We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

We define the notion of a completely determined Borel code in reverse mathematics, and consider the principle $CD - PB$, which states that every completely determined Borel set has the property of Baire. We show that this principle is strictly weaker than $AT{R_0}$. Any ω-model of $CD - PB$ must be closed under hyperarithmetic reduction, but $CD - PB$ is not a theory of hyperarithmetic analysis. We show that whenever $M \subseteq {2^\omega }$ is the second-order part of an ω-model (...) of $CD - PB$, then for every $Z \in M$, there is a $G \in M$ such that G is ${\rm{\Delta }}_1^1$-generic relative to Z. (shrink)

At the forefront of international concerns about global legislation and regulation, a host of noted environmentalists and business ethicists examine ethical issues in consumption from the points of view of environmental sustainability, economic development, and free enterprise.

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Fyodor Dostoyevsky expressed a strange and surprising sentiment through one of the characters of The Brothers Karamazov. A dying young man named Markel declares: Every one of us has sinned against all men, and I more than others." He later says: "...every one of us is answerable for everyone else and for everything." Markel's absurd claims have engendered many reflections on the nature of suffering and what it means to be responsible for someone else's suffering. The world has no shortage (...) of pain and evil; what exactly is the relationship between suffering and responsibility? Markel's declarations press forward a question that drives this essay collection: how responsible should we consider ourselves for the suffering of the world? This volume is a collection of essays that struggle in various ways to understand and respond to several philosophical, theological and practical problems. In each case the authors grapple with issues surrounding suffering, immorality, evil, exploitation and oppression. The contributors share a clear concern for the ways that philosophers and theologians should respond to the problems of suffering and evil. They also share a conviction that these remain intense and central problems for philosophy and theology. Evil is an obstacle for belief, for morality, for hospitality, and for hope. This book struggles to address the particular and strong sense of responsibility that falls on Christians when it comes to understanding and, more importantly, responding to the problems of suffering and evil in the world. (shrink)

Physical Relativity explores the nature of the distinction at the heart of Einstein's 1905 formulation of his special theory of relativity: that between kinematics and dynamics. Einstein himself became increasingly uncomfortable with this distinction, and with the limitations of what he called the 'principle theory' approach inspired by the logic of thermodynamics. A handful of physicists and philosophers have over the last century likewise expressed doubts about Einstein's treatment of the relativistic behaviour of rigid bodies and clocks in motion in (...) the kinematical part of his great paper, and suggested that the dynamical understanding of length contraction and time dilation intimated by the immediate precursors of Einstein is more fundamental. Harvey Brown both examines and extends these arguments, after giving a careful analysis of key features of the pre-history of relativity theory. He argues furthermore that the geometrization of the theory by Minkowski in 1908 brought illumination, but not a causal explanation of relativistic effects. Finally, Brown tries to show that the dynamical interpretation of special relativity defended in the book is consistent with the role this theory must play as a limiting case of Einstein's 1915 theory of gravity: the general theory of relativity.Appearing in the centennial year of Einstein's celebrated paper on special relativity, Physical Relativity is an unusual, critical examination of the way Einstein formulated his theory. It also examines in detail certain specific historical and conceptual issues that have long given rise to debate in both special and general relativity theory, such as the conventionality of simultaneity, the principle of general covariance, and the consistency or otherwise of the special theory with quantum mechanics. Harvey Brown' s new interpretation of relativity theory will interest anyone working on these central topics in modern physics. (shrink)

The periodic table of the elements is one of the most powerful icons in science: a single document that captures the essence of chemistry in an elegant pattern. Indeed, nothing quite like it exists in biology or physics, or any other branch of science, for that matter. One sees periodic tables everywhere: in industrial labs, workshops, academic labs, and of course, lecture halls. It is sometimes said that chemistry has no deep ideas, unlike physics, which can boast quantum mechanics and (...) relativity, and biology, which has produced the theory of evolution. This view is mistaken, however, since there are in fact two big ideas in chemistry. They are chemical periodicity and chemical bonding, and they are deeply interconnected. The observation that certain elements prefer to combine with specific kinds of elements prompted early chemists to classify the elements in tables of chemical affinity. Later these tables would lead, somewhat indirectly, to the discovery of the periodic system, perhaps the biggest idea in the whole of chemistry. Indeed, periodic tables arose partly through the attempts by Dimitri Mendeleev and numerous others to make sense of the way in which particular elements enter into chemical bonding. (shrink)

In this philosophy classic, which was first published in 1951, E. R. Dodds takes on the traditional view of Greek culture as a triumph of rationalism. Using the analytical tools of modern anthropology and psychology, Dodds asks, "Why should we attribute to the ancient Greeks an immunity from 'primitive' modes of thought which we do not find in any society open to our direct observation?" Praised by reviewers as "an event in modern Greek scholarship" and "a book which it would (...) be difficult to over-praise," _The Greeks and the Irrational _was Volume 25 of the Sather Classical Lectures series. (shrink)

The main thrust of the paper involves a theoretical and philosophical analysis of the claim made in September 1999 that atomic orbitals have been directly imaged for the first time. After a brief account of the recent claims the paper reviews the development of the orbit and later orbital concepts and analyzes the theoretical status of atomic orbitals. The conclusion is that contrary to these claims, atomic orbitals have not in fact been observed. The non-referring nature of modern atomic orbitals (...) is discussed in the context of Laudan's writings on realism, the success of theories, and whether or not scientific terms refer. I conclude that the failure to observe orbitals is a good prima facie case for divorcing the success of theories from the question of whether their central terms refer. The added relevance of this case is that it concerns a current and highly successful theory. Finally, the relevance of this ‘floating model’ to contemporary discussions on scientific models is briefly considered. (shrink)

For a period of several years the philosopher of science Hasok Chang has promoted various inter-related views including pluralism, pragmatism, and an associated view of natural kinds. He has also argued for what he calls the persistence of everyday terms in the scientific view. Chang claims that terms like phlogiston were never truly abandoned but became transformed into different concepts that remain useful. On the other hand, Chang argues that some scientific terms such as acidity have suffered a form of (...) “rupture”, especially in the case of the modern Lewis definition of acids. Chang also complains that the degree of acidity of a Lewis acid cannot be measured using a pH meter and seems to regard this as a serious problem. The present paper examines some of these views, especially what Chang claims to be a rupture in the definition of acidity. It is suggested that there has been no such rupture but a genuine generalization, on moving from the Brønsted-Lowry theory to the Lewis theory of acidity. It will be shown how the quantification and measurement of Lewis acidity can easily be realized through the use of equilibrium theory and the use of stability constants. (shrink)

The debate about the relative epistemic weights carried in favour of a theory by predictions of new phenomena as opposed to accommodations of already known phenomena has a long history. We readdress the issue through a detailed re-examination of a particular historical case that has often been discussed in connection with it—that of Mendeleev and the prediction by his periodic law of the three ‘new’ elements, gallium, scandium and germanium. We find little support for the standard story that these predictive (...) successes were outstandingly important in the success of Mendeleev's scheme. Accommodations played an equal role—notably that of argon, the first of the ‘noble gases’ to be discovered; and the methodological situation in this chemical example turns out to be in interesting ways different from that in other cases—invariably from physics—that have been discussed in this connection. The historical episode when accurately analysed provides support for a different account of the relative weight of prediction and accommodation—one that is further articulated here. (shrink)

In his latest book, Eric Scerri presents a completely original account of the nature of scientific progress. It consists of a holistic and unified approach in which science is seen as a living and evolving single organism. Instead of scientific revolutions featuring exceptionally gifted individuals, Scerri argues that the "little people" contribute as much as the "heroes" of science. To do this he examines seven case studies of virtually unknown chemists and physicists in the early 20th century quest to (...) discover the structure of the atom. They include the amateur scientist Anton van den Broek who pioneered the notion of atomic number as well as Edmund Stoner a then physics graduate student who provided the seed for Pauli's Exclusion Principle. Another case is the physicist John Nicholson who is virtually unknown and yet was the first to propose the notion of quantization of angular momentum that was soon put to good use by Niels Bohr. Instead of focusing on the logic and rationality of science, Scerri elevates the role of trial and error and multiple discovery and moves beyond the notion of scientific developments being right or wrong. While criticizing Thomas Kuhn's notion of scientific revolutions he agrees with Kuhn that science is not drawn towards an external truth but is rather driven from within. The book will enliven the long-standing debate on the nature of science, which has increasingly shied away from the big question of "what is science?". (shrink)

The historical development of the electronic configuration model is traced and the status of the model with respect to quantum mechanics is examined. The successes and problems raised by the model are explored, particularly in chemical ab initio calculations. The relevance of these issues to whether chemistry has been reduced to quantum mechanics is discussed, as are some general notions on reduction.

The article examines a recent interventionist account of causation by Ross, in which electronic configurations of atoms are considered to be the cause of chemical behavior. More specifically I respond to the claim that a change in electronic configuration of an atom, such as occurs in the artificial synthesis of elements, causes a change in the behavior of the atom in question. I argue that chemical behavior is governed as much by the nuclear charge of an atom as it is (...) by its electronic structure. It is suggested that an adequate analysis requires attention to the dynamical interactions between nuclear charges and those of electrons, as typically carried out through the application of the Schrödinger equation. It is concluded that electronic configurations can only be said be causal in a weak sense that is somewhat analogous to the causal arguments that are invoked in folk physics. (shrink)

As ecologically and socially oriented food initiatives proliferate, the significance of these initiatives with respect to conventional food systems remains unclear. This paper addresses the transformative potential of alternative food networks by drawing on insights from recent research on food and embodiment, diverse food economies, and more-than-human food geographies. I identify several synergies between these literatures, including an emphasis on the pedagogic capacities of AFNs; the role of the researcher; and the analytical and political value of using assemblage and actor-network (...) thinking to understand the far-reaching forces and power disparities confronting proponents of more ethical and sustainable food futures. (shrink)

Differing views on reduction are briefly reviewed and a suggestion is made for a working definition of 'approximate reduction'. Ab initio studies in quantum chemistry are then considered, including the issues of convergence and error bounds. This includes an examination of the classic studies on CH2 and the recent work on the Si2C molecule. I conclude that chemistry has not even been approximately reduced.

A chronological approach that examines the progression of Levinas's deliberations on time over six decades, thus providing new insights about aspects of Levinasian thought that have consistently troubled readers, including the differences between Levinas's early and later writings, his controversial invocation of the feminine, and the blurry line between philosophy and religion in his work"--Provided by publisher.

Although the periodic system of elements is central to the study of chemistry and has been influential in the development of quantum theory and quantum mechanics, its study has been largely neglected in philosophy of science. The present article is a detailed criticism of one notable exception, an attempt by Hettema and Kuipers to axiomatize the periodic table and to discuss the reduction of chemistry in this context.

The article begins with a response to a recent contribution by Jensen, in which he has criticized several aspects of the use of triads of elements, including Döbereiner’s original introduction of the concept and the modern use of atomic number triads by some authors including myself. Such triads are groups of three elements, one of which has approximately the average atomic weight of the other two elements, as well as having intermediate chemical reactivity. I also examine Jensen’s attempted reconstruction Mendeleev’s (...) use of triads in predicting the atomic weights of three hitherto unknown elements, that were subsequently named gallium, germanium and scandium. The present article then considers the use of atomic number triads, in conjunction with the phenomenon of first member anomaly, in order to offer support for Janet’s left-step periodic table, in which helium is relocated into group 2 of the table. Such a table features triads in which the 2nd and third elements of each group, without fail, fall into periods of equal length, a feature that is absent in the conventional 18-column or the conventional 32-column table. The dual sense of the term element, which is the source of much discussion in the philosophy of chemistry, is alluded to in further support of such a relocation of helium that may at first appear to contradict chemical intuition. (shrink)

This article considers two important traditions concerning the chemical elements. The first is the meaning of the term “element” including the distinctions between element as basic substance, as simple substance and as combined simple substance. In addition to briefly tracing the historical development of these distinctions, I make comments on the recent attempts to clarify the fundamental notion of element as basic substance for which I believe the term “element” is best reserved. This discussion has focused on the writings of (...) Fritz Paneth which are here analyzed from a new perspective. The other tradition concerns the reduction of chemistry to quantum mechanics and an understanding of chemical elements through their microscopic components such as protons, neutrons and electrons. I claim that the use of electronic configurations has still not yet settled the question of the placement of several elements and discuss an alternative criterion based on maximizing triads of elements. I also point out another possible limitation to the reductive approach, namely the failure, up to now, to obtain a derivation of the Madelung rule. Mention is made of some recent similarity studies which could be used to clarify the nature of ‘elements’. Although it has been suggested that the notion of element as basic substance should be considered in terms of fundamental particles like protons and electrons, I resist this move and conclude that the quantum mechanical tradition has not had much impact on the question of what is an element which remains an essentially philosophical issue. (shrink)

The chemical nature of element 72, subsequently named hafnium, is generally regarded as a prediction from Bohr's theory of the periodic system and hence as a prediction from quantum theory. It is argued that both of these views and in particular the latter are mistaken. The claim in favour of Bohr's theory is weakened by his accommodation of independent chemical arguments and the claim in favour of quantum theory is untenable since the prediction is not strictly deductive.

I claim that the question of whether chemistry is reduced to quantum mechanics is more ambiguous and multi-faceted than generally supposed. For example, chemistry appears to be both reduced and not reduced at the same time depending on the perspective that one adopts. Similarly, I argue that some conceptual issues in quantum mechanics are ambiguous and can only be laid to rest by embracing paradox and ambiguity rather than regarding them as obstacles to be overcome. Recent work in the reduction (...) of chemistry is also reviewed, including discussions of the ontological reduction of chemistry and the question of the emergence of chemistry from physics. (shrink)

The main thrust of the paper involves a theoretical and philosophical analysis of the claim made in September 1999 that atomic orbitals have been directly imaged for the first time. After a brief account of the recent claims the paper reviews the development of the orbit and later orbital concepts and analyzes the theoretical status of atomic orbitals. The conclusion is that contrary to these claims, atomic orbitals have not in fact been observed. The non-referring nature of modern atomic orbitals (...) is discussed in the context of Laudan's writings on realism, the success of theories, and whether or not scientific terms refer. I conclude that the failure to observe orbitals is a good prima facie case for divorcing the success of theories from the question of whether their central terms refer. The added relevance of this case is that it concerns a current and highly successful theory. Finally, the relevance of this 'floating model' to contemporary discussions on scientific models is briefly considered. (shrink)

Appeals to the public interest in law are commonplace, but typically made without clarifying what the public interest is and how it can be determined. In law, this has led to ad hoc applications of the public interest and, consequently, to “judicial idiosyncrasy,” posing a threat to legal certainty. This paper aims to remedy these problems by providing much‐needed conceptual clarification. It proposes that something is in the public interest if it increases the opportunities of the members of the public (...) to pursue and realize the (permissible) ends they all share qua equal members of the public. (shrink)

A critique of LaPorte's views on chemical kinds, like jade and ruby, is presented. More positively, a new slant is provided on the question of whether elements are natural kinds. This is carried out by appeal to the dual nature of elements, a topic that has been debated in the philosophy of chemistry but not in the natural kinds literature. It is claimed that the abstract notion of elements, as opposed to their being simple substances, is relevant to the Kripke–Putnam (...) approach to natural kinds and to some criticisms that have been raised against it, although I do not support the K–P account. The proposed view avoids the traditional microstructuralist approach to natural kinds. The article also addresses the question of whether natural kinds concern metaphysical or epistemological considerations. Recent attempts by chemists to modify the periodic table are brought to bear on the question of classification and consequently on whether the identification of elements is interest dependent. (shrink)

The article discusses some of Heinz Post's views on correspondence and whether revolutions occur in science a la Kuhn. For example Post points out that the periodic table of the chemical elements has withstood any revolutions. Specific issues examined include the Paneth-Fajans controversy, the extent to which quantum mechanics provides an explanation for the periodic table and ab initio calculations in quantum chemistry.

The article disputes the recent claim featured in "Nature" magazine and many other science magazines to the effect that atomic orbitals have been observed for the first time. The claim is incorrect in view of the unconvincing nature of the evidence adduced and since atomic orbitals are deemed unobservable in principle by quantum mechanics. In addition, the possible educational drawbacks of this incorrect claim are discussed.

The philosopher of chemistry Andrea Woody has recently published a wide-ranging article concerning the turn to practice in the philosophy of science. Her primary example consists of the use of different forms of representations by Lothar Meyer and Mendeleev when they presented their views on chemical periodicity. Woody believes that this distinction can cast light on various issues including why Mendeleev was able to make predictions while Meyer was not. Secondly, she claims that it can clarify the much-debated question concerning (...) the relative values of prediction and accommodation of data in the way that the periodic system was accepted. Thirdly, Woody believes that such differences in the representation of periodicity can be used to argue for the explanatory nature of the periodic table in contrast with the more traditional view that the periodic table is not explanatory. (shrink)

This essay interprets John Locke's teachings about private societies, or free private associations. The essay proceeds by interpreting Locke's mature writings on ethics, politics, and philosophy, and then by illustrating Locke's teachings as they apply to two contemporary problems in associational freedom. Although Locke wrote about private societies primarily in the course of arguing for religious toleration, throughout his mature corpus he develops an internally consistent general theory of associational freedom. At first glance, Locke seems to suggest that all citizens (...) are entitled to associate for any end of their choosing, to control admission into and expulsion from their membership, and to enforce their own internal rules of governance. However, Locke qualifies this broad right to bar societies from organizing around ends inconsistent with the minimal moral and political conditions of liberalism. Ultimately, Locke suggests, citizens deserve a broad right of private society only to the extent that they are well enough formed by their regime and its private institutions to be capable of governing themselves in both private and public life.In contrast with contemporary practice, Locke's justification is broader in some respects and narrower in others. The essay illustrates the implications by considering how Locke's teachings justify limiting the scope of anti-discrimination laws and enlarging the scope of government efforts to dissolve seditious associations. (shrink)

The article concerns five traditionally difficult issues that chemical educators encounter and how they should be resolved. In some cases I propose the examination of necessary and sufficient conditions in order to cast light on the relationships under discussion. The five educational issues are, the notion that a pH value of seven implies a neutral solution of water and vice versa, the use of Le Châtelier’s Principle, the relative occupation and ionization of 4s and 3d orbitals, the explanation of anomalous (...) electronic configurations and the elements that make up group 3 of the periodic table. (shrink)

Sir Karl Popper is one of the few authors to have discussed the reduction of chemistry. His approach consists of what I term naturalistic reduction, which I suggest bears close similarities to the way in which scientists regard reduction. The present article aims to build on Popper's insights into the nature of reduction in science and more specifically to suggest an approach to characterizing a specific sense of the notion of approximate reduction in the context of chemistry. In the course (...) of the discussion, one of Popper's better known passages on the reduction of chemistry is analysed in some detail. (shrink)

This article carefully analyzes a recent paper by Weisberg in which it is claimed that when Mendeleev discovered the periodic table he was not working as a modeler but instead as a theorist. I argue that Weisberg is mistaken in several respects and that the periodic table should be regarded as a classification, not as a theory. In the second part of the article an attempt is made to elevate the status of classifications by suggesting that they provide a form (...) of ‘side-ways explanation’. (shrink)

As ecologically and socially oriented food initiatives proliferate, the significance of these initiatives with respect to conventional food systems remains unclear. This paper addresses the transformative potential of alternative food networks by drawing on insights from recent research on food and embodiment, diverse food economies, and more-than-human food geographies. I identify several synergies between these literatures, including an emphasis on the pedagogic capacities of AFNs; the role of the researcher; and the analytical and political value of using assemblage and actor-network (...) thinking to understand the far-reaching forces and power disparities confronting proponents of more ethical and sustainable food futures. (shrink)

Robin Hendry has recently argued that although the term ‘element’ has traditionally been used in two different senses, there has nonetheless been a continuity of reference. The present article examines this author’s historical and philosophical claims and suggests that he has misdiagnosed the situation in several respects. In particular it is claimed that Hendry’s arguments for the nature of one particular element, oxygen, do not generalize to all elements as he implies. The second main objection is to Hendry’s view that (...) the qua problem can be illuminated by appeal to the intention of scientists.Keywords: Element; Simple substance; Basic substance; Antoine Lavoisier; Dmitri Mendeleev; Reference; Qua problem. (shrink)

Though whistleblowing is quickly becoming an accepted means of addressing wrongdoing, whistleblower protection laws and the relevant case law are either awkwardly silent, unclear or mutually inconsistent concerning public disclosures of classified government information. I remedy this problem by first arguing that such disclosures constitute a pro tanto wrong as they violate (1) promissory obligations, (2) role obligations and (3) the obligation to respect the democratic allocation of power. However, they may be justified if (1) the information disclosed concerns grave (...) government wrongdoing, (2) alternative channels of disclosure are first exhausted and (3) steps are taken to minimize harm. (shrink)

With the originality and energy that have marked his earlier works, Eric Wolf now explores the historical relationship of ideas, power, and culture. Responding to anthropology's long reliance on a concept of culture that takes little account of power, Wolf argues that power is crucial in shaping the circumstances of cultural production. Responding to social-science notions of ideology that incorporate power but disregard the ways ideas respond to cultural promptings, he demonstrates how power and ideas connect through the medium (...) of culture. Wolf advances his argument by examining three very different societies, each remarkable for its flamboyant ideological expressions: the Kwakiutl Indians of the Northwest Pacific Coast, the Aztecs of pre-Hispanic Mexico, and National Socialist Germany. Tracing the history of each case, he shows how these societies faced tensions posed by ecological, social, political, or psychological crises, prompting ideological responses that drew on distinctive, historically rooted cultural understandings. In each case study, Wolf analyzes how the regnant ideology intertwines with power around the pivotal relationships that govern social labor. Anyone interested in the history of anthropology or in how the social sciences make comparisons will want to join Wolf in _Envisioning Power_. (shrink)