This article analyses the tradition of "articulating xing in terms of sheng" and related other expressions, and also examines the debate between Mencius and Gaozi concerning "xing is known by sheng" It claims that while Mencius' "human nature is good" discourse is influenced by the interpretive tradition of "articulating xing in terms of sheng", Mencius also transcends and develops this tradition. Therefore it is only when Mencius' views about the goodness of human nature are understood in the context of this (...) interpretive tradition that his ideas can be fully understood. Utilizing this framework, the Confucian understanding of rights is then explored. /// 通过对"以生言性"的传统及其不同命题表述的详尽分析，对孟子、告子"生 之谓性"的辩论做出梳理，指出孟子性善论一方面受到了"以生言性"传统的影响， 另一方面则超越、发展了这一传统，故只有将孟子性善论放在"以生言性"的传统 下才能得到真正的理解。从这一角度出发，为探讨儒家的权利观念提供了可能。. (shrink)

The political philosophy of early Confucianism mainly focuses on the “ shi ± (scholar).” It is built on ideas such as that of “establishing a ruler in consideration of the people,” “taking yi 义 (righteousness) as li 利 (benefit)” and “following the Dao but not the ruler,” which demonstrate the foundations of political legitimacy, justice as a political principle, and principles of a scholar to become an official. Although the political thought of early Confucianism has its historical limitations, such as (...) the lack of both political equality and the universal recognition of rights, there is both a demand for and possibility of democratic politics in the philosophy. Thus, how to extend awareness of scholars to awareness of people and how to transform a focus on virtue into a focus on rights become the crucial theoretical questions that Confucianism faces in the contemporary world. (shrink)

According to recently excavated bamboo and silk material, the idea of du 獨 in the concept shendu 慎獨 does not refer to a spatial notion of dwelling in solitude or a solitary dwelling; rather it is the state before having made contact with external things, or the state “before feelings are aroused” (weifa 未發) of the inner heart/mind. It refers to internal thoughts and volitions, or “casting aside external sensations” (sheti 舍體). Shen 慎 should be glossed in accordance with the (...) Erya 爾雅 (Approaching Elegance), rendering it as “sincerity” (cheng 誠). Shendu then means to “cause one’s will to be sincere” (chengqiyi 誠其意). Zheng Xuan 鄭玄, in explaining shendu as being “cautious of the actions one performs in private” (shen qi xianju suowei 慎其閒居所為), completely strayed from the original meaning as found in the bamboo-silk texts. Zhu Xi 朱熹, seeing the insufficiencies of Zheng Xuan’s interpretation of shendu, broadened the meaning of du, and in particular added a spiritual meaning to it. However, due to influence by Zheng Xuan, Zhu Xi still preserved some misreadings of the term; especially in his interpretation of shendu in the Daxue 大學 (Great Learning) and Zhongyong 中庸 (Doctrine of the Mean). Considering that the Neo-Confucian methods of cultivation embodied in the ideas of “abiding in reverence and enriching the self” (jujing hanyang 居敬涵養), and “being refined and focused” (weijing weiyi 惟精惟一) actually accorded more with the original meaning of shendu, Zhu Xi’s misreading of shendu is indirectly related to the loss of its original meaning due to the broken transmission of the ancient texts. (shrink)

Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET) family, recognizes acetylated histones and is of importance in transcription, replication, and DNA repair. It also binds non‐histone proteins, DNA and RNA, contributing to development, tissue growth, and various physiological processes. Additionally, BRD4 has been implicated in driving diverse diseases, ranging from cancer, viral infection, inflammation to neurological disorders. Inhibiting its functions with BET inhibitors (BETis) suppresses the progression of several types of cancer, creating an impetus for translating these chemicals (...) to the clinic. The diverse roles of BRD4 are largely dependent on its interaction partners in different contexts. In this review we discuss the molecular mechanisms of BRD4 with its interacting partners in physiology and pathology. Current development of BETis is also summarized. Further understanding the functions of BRD4 and its partners will facilitate resolving the liabilities of present BETis and accelerate their clinical translation. (shrink)

This article analyses the tradition of “articulating xing in terms of sheng ” and related other expressions, and also examines the debate between Mencius and Gaozi concerning “ xing is known by sheng .” It claims that while Mencius’ “human nature is good” discourse is influenced by the interpretive tradition of “articulating xing in terms of sheng ”, Mencius also transcends and develops this tradition. Therefore it is only when Mencius’ views about the goodness of human nature are understood in (...) the context of this interpretive tradition that his ideas can be fully understood. Utilizing this framework, the Confucian understanding of rights is then explored. (shrink)

Word order variation in Mandarin Chinese results in two constructions consisting of a noun phrase, a cluster of a demonstrative and a classifier, and a relative clause : the OMN with the RC+DM+NP order and the IMN with DM+RC+NP order. This study used corpus data to show correlational patterns of constructional choices. Specifically, OMN is associated with new and inanimate NPs serving the grammatical role of object in the relative clause that serves the discourse function of identification. By contrast, for (...) IMN, the head NP tends to carry given information, tends to be an animate entity, tends to serve the grammatical role of subject in the relative clause, and tends to have an RC that serves the discourse function of characterization. We suggest that the usage patterns can be interpreted in terms of the cognitive and communicative principles of relevance. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Our previous study has shown impaired blood oxygen level-dependent /functional magnetic resonance imaging activation of the visual attention network in strabismic amblyopia. However, there has been no comparison of resting state fMRI activation and functional connectivity in brain regions of interest along the visual attention network including visual cortex, intraparietal sulcus, and frontal eye fields during closed eye resting across the SA, or anisometropic amblyopes groups. Hence, we compared, gray matter volume, amplitude of low frequency fluctuations, regional homogeneity, and FC (...) in the left and right hemisphere ROIs of the visual attention network in SA, AA, and healthy controls. Correlation analyses of corrected visual acuity of amblyopic eye and MRI results were also performed and showed that the LogMAR cVA of the amblyopic eye positively correlated with right zALFF and zReHo FEF of SA and right IPS of AA only. GMV of both left and right hemisphere V1 areas was significantly greater but ALFF was significantly lower for SA compared to AA and HC groups. zALFF and zReHo analyses in the AA and SA groups indicated significantly higher activation than that in the HC group in the right FEF and IPS but lower than that in the HC group in the left FEF, and only the SA group showed lower activation in both V1 areas than the HC group. FC values of the right FEF–left V1, right FEF–right V1, and right FEF–right IPS pathways in the SA and AA groups were also significantly higher than those in the HC group whereas all other FC values were non-significant. Thus, this study indicates that even during resting-state the visual attention network function is impaired in SA and AA participants with only right hemisphere FEF showing significant activation in SA and IPS in AA suggesting that the slower saccade activation times characteristic of amblyopic eyes lead to the dominant eye controlling activation of the visual attention network. (shrink)

Economy is one of the major issues in the United States presidential election campaign. In order to investigate the impact of the US presidential election on the economy, this paper first constructs an analysis model of the economic impact on the United States based on stepwise regression and principal component analysis to analyze the focus of different candidates’ attention on the economic issues and its possible impact on the US economy in the election year and after the election; secondly, a (...) Chinese economic impact analysis model based on factor analysis and machine learning logistic regression was constructed to analyze the impact of the US presidential election on the Chinese economy. At the same time, the future economic development of the United States and China based on the time series prediction model is forecast and analyzed, respectively. Finally, the countermeasures and policy suggestions on China’s related economic development are put forward. (shrink)

Different countries have different education systems and their advantages and disadvantages. It is necessary to optimize their own higher education system and formulate policy plans to fully realize the optimization of the higher education system. For this reason, we propose to establish a continuous evaluation model of higher education health. This study mainly uses principal component analysis and entropy weight method to determine the evaluation model of higher education health status and makes autoregressive moving average model time series analysis based (...) on the higher education evaluation model, which is obtained by studying long-term trends. The future development of education realizes the evaluation of sustainability. For Vietnam, that needs to be adjusted, the evaluation indicators based on the health status of the higher education system in developing countries will be added, tested, and adjusted and combined with the ARMA model prediction to determine the time period for the policy to meet reasonable expectations, and targeted development policies are proposed. Finally, we test the sensitivity of the established model, evaluate and analyze the advantages and disadvantages of the model, And combine the full text analysis to get the final conclusion. (shrink)

In this work, we investigated a covert communication method in wireless networks, which is realized by multiantenna full-duplex single relay. In the first stage, the source node sends covert messages to the relay, and the relay uses a single antenna to send interference signals to the adversary node to protect the covert information being transmitted. In the second stage, the relay decodes and forwards the covert information received in the first stage; at the same time, the relay uses zero-forcing beamforming (...) to send interference signals to the warden to ensure covert transmission. The detection error rate, transmission outage probability, maximum effective covert rate, and other performance indicators are derived in two stages, and the total performance of the system is derived and analyzed. Then, the performance indicators are verified and analyzed by simulation. Our analysis shows that the maximum effective covert rate of using the characteristics of multiantenna to interfere with Willie in the second stage is taken as the total covert performance of the system, and the transmission interruption probability is significantly less than that of the first stage, so the corresponding maximum effective concealment efficiency will be greater. (shrink)

Drawing on ancient and modern sources, "a lucid discussion of Taoism and the Chinese language [that's] profound, reflective, and enlightening." —Boston Globe According to Deepak Chopra, "Watts was a spiritual polymatch, the first and possibly greatest." Watts treats the Chinese philosophy of Tao in much the same way as he did Zen Buddhism in his classic The Way of Zen. Critics agree that this last work stands as a perfect monument to the life and literature of Alan Watts. "Perhaps the (...) foremost interpreter of Eastern disciplines for the contemporary West,... Watts begins with scholarship and intellect and proceeds with art and eloquence to the frontiers of the spirit."—Los Angeles Times. (shrink)

I believe the material should be utilized as supplemental data for exploring Ch'en Liang's intellectual development.Ch'en's thought evolved through a tao-hsueh ...

Our paper draws attention to a neglected channel of corruption—the bribe payments by state-owned enterprises. This is an important phenomenon as bribe payments by SOEs fruitlessly waste national resources, compromising public welfare and national prosperity. Using a large dataset of 30,249 firms from 50 countries, we show that, in general, SOEs are less likely to pay bribes for achieving organizational objectives owing to their political connectivity. However, in deteriorated institutional environments, SOEs may be subjected to potential managerial rent-seeking behaviors, which (...) disproportionately increase SOE bribe propensity relative to privately owned enterprises. Specifically, our findings highlight the importance of fostering democracy and rule of law, reducing prevalence of corruption and shortening power distance in reducing the incidence of SOE bribery. (shrink)

本书在故乡的土地上出现过一代又一代的文化名人和仁人志士而感到骄傲和自豪。书中以文学传记的形式,将他们中杰出人物介绍给广大读者,他们坚韧不拔、克服困难和精神给人以鼓舞,他们各具特色的人生经历和杰出贡献给 人以启发。.

Liang Qichao was a leading political thinker and publicist. His manifesto, On the New People, was published serially in Japan, where Liang—like many other progressive intellectuals in the late Qing—lived and worked for a decade in order to avoid governmental suppression. The present essay was published in 1902 as part of On the New People. Liang began writing about rights as early as 1896; they came to occupy a prominent place in his theorizing after he arrived in (...) Japan in 1898. He was influenced by the Social Darwinist ideas of Kato Hiroyuki, which can be seen most clearly in Liang's 1899 essay "The Right of the Strongest." Although some of these ideas are still present in the current essay, Liang had by this time developed a more complex position, partly through reading and interpreting the ideas of Rudolph von Jhering , a pioneering German legal theorist whose influence on Liang was significant, as Liang himself declares early in this essay. (shrink)

In recent years, with the development of society and the rapid development of the animation industry, people are paying more and more attention to and requirements for animation production. As an indispensable part of animation production, picture composition plays a major role in animation production. It can give full play to the application of color matching and light and shadow design and enhance the depth and space of the animation screen. Tone space conversion refers to the conversion or representation of (...) color data in one color space into corresponding data in another color space. Its purpose is to distinguish and process color components such as hue and saturation in an image. This article first introduces the domestic and foreign research status of digital image preprocessing and analyzes the basic principles of several color space conversions in detail. Then, several color space conversion algorithms are studied, and the performance of the algorithms is compared and analyzed. The paper focuses on the hardware implementation and optimization of the algorithm for converting RGB color space into HSI color space to meet the real-time requirements. This article focuses on the mutual conversion between the RGB tone space and the HSI tone space and describes in detail how each color component in the HSI tone space is converted from the three RGB color components from a geometric perspective, and then the conversion is derived, and several general conversion methods of RGB to HSI tone space are introduced; two conversion methods of geometric derivation method and standard modulus algorithm are implemented in the software, and the comparison verification is carried out, and the comparison is made from the perspective of hardware implementation. The pros and cons of the two methods are discussed. Finally, the paper summarizes the shortcomings in the design and proposes further research directions in the future. (shrink)

Compared with the related western studies, Russian ecological philosophy has paid more attention to Eschatology and represented a unique path of thinking, that is, an intense rational conception and a religious consciousness. In the era of globalization, Russian ecological Eschatology, as an active response of Russian ideology to the world ecosystem crisis, contains a strong eschatological emotion and a spirit of salvation. It mainly deals with the sin and punishment between the nature and human being as well as the endeavor (...) of atoning humanity. The first part of the essay traces back the origin and evolution of eschatology and ecology in the two systems of Russian philosophy—humanism and cosmism, with a trimming of the original relationship between the ecological eschatology and the traditional eschatology. The second part explores the way of salvation for the human being in crisis directed by Russian ecological philosophy, which is nourished by the profound spiritual tradition. For the human being, the way of civilization lies in a rebuild of rationality by faith. The goal of faith is to achieve a self-completeness in morality by a heart-open through God. In this way, the destiny of the world may be changed. This is the only hope of the human being and, therefore, a new chapter of salvation for our times. (shrink)

The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist in spite of prolonged highly active antiretroviral therapy and present a major barrier to a cure of HIV‐1 infection. In this review, we discuss the current understanding of HIV‐1 persistence and latent viral infection in the context of effective antiretroviral therapy and the recent progress in purging latent viral reservoirs. Recent studies (...) demonstrate that reactivation of latent HIV‐1 is a promising strategy for the depletion of these viral reservoirs. A thorough evaluation of the anti‐latency activity of drug candidates should include the measurement of changes in intracellular viral RNA, plasma virus levels, and the size of latent viral reservoirs, as well as potential adverse effects. Currently, there are several technical barriers to the evaluation of anti‐latency drugs in vivo. We also discuss these challenging issues that remain unresolved. (shrink)

On August 24, 1966, during the so-called Great Cultural Revolution, my home was ransacked by the "young generals" who called themselves the Red Guards. All my personal belongings, clothes, and books were taken; nothing remained behind after the sweep. Furthermore, I was forced to move from the rooms in the northern wing of the building and to make my abode in the small cottage in the southern part. At the time I was quite upset, but soon I learned to put (...) the matter aside and make nothing of it. In that period of "leisure," I was able to write the following essays in draft form. Since I didn't have a single book for reference, the writing was entirely from memory. By September 6 I had completed the first essay, and subsequently, on November 10, the second was produced. As for the third, I can no longer recall the date of its completion. (shrink)

This book rewrites the story of classical Chinese philosophy, which has always been considered the single most creative and vibrant chapter in the history of Chinese philosophy. Works attributed to Confucius, Mozi, Mencius, Laozi, Zhuangzi, Xunzi, Han Feizi and many others represent the very origins of moral and political thinking in China. As testimony to their enduring stature, in recent decades many Chinese intellectuals, and even leading politicians, have turned to those classics, especially Confucian texts, for alternative or complementary sources (...) of moral authority and political legitimacy. Therefore, philosophical inquiries into core normative values embedded in those classical texts are crucial to the ongoing scholarly discussion about China as China turns more culturally inward. It can also contribute to the spirited contemporary debate about the nature of philosophical reasoning, especially in the non-Western traditions. -/- This book offers a new narrative and interpretative framework about the origins of moral-political philosophy that tracks how the three normative values, humaneness, justice, and personal freedom, were formulated, reformulated, and contested by early Chinese philosophers in their effort to negotiate the relationship among three distinct domains, the personal, the familial, and the political. Such efforts took place as those thinkers were reimagining a new moral-political order, debating its guiding norms, and exploring possible sources within the context of an evolving understanding of Heaven and its relationship with the humans. Tao Jiang argues that the competing visions in that debate can be characterized as a contestation between partialist humaneness and impartialist justice as the guiding norm for the newly imagined moral-political order, with the Confucians, the Mohists, the Laoists, and the so-called fajia thinkers being the major participants, constituting the mainstream philosophical project during this period. Thinkers lined up differently along the justice-humaneness spectrum with earlier ones maintaining some continuity between the two normative values (or at least trying to accommodate both to some extent) while later ones leaning more toward their exclusivity in the political/public domain. Zhuangzi and the Zhuangists were the outliers of the mainstream moral-political debate who rejected the very parameter of humaneness versus justice in that discourse. They were a lone voice advocating personal freedom, but the Zhuangist expressions of freedom were self-restricted to the margins of the political world and the interiority of one's heartmind. Such a take can shed new light on how the Zhuangist approach to personal freedom would profoundly impact the development of this idea in pre-modern Chinese political and intellectual history. (shrink)

The study is based on validating and exploring the effects of a mega project plan on infrastructure development and Sustainable Project Management. The CPEC has great importance to infrastructure development and economy-boosting. The current study's primary aim is to deal with environmental protection, economic boost up, international relations influencing to the Project's success. The paper also addressed project management as a moderator between environmental protection, economic boost up, international relations, and the CPEC project's success. The primary data has been gathered (...) by using questionnaires, and PLS-SEM has been employed for the analysis. The results revealed that environmental protection, economy boost up, and international relations have a positive association with the success of CPEC. The outcomes also exposed that project management moderating among the nexus of economy boosts up the international relations and success of CPEC. The present study results guided how Pakistan and China make the CPEC project stronger with the efficient implementation of practices required for protecting the environment, with the economic growth and boost up, and good strong relations with foreign countries. This study was an attempt to validate the different factors to check their association with each other in a new environment, resulting in a leading edge for the success of mega projects that influence project management. (shrink)