Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

The shared circuits model (SCM) is a useful explanatory framework that can be applied to interpersonal synchrony by incorporating temporal dynamics. Temporally precise predictive simulations and mirroring enable interpersonal synchrony. When partners' movements are highly synchronous, the self/other distinction can be blurred.

Listening to the Concerto for Violin and Orchestra in D-major by Brahms takes twenty-two minutes. It varies a few minutes depending of the soloist and conductor, but the duration is fairly constant. Reading Anna Karenina by Leo Tolstoy takes many hours. The duration varies a lot depending on the reader's pace, but reading literature, just as listening to music, takes a considerable amount of time. Looking at a work of visual art, on the other hand, typically takes less than a (...) minute. This may be an exaggeration, but museum studies show that visitors to an art museum usually spend only a few moments in front of the individual work of art. Jeffrey K. Smith and Lisa F. Smith found that visitors to the Metropolitan... (shrink)

The influence of conscience on nurses in terms of guilt has frequently been described but its impact on care has received less attention. The aim of this study was to describe nurses' conceptions of the influence of conscience on the provision of inpatient care. The study employed a phenomenographic approach and analysis method. Fifteen nurses from three hospitals in western Sweden were interviewed. The results showed that these nurses considered conscience to be an important factor in the exercise of their (...) profession, as revealed by the descriptive categories: conscience as a driving force; conscience as a restricting factor; and conscience as a source of sensitivity. They perceived that conscience played a role in nursing actions involving patients and next of kin, and was an asset that guided them in their efforts to provide high quality care. (shrink)

In this text, the author analyses and considers the critic of German philosopher Jürgen Habermas over the political liberalism of his american homologue John Rawls. The author first looks at the critics formulated against Rawls's model of political and individual autonomy. The author then proceeds to examine Habermas's position regarding Rawls's discourse on norm formation. This study shows certain lacunas in Rawls's theory in regard of today's society and proposes an alternative approach which would take into account democracy and inter (...) subjectivity. (shrink)

In this book, Andreas Serafim sets out to investigate the use of religious discourse, by which he means any reference to religious ideas, beliefs, and attitudes in public speaking contexts in classical Athens. Like Gunther Martin (Divine Talk: Religious Argumentation in Demosthenes, 2009), Serafim examines religion primarily as a tool for persuasion, but he differentiates himself from Martin’s book by offering a more comprehensive study: he aims to take into account all extant speeches from t...

The desire to guide research and innovation in more ‘responsible’ directions is increasingly emphasised in national and international policies, the funding of inter- and trans-disciplinary collaborations and academic scholarship on science policy and technology governance. Much of this growth has occurred simultaneously with the development of nanoscale sciences and technologies, where emphasis on the need for responsible research and innovation has been particularly widespread. This paper describes an empirical study exploring the potential for RRI within nanosafety research in Norway and (...) Denmark. It identifies three different ways nanosafety scientists relate to core RRI criteria, demonstrating areas of both convergence and divergence between their views and those of academics and policymakers currently defining and working to promote RRI. The paper identifies a range of practical barriers and cultural differences that are creating such divergences and inhibiting the enactment of RRI within the particular site of research laboratories. It concludes that the identified differences and challenges demand critical reflection on both the appropriateness and applicability of RRI characteristics for enactment at the level of individual research scientists. Significant changes are therefore advocated as required if RRI, as currently imagined and promoted, is to become an integral mode of scientific culture. (shrink)

The psychological effects of aesthetic education have often been discussed, and major studies such as Michael Parsons’s inquiry into art understanding show that the development of understanding works of visual art is influenced by education.1 His findings show that the way people talk about art can be structured in five stages of development according to the model of Jean Piaget’s theory of cognitive development. He believes that the understanding of art, just like general cognition, is based on mental maturation but (...) that some kind of education is necessary to acquire the different skills of the understanding of art at each stage of development. Parsons’s study does not include educational strategies, but his .. (shrink)

How does man find himself in a society that cannot offer clear answers to the fundamental question: What is the meaning of existence? This introduction to Søren Kierkegaard's psychological thinking may provide part of the answer. For those interested in psychology and philosophy and anyone else interested in existential dilemmas.

In lieu of an abstract, here is a brief excerpt of the content:Communicative Implications of Kant’s Aesthetic TheoryThomas HoveIn recent discussions of aesthetic theory, critics who raise social, cultural, and political concerns have issued important challenges to the Kantian legacy. Kant’s Critique of the Power of Judgment (1790) continues to be widely regarded as one of the founding documents of modern aesthetic theory. But the arguments he laid out in that notoriously enigmatic work remain controversial on a variety of fronts. (...) One of those arguments concerns his distinction between pleasures that are beautiful and those that are agreeable. According to Kant’s definition, what makes experiences of the beautiful special is that they have a potentially communicable universal validity. By contrast, pleasures that are merely agreeable are incommunicable and remain confined to private sensation. Philosophers have found this distinction problematic for a variety of reasons. Their detailed commentaries have examined the intricate logical and conceptual difficulties that Kant’s theory raises (see Allison 2001; Guyer 1982, 1997, 2002; Kalar 2000; Wenzel 2005). On another front, sociologists and cultural critics—whom I will broadly refer to as “social critics”—typically raise concerns about the theory’s hidden social implications (Bourdieu 1984; Eagleton 1990; Smith 1988; Shumway 2005). Specifically, they question Kant’s proposal that judgments about the beautiful ought to have universal validity. Taking an external standpoint, they tend to regard aesthetic judgments either as the peculiar habits of [End Page 103] specific social classes, or as badges of hierarchical distinction, or as weapons in symbolic struggles for cultural dominance.To suggest why Kant’s theory is worth revisiting in the wake of such critiques, the following analysis defends his theoretical effort to distinguish the experience of the beautiful from that of the agreeable. This feature of his aesthetic theory highlights an alternative to the cognitive and practical concerns that social critics emphasize. In particular, I indicate how Kant’s aesthetic theory offers directions for the effort to explain how aesthetic experience promotes communicative sociability. By emphasizing this theme, I hope to supplement the rival emphasis that social critics place on the Kantian legacy’s elitist undercurrents. Social critiques characteristically overlook the affective type of sociability to which aesthetic experience gives rise. This oversight occurs because those critiques tend to privilege the theoretical and practical dimensions of communication. In the process, they disregard the special types of validity claims that are unique to aesthetic discourse. Following the lead of his academic precursors Meier and Baumgarten, Kant tried to define a possible third mental “faculty” that differs from cognitive and practical reason (see Henrich 1992, 31–36). But the difficulty of defining this third faculty, much less determining its existence, continues to vex both philosophers and communication theorists.Kant’s Account of Aesthetic Experience and Its CriticsIn the opening sections of the Critique of Judgment, Kant attempts to establish the independence of aesthetic judgment from theoretical and practical cognition. Those faculties are concerned with cognitive and moral concepts. By contrast, the aesthetic properties that concern taste judgments have a unique ontological and epistemological status. Kant’s argument about that status is itself enormously complex, involving as it does an intricate network of idiosyncratically defined concepts (for example, the understanding, the imagination, intuition, representations, objects, etc.). But to avoid getting lost in those intricacies, we can bracket them by simply referring to aesthetic “experience.” Also, we can concentrate on the two properties that distinguish aesthetic experience from other kinds of experience. First, aesthetic properties relate to the feelings of pleasure that are aroused by certain encounters with objects. Second, aesthetic properties are “merely subjective” (Kant 2000, 75). They do not have an objective status because we cannot associate the feelings they arouse with determinate concepts and objects. [End Page 104] As Miles Rind puts it, “in making a cognitive judgment one requires everyone to conceptualize an object in a certain way, while in making a judgment of taste one requires others to share one’s liking for an object” (Rind 2000, 83). In sum, Kant differentiates aesthetic judgment from both theoretical and practical cognition because it is radically subjective and because its unique grounding lies in feelings of pleasure and displeasure.Social critics tend to downplay the idea that there... (shrink)

Bjarne Melkevik, docteur s droit de Paris II, est professeur titulaire la Facult de droit de l'Universit Laval (Qubec) et professeur associ au Dpartement de droit et Justice, Universit Laurentienne (Ontario).

Purpose. The purpose of this study is to investigate how professionals learn from varying experiences with errors in health-care digitalization and develop and use negative knowledge and digital ignorance in efforts to improve digitalized health care. Design/methodology/approach. A two-year qualitative field study was conducted in the context of a public health-care organization working with digital patient communication. The data consisted of participant observation, semistructured interviews and document data. Inductive coding and a theoretically informed generation of themes were applied. Findings. The (...) findings show that both health-care and digital communication professionals learn through experiences with digital “rule-” and “knowledge-based” errors in patient communication and develop negative knowledge and awareness of digital ignorance. In their joint efforts, they use negative knowledge to “bend the rules” and to explore digital ignorance in efforts to improve patient communication. Originality/value. This study provides insight into the importance of collaboration between professionals with varying experience of errors in digitalizing patient communication. Such collaboration is required to acknowledge own shortcomings and create complementary negative knowledge to improve digital patient communication. This is particularly important when working with innovative digitalization in health care. (shrink)

Abstract: In this article, I offer a proposal to clarify what I believe is the proper relation between value maximization and stakeholder theory, which I call enlightened value maximization. Enlightened value maximization utilizes much of the structure of stakeholder theory but accepts maximization of the long-run value of the firm as the criterion for making the requisite tradeoffs among its stakeholders, and specifies long-term value maximization or value seeking as the firm’s objective. This proposal therefore solves the problems that arise (...) from the multiple objectives that accompany traditional stakeholder theory. I also discuss the Balanced Scorecard, which is the managerial equivalent of stakeholder theory, explaining how this theory is flawed because it presents managers with a scorecard that gives no score—that is, no single-valued measure of how they have performed. Thus managers evaluated with such a system (which can easily have two dozen measures and provides no information on the tradeoffs between them) have no way to make principled or purposeful decisions. The solution is to define a true (single dimensional) score for measuring performance for the organization or division (and it must be consistent with the organization’s strategy), and as long as their score is defined properly, (and for lower levels in the organization it will generally not be value) this will enhance their contribution to the firm. (shrink)

In the past decade, the meaning of Hegel's idea of a ‘science of logic’ has become a matter of intense philosophical debate. This article examines the two most influential yet opposed contemporary readings of the Science of Logic—often referred to as the ‘metaphysical’ and ‘non-metaphysical’ interpretations. I argue that this debate should be reframed as a contest between logic as ontology (LAO) and logic as metaphysics (LAM). According to Stephen Houlgate's interpretation of logic as ontology, the science of logic is (...) a progressively explicit unfolding of the categories of thought, which is at the same time the process by which being itself determines what it is to be. A second interpretation has been pursued by Sebastian Rödl and Robert Pippin, who read Hegel's logic as metaphysics. On this reading, the science of logic is a progressively coherent unfolding of the categories of thought, which articulate all that it could intelligibly mean to be. This article intervenes in this debate in three key ways. First, I argue that Houlgate's ontological approach undermines his attempt to establish the objective validity of the categories. Second, I show that the LAM emphasis on the crucial idea of apperception enables it to succeed where Houlgate fails by doing justice to the rational necessity with which the Logic unfolds. Third, I argue that, despite this success, the LAM program remains unrealized because of its neglect of Hegel's understanding of cognition as a form of life. While LAM has compellingly unfolded the ‘thought of being’, it has ignored the inverse question of the ‘being of thought’. I attempt to fulfil the LAM program by elaborating Hegel's account of what it means to be a thinker. (shrink)

New-born screening programs for congenital disorders and chronic disease are expanding worldwide and children “at risk” are identified by nationwide tracking systems at the earliest possible stage. These practices are never neutral and raise important social and ethical questions. An emergent concern is that a reflexive professionalism should interrogate the ever earlier interference in children’s lives. The Flemish community of Belgium was among the first to generalize the screening for hearing loss in young children and is an interesting case to (...) study the public justification of early interventions for families with deaf children. This article uses a critical lens to study the archive of the government child healthcare organization in Flanders in order to uncover underlying constructions of childhood, deafness, and preventive health. We focus on two interrelated themes. The first is the notion of exclusion of the human factor through the mediation of technology. The second is the idea of deafness as endangering a healthy development, an impairment that can nevertheless be treated if detected early enough. It is argued that, since deafness cannot be viewed as a life-threatening condition, the public interest which is implicitly defended is not the rescue of deaf children rather the exclusion of otherness. (shrink)

Although Denmark managed to stay neutral throughout World War I, it nevertheless generated a heated debate in the country; most people took a clear stand for one side or the other. After the traumatic Danish defeat in the 1864 war with Prussia and Austria, Germany was regarded as the arch enemy and not unexpectedly mostDanes sided against the Central Powers in the public debate. This was not least the case amongst the national-conservative politicians, intellectuals and artists. They form the focus (...) of my article, and the questions I address are: how did the national-conservatives experience the mental watershed of the war? Was it as a blessing or a curse? (shrink)

In this text, the author analyses and considers the critic of German philosopher Jürgen Habermas over the political liberalism of his american homologue John Rawls. The author first looks at the critics formulated against Rawls's model of political and individual autonomy. The author then proceeds to examine Habermas's position regarding Rawls's discourse on norm formation. This study shows certain lacunas in Rawls's theory in regard of today's society and proposes an alternative approach which would take into account democracy and inter (...) subjectivity. (shrink)

La philosophie du droit a pour fonction d’assister la réflexion sur le monde du juridique, sur « le droit qui se fait », sur la doctrine juridique et notre façon de l’écrire, et sur l’appréciation (ou l’indifférence, l’hostilité, etc.) qu’un individu distancié peut éprouver à l’égard du droit et des juristes. Elle assiste et elle participe en examinant notre façon d’opérationnaliser les sources du droit, de forger des arguments pouvant être juridiques, d’évaluer les narrations qui se présentent au droit, d’examiner (...) la pertinence de la doctrine, notre façon de pratiquer le droit et de faire des jugements judiciaires. Elle ne réside de toute évidence pas « en haut » et elle ne « surplombe » pas l’écriture de la doctrine. Elle ne se glorifie pas en distribuant (en toute incompétence) l’étiquette de « scientificité » au bon candidat, que celui-ci soit auteur d’un article, d’un livre ou d’une théorie. Admettons plutôt lucidement que la philosophie du droit ne donne pas de certificat de « scientificité » et que toute revendication en ce « sens » n’a pas de « sens ». (shrink)

Den historiske udvikling af teoretisk pædagogik i dansk sammenhæng.

Health communication researchers and practitioners continue to debate about the types of influence that are appropriate in health promotion. A widely held assumption is that health campaigns and communicators should respect the autonomy of their audiences, and that the most appropriate way to do so is to persuade them by means of truthful substantive information. This approach to ethical persuasion, though, suffers from certain blind spots. To account for circumstances when respecting autonomy might take a back seat to other ethical (...) considerations, a comprehensive framework for the ethics of health communication needs to acknowledge types of communication that aim to do something other than provide substantive information (disclosive and directive communication), and subjective circumstances when people are not motivated to process information or make active choices (low processing motivation and decision aversion). (shrink)

Ethical decision making is of concern to researchers across all fields. However, researchers typically focus on the biases that may act to undermine ethical decision making. Taking a new approach, this study focused on identifying the most common compensatory strategies that counteract those biases. These strategies were identified using a series of interviews with university researchers in a variety of areas, including biological, physical, social, and health as well as scholarship and the performing arts. Interview transcripts were assessed with two (...) scoring procedures, an expert rating system and computer-assisted qualitative analysis. Although the expert rating system identified Understanding Guidelines, Recognition of Insufficient Information, and Recognizing Boundaries as the most frequently used compensatory strategies across fields, other strategies, Striving for Transparency, Value/norm Assessment, and Following Appropriate Role Models, were identified as most common by the computer-assisted qualitative analyses. Potential reasons for these findings and implications for training and practice are identified and discussed. (shrink)

The anti-commodification and social responsibility traditions of media criticism emphasize journalism's function as a public good. This commentary supplements that perspective by calling attention to the status of journalistic authority as a “positional” good. Such goods can be possessed only by a limited number of people in relation to others. For news producers, the reputation of journalistic authority cannot itself be a public good. When news is conveyed to mass audiences, some voices will be perceived to have that authority while (...) most will not. To illustrate the social laws of competition for journalistic authority, a theme in media criticism from the liberal blogosphere is discussed. The point of this discussion is to highlight the social dynamic that informs perceptions of journalistic authority when that authority cannot always be inspected through rational-critical analysis. (shrink)

Starting out from the presumption that inscriptions are texts indissolubly connected to the physical objects on which they are written, this collection of essays aims to provide a multi-disciplinary perspective on the physical and material aspects of writing in antiquity. It argues that there is a need to ‘increase modern sensibilities to material aspects of our texts which are often elided in modern printed editions’. This call is not new: recognition of the importance of the materiality of...