Objective: Pulmonary complications could badly affect the recovery of neurological function and neurological prognosis of neurological critically ill patients. This study evaluated the effect of high-flow nasal cannula therapy on decreasing pulmonary complications in neurologically critically ill patients.Patients and Methods: The patients admitted to the intensive care unit with serious neurological disease and receiving oxygen therapy were retrospectively reviewed. Patients were divided into the HFNC group and the conventional oxygen therapy group. We analyzed the data within these two groups, including (...) patients’ baseline data, short-term outcomes of respiratory complications, general outcomes including hospital stay, ICU stay and mortality, and neurological functions. To analyze the relevant factors, we performed multivariable logistic regression analysis.Results: A total of 283 patients met the criteria, including 164 cases in the HFNC group and 119 cases in the COT group. The HFNC group had remarkably less mechanical ventilation requirement with lower phlegm viscosity. Even more, ICU stay and total hospital stay were significantly shortened in the HNFC group.Conclusion: HFNC decreased pulmonary complications in neurologically critically ill patients and improved recovery of neurological function and neurological prognosis. (shrink)

T cells, which are derived from hematopoietic stem cells (HSCs), are the most important components of adaptive immune system. Based on the expression of αβ and γδ receptors, T cells are mainly divided into αβ and γδ T cells. In the thymus, they share common progenitor cells, while undergoing a series of well‐characterized and different developmental processes. N6‐Methyladenosine (m6A), one of the most abundant modifications in mRNAs, plays critical roles in cell development and maintenance of function. Recently, we have demonstrated (...) that the depletion of m6A demethylase ALKBH5 in lymphocytes specifically induces an expansion of γδ T cells through the regulation of Jag1/Notch2 signaling, but not αβ T cells, indicating a checkpoint role of ALKBH5 and m6A modification in the early development of γδ T cells. Based on previous studies, many key pathway molecules, which exert dominant roles in γδ T cell fate determination, have been identified as the targets regulated by m6A modification. In this review, we mainly summarize the potential regulation between m6A modification and these key signaling molecules in the γδ T cell lineage commitment, to provide new perspectives in the checkpoint of γδ T cell development. (shrink)

Ben shu gong you ba jiang zu cheng, fen bie shi sheng ren bi ke xue er zhi, Wang Yangming de xin xue ti xi, shi gong yu bing xue, wen xue si xiang yu shi wen chuang zuo, jiao yu si xiang yu shi jian, Yangming hou xue, Yangming xue zai jin xian dai de ying xiang, Yangming wen hua yu Guizhou lü you. Mei ge lun ti lun shu ji zhong, shen du shi zhong, xu shu xing (...) yu yan tong su liu chang, gu shi xing qiang, hen shi he da zhong du zhe yue du. wei qi fa du zhe si kao, zeng qiang yue du xiao guo, zai mei yi jiang zhi hou shi liang she zhi le yi xie ming ci jie shi, jian da tao lun ti. ling pei he xiang guan wen zi, she zhi le yi xie tu pian, bei ke he Yangming shu fa zuo pin deng, ju you ji jia de guan shang xing. (shrink)

Call "radical moral theorizing" the project of developing a moral theory that not only tries to conform to our existing moral intuitions, but also manifests various theoretical virtues: consistency, simplicity, explanatory depth, and so on. Many moral philosophers assume that radical moral theorizing does not require any particular metaethical commitments. In this paper, I argue against this assumption. The most natural justification for radical moral theorizing presupposes moral realism, broadly construed; in contrast, there may be no justification for radical moral (...) theorizing if moral anti-realism is true. (shrink)

It is a commonplace in economics that we should disregard sunk costs. The sunk cost effect might be widespread, goes the conventional wisdom, but we would be better off if we could rid ourselves of it. In this paper, I argue against the orthodoxy by showing that the sunk cost effect is often beneficial. Drawing on discussions of related topics in dynamic choice theory, I show that, in a range of cases, being disposed to honor sunk costs allows an agent (...) to mimic a resolute chooser, someone who adopts the best plan at the outset of a decision problem and sticks with it, even when resoluteness is unfeasible. I discuss several kinds of cases in which honoring sunk costs coincides with resolute choice. (shrink)

According to the received account of guilt in the philosophical literature, one cannot feel guilt unless one takes oneself to have done something morally wrong. But ordinary people feel guilt in many cases in which they do not take themselves to have done anything morally wrong. In this paper, I focus on one kind of guilt without perceived wrongdoing, guilt about being merely causally responsible for a bad state-of-affairs. I go on to present a novel account of guilt that explains (...) guilt about mere causal responsibility, according to which guilt represents part of the self as bound up with what is bad. (shrink)

Ben shu bao han zheng zhi dao de de qi yuan he fa zhan, zheng zhi dao de de ben zhi, jie gou he she hui zuo yong deng shi si zhang de nei rong.

According to the safety principle, if one knows that p, one's belief that p could not easily have been false. One problem besetting this principle is the lottery problem – that of explaining why one does not seem to know that one will lose the lottery purely based on probabilistic considerations, prior to the announcement of the lottery result. As Greco points out, it is difficult for a safety theorist to solve this problem, without paying a heavy price. In this (...) paper, I first reject three existing safety-based solutions to the lottery problem, due to Pritchard, Sosa, and Broncano-Berrocal. Failure of these accounts reveals that there is something crucial missing in the safety principle. By way of remedying this, I propose to integrate a safety principle with a condition regarding one's own awareness of (nearby) error-possibilities. The resulting account, as I argue, enjoys a number of theoretical advantages, including its capacity to handle the lottery problem. (shrink)

Ben shu zhu yao lun shu ru,Mo liang jia fa zheng si xiang,Bing fu lu xian dai xing fa dui bi fo jiao jie lü lun wen yi pian.Xie zuo te se yao fen wei er:yi,Zai yan jiu fang fa shang,Cai qu bi jiao fa xue yan jiu jin lu,Jian shi chuan tong si xiang yu xian dai jia zhi ti xi xian zhuan gong gou zhi ke neng.Shi gu wen zhang lun shu zhong xin bu zai chan shu (...) ru,Mo nei sheng dao de gong fu lun mian xiang,Er geng ce zhong qi yu xian dai fa li nian ji xian xing fa zhi du zhi dui bi fen xi.Er,Zai lun shu nei rong fang mian,Chuan tong yan jiu zhu yao tong guo jia zhi xi tong nei,Ji ken ding chuan tong wen hua zhi zhuan ye yan jiu zhe li chang chu fa,Zhang xian zhong guo zhe xue shi dai he li xing. (shrink)

Sensitivity account of knowledge states that if one knows that _p_ (via method M), then were _p_ false, one would not believe that _p_ via M. This account has been highly controversial. However, even its critics tend to agree that the account enjoys an important advantage of solving the Gettier problem—that is, it explains why Gettierized beliefs are not knowledge. In this paper, I argue that this purported advantage of sensitivity is merely illusory. The account cannot, in principle, solve the (...) Gettier problem. Moreover, another formulation of sensitivity—which is fully in line with Nozick’s original account—is not unscathed either. (shrink)

One interesting and potentially attractive feature of the sensitivity account of knowledge is that it not only preserves knowledge of ordinary propositions, but also concedes the skeptic's intuition that we do not know skeptical hypotheses do not obtain. This paper challenges the sensitivity‐based reply to the skeptic, advocated by Robert Nozick, among others. Sensitivity generates an implausibly bizarre result that although we do not know we are not brains in vats (because a belief to this effect is insensitive), a real (...) BIV who is in a much worse epistemic situation can sensitively believe that it is not in the good case. This result reveals a fundamental problem with the sensitivity conditional: its antecedent is not suitable for picking out possibilities that are relevant for our epistemic evaluation. I then offer a systematic explanation of why it is the safety account—the main competitor of sensitivity—that picks out a more suitable set of possibilities. A consequence of this comparison is that the safety account delivers an overall more satisfying reply to the skeptic than sensitivity does. (shrink)

This paper examines the role existence plays in measurement validity. I argue that existing popular theories of measurement and of validity follow a correspondence framework, which starts by assuming that an entity exists in the real world with certain properties that allow it to be measurable. Drawing on literature from the sociology of measurement, I show that the correspondence framework faces several theoretical and practical challenges. I suggested the validity-first framework of measurement, which starts with a practice-based validation process as (...) the basis for a measurement theory, and only posits objective existence when it is scientifically useful to do so. (shrink)

In this paper, I first seek a relatively plausible formulation of the safety principle. To this end, I refute a recent form of safety by Duncan Pritchard and then defend another weaker form of safe...

本書稿已獲國家社科基金後期資助項目立項。該書從禮理會通的角度，將經學研究與哲學研究結合起來，並提煉出「禮樂哲學」這一新的學術概念，從禮樂形上學、價值論、實踐觀三個方面對朱子禮學的哲學體系做了較為系統的 詮釋與建構。該書指出，禮、理是朱熹思想的兩個基本面向，禮學是其理學下學實踐的基礎，理學是其禮學的形上依據，二者相融互補，使得朱熹的思想世界在理論與實踐兩個層面都顯得豐滿而自洽。與此同時，朱熹的禮樂哲學 思想也具有充分的現實價值。 馮兵，重慶奉節人，哲學博士，國立華僑大學哲學與社會發展學院教授，博士生導師，國際儒學研究院副院長，《國際孔孟學刊》副主編，國家一級學會「朱子學會」理事，全國名山名川名觀學術委員會高級顧問。畢業於廈門大 學哲學系(2010)，曾赴台灣「中央」研究院文哲所訪學(2015—2016)，主要從事儒家禮樂哲學以及傳統禮樂文化的當代傳承與應用研究。主持國家社科基金項目、教育部人文社科基金項目、教育部社科重大攻關 項目子課題各1項，福建省社科基金重大項目2項，貴州省社科規劃國學單列課題1項，參與國家社科基金重大項目及一般項目、教育部社科基金項目等數項。在《哲學研究》《哲學與文化》(A&HCI)《哲學動態》《中國 哲學史》《學術月刊》《光明日報》等海內外權威及核心學術刊物上發表論文數十篇，出版專著1部。曾獲得過福建省優秀博士學位論文獎、全國聯校教育社科醫學論文獎以及廈門市優秀社科成果獎。先後入選福建省新世紀優秀 人才計劃、華僑大學百名優秀學者成長計劃等人才項目。.

Given the rapid growth of music technology, this study reports Chinese pre-service music teachers’ perceptions of musical instrument learning assisted by augmented reality. In this study, we conducted a small-scale case study with six pre-service teachers enrolled in a music teacher training programme at a comprehensive university in China. Participants engaged in semi-structured, face-to-face interviews after hands-on experiences with an AR-based piano learning app. Thematic analysis revealed that the participants were generally aware of the potential of this instructional approach but (...) doubted its efficacy and exhibited weak intention to adopt it in their future classrooms. Implications of the findings for music teacher training are discussed. (shrink)

Seepage analysis is always a concern in dam safety and stability research. The prediction and analysis of seepage pressure monitoring data is an effective way to ensure the safety and stability of dam seepage. With the timeliness of a change in a monitoring value and lag due to external influences, a RS-LSTM model written in Python is developed in this paper which combines rough set theory and the long- and short-term memory network model. The model proposed calculates the prediction score (...) of the seepage pressure of a dam experiencing multiple effects by preordering factor importance values to eliminate the interference of redundant factors. A case study shows that the water level, rainfall, temperature, and duration are all factors that affect the seepage pressure, and their importance values decrease successively. Thus, the seepage pressure of a dam can be predicted with a determination coefficient R2 of 0.96. Compared with the recurrent neural network model and BP neural network model, the training time of the RS-LSTM model proposed is 6.37 s, and the operation efficiency is 41% and 59% higher than that of the RNN and BP models, respectively. The mean relative error is also 3.00%, which is 50% lower than that of the RNN model and 31% lower than that of the BP model. Based on these results, this model has the advantages of fast computation speed and high accuracy in prediction. (shrink)

本书是一本哲学自选文集,它收录了赵汀阳的《伦理学思路的改变》、《道德的维度或生活的维度》、《法律的道德余地》、《人之常情》等19篇文章。.

Since the beginning of the twentieth century, Chinese scholars have tended to traditional Chinese learning split apart and rearrange it according to the systematics of modern Western academic disciplines. By examining the meaning of Western "philosophy" and "ethics," it is demonstrated that Western and Chinese learning should not be lumped together according to the same systematics. Moreover, classical Chinese learning has always had its own complex systematics and its own long tradition, and it has undergone constant development over time. Thus, (...) it is well beyond any criticism that may be leveled at it from the standpoint of Western systematics. Even so, modern Chinese intellectuals have become accustomed to understanding classical Chinese learning through a Western prism. (shrink)

该书考察了传统理性主义的理性观从发端、变异到确立、扩展的历史演变,从中对理性与其相关的范畴进行了辨析;分析了由传统理性主义到非理性主义及反理性主义的转向等内容。.

Since the beginning of the twentieth century, Chinese scholars have tended to traditional Chinese learning split apart and rearrange it according to the systematics of modern Western academic disciplines. By examining the meaning of Western "philosophy" and "ethics," it is demonstrated that Western and Chinese learning should not be lumped together according to the same systematics. Moreover, classical Chinese learning has always had its own complex systematics and its own long tradition, and it has undergone constant development over time. Thus, (...) it is well beyond any criticism that may be leveled at it from the standpoint of Western systematics. Even so, modern Chinese intellectuals have become accustomed to understanding classical Chinese learning through a Western prism. (shrink)

本书介绍了当代西方哲学思潮的兴起和演变过程,着重评介了对当今中国大学生震动强烈的实用主义思想、观点、实质及造成影响的时代背景和大学生的心理基础.

本书分两部分,一部分是就先秦每一时代及其重要思想家的重要思想进行了阐述;另一部分是对先秦思想史的部分重要学术问题进行了探讨。.

This open access book sheds light on the term gongsheng/kyōsei, which is used in Chinese and Japanese to not only translate “symbiosis” in biology but also broadly deployed in philosophical, social and political contexts. It is a cross-contextual attempt to study the foundation of gongsheng/kyōsei as a philosophy of co-becoming, with exploration of its significance for thinking about the planetary challenges of our times.

This book centers on rethinking foundational values in the era of frontier technologies by tapping into the wisdom of Chinese philosophical traditions. It tries to answer the following questions: How is the essence underpinning humans, nature, and machines changing in this age of frontier technologies? What is the appropriate ethical framework for regulating human–machine relationships? What human values should be embedded in or learnt by AI? Some interesting points emerged from the discussions. For example, the three dominant schools of Chinese (...) thinking–Confucianism, Daoism and Buddhism– invariably reflect non-anthropocentric perspectives and none of them places humanity in a supreme position in the universe. While many Chinese philosophers are not convinced by the prospect of machine intelligence exceeding that of humans, the strong influence of non-anthropocentrism in the Chinese thinking contributed to much less panic in China than in the West about the existential risks of AI. The thinking is that as human beings have always lived with other forms of existence, living with programs or other forms of “beings,” which may become more capable than humans, will not inevitably lead to a dystopia. Second, all three schools emphasize self-restraint, constant introspection, and the pursuit of sage-hood or enlightenment. These views therefore see the potential risks posed by frontier technologies as an opportunity for the humanity to engage in introspection on the lessons learned from our social and political history. It is long overdue that humanity shall rethink its foundational values to take into account a multi-being planetary outlook. This book consists of nine leading Chinese philosophers’ reflections on AI’s impact on human nature and the human society. This is a groundbreaking work, which has pioneered the in-depth intellectual exploration involving traditional Chinese philosophy and frontier technologies and has inspired multidisciplinary and across area studies on AI, philosophy, and ethical implications. (shrink)

According to the sensitivity account of knowledge, if one knows that p, then (roughly) were p false, one would not believe that p. One important issue regarding sensitivity is whether or not it preserves inductive knowledge. Critics including Jonathan Vogel, Ernest Sosa, and Duncan Pritchard argue that it does not. Proponents including Kevin Wallbridge insist that it does. In this paper, I first draw attention to an often-neglected distinction between two different versions of sensitivity—a distinction that has important implications for (...) the debate regarding inductive knowledge. In particular, I distinguish between the sensitivity principle originally defended by Robert Nozick and another version that has been the focus of many recent discussions. With the distinction in place, it is shown that a sensitivity theorist cannot preserve inductive knowledge while being unscathed. For neither account can simultaneously preserve inductive knowledge while properly handling the Gettier problem. Overall, sensitivity theorists are in trouble. (shrink)

本书收录“关于命运的知识”、“从知识眼光到创作眼光”、“一个或所有问题”、“千年观念故事”、“理解20世纪的精神财富”等19篇文章。.

This speculative paper enquires into the discourse of the ‘end of labour’ or ‘disappearance of labour’ as a result of the development of ‘intelligent capitalism’ clearly seen in ‘intelligent manufacturing’ systems that are now pursued and developed as Industry 4.0 strategy in East Asia, Germany and others parts of the world. When ‘intelligent capitalism’ becomes the norm rather the exception what happens to labour as a factor of production and what happens to economy and society based on capital and labour? (...) The paper briefly reviews the sociology of labour from a Marxist view to examine conceptions of Fordist and post-Fordist capitalism, and explore the advert of ‘intelligent capitalism’ to pose the question concerning education. (shrink)

本书精选二十世纪外国美学文艺学名著175种,分别介绍其体系构架和主要观点,并兼及史实性、资料性的说明。.

本书的思想创新和理论力度颇有古代哲学家气度,作者认为伦理学只有幸福和公正两个基本问题,并且声称发现了关于幸福和公正的最好理论,并提出了著名的“无立场”哲学方法论。.

本书将马克思主义与科学社会主义置于“当代诠释学的视野”加以解读、追问和探寻,试图在新时代地平线上构建一个当代诠释学与马克思主义相融通的视域。.

With the emergence of online communities, more and more people are participating in online technology communities to meet personalized learning needs. This study aims to investigate whether and how male and female users behave differently in online technology communities. Using text data from Python Technology Community, through LDA (Latent Dirichlet Allocation) model, sentiment analysis and regression analysis, this paper reveals the different topics of male and female users in the online technology community, their sentimental tendencies and activity under different topics, (...) and their correlation and their mutual influence. The results show that: (1) Male users tend to provide information help, while female users prefer to participate in the topic of making friends and advertising. (2) When communicating in the technology community, male and female users mostly express positive emotions, but female users express positive emotions more frequently. (3) Different emotional tendencies of male and female users under different topics have different effects on their activity in the community. The activity of female users is more susceptible to emotional orientation. (shrink)