BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

All organised bodies are composed of parts, similar to those composing inorganic nature, and which have even themselves existed in an inorganic state; but the phenomena of life, which result from the juxtaposition of those parts in a certain manner, bear no analogy to any of the effects which would be produced by the action of the component substances considered as mere physical agents. To whatever degree we might imagine our knowledge of the properties of the several ingredients of a (...) living body to be extended and perfected, it is certain that no mere summing up of the separate actions of those elements will ever amount to the action of the living body itself. (shrink)

In what follows, I will contend that the commonsense view of ourselves as fundamental causal agents - for which some have used the term “unmoved movers" but which I think might more accurately be expressed as “not wholly moved movers” - is theoretically understandable, internally consistent, and consistent with what we have thus far come to know about the nature and workings of the natural world. In the section that follows, I try to show how the concept of ‘agent’ causation (...) can be understood as a distinct species (from ‘event’ causation) of the primitive idea, which I’ll term “causal production”, underlying realist or non-Humean conceptions of event causation. In section III, I respond to a number of contemporary objections to the theory of agent causation. Sections IV-V are devoted to showing that the theory is compatible with ordinary reasons explanations of action, which then places me in a position to respond, in the final section, to the contention that we could never know, in principle, whether the agency theory actually describes a significant portion of human activity. (shrink)

Many philosophers are persuaded by familiar arguments that free will is incompatible with causal determinism. Yet, notoriously, past attempts to articulate how the right type of indeterminism might secure the capacity for autonomous action have generally been regarded as either demonstrably inadequate or irremediably obscure. This volume gathers together the most significant recent discussions concerning the prospects for devising a satisfactory indeterministic account of freedom of action. These essays give greater precision to traditional formulations of the problems associated with indeterministic (...) accounts and to the range of theoretical avenues for pursuing resolutions. The first four essays set out different challenges (from both compatibilists and those skeptical of the possibility of free will) to the adequacy of standard indeterministic theories. The next seven essays meet one or more of these challenges. Each of the fundamental types of approach--simple indeterminism, causal indeterminism, and agent causation--is represented in these novel and sophisticated proposals. The collection finishes with two essays that debate whether compatibilism entails that freedom of choice is a comparatively rare phenomenon within an individual's life. Eloquently presenting some of the most compelling and accessible arguments surrounding this central philosophical issue, Agents, Causes, and Events makes a valuable contribution to courses in free will/action theory and metaphysics. (shrink)

One familiar affirmative answer to this question holds that these facts suffice to entail that Descartes' picture of the human mind must be mistaken. On Descartes' view, our mind or soul (the only essential part of ourselves) has no spatial location. Yet it directly interacts with but one physical object, the brain of that body with which it is, 'as it were, intermingled,' so as to 'form one unit.' The radical disparity posited between a nonspatial mind, whose intentional and conscious (...) properties are had by no physical object, and a spatial body, all of whose properties are had by no mind, has prompted some to conclude that, pace Descartes, causal interaction between the two is impossible. Jaegwon Kim has recently given a new twist to this old line of thought.(1) In the present essay, I will use Kim's argument as a springboard for motivating my own favored picture of the metaphysics of mind and body and then discussing how an often vilified account of freedom of the will may be realized within it. (shrink)

This provocative book refurbishes the traditional account of freedom of will as reasons-guided "agent" causation, situating its account within a general metaphysics. O'Connor's discussion of the general concept of causation and of ontological reductionism v. emergence will specially interest metaphysicians and philosophers of mind.

In this new book, Alessandra Tanesini demonstrates that feminist thought has a lot to offer to the study of Wittgenstein's philosophical work, and that -at the same time-that work can inspire feminist reflection in new directions. In Wittgenstein, Tanesini offers a highly original interpretation of several themes in Wittgenstein's philosophy. She argues that when we look at his work through feminist eyes we discover that he is not primarily concerned with providing solutions to technical problems in the philosophy of mind, (...) mathematics, and language. Instead, his remarks on these topics are intended to offer insights about human finitude, the loneliness of the modern autonomous self, and our relations to other human beings. Thus, the modern conception of the individual emerges as the critical target of Wittgenstein's philosophical work, both early and late. This conception has also been one of the dominant concerns of contemporary feminist philosophy. In this book, Wittgenstein's insights are deployed to further feminist debates on issues such as identity, difference, the masculine character of the modern self. (shrink)

It is a commonplace of philosophy that the notion of free will is a hard nut to crack. A simple, compelling argument can be made to show that behavior for which an agent is morally responsible cannot be the outcome of prior determining causal factors.1 Yet the smug satisfaction with which we incompatibilists are prone to trot out this argument has a tendency to turn to embarrassment when we're asked to explain just how it is that morally responsible action might (...) obtain under the assumption of indeterminism. Despair over the prospect of giving a satisfactory answer to this question has led some contemporary philosophers to a position rarely, if ever, held in the history of philosophy: free, responsible action is an incoherent concept.2. (shrink)

"Why should we care about having true beliefs? And why do demonstrably false beliefs persist and spread despite consequences for the people who hold them? Philosophers of science Cailin O’Connor and James Weatherall argue that social factors, rather than individual psychology, are what’s essential to understanding the spread and persistence of false belief. It might seem that there’s an obvious reason that true beliefs matter: false beliefs will hurt you. But if that’s right, then why is it irrelevant to many (...) people whether they believe true things or not? In an age riven by "fake news," "alternative facts," and disputes over the validity of everything from climate change to the size of inauguration crowds, the authors argue that social factors, not individual psychology, are what’s essential to understanding the persistence of false belief and that we must know how those social forces work in order to fight misinformation effectively."–Publisher’s description. (shrink)

In almost every human society some people get more and others get less. Why is inequity the rule in human societies? Philosopher Cailin O'Connor reveals how cultural evolution works on social categories such as race and gender to generate unfairness.

First published in 1975, The Correspondence Theory of Truth examines the simplest statements of empirical fact and establishes what we can mean when we say that such statements are true. In particular, the author has considered whether any or all of beliefs, sentences, statements, or propositions are properly said to be true or false. He proceeds to examine what we mean by the term 'fact' and what possible relation between facts and beliefs could be meant by the term 'correspondence'. The (...) second part of the book is a critical survey of important contemporary accounts of truth. The author examines Tarski's semantic theory to see if it offers a satisfactory reconstruction of the essence of the traditional notion of correspondence, then J.L. Austin's recent and famous version of the correspondence theory and some criticisms of it by Professor P. E. Strawson. A final chapter summarizes the viable content of the correspondence theory and suggests what problems about truth still remain for discussion if the theory is accepted. This book will be an essential read for students and scholars of Philosophy. (shrink)

I Introduction This essay will canvass recent philosophical accounts of human agency that deploy a notion of 'self' (or 'agent') causation. Some of these accounts try to explicate this notion, whereas others only hint at its nature by way of contrast with the causality exhibited by impersonal physical systems. In these latter theories, the authors' main argumentative burden is that the apparent fundamental differences between personal and impersonal causal activity strongly suggest mind-body dualism. I begin by noting two distinct, yet (...) not commonly distinguished, philosophical motivations for pursuing an agent-causal account of human agency. In the course of discussing the accounts that some philosophers have developed in response to these considerations, I reconsider both the linkage of agent causation with mind-body dualism and its sharp cleavage from impersonal (or 'event') causation. (shrink)

Since Alasdair MacIntyre’s landmark book After Virtue, there has been renewed interest in the role of the virtues in the moral life and attention paid to reappropriating the Aristotelian notion of "practice." Recent reappropriations of the virtues and virtue theory in medical ethics have contributed to conceiving more adequately the nature of good medicine. I wish to explore some of these insights and the special relevance the notion of practice has in an account of good medicine. Yet, I also want (...) to suggest that much remains to be done. This renewed attention to the virtues needs to be supplemented by a similar reappropriation and transposition of the notion of nature in order to navigate successfully the Dardanelles of an ahistorical essentialism and the Bosphorus of a historical relativism. (shrink)

“Free Will” is a philosophical term of art for a particular sort of capacity of rational agents to choose a course of action from among various alternatives. Which sort is the free will sort is what all the fuss is about. (And what a fuss it has been: philosophers have debated this question for over two millenia, and just about every major philosopher has had something to say about it.) Most philosophers suppose that the concept of free will is very (...) closely connected to the concept of moral responsibility. Acting with free will, on such views, is just to satisfy the metaphysical requirement on being responsible for one's action. (Clearly, there will also be epistemic conditions on responsibility as well, such as being aware—or failing that, being culpably unaware—of relevant alternatives to one's action and of the alternatives' moral significance.) But the significance of free will is not exhausted by its connection to moral responsibility. Free will also appears to be a condition on desert for one's accomplishments (why sustained effort and creative work are praiseworthy); on the autonomy and dignity of persons; and on the value we accord to love and friendship. (See Kane 1996, 81ff. and Clarke 2003, Ch.1.). (shrink)

Theodor W. Adorno, İkinci Dünya Savaşı sonrası dönemin önde gelen filozof ve toplum kuramcılarından biridir. Eleştirel Kuramın gelişmesinde önemli rolü olan, özgün ve de genellikle zor olan yazıları sadece temel felsefi sorular ileri sürmekle kalmayıp aynı zamanda edebiyat, sanat, müzik, sosyoloji ve siyaset kuramına ilişkin derin analizler de sunar. Bu kapsamlı kitapta Brian O’Connor, Adorno’nun felsefesini, onun eserleriyle ilk kez karşılaşanlara açıklamaktadır. O’Connor, bu amaçla, yaşamı ve entelektüel çevresinin bağlamını oluşturan ana felsefi görüşleri aracılığıyla Adorno felsefesinin merkezi unsurlarını değerlendiriyor. Bu (...) bağlamda Aydınlanmanın diyalektiği, şeyleşme, bütünsellik, dolayımlama, özdeşlik, özdeşsizlik, deneyim, negatif diyalektik, içkinlik, özgürlük, özerklik ve sanatta taklit gibi kavramları, felsefesinin temel alanları üzerinden tartışıyor. Kronoloji ve terimler sözlüğünün yanı sıra ek okuma önerileri de içeren Adorno, felsefe, edebiyat, sosyoloji ve kültürel çalışmalarla ilgilenenler için ideal bir giriş kitabı... (shrink)

What makes ethical accounts natural law ethical is, I argue, commonly misrepresented in teaching within much of the philosophical academy. Yet those immersed in the field of natural law and ethics rarely give definitions/brief characterisations of what makes ethical accounts natural law ethical. I suggest theoretical reasons for the lack. I argue that bringing natural law into ethics is best understood as leading to theoretically unitary accounts, not simply collections of positions detachable from each other: an overlooked and significant point (...) when defending natural law ethical accounts. My arguments throughout rely on the metaethical/normative ethical distinction, which is relatively little used in the natural law literature. I argue that the distinction helps clarify what is distinctive of natural law ethical accounts in general, especially to the secular contemporary philosophical academy, where appreciation of natural law ethical accounts is commonly appreciably lower than in philosophical contexts with a religious ethos. (shrink)

D J O’Connor; Two Concepts of Education, Journal of Philosophy of Education, Volume 16, Issue 2, 30 May 2006, Pages 137–146, https://doi.org/10.1111/j.1467-9752.

In this classic, exciting, and thoughtful text, Metaphysics , Peter van Inwagen examines three profound questions: What are the most general features of the world? Why is there a world? and What is the place of human beings in the world? Metaphysics introduces to readers the curious notion that is metaphysics, how it is conceived both historically and currently. The author's work can serve either as a textbook in a university course on metaphysics or as an introduction to metaphysical thinking (...) for the interested reader. This second edition, revised though not fundamentally changed, includes the basis of the first edition with a new chapter on the nature of time. (shrink)

Contemporary societies are often “polarized”, in the sense that sub-groups within these societies hold stably opposing beliefs, even when there is a fact of the matter. Extant models of polarization do not capture the idea that some beliefs are true and others false. Here we present a model, based on the network epistemology framework of Bala and Goyal, 784–811 1998), in which polarization emerges even though agents gather evidence about their beliefs, and true belief yields a pay-off advantage. As we (...) discuss, these results are especially relevant to polarization in scientific communities, for these reasons. The key mechanism that generates polarization involves treating evidence generated by other agents as uncertain when their beliefs are relatively different from one’s own. (shrink)

An expansive, yet succinct, analysis of the Philosophy of Religion – from metaphysics through theology. Organized into two sections, the text first examines truths concerning what is possible and what is necessary. These chapters lay the foundation for the book’s second part – the search for a metaphysical framework that permits the possibility of an ultimate explanation that is correct and complete. A cutting-edge scholarly work which engages with the traditional metaphysician’s quest for a true ultimate explanation of the most (...) general features of the world we inhabit Develops an original view concerning the epistemology and metaphysics of modality, or truths concerning what is possible or necessary Applies this framework to a re-examination of the cosmological argument for theism Defends a novel version of the Leibnizian cosmological argument. (shrink)

There is rising skepticism within public discourse about the nature of AI. By skepticism, I mean doubt about what we know about AI. At the same time, some AI speakers are raising the kinds of issues that usually really matter in analysis, such as issues relating to consent and coercion. This essay takes up the question of whether we should analyze a conversation differently because it is between a human and AI instead of between two humans and, if so, why. (...) When is it okay, for instance, to read the phrases “please stop” or “please respect my boundaries” as meaning something other than what those phrases ordinarily mean – and what makes it so? If we ignore denials of consent, or put them in scare quotes, we should have a good reason. This essay focuses on two thinkers, Alan Turing and Stanley Cavell, who in different ways answer the question of whether it matters that a speaker is a machine. It proposes that Cavell’s work on the problem of other minds, in particular Cavell’s story in The Claim of Reason of an automaton whom he imagines meeting in a craftsman’s garden, may be especially helpful in thinking about how to analyze what AI has to say. (shrink)

Why did the omnipotent, omniscient, unsurpassably, and perfectly good being who is necessary in Himself, and having a supremely rational will, contingently create ex nihilo? What motivation could account for such freely undertaken activity, displaying it as neither necessary nor less than fully rational? The chapter considers and criticizes answers recently offered by Mark Johnston and Alex Pruss. It is argued that creation of some contingent reality or other is necessary, and that plausible reflections on the ordered complexity in God’s (...) motivations indicate that the scope of contingency regarding what to create is highly constricted—though not to the point of complete modal collapse. A perfect creator would create either an infinite and richly varied multiverse or an infinitely improving universe realizing a wide array of kinds of goods. Finally, a rebuttal is given to the contention that any element of contingency in a divine choice entails a rational-explanatory deficiency. (shrink)