Recent developments in 3D cultures exploiting the self‐organization ability of pluripotent stem cells have enabled the generation of powerful in vitro systems termed brain organoids. These 3D tissues recapitulate many aspects of human brain development and disorders occurring in vivo. When combined with improved differentiation methods, these in vitro systems allow the generation of more complex “assembloids,” which are able to reveal cell diversities, microcircuits, and cell–cell interactions within their 3D organization. Here, the ways in which human brain organoids have (...) contributed to demystifying the complexities of brain development and modeling of developmental disorders is reviewed and discussed. Furthermore, challenging questions that are yet to be addressed by emerging brain organoid research are discussed. (shrink)

In six compelling chapters, this book recounts conversations that discuss what is ethical, why it does not occur more often, and how can we improve ethical conduct in our personal and public lives. The conversations include Knowing Ethical Principles, Learning How to Apply Principles in Practice, Moral Reminders, Accountability for Conduct, Addressing Structural Problems, and Ethical Vigilance. Major ethical perspectives are discussed in conversational format, as are fascinating ethical dilemmas taken from actual cases to evaluate and improve our ability to (...) identify ethical principles and make decisions that reflect concerns beyond self-interest. (shrink)

Many philosophers accept that ought implies can (OIC), but it is not obvious that we have a good argument for that principle. I consider one sort of argument for it, which seems to be a development of an Aristotelian idea about practical deliberation and which is endorsed by, amongst others, R. M. Hare and James Griffin. After briefly rehearsing some well-known objections to that sort of argument (which is based on the supposed pointlessness of impossible obligations), I present a further (...) objection, based on a maximally charitable reading of the argument, and conclude that nobody ought to think that it gives them a reason to accept OIC. (shrink)

A critical discussion of Bernard Reginster's book The Will to Nothingness. The contribution engages with Reginster's interpretation of Nietzschean ressentiment, arguing that it is an essentially interpersonal attitude in two different senses. It is a response to a social situation of structural deprivation, and it involves an element of antagonism toward those who are better off within this social structure. The contribution then discusses Reginster's claim that modern morality restores the sense of power of the masses by adjusting the goals (...) that they aim to pursue. I argue that this interesting interpretation does not do full justice to the themes of hostility or hatred that permeate the Genealogy of Morals, extending from Nietzsche's discussion of the slave revolt to his treatments of the bad conscience and of ascetic ideals. (shrink)

Thomas Friedman’s best-selling The World is Flat has exerted much influence in the west by providing both an accessible analysis of globalisation and its economic and social effects, and a powerful cultural metaphor for globalisation. In this review, we more closely examine Friedman’s notion of the social contract, the moral centre of his hopeful vision of a globalised world. While Friedman’s social contract holds a more generous view of social and state obligation than his neoliberal economic analysis might otherwise allow, (...) his fallacious assumptions about education rest on poorly argued claims about the nature of human beings, the proper aims of schooling, and meanings of justice in a globalised world. (shrink)

In the iconic measurements of atomic spin-1/2 or photon polarization, one employs two separate noninteracting detectors. Each detector is binary, registering the presence or absence of the atom or the photon. For measurements on a d-state particle, we recast the standard von Neumann measurement formalism by replacing the familiar pointer variable with an array of such detectors, one for each of the d possible outcomes. We show that the unitary dynamics of the pre-measurement process restricts the detector outputs to the (...) subspace of single outcomes, so that the pointer emerges from the apparatus. We propose a physical extension of this apparatus which replaces each detector with an ancilla qubit coupled to a readout device. This explicitly separates the pointer into distinct quantum and (effectively) classical parts, and delays the quantum to classical transition. As a result, one not only recovers the collapse scenario of an ordinary apparatus, but one can also observe a superposition of the quantum pointer states. (shrink)

This mixed-methods case study describes the experiences of a rural health organization in Canada that was a pioneer in undergoing institutionally driven radical change. This change was advocated by senior managers and physicians with the strong backing of the government. The senior managers and physicians made a strong case for the radical change and argued that a focus on efficiency and wellness would lead to improved service and quality of patient-care. However, this radical change initiative was resisted by nurses and (...) support staff who perceived that these changes were being driven by market-based institutional logics and questioned their ethical appropriateness in a public system. They also expressed a lack of trust given the large-scale layoffs in a prior restructuring. These findings run counter to extant theory by highlighting the role of agency despite institutional pressures. Specifically, change implementers not only face the burden of justifying ethical appropriateness of institutional logics, but also are required to engage in persuasive discourse that these institutional logics protect the interests of the members. (shrink)

Listening and responding to patients’ stories for over 20 years as an emergency physician has strengthened my appreciation for the many ways that the skills and principles drawn from writing fiction double as necessary clinical skills. The best medicine doesn’t work on the wrong story, and the stories patients tell sometimes feel like first drafts—vital and fragile works-in-progress. Increasingly complex health challenges compounded by social, financial, and psychological burdens make for stories that are difficult to articulate and comprehend. In this (...) essay, I argue that healthcare providers need to think like creative writers and the skills and sensitivities necessary to story construction deserve a vital space in medical education. A thorough understanding of story anatomy and the imaginative flexibility to work stories into open spaces serve as antidotes to the reductive nature of clinical decision making and have implications as patient safety and risk management strategies. The examples that I have selected demonstrate how thinking like a creative writer functions at the bedside, providing tools for clinical excellence and empathy. This approach asks that we re-imagine the importance of story in clinical care: from a vehicle to a diagnosis to its place as a critical destination. (shrink)

Michael Lynch has recently proposed an updated version of alethic functionalism according to which the relation between truth per se and lower-level truth properties is not the realization relation, as might be expected, and as Lynch himself formerly held, but the manifestation relation. I argue that the manifestation relation is merely a resemblance relation and is inadequate to properly relate truth per se to lower-level truth properties. I also argue that alethic functionalism does not justify the claim that truth per (...) se exists, or that truth per se is a functional property. Finally, I suggest a replacement for the manifestation relation. I argue that the resulting theory is a strict improvement over alethic functionalism on two counts, but that the improved theory does not justify the claim that truth per se exists. Since no further improvements to the theory are apparent, the prospects for alethic functionalism are dim. (shrink)

Virtual Reality Therapy has been shown to be effective in treating anxiety disorders and phobias, but has not yet been widely tested for Substance Use Disorders and it is not known whether health care practitioners working with SUDs would use VRT if it were available. We report the results of an interview study exploring practitioners’ and researchers’ views on the utility of VRT for SUD treatment. Practitioners and researchers with at least two years’ experience delivering or researching and designing SUD (...) treatments were recruited. Interviews were thematically analyzed, resulting in themes relating to the safety and realism of VRT, and the opportunity for the additional insight it could offer to during SUD treatment. Participants were positive about employing VRT as an additional treatment for SUD. VRT was thought suitable for treating adults and people with mental health issues or trauma, provided that risks were appropriately managed. Subsequent relapse, trauma and over-confidence in the success of treatment were identified as risks. The opportunity VRT offered to include other actors in therapy, and observe reactions, were benefits that could not currently be achieved with other forms of therapy. Overall, VRT was thought to offer the potential for safe, realistic, personalized and insightful exposure to diverse triggering scenarios, and to be acceptable for integration into a wide range of SUD treatments. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Many of the ethical problems that are posed by development can be illuminated by clarifying some of the differences between development that is worthwhile and ethically undesirable ?maldevelopment?. So it is with development projects that displace communities that physically stand in their way: typically the ?oustees? are victimized and disempowered, in some cases by projects that are also indefensible in other ways. Can this help us to clarify what is owed to people who are displaced by climate change, the ?climate (...) migrants? or ?climate refugees?? These people, I will show, have a distinctive set of moral entitlements, which may include compensation and aid for resilience or resettlement; in addition, they are entitled to be included in decision-making in ways that are empowering. (shrink)

The author provides insights into his intellectual career as a founding member of the Frankfurt Institute of Social Research and includes remembrances of many of his former colleagues.

By the start of the Victorian period the school of British economists acknowledging Adam Smith as its master was in the ascendancy. 'Political Economy', a catch-all title which ignored the diversity of viewpoints to be found amongst the discipline's leading proponents, became associated in the popular mind with moral and political forces held to be uniquely conducive to the progress of an increasingly industrialised and competitive society. 'Political Economy' served in turn as the focus for critics of equally diverse moral (...) and political persuasions, who sought to challenge the materialism of contemporary society and offer their own assessments of the profound social changes of the time. In the introductory essay to the collection of readings from such 'critics of capitalism', the editors review the principles of the early economists, the way in which these principles were appropriated and applied by their Victorian successors and the contrasting modes which critics of popular economic ideas assumed. Subsequent extracts from the writings of the Owenite Socialist John Bray, Carlyle, Marx and Engels, J. S. Mill, Ruskin, Arnold, T. H. Green, William Morris and G. B. Shaw, demonstrate both the breadth of the possible grounds for ideological opposition to the prevailing philosophy and the shifting nature of the debate as 'Political Economy' itself was revealed as incapable of explaining or responding to the changing conditions of the 1870s. Headnotes to the extracts describe the genesis of individual debate and discuss distinctive stylistic features. Annotation in the form of footnotes and endnotes has been designed to gloss obscure allusions and arguments. In making more accessible the socio-economic writings of those authors now better known for their imaginative work, this volume will enable readers to reach a more profound appreciation of the central role such work played in developing the moral vision embodied in their more lastingly popular books and essays. (shrink)

The popularity of films like Titanic betokens a massive shift in the nature of aesthetic spectatorship in our time. The contemplative, distanced viewer who is able to judge from afar the spectacle before him or her, has been replaced by a more proximate, involved "kinaesthetic" subject whose body is stimulated as much as his or her eye. This is evident not only in mass culture with amusement thrill rides and the return of what has been called the "cinema of attractions"; (...) this new spectator can also be discerned in avant-garde culture, as shown by the Sensation exhibition of Young British Artists which caused such a stir in London and New York. This spectator is especially attracted to simulacral scenes of destruction and catastrophe, in which he or she is virtually immersed. If aesthetic judgement is to be a model for its political counterpart, as has been argued by theorists like Lyotard and Arendt, it cannot do so on the basis of this aesthetics of violent immersion. (shrink)

La notion de compétence demeure singulièrement complexe à penser dans les dispositifs de formation. Généralement définie comme savoir-agir situé, elle est souvent réduite à son acception instrumentale, rendant flagrante l’opposition entre théorie et pratique dans la formation universitaire à visée professionnalisante. Cette conception de l’apprentissage interroge la place de la pratique dans les dispositifs de formation : simple redondance ou lieu d’un véritable apprentissage? Pour dépasser cette opposition entre théorie et pratique qui se niche dans les définitions mêmes de la (...) compétence, nous proposons une lecture pragmatiste de la notion de compétence, en menant l’enquête avec John Dewey. Nous serons ainsi invités à penser la compétence comme un processus appartenant au continuum de l’expérience et à interroger le principe même de l’enseignement d’une compétence éthique. (shrink)

Razširjeno sumničenje nadvlade vida v moderni kulturi, ki so ga v tem stoletju izrazili številni francoski intelektualci, je vplivalo na prakso in samorazumevanje nedavne ameriške umetnosti. S sledenjem vpliva mislecev, kakršni so Bataille, Foucault in Derrida ter umetnikov, kot je Duchamp, skuša članek razložiti zavračanje visokomodernističnega vrednotenja čiste optičnosti, ki sta ga v dobi neposredno po drugi svetovni vojni zagovarjala Clement Greenberg ter Michael Fried. Čeprav so pogosto komentirali premestitev težišča modernistične umetnosti iz Pariza v New York po letu 1945, (...) to ne velja za kasnejše »maščevanje« francoske teorije, ki so ga v angloameriški kulturni prostor prenesli kritiki, kakršna sta Rosalind Krauss in Norman Bryson. Vpliv te teorije je pomagal spodkopati vrednost abstraktnega ekspresionizma v korist drugih gibanj, kakršna so neodada, konceptualna umetnost in minimalizem, kijih lahko delno razumemo kot zavračanje prvenstvenosti vizualnih vrednot. (shrink)