their collective identity during development and how signaling information from the group’s environment is received by the constituent cells. In a “test case” for our account of multicellular modules, we consider the vertebrate neural crest, a migratory cell population made up of several subpopulations. The neural crest proves yet again to be a complex case, showing the importance of taking into account both developmental and evolutionary transformations of multicellular modules. (shrink)

Embryonic development and ontogeny occupy whatis often depicted as the black box betweengenes – the genotype – and the features(structures, functions, behaviors) of organisms– the phenotype; the phenotype is not merelya one-to-one readout of the genotype. Thegenes home, context, and locus of operation isthe cell. Initially, in ontogeny, that cell isthe single-celled zygote. As developmentensues, multicellular assemblages of like cells(modules) progressively organized as germlayers, embryonic fields, anlage,condensations, or blastemata, enable genes toplay their roles in development and evolution.As modules, condensations are (...) fundamentaldevelopmental and selectable units ofmorphology (morphogenetic units) that mediateinteractions between genotype and phenotype viaevolutionary developmental mechanisms. In ahierarchy of emergent processes, gene networksand gene cascades (genetic modules) link thegenotype with morphogenetic units such ascondensations, while epigenetic processes suchas embryonic inductions, tissue interactionsand functional integration, link morphogeneticunits to the phenotype. To support theseconclusions I distinguish units of heredityfrom units of transmission and discussepigenetic inheritance by tracing the historyof relationship between embryology andevolution, especially the role(s) assigned tocells or to cellular components in generatingtheories of morphological change in evolution.The concept of cells as modular morphogeneticunits is modeled and illustrated using themammalian dentary bone. (shrink)

Organic selection (the Baldwin Effect) by which an environmentally elicitedphenotypic adaptation comes under genotypic control following selectionwas proposed independently in 1896 by the psychologists James Baldwinand Conwy Lloyd Morgan and by the paleontologist Henry Fairfield Osborn.Modified forms of organic selection were proposed as autonomization bySchmalhausen in 1938, as genetic assimilation by Waddington in 1942, andas an explanation for evolution in changing environments or for speciationby Matsuda and West-Eberhard in the 1980s. Organic selection as amechanism mediating proximate environmental effects on the (...) evolution ofmorphology and behaviour is the topic of this essay. Discussion includesthe context in which organic selection was proposed, Lamarckian or neo-Lamarckian implications of organic selection, Waddingtons experimentalstudies demonstrating the existence and efficacy of genetic assimilation,stabilizing selection and norms of reaction favoured by Schmalhausen, andMatsudas search for a mechanism of organic selection in endocrine changesand in heterochrony. (shrink)

Several scholars have claimed that small-scale agriculture in which farmers sell goods to the local market has the potential to strengthen social ties and a sense of community, a phenomenon referred to as “civic agriculture.” Proponents see promise in the increase in the number of community supported agriculture programs, farmers markets, and other locally orientated distribution systems as well as the growing interest among consumers for buying locally produced goods. Yet others have suggested that these novel or reborn distribution mechanisms (...) are still primarily means of instrumental economic exchange and that optimistic characterizations of a renewed sense of community emerging from these practices are unfounded. This study provides an empirical assessment of the extent to which these community-based agriculture markets are associated with connection to community, volunteerism, and civic and political activities. In order to assess the relationship between civic agriculture and community engagement, we surveyed over 1,300 people in the Mid-Hudson region of New York State. The study design includes “civic agriculture participants” as the unit of analysis, defined as CSA farm members, shoppers at independent health food stores, and farmers market patrons. For comparison, a telephone survey of randomly selected residents of the region’s general population was also conducted. Unlike studies that focus solely on the perceptions of certain civic agriculture participants, by comparing the perceptions and behaviors of those engaged in a range of civic agriculture practices, we are able to identify the effects of different forms of participation. The results demonstrate higher levels of voluntarism and engagement in local politics among civic agriculture participants relative to the general population. In addition, we found variation among those engaged in different forms of civic agriculture, with those immersed in more socially embedded forms of exchange demonstrating greater community and political involvement. These findings lend empirical support to the civic agriculture thesis. (shrink)

The popularity of direct-to-consumer genetic ancestry services has exploded over the past five years, with as many as 250 direct-to-consumer genetic ancestry testing companies currently operating and estimates that 1 in 5 Americans are customers of one or more of those companies. Marketing of genetic ancestry testing has consistently linked the results of DNA testing to a consumer’s racial and ethnic identity, and, because of that, can help consumers find out “who they really are.” We argue that the “biologization” of (...) race and ethnicity promoted in such marketing violates norms of marketing ethics. In particular, we show that this marketing technique violates a number of the core commitments and values of the American Marketing Association Statement of Ethics. (shrink)

This book argues that, despite recent calls to arms to seek out and remove "corporate psychopaths" from the business world, efforts to eliminate the corporate psychopath presence would be illegal as well as unethical.

This paper examines the philosophical basis for the argument that there is a connection between ethical behavior and profitability. Both sides of this argument – that good ethics is good business and that bad ethics is bad business – are explored. The possibility of a moral floor above which ethical behavior is not rewarded is considered, and an economic experiment testing such a proposition is discussed. Johnson & Johnson suffers a potentially devastating blow when some cyanide-laced Tylenol capsules cause several (...) deaths. Johnson & Johnson voluntarily pulls Tylenol off the shelf, to universal acclaim. When Tylenol is returned to the marketplace, its share of the over-the-counter painkiller market becomes greater than it was before the tragedy. Arthur Andersen, the venerable accounting firm, is caught in the web surrounding the downfall of Enron, Inc. As Enron’s various sins are discovered, it is found that Arthur Andersen auditors had signed off on flawed audits and had shredded documents to cover themselves. Andersen is prosecuted for, and convicted of, obstructing justice (although the conviction is later overturned). Today the firm barely exists and has no resemblance to the Big Five accounting giant of 1999. These stories seem to indicate that ethical (or unethical) behavior leads to positive (or negative) financial results. But the philosophical arguments underpinning such statements are seldom subjected to proper analysis. They are perhaps wishful thinking, or perhaps based on examples such as the above without considering other examples that may reinforce a contrary position. This paper will explore the philosophical arguments and empirical evidence regarding these statements and state some research questions for exploration in this area. In particular we will propose the possibility that a moral floor exists above which firms that engage in ethical activities will not reap rewards, but below which firms that engage in unethical activities will be punished by actors in the economic marketplace. We will discuss an economic experiment to determine if such actors indeed form a moral floor. (shrink)

ABSTRACT: In this paper, I raise the following question: can the ethical thought of Jurgen Habermas and Karl-Otto Apel provide us with a way of showing that morality is a rational requirement? The answer I give is that it cannot. I argue for this claim by showing that a decisive objection to Alan Gewirth’s line of thought in Reason and Morality also applies to discourse ethical arguments that try to show an inescapable commitment to a moral principle. RÉSUMÉ: La pensée (...) ethique de Jurgen Habermas et Karl-Otto Apel peut-elle nous fournir une façon de montrer que la moralité répond à un besoin rationnel? Ma réponse, malheureusement, est que non, elle ne le peut pas. Je défends cet argument en montrant qu’une objection décisive à ce courant de pensée, tel qu’il est présenté par Alan Gerwirth Raison et Moralité, s’applique aussi aux arguments ethiques qui essaient de prouver leur lien incontournable avec un principe moral. (shrink)

Toward Unity among Environmentalists is Bryan Norton’s most developed effort to surmount the frequently intractable debate between anthropocentrists and nonanthropocentrists. Norton argues that the basic axiological differences between the two positions have become irrelevant at the level of policy formation. His thesis is that the two camps converge when dealing with practical goals and aims for environmental management. I argue that Norton’s approach falls significantly short of establishing such a convergence because of the overall methodological framework for policy formation that (...) he defends. The key problem with that framework is that it fails to provide for the degree of species protection most suitable to the nonanthropocentrist position. (shrink)

The phenomenon of globalization of markets has been accompanied by calls for a globalization of ethical norms. One principle often referred to in such calls is the so-called Golden Rule. The rule, often stated as Do unto others as you would have others do unto you, has long been used and referenced in the business literature. But those who use it often do so without full realization of the rule itself and what it stands for. This paper examines the history, (...) meaning, and problems of the rule and attempts to show, through a case analysis, how these problems surface when using the rule in a business context. In so doing it attempts to clarify exactly what the rule means and how it can fit into a universal code of morality. (shrink)

After decades of vigorous debate, many contemporary philosophers in the Kantian tradition continue to believe, or at least hope, that morality can be given a firm grounding by showing that rational agents cannot consistently reject moral requirements. In the present paper, I do not take a stand on the possibility of bringing out the alleged inconsistency. Instead I argue that, even if a successful argument could be given for this inconsistency, this would not provide an adequate answer to “the normative (...) question” (i.e., “why should I be moral?”). My defense of this claim emerges from a defense of a claim about Kant, namely, that he did not attempt to answer the normative question in this way. After carefully articulating Kant’s answer to the normative question, I argue that his answer to this question contains a lesson about why we should not embrace the approach that is popular among many contemporary Kantians. (shrink)

In the 17th century Sir Francis Bacon advocated the patient study of Nature for the benefit of mankind. Most of science today, in its study of medicine, genetics, electronics etc., continues that pragmatic Baconian tradition without fuss. Over the years, however, as its investigation of Nature probed ever deeper into regions far removed from common experience, science has increasingly exhibited traits more usually associated with fundamentalist religion that with dispassionate study. Articulate voices from biology preach the belief in 18th century (...) materialism in the study of evolution; those from physics promulgate a kind of mathematical theology in its study of elementary particles and cosmology; both inveigh against heresy. But science should be beyond that sort of belief. It should not see its undoubted success in manipulating matter as justifying any sort of religious status, as offering a spiritual foundation alternative to religion. As a scientist himself, Brian Ridley is appalled by such theological trends, hence this book. It is an attempt to address these concerns, to reform science, to place science in its broad historical and philosophical context where dogmatic belief has no place, to remind science itself that it has limitations. (shrink)

One popular sort of argument for the death penalty depends on the idea of possibly saving innocent lives through added deterrent value. Defenders of such arguments generally concede that: a) we do not know whether or not the death penalty actually adds marginal deterrent value beyond life in prison, and b) any actual death penalty regime is likely to include the execution of some innocent people. Use of the death penalty might save some innocent people, but it is also likely (...) that it will lead us to kill some innocent people. In the present paper, I attempt to give consideration to both sorts of innocents. I argue that it is morally more serious to intentionally kill people who are innocent than it is to fail to save innocent people whose death is in no way intended. Thus, in the absence of compelling evidence that our use of the death penalty would save significantly more innocent people than it would kill, we should err on the side of not using the death penalty as a means to try to achieve added deterrent value. (shrink)

The mysterious phrase, ‘the eternal validity of the self,’ is clearly quite important in Kierkegaard’s pseudonymous works. A reader of those works will see that becoming aware of your eternal validity is a prerequisite for becoming both Judge William’s ‘ethical man’ and Johannes de Silentio’s ‘knight of faith,’ but the same reader is likely to be unsure just what it means to become aware of yourself in your eternal validity. In this paper, I discuss and critique various accounts of the (...) concept of the eternal validity of the self. Then, I offer an account of that notion which proceeds from careful attention to Judge William’s use of the phrase in Either/or. Finally, I connect my account with some of Kierkegaard’s writings beyond Either/or. (shrink)

Argues that the concept of the ethical is central to Hegel’s philosophy of art.

Hegel’s lectures on fine art, given in the 1820s, were published for the first time in 1835 and continued to influence thinking about aesthetics for the rest of the nineteenth century. After a long period of relative neglect in this century, when idealism in general fell into disfavor, Hegel’s Aesthetics has begun to awaken renewed interest. Appropriately, the larger questions of the relation of art, beauty, and truth have attracted the most attention. His treatment of musical aesthetics, on the other (...) hand, has generally been regarded as much less satisfactory, in spite of his being more qualified than most philosophers of his day to discuss music. It is known that Hegel sang in a choral group at one point, that he had attended operas by Gluck, Mozart, Rossini, and Weber, and that he had heard performances of symphonies and string quartets by Haydn and Mozart. Yet his remarks on music have been dismissed as the product of someone who knew very little about music and who had little sympathy for the newer genres and styles of music that still loom so large in the repertoire today. The important question, however, is whether his aesthetic of music makes sense musically and is philosophically coherent. If so, then his arguments are of more significance than has been recognized. In fact, they reveal the principles and aims of the art of music as it was practiced in his day and as it continued to be understood by many critics in the nineteenth century. They pose a challenge, moreover, to the prevailing ahistorical ways of understanding music in the twentieth century. (shrink)

Abstract In this paper, I pursue an interpretive goal and a critical goal. My interpretive goal is to offer a clear restatement of Nagel's argument for a requirement of altruism (as found in The Possibility of Altruism). My critical goal is to explain why this argument is unsuccessful, and to make a case for the thesis that any argument of its kind must fail.

This study investigates possible links between small-business managers’ perceptions of stakeholder salience and their views of the ethicality of business decisions. Results indicate few if any links between the two concepts exist. They provide evidence that small-business managers make decisions in line with internal viewpoints rather than external pressures.

This study investigates possible links between small-business managers’ perceptions of stakeholder salience and their views of the ethicality of business decisions. Results indicate few if any links between the two concepts exist. They provide evidence that small-business managers make decisions in line with internal viewpoints rather than external pressures.