The T lymphocyte receptor for antigen, which operates in conjunction with gene products of the major histocompatibility complex (MHC), is a molecular complex comprised of five polypeptide chains. Both the 49 kDa alpha and 43 kDa beta chains are immunoglobulin‐like and thus contain variable domains responsible for ligand binding. In contrast, the 20–25 kDa T3 gamma, delta and epsilon chains are monomorphic structures presumably involved in transmembrane signalling. The alpha and beta subunits are disulfide bonded to each other and held (...) in noncovalent association with the T3 chains. T3‐Ti receptor crosslinking leads to conformational modification of a second T lineage specific molecule, termed the 50 kDa T11 structure which in turn leads to protein kinase C activation, elevation in intracytoplasmic free calcium and Na+/H+ antiport stimulation. (shrink)

To date, research examining the socio-spatial effects of smart city technologies have charted how they are reconfiguring the production of space, spatiality and mobility, and how urban space is governed, but have paid little attention to how the temporality of cities is being reshaped by systems and infrastructure that capture, process and act on real-time data. In this article, we map out the ways in which city-scale Internet of Things infrastructures, and their associated networks of sensors, meters, transponders, actuators and (...) algorithms, are used to measure, monitor and regulate the polymorphic temporal rhythms of urban life. Drawing on Lefebvre, and subsequent research, we employ rhythmanalysis in conjunction with Miyazaki’s notion of ‘algorhythm’ and nascent work on algorithmic governance, to develop a concept of ‘algorhythmic governance’. We then use this framing to make sense of two empirical case studies: a traffic management system and sound monitoring and modelling. Our analysis reveals: how smart city technologies computationally perform rhythmanalysis and undertake rhythm-making that intervenes in space-time processes; distinct forms of algorhythmic governance, varying on the basis of adaptiveness, immediacy of action, and whether humans are in-, on-, or, off-the-loop; and a number of factors that shape how algorhythmic governance works in practice. (shrink)

The denial of voting rights to certain types of persons continues to be a moral problem of practical significance. The disenfranchisement of persons with mental impairments, minors, noncitizen residents, nonresident citizens, and criminal offenders is a matter of controversy. This book makes a contribution to this largely neglected yet key topic.

This article compares the ‘enfranchisement lottery’, a novel method for allocating the right to vote, with universal suffrage. The comparison is conducted exclusively on the basis of the expected consequences of the two systems. Each scheme seems to have a relative advantage. On the one hand, the enfranchisement lottery would create a better informed electorate and thus improve the quality of electoral outcomes. On the other hand, universal suffrage is more likely to ensure that elections are seen to be fair, (...) which is important for political stability. This article concludes that, on balance, universal suffrage is prima facie superior to the enfranchisement lottery. Yet the analysis shows that the instrumental case for the ‘one person, one vote’ principle is less conclusive than democratic theorists usually suppose. (shrink)

Kant ha subrayado el carácter problemático del auto-conocimiento en el campo de la antropología y la psicología: desde sus primeras obras insistió en la imposibilidad de conocer con certeza, sobre la base de las acciones, la disposición moral subjetiva, la única que da a la acción un valor moral. Esta dificultad no se atenúa cuando el juicio moral es dirigido sobre el sujeto mismo. A los problemas cognitivos se añade una tendencia al auto-engaño que está activa en toda la vida (...) moral. Si se mantiene la importancia de este argumento, puede emerger una caracterización de la Gesinnung que la distingue de cualquier “intención” subjetiva. Aquella puede ser concebida más bien como una estructura “objetiva”, independiente de la conciencia subjetiva y análoga a una idea regulativa, que obliga a interpretar las acciones morales sobre la base de un principio que es necesario asumir, pero que no es posible conocer. (shrink)

Este trabajo se propone discutir el concepto kantiano de Ilustración en un triple aspecto: 1) la noción de saber implícita en el uso del lema sapere aude, referida no al conocimiento , sino a una noción de razón que culmina en la sabiduría (Weisheit.

A scholarly annotated epic poem on the pitfalls and tribulations of “good philosophizing”. Divided into twenty-eight cantos (in medieval Italian hendecasyllabic terza rima), the poem tells of an allegorical journey through the downward spiral of the philosophers’ hell, where all sorts of thinkers are punished for their faults and mistakes, in the endeavor to reach a way out of the condition of intellectual impasse in which the narrator has found himself. The affinities with Dante’s Inferno are apparent. Whereas Dante’s poem (...) is about human sins and moral felonies, this one is about philosophical errors and fallacies; whereas Virgil takes Dante through the gluttons, the wrathful, the violent, the traitors to parties and countries, etc., here Socrates takes us through the realists, the skeptics, the dualists, the nichilists, the worshipers of language and easy mythos, etc. And yet this is not just a philosophical counterpart of Dante’s masterpiece, even less a parody. We can’t say exactly when, how, and why it was written, but this is an authentic piece of philosophy, a poem of love, a passionate testimony of militant metaphysics. It is the inspired and inspiring journey of someone, anyone, who is truly moved by the Love for Wisdom and by the grueling purification of the intellect that it demands. (shrink)

James procurou superar a cisão da personalidade por meio de uma antropologia da ação em que combinou vários materiais intelectuais que não respeitam fronteiras epistemológicas. Apropriou-se estrategicamente de diferentes fontes culturais e avanços da psicopatologia para pensar a liberação das possibilidades da consciência e da experiência. Entre eles, serão exploradas suas leituras de Giovanni Papini e Pierre Janet para dar conta do modo preciso como essas contribuições intelectuais atuam em sua antropologia da superação.

El artículo presenta los resultados de una investigación empírica que busca caracterizar el campo de las ciencias sociales en Chile, en el período 2000-2006, en cuanto a su proceso cognitivo, comparando entre las disciplinas. Para ello se constituyó un corpus de 479 publicaciones en las cuales se re..

Este artículo analiza el proceso de integración del Mercosur en el que participan Argentina, Brasil, Paraguay y Uruguay y sus efectos sobre la ciudadanía política y social. En la primera parte del mismo los autores examinan los rasgos, el contexto de nacimiento y la filosofía del proceso de integración mercosureño. La segunda parte analiza la evolución de la democracia y de la justicia social durante el proceso de integración. Los autores llegan a la conclusión de que el modelo de integración (...) mercosureño no puede contrarrestar la crisis de la democracia y de la justicia social que tienen lugar especialmente en Argentina y Brasil. (shrink)

In this paper we review some properties of fuzzy observables, mainly as realized by commutative positive operator valued measures. In this context we discuss two representation theorems for commutative positive operator valued measures in terms of projection valued measures and describe, in some detail, the general notion of fuzzification. We also make some related observations on joint measurements.

The deep operation of androcentrism in scientific argumentation demands recognition as a form of fallacy. On Walton’s account, fallacies are serious mistakes in argumentation that employ presumptions acceptable in other circumstances. There are only isolated cases in which androcentric pre-sumptions are acceptable, and I argue that androcentrism affects an overarching theme of generalization in science rather than an isolated scheme. Androcentrism is related to other ways of treating privileged people as exemplary humans, whose negative impact on processes of argumentation can (...) be described as the fallacy of “appeal to the standard.”. (shrink)

This research note presents data concerning the community engagement activities of 2,096 Swiss companies as reported by a single company respondent in an online survey. Switzerland affords an interesting opportunity to compare engagement activities in a single country with multiple culture systems across companies varying in size from large to small and medium enterprises. Study results show that 78% of the surveyed firms pursue some community engagement activities. While engagement is mostly practiced in traditional forms, more active forms are not (...) uncommon. The main motivating factor is a concern for the communities in which the firms operate. Engagement activities are mostly employed independent of financial considerations and are conducted flexibly to serve personal interests of the firms’ decision makers. Swiss firms’ reported environmental assessment activities show no specific patterning. Perceiving engagement to be on the rise globally and in Switzerland is associated with a greater likelihood to be involved. Accordingly, knowing other engagement pursuing firms increases the individual firm engagement probability. The German speaking part of Switzerland is more active in engagement than the French and Italian speaking parts. Bigger companies pursue engagement activities more intensively and strategically than do SMEs. (shrink)

Primeiramente, oferecemos uma apresentação teórica da representação do pensamento prático, começando pela distinção entre silogismo dialético e silogismo demonstrativo. Fazemos referência à crítica de Toulmin contra o dedutivismo dominante de seu tempo. Em seguida, fornecemos argumentos para apoiar a relevância heurística do modelo de Toulmin para entender a discussão sobre a inclusão da lógica padrão na representação do pensamento comum. Afirmamos que o projeto analítico toulmaniano permite entender, com clareza metódica, a derrotabilidade dos argumentos do senso comum por meio da (...) investigação da noção modal de probabilidade na linguagem comum. First, we offer theoretical resemblance of the representation of practical reasoning, beginning with the distinction between demonstrative and dialectical syllogism. We make reference to the Toulmin’s critique against to the dominant deductivism in his time. Then we give arguments to sustain the heuristic relevance of Toulmin’s model to understand the discussion about the inclusion of default logics in the representation of ordinary reasoning. We assert that the Toulminian analytic design allows to understand, with methodical clarity, the defeasibility of common sense arguments by means of the investigation of the modal notion of probability in ordinary language. (shrink)

Am 26. Dezember 2005, einen Tag vor seinem 74. Geburtstag, starb Silvestro Marcucci, Erster Vorsitzender der „Società Italiana di Studi Kantiani“, sowie Begründer und Herausgeber der Zeitschrift „Studi kantiani“. Sein Tod kam gänzlich unerwartet in einer Zeit, da er, seit dem 31. Oktober 2005 frei von akademischen Verpflichtungen, seine wissenschaftliche Tätigkeit fortsetzte, vielleicht mit noch größerer Freude und mehr Engagement als zuvor. Die letzten Wochen seines Lebens waren mit dem Gedanken an der Organisation des XI. Internationalen Kant-Kongresses 2010 erfüllt, der (...) nach dem Beschluss der Kant-Gesellschaft im Oktober 2005 von der Società di studi kantiani in Pisa veranstaltet werden wird. Marcucci trug wie kaum ein anderer dazu bei, der italienischen Kant-Forschung, die ohnehin schon lange internationale Anerkennung gewonnen hat, ein prägnantes Profil zu verleihen: er hatte die Fähigkeit, die zahlreichen italienischen Forscher einem intensiveren wissenschaftlichen Austausch und dadurch zu neuen Leistungen zuzuführen. (shrink)

Arnaud Milanese | : La philosophie pratique de Hobbes est problématique parce que son déterminisme ne semble pas permettre une théorie de l’action : comment penser l’imputation des actes, si l’on soutient que le libre-arbitre n’existe pas ? 1) Son analyse se construit à travers la critique de la théorie scolastique du libre arbitre (dans la controverse avec Bramhall), et, à cette fin, Hobbes semble puiser dans l’analyse d’Aristote pour y reprendre sa distinction entre actions volontaires et involontaires. 2) (...) Mais il ne peut penser cependant la spécificité des actions humaines, comme d’Aristote, par la contingence. 3) Il ne lui reste alors, pour penser l’imputation dans une ontologie déterministe, qu’à constituer une conception de l’individualité de l’agent qui repense le motif aristotélicien de la détermination intérieure à agir, mais sans libre-arbitre ni contingence. 4) Si les difficultés théologiques subsistent, c’est parce que, pour Hobbes, aucune philosophie ne peut résoudre les mystères de la foi. | : The hobbesian philosophy of action is problematical because his determinism seems unable to frame a theory of action : how could it be possible to conceive imputation of actions, if free will does not exist ? 1) This analysis is built on a criticism of scholastic theory of free will (in controversy with Bramhall), and, to this end, Hobbes seems to draw in the aristotelian analysis and makes use of his distinction between voluntary and involuntary actions. 2) But however, he cannot conceive the specificity of human actions the same way Aristotle did, that is, by the concept of contingency. 3) So, the only remaining way of thinking imputation in his determinist ontology seems to suppose a certain conception of the individuality of agents, and to rethink this way the aristotelian concept of inner determination to act, but without free will nor contingency. 4) Theological difficulties remains, of course, but only because, according to Hobbes, philosophy cannot solve the mysteries of faith. (shrink)

The œuvre of Portuguese photographer Jorge Molder can be construed as a series of series. These series are filled with a wealth of absent presences, of possibilities that arise and fade without ever reaching actualization or confirmation, thereby contributing to create a ‘detective-story’ atmosphere. This also proves to be true as regards Molder’s own body. Indeed, his face, his hands are recurrent “subjects” running through his 40 years of work. Even so, when we ask who the man is that we (...) see in Molder’s series, the answer is problematic. On the one hand, we know it is “him”, insofar as he himself is the model for his iconic “constructions”. On the other hand, Molder’s images are not “self-portraits” aiming to reveal the essence of his self, but rather “self-representations” creating a peculiar “character” who is and yet is not him: a double. (shrink)

This volume serves as a reference on the field of cognitive semantics. It offers a systematic and original discussion of the issues at the core of the debate in semiotics and the cognitive sciences. It takes into account the problems of representation, the nature of mind, the structure of perception, beliefs associated with habits, social cognition, autism, intersubjectivity and subjectivity. The chapters in this volume present the foundation of semiotics as a theory of cognition, offer a semiotic model of cognitive (...) integration that combines Enactivism and the Extended Mind Theory, and investigate the role of imagination as the origin of perception. The author develops an account of beliefs that are associated with habits and meaning, grounded in Pragmatism, testing his Narrative Practice Semiotic Hypothesis on persons with autism spectrum disorders. He also integrates his ideas about the formation of the theory of mind with a theory of subjectivity, understood as self-consciousness which derives from semiotic cognitive abilities. This text appeals to students, professors and researchers in the field. (shrink)

Accountability is a cornerstone of the governance of artificial intelligence (AI). However, it is often defined too imprecisely because its multifaceted nature and the sociotechnical structure of AI systems imply a variety of values, practices, and measures to which accountability in AI can refer. We address this lack of clarity by defining accountability in terms of answerability, identifying three conditions of possibility (authority recognition, interrogation, and limitation of power), and an architecture of seven features (context, range, agent, forum, standards, process, (...) and implications). We analyse this architecture through four accountability goals (compliance, report, oversight, and enforcement). We argue that these goals are often complementary and that policy-makers emphasise or prioritise some over others depending on the proactive or reactive use of accountability and the missions of AI governance. (shrink)

La reconstruction baconienne est à la fois philosophique et politique : par la critique de nos conditions historiques, saisir le système des institutions épistémiques et politiques, et commencer une nouvelle histoire centrée sur l'invention. Tel est le sens qu'il a imprimé à la modernité.

Penelope Maddy has recently addressed the set-theoretic multiverseset-theoretic multiverse, and expressed reservations on its status and merits Foundations of mathematics. Essays in honor of W. Hugh Woodin’s 60th birthday. Contemporary mathematics. American Mathematical Society, Providence, pp. 289–322, 2017). The purpose of the paper is to examine her concerns, by using the interpretative framework of set-theoretic naturalismset-theoretic naturalism. I first distinguish three main forms of ‘multiversism’multiversism, and then I proceed to analyse MaddyMaddy’s concerns. Among other things, I take into account salient (...) aspects of multiverse-related mathematics, in particular, research programmes in set theory for which the use of the multiverse seems to be crucial, and show how one may provide responses to MaddyMaddy’s concerns based on a careful analysis of ‘multiverse practice’. (shrink)

In this paper, I shall set out the pros and cons of assigning legal personhood on artificial intelligence systems under civil law. More specifically, I will provide arguments supporting a functionalist justification for conferring personhood on AIs, and I will try to identify what content this legal status might have from a regulatory perspective. Being a person in law implies the entitlement to one or more legal positions. I will mainly focus on liability as it is one of the main (...) grounds for the attribution of legal personhood, like for collective legal entities. A better distribution of responsibilities resulting from unpredictably illegal and/or harmful behaviour may be one of the main reasons to justify the attribution of personhood also for AI systems. This means an efficient allocation of the risks and social costs associated with the use of AIs, ensuring the protection of victims, incentives for production, and technological innovation. However, the paper also considers other legal positions triggered by personhood in addition to responsibility: specific competencies and powers such as, for example, financial autonomy, the ability to hold property, make contracts, sue. (shrink)