Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The general aim of this book is to provide an elementary exposition of some basic concepts in terms of which both classical and non-dassicallogirs may be studied and appraised. Although quantificational logic is dealt with briefly in the last chapter, the discussion is chiefly concemed with propo gjtional cakuli. Still, the subject, as it stands today, cannot br covered in one book of reasonable length. Rather than to try to include in the volume as much as possible, I have put (...) emphasis on some selected topics. Even these could not be roverrd completely, but for each topic I have attempted to present a detailed and precise t’Xposition of several basic results including some which are non-trivial. The roots of some of the central ideas in the volume go back to J. Luka siewicz’s seminar on mathematicallogi. (shrink)

This paper aims to present the main contours of Burns’s literary output which, interestingly enough, grows into a personal understanding of the collective mindset of -Troubles Northern Ireland. It is legitimate, I argue, to construe her fiction as a body of work shedding light on certain underlying mechanisms of sectarian violence. Notwithstanding the lapse of time between 1998 and 2020, the Troubles’ toxic legacy has indeed woven an unbroken thread in the social fabric of the region. My reading of the (...) novelist’s selected works intends to show how the local public have been fed by an unjustified—maybe even false—sense of security. Burns, in that regard, has positioned herself amongst the aggregate of writers who feel anxious rather than placated, hence their persistence in returning to the roots of Northern Irish societal divisions. Burns’s writing, in the above context, though immersed in the world of the Troubles, paradoxically communicates “an idiosyncratic spatiotemporality”, namely an experience beyond the self-imposing, historical time limits. As such, it gains the ability to provide insightful commentaries on conflict-prone relations, the patterns of which can be repeatedly observed in Northern Ireland’s socio-political milieu. Overall, the main idea here is to discuss and present the narrative realm proposed by Burns as determinate, liminal in terms of time and space, positioning readers between “then” and “now” of the region. (shrink)

This paper was written with two aims in mind. A large part of it is just an exposition of Tarski’s theory of truth. Philosophers do not agree on how Tarski’s theory is related to their investigations. Some of them doubt whether that theory has any relevance to philosophical issues and in particular whether it can be applied in dealing with the problems of philosophy (theory) of science. In this paper I argue that Tarski’s chief concern was the following question. Suppose (...) a language L belongs to the class of languages for which, in full accordance with some formal conditions set in advance, we are able to define the class of all the semantic interpretations the language may acquire. Every interpretation of L can be viewed as a certain structure to which the expressions of the language may refer. Suppose that a specific interpretation of the language L was singled out as the intended one. Suppose, moreover, that the intended interpretation can be characterized in a metalanguage L +. If the above assumptions are satisfied, can the notion of truth for L be defined in the metalanguage L + and, if it can, how can this be done? Many students of Tarski’s conception will find the above exposition inconsistent with their own views on the essence of Tarski’s conception. On the other hand, as it is argued in this paper, the proposed interpretation of Tarski’s ideas allows one to use Tarski’s theory as a fundamental tool for semantic analyses of various theories, factual theories in particular. More specifically, it is argued that Tarski’s theory of truth allows one to clearly oppose a theory meant to be certain deductive system (a set of accepted sentences, say axioms, and a logical machinery for deducing from them new ones) and a theory meant to be a certain semantic system, i.e a set of sentences that serve to communicate some states of affairs and to use that opposition to explicate and occasionally also define the notion of truth. The opposition in question is of the utmost significance for analyzing some developments in both mathematics and factual sciences. The approach which is concerned with the logical relations between the elements of science such an approach is throughout this paper called analytical is put into question. The growth of science is determined by how well scientific theories are able to account for factual states of affairs. The intuitive notion of truth applied by the scientists does not necessarily correspond in a straightforward way to its Tarskian counterpart. On the other hand, as is claimed in this paper, the Tarskian notion of truth offers as adequate explication of intuitive notion of truth as possible. (shrink)

This paper was written with two aims in mind. A large part of it is just an exposition of Tarski’s theory of truth. Philosophers do not agree on how Tarski’s theory is related to their investigations. Some of them doubt whether that theory has any relevance to philosophical issues and in particular whether it can be applied in dealing with the problems of philosophy (theory) of science. In this paper I argue that Tarski’s chief concern was the following question. Suppose (...) a language L belongs to the class of languages for which, in full accordance with some formal conditions set in advance, we are able to define the class of all the semantic interpretations the language may acquire. Every interpretation of L can be viewed as a certain structure to which the expressions of the language may refer. Suppose that a specific interpretation of the language L was singled out as the intended one. Suppose, moreover, that the intended interpretation can be characterized in a metalanguage L +. If the above assumptions are satisfied, can the notion of truth for L be defined in the metalanguage L + and, if it can, how can this be done? Many students of Tarski’s conception will find the above exposition inconsistent with their own views on the essence of Tarski’s conception. On the other hand, as it is argued in this paper, the proposed interpretation of Tarski’s ideas allows one to use Tarski’s theory as a fundamental tool for semantic analyses of various theories, factual theories in particular. More specifically, it is argued that Tarski’s theory of truth allows one to clearly oppose a theory meant to be certain deductive system (a set of accepted sentences, say axioms, and a logical machinery for deducing from them new ones) and a theory meant to be a certain semantic system, i.e a set of sentences that serve to communicate some states of affairs and to use that opposition to explicate and occasionally also define the notion of truth. The opposition in question is of the utmost significance for analyzing some developments in both mathematics and factual sciences. The approach which is concerned with the logical relations between the elements of science such an approach is throughout this paper called analytical is put into question. The growth of science is determined by how well scientific theories are able to account for factual states of affairs. The intuitive notion of truth applied by the scientists does not necessarily correspond in a straightforward way to its Tarskian counterpart. On the other hand, as is claimed in this paper, the Tarskian notion of truth offers as adequate explication of intuitive notion of truth as possible. (shrink)

Piero della Francesca is best known as a painter but he was also a mathematician. His treatise De prospectiva pingendi is a superb example of a union between the fne arts and mathemati‑ cal sciences of arithmetic and geometry. In this paper, I explain some reasons why his paint‑ ing is considered as a part of perspective and, therefore, can be identifed with a branch of geometry.

This paper addresses the question of the relationship between the object of formal logic and the object of ontology. The history of logic and philosophy shows a kinship and overlapping between the two sciences. The analyses were conducted on the basis of three approaches to formal logic, i.e. Aristotle’s logic Rus­sell’s and Whitehead’s logic, and Leśniewski’s logic. At the same time, it sought to grasp its material and formal object. Now with regard to ontology mainly Aristotelian and Leibnizean understanding of (...) ontology was taken into account as an instance of philosophical ontology and set theory ontology as an example of ontology constructed with a view to play the role of a semantic background for the formulas of logical calculi. The considerations under study allow us to state that even if material objects in the two sciences overlap, especially in the case when the formulas of logic are interpreted by way of ontology, their formal objects seem to be different. Logic does not focus on the question of the cate­gorisation of reality; the essences belonging to respective ontological categories are only “truth-making” factors for the statements formulated by formal logic. (shrink)

DEFINING GOD IN THE BOOK OF GENESIS AND EXPERIENCING THE ABSOLUTE The paper presents the philosophical interpretation of the Biblical story on anthropogenesis, contained in the introductory chapters of the Book of Genesis. The interpretation is developed on the base of the suggestion got out from „Plato's dilemma” and author's concept of metaphysics. The opinion about the relationship between philosophy and religion and the complex structure of the notion of „god” and the contents of the „mystic experience” is given.

In lieu of an abstract, here is a brief excerpt of the content:Henry James—Aristotle's Ally, An Exclusive Pact?Jane SingletonIMany claims are advanced for the importance of narrative art works in philosophy. This paper will concentrate on one specific thesis put forward by Martha Nussbaum about the relationship between certain works of literature and moral philosophy. Although Nussbaum explores many roles for narrative artworks in philosophy,1 I shall concentrate on those works where she argues for a close connection between the novels (...) of Henry James and Aristotle's ethics. These are Love's Knowledge,2 where other authors other than James are also considered, and "Exactly and Responsibly: A Defense of Ethical Criticism," an article that formed part of a debate with Richard Posner and Wayne Booth in 1997 and 1998 in Philosophy and Literature.3 It is this latter work that provides the central thesis to be considered.I argue that there are least four possible attributes or combinations of them that Nussbaum might be suggesting are present in James's novels when she claims that James is an ally of Aristotle. My claim will be that James can only be regarded as an ally of Aristotle with respect to some of these attributes. It is a second question to determine precisely how the legitimate attributes isolated in James's novels are to be used to provide an ally for Aristotle's ethics. I shall claim that in any sense in which it is legitimate to regard James as an ally of Aristotle, he could also be regarded as an ally of a generalist theory. This is an important point to emphasise since Nussbaum explicitly enlists James as an ally of Aristotle because of the normative primacy that he gives to the particular. I shall use Kant's theory as an example of a generalist theory. Henry [End Page 61] James, I argue, can be an ally of both Aristotle and Kant but both can adopt an isolationist policy.IIThe specific thesis put forward by Nussbaum in 1998 is as follows:My claim is that in order to investigate this Aristotelian ethical view fully and fairly, we need to turn to texts in which the case for that sort of rationality is made out in a powerful and convincing way—and this cannot be done if we confine ourselves to works written in the abstract style characteristic of most contemporary theory... Aristotle's conception is much more dependent on "allies" who will make out the force of such obscure claims as the claim that "the discernment rests with perception," and that correct action "lies in a mean." Because Aristotle's conception leaves so much to particularized contextual judgment, one cannot well assess the conception without studying complex examples of such particularized judgment; and of course Aristotle's text does not supply such material. I claim that Henry James is a powerful ally of Aristotle, and one whom Aristotle badly needs if he is to convince us of his claims.("ER," pp. 347–48)It is the clarification and discussion of this that provides my point of departure. I shall then consider the four possible characteristics of James's novels that I have isolated. These are: exemplars of good choice, illustrations of the direction of thought to follow for the discernment of the particular, vehicles for developing imagination and sources that enable us to develop an understanding of and engagement of emotions. In each case I shall consider how, if at all, these characteristics enable James to be an ally of either Aristotle or Kant.IIINussbaum's thesis is limited to the late novels of James. "I assert that there is a distinctive type of ethical view... that requires literary works of a very specific type, primarily exemplified by the late novels of James, for its complete investigation" ("ER," p. 348). These include The Wings of the Dove (1902), The Ambassadors (1903), and The Golden Bowl (1904). I shall use examples from each of these although, as Posner notes, The Wings of The Dove, is one book that Nussbaum does not discuss in the article.4 [End Page 62]What attributes or characteristics do these late novels of James possess? They all have in common... (shrink)

Eternity and Omniscience This paper addresses the problem of the relationship between the two attributes: eternity and omniscience. Einstein’s theory of relativity and the related concept of time allows for a convincing reinterpretation of the classical conception of eternity as timelessness. I introduce this conception in the terms proposed by two analytical Thomists,Eleonore Stump and Norman Kretzmann. Given their conception of eternity, we can consistently define other attributes of the absolute being and defend the strong concept of omniscience. Keywords: God’s (...) attributes, omniscience, time, Eleonore Stump, Norman Kretzmann, conception of eternity. (shrink)

Reading Beauvoir's “Must We Burn Sade?” alongside the chapter called “Sexual Initiation” in The Second Sex, I argue that the problem with Sade is not his perversity, but his perpetual virginity. In The Second Sex, Beauvoir advances a new understanding of sexual initiation as a physical and spiritual movement toward the other, disqualifying any purely physical machination as sufficient to initiate one into “authentic erotic reality.” Sade's refusal of Eros as described in “Must We Burn Sade?” demonstrates that the Marquis's (...) commitment to his characteristic Sadism in fact condemned him to a barren promiscuity, a trenchant and joyless virginity that he elected to perpetuate. Finally, I argue that we should reread Sadism not as a perversion but as based on the Greek model of the “virgin ailment.” As such, Sadism may turn out to be a more genuine and widespread threat than we ordinarily acknowledge. (shrink)

Like many libertarian thinkers, Simpson assumes that the minimal state is culturally neutral. This is false. Libertarianism is a theory opposed to hierarchy at the state level. As such, it also undermines the grounds for hierarchy at the community level. Since communities require some form of hierarchy not only to exist but to generate meaningful culture, libertarianism is inherently nonneutral towards culture. From this it follows that Simpson's idea of a minimal state overseeing various nonliberal communities cannot be realized within (...) the libertarian framework. In its place, I defend republicanism, which makes no pretensions toward cultural neutrality. (shrink)

In this article I shall be supporting two main claims. The first is that the essence of the difference between particularism and generalism lies in where they locate ethical correctness. The second is that generalism, although to be preferred to particularism, is not the final resting place for ethical correctness. Ultimately, ethical correctness resides in ethical theories that provide the rationale for generalism. Particularism is presented as a theory that allows attention to be paid to specific cases and shows a (...) sensitivity to the particular case. Generalism, with its appeal to moral principles, is supposed to lack this sensitivity to specific cases. I argue that although this might be true of subsumptive generalism, it is not true of what I call judgmental generalism. This latter type of generalism retains an appeal to moral principles while requiring sensitivity to the particular case. I consider Kantian ethics as an example of this sort of generalism. Furthermore, I support the claim that this judgmental generalism is to be preferred to particularism. I argue against a prominent form of particularism, put forward by Jonathan Dancy, based on an appeal to the holism of reasons. This doctrine involves the claim that the value of a complex whole is not necessarily identical with the value of its parts. I show that Dancy’s discussion of this involves inconsistencies and also appears to incorporate subsumptive generalism. This statement of particularism is ultimately incoherent. (shrink)

GOD AND RELIGION OF ENLIGHTENED MAN ACCORDING TO KANT Having revealed an illusion of man’s cognitive efforts, Kant sealed the progress of enlightenment inscribed into a historical process, with a deep conviction that an ancient Greek prescription to „know thyself” was finally fulfilled. A man became aware of being equipped with a mind, and accordingly, with freedom as well as the ability to act morally, still of remaining a finite natural being with cognitive skills limited. This critical self-knowledge of an (...) enlightened man relieved him of his nonage to open his eyes for a new vision of both the world and a man himself regarded as a self-conscious subject and active creator of his fate. The character and ontological status of religious beliefs the enlightened man confesses are in fact defined by the famous Kantian formula: as if (als ob.) Driven by moral reasons, they are distinguished with a rationality for which a fundamental value is the Highest Good, purely rationalistic construction, a kind of god thought to be an essential being and a ration for existence of the phenomenal world. (shrink)

Traditional theism (in Christianity, Judaism and Islam) understands God as possessing certain attributes including omnipotence. God is omnipotent in the sense that God possesses unlimited (maximal) power. For some classical philosophers and theologians (PetrusDamiani, René Descartes) God’s omnipotence requires his being able to do absolutely anything, including the logically impossible. But in Thomas Aquinas’ opinion, to do what is logically impossible is not an act of power but is self-contradictory action. For Aquinas, a logically impossible action is not an action. (...) The contemporary British philosopher of religion, Richard Swinburne, considers omnipotence from an analytic perspective and, partially,within Aquinas’ tradition. For Swinburne, omnipotence includes the power to perform only logically possible and consistent tasks. In this paper, I discuss systematically (§§ 3-6) the philosophical and logical problems of omnipotence and the relation between God and logic from the perspective of Jan Łukasiewicz’s logical investigations. Keywords: Omnipotence, God, logic, rationality, Richard Swinburne, Jan Łukasiewicz. (shrink)

The author presents an argument that the notion of rationality of beliefs must not be so restrictive as it is according to usual definitions. I.a. The postulate of effective elimination of all contradictory beliefs should be qithdrawn because nobody had the pssibility to derive and examine all the consequences of his beliefs. The final author's proposal is to enclose a kind of merely potential mechanism of elimination of contradictory beliefs into the notion concerned.

Several remarks on the book by Professor Andrzej Kisielewicz, Logic and Argumentation. Practical Course in Critical ThinkingProfessor Andrzej Kisielewicz’s book concerns active forms and methods of teaching logic, also outside the context of university education. It possesses prac­tical value and may also be an auxiliary material for, among others, high school students. Despite some shortcomings, such as unjustified ascription of the status of hypothesis to statements, a flawed definition of the methodological and epistemological concept of a historical fact, it contains (...) many valuable and original logical propositions pertaining to critical and logical thinking.Undoubtedly, the book will be useful in education and helpful in introducing teachers and learners to using grammatical and logical rules. It will allow the reader to detect post-truth in the media or the shuffling of premises in argumentation. After implementing indispensable corrections and additions, it should become an obligatory reading — not only in the context of university education. (shrink)

The occurrence of business cycles is a feature of every economic system, so they were also observed in Poland. The article is an attempt to assess the structure and most important morphological features of the business cycles in Poland’s economy, taking into account how they were influenced by the consequences of the financial crisis 2007+ and COVID-19 pandemic. In the study the authors used the concept of deviation cycles which makes it possible to characterize the components of the business cycle’s (...) structure, i.e. identification of its turning points, particular phases and most important morphological features (i.e. duration of phases and the whole cycle, amplitude of fluctuations). The most significant empirical indicators which characterize the real cyclical processes, i.e. GDP, consumption and investment, were the subject of statistical analyses. (shrink)

This paper was written with two aims in mind. A large part of it is just an exposition of Tarski's theory of truth. Philosophers do not agree on how Tarski's theory is related to their investigations. Some of them doubt whether that theory has any relevance to philosophical issues and in particular whether it can be applied in dealing with the problems of philosophy (theory) of science.In this paper I argue that Tarski's chief concern was the following question. Suppose a (...) language L belongs to the class of languages for which, in full accordance with some formal conditions set in advance, we are able to define the class of all the semantic interpretations the language may acquire. Every interpretation of L can be viewed as a certain structure to which the expressions of the language may refer. Suppose that a specific interpretation of the language L was singled out as the intended one. Suppose, moreover, that the intended interpretation can be characterized in a metalanguage L +. If the above assumptions are satisfied, can the notion of truth for L be defined in the metalanguage L + and, if it can, how can this be done? (shrink)

We examine the possible role played by field angular momentum in two systems of vastly different sizes: (i) the nucleon and (ii) highly magnetic white dwarf stars. For the nucleon we study the restrictions on the nucleon's structure that arise from the requirement that the total field angular (spin, orbital and field angular momentum) should satisfy the standard angular momentum commutation relationship. For the magnetic white dwarfs we argue that the magnetic field may alter the statistics of some fraction of (...) the white dwarf's electrons from fermionic to bosonic. This would effect the stars structure, giving it a smaller than expected radius, and a lower than expected temperature. In some extreme cases one could imagine that this effect could lead to the collapse of the white dwarf into a neutron star despite being below the Chandreshekar limit. (shrink)

The approach used by physics is based on the identification and study of ideal objects, which is also the basis of biophysics, in combination with von Neumann heuristic modeling and functional fractionation according to R.Rosen is discussed as a tool for studying the properties of consciousness. The object of the study is a kind of line of analog systems: the human brain, the vertebrate brain, the invertebrate brain and artificial neural networks capable of reflection, which is a key property characteristic (...) of consciousness. Reflection in the broad sense of the word, understood as an internal representation of the external world, is characteristic of a wide range of animals, and some of them (bumblebees, fish) even demonstrate reflection in the narrow sense of the word, understood as an inner self-representation. This complex behavior is realized by miniature brains of ~1 million neurons. The use of simple recurrent neural networks (RNNs) to obtain answers to general questions is illustrated. For example, it has been shown a small RNS is able to pass delayed matching to sample (DMTS) test, forming an individual dynamic representation of the received stimulus, allowing decoding by a special external neural detector.. It has been demonstrated in the reflexive game “even-odd”, the RNS has a huge advantage over a multi-layered neural network, with the same and a larger number of neurons – reflection defeats regression. It was found that the asymmetry of outcomes in the odd-even game, which was explained by various causes, including psychological ones – “it’s easier to catch up than to run away”, is reproduced in the game of two RNNs. Obviously, there are no psychological causes here and the advantage of the player playing for “even” is explained by the more complex strategy of the “odd” player – he needs to predict the opponent’s move and choose the opposite one. (shrink)