A class of maize mutants, collectively known as disease lesion mimics, display discrete disease‐like symptoms in the absence of pathogens. It is intriguing that a majority of these lesion mimics behave as dominant gain‐of‐function mutations. The production of lesions is strongly influenced by light, temperature, developmental state and genetic background. Presently, the biological significance of this lesion mimicry is not clear, although suggestions have been made that they may represent defects in the plants' recognition of, or response to, pathogens. One (...) feature that is common to all lesion mimics is their association with cell death. In plants, as in animals, a number of developmental and pathological processes exist where controlled cell death, whether programmed or triggered in response to physiological or environmental stimuli, constitutes the normal aspect of life. Might disease lesion mimic mutations represent variants where regulation of desirable cell death has gone awry? In this paper we argue that this might be the case, and further conjecture that these mutants offer a unique opportunity for studying the genetic and cellular mechanisms of cell death in plants. (shrink)

HAMILTON WORRIED THAT THERE WERE REPRESENTATIVE ELEMENTS\nIN REID'S EPISTEMOLOGY, WHILE J S MILL FLATLY CHARACTERIZED\nTHE SCOT AS A REPRESENTATIVE REALIST. I ARGUE THAT HAMILTON\nAND MILL WERE MISTAKEN AND THAT THEIR MISTAKES AROSE FROM\nAN INSUFFICIENT UNDERSTANDING AND APPRECIATION OF THE\nNATIVISTIC ELEMENTS OF THE UNDERSTANDING INTRODUCED BY\nREID; AND TO INSUFFICIENT AWARENESS OF REID'S\nCHARACTERIZATION OF PERCEPTION AS ACTIVE IN CONTRAST TO\nBRITISH EMPIRICIST RELIANCE ON A PASSIVELY GIVEN EPISTEMIC\nBASE. REID REJECTED EVERY VARIETY OF THE "MESSENGER"\nTHEORY.

Why everybody needs a philosophy.--What is philosophy, anyway?--The place of philosophy in American universities.--The spirit of man.--Social life.--Religion.--The life of knowledge.--Philosophy and politics.--The new alignment of the British commonwealth of nations.--Discussion in America.--The Scot abroad.--On the anniversary of Sir Walter Scott's birthday.

The standard version of the psychological criterion or theory of personal identity takes it that psychological connectedness is not necessary for personal identity, or for what matters in survival. That is, a future person can be you, and/or have what matters in survival for you, even though there is no psychological connectedness between you and that future person. David Lewis, however, holds that psychological connectedness is necessary to both identity and what matters (which he takes to coincide). This entails, Lewis (...) acknowledges, that if a human body were to live longer than connectedness lasts, then that body would ‘embody’ or ‘constitute’ a different person later on than it did to begin with. Moreover, Lewis accepts, a body may embody more than one person at any one time. Lewis claims that this can be reconciled to some degree with common sense if we count by person stages rather than by persons. I show, though, that Lewis' view cannot be salvaged in this way, and, moreover, that it leads to further absurdities. I conclude that as an account of identity and of what matters in survival, it is highly implausible, and most unsatisfactory. (shrink)

This study employs a pretest-posttest experimental design to extend recent research pertaining to the effects of teaching business ethics material. Results on a variety of perceptual and attitudinal measures are compared across three groups of students — one which discussed the ethicality of brief business situations (the business scenario discussion approach), one which was given a more philosophically oriented lecture (the philosophical lecture approach), and a third group which received no specific lecture or discussion pertaining to business ethics. Results showed (...) some significant differences across the three groups and demonstrated that for a single lecture, the method used to teach ethics can differentially impact ethical attitudes and perceptions. Various demographic and background variables did not moderate the relationship between the teaching method and the dependent variables, but the sex of the student was strongly associated with the ethical attitude and perception measures. (shrink)

Health policy sometimes hinges on claims about the responsibility borne by people or corporations for health outcomes. We don't want these claims to be arbitrary, so we construe them as discoveries of plain fact. But we're mistaken. They are interwoven with our values and social institutions. Recognizing that they are allows us to debate them more honestly and thoroughly.

Next SectionPublic and healthcare professionals differ in their attitudes towards euthanasia and physician-assisted suicide (PAS), the legal status of which is currently in the spotlight in the UK. In addition to medical training and experience, religiosity, locus of control and patient characteristics (eg, patient age, pain levels, number of euthanasia requests) are known influencing factors. Previous research tends toward basic designs reporting on attitudes in the context of just one or two potentially influencing factors; we aimed to test the comparative (...) importance of a larger range of variables in a sample of nursing trainees and non-nursing controls. One hundred and fifty-one undergraduate students (early-stage nursing training, late-stage nursing training and non-nursing controls) were approached on a UK university campus and asked to complete a self-report questionnaire. Participants were of mixed gender and were on average 25.5 years old. No significant differences in attitude were found between nursing and non-nursing students. There was a significant positive correlation between higher religiosity and positive attitude toward euthanasia (r=0.19, p<0.05) and a significant negative relationship between internal locus of control and positive attitude toward PAS (r=−0.263, p<0.01). Multivariate analyses revealed differing predictor models for attitudes towards euthanasia and PAS, and confirm the importance of individual differences in determining these attitudes. The unexpected direction of association between religiosity and attitudes may reflect a broader cultural shift in attitudes since earlier research in this area. Furthermore, these findings suggest it possible that experience, more than training itself, may be a bigger influence on attitudinal differences in healthcare professionals. (shrink)

The extent to which the artist’s intentions are a relevant consideration in the interpretation of art has long been the subject of critical debate. First, I outline the various philosophical positions which have been established, specifically focusing on the debate between hypothetical intentionalism and moderate actual intentionalism. Then I look at some previous test cases which have, as yet, failed to demonstrate a decisive victory for either side. Finally, I offer two new test cases, one from the field of contemporary (...) visual art and the other from literary theory. I argue that the former serves to debunk hypothetical intentionalism and the latter lends support to the moderate actual intentionalist position. (shrink)

Leading researchers describe the field of special education as sharply divided between two different theories of disability. In this article Scot Danforth takes as his project addressing that division from the perspective of a Deweyan philosophy of the education of students with intellectual disabilities. In 1922, John Dewey authored two articles in New Republic that criticized the use of intelligence tests as both undemocratic and impractical in meeting the needs of teachers. Drawing from these two articles and a variety (...) of Dewey’s other works, Danforth puts forward a Deweyan educational theory of intellectual disability. This theory is perhaps encapsulated in Dewey’s observation that “The democratic faith in human equality is belief that every human being, independent of the quantity or range of his personal endowment, has the right to equal opportunity with every other person for development of whatever gifts he has.”1. (shrink)

A growing, interdisciplinary field of cognitive linguistics has developed in recent decades, bringing together research from many fields to explore the ways that metaphors provide structure and semantic content to thought and language. In this article, the American public school disability emotional/behavioral disorder (E/BD) is examined in regard to the primary metaphors that frame the basic concepts of the disorder. The metaphors of 2 versions of E/BD, psychodynamic and behavioral, are investigated. A series of critical questions about the E/BD construct (...) are posed, and possibilities for new metaphors are proposed. (shrink)

Envisioned as a cosmic Cabaret beyond ttie space-time continuum, Gadfly explores the power of the establishment to determine what we call accepted truth, and chronicles how it has historically been the outsider that has moved our understanding of truth forward. Special guests are invited to defend their teachings or actions, including Socrates, Luther, Copernicus, Galileo, Darwin, Einstein, Picasso, Beckett, and science philosopher William Dembski. These visitations are marshaled by a musical Poet Guide named Virgil (shades of Dante), who is backed (...) by a British threesome with a ukulele and a squeeze box. Virgil keeps the action moving forward as the "Idols of the Institution" play judge and jury over the minds of history's greatest thinkers. The resulting journey beyond space and time sheds light on the present claims of science as compared to the claims ofthe greatest thinkers down through the ages. It is, above all else, an exoneration of contemporary scholars choosing to explore Intelligent Design as a legitimate discipline in the academy, both scientifically and philosophically. (shrink)

A recent paper by Nisoli et al.1 provides the first evidence that elevated levels of nitric oxide (NO) stimulate mitochondrial biogenesis in a number of cell lines via a soluble guanylate‐cyclase‐dependent signaling pathway that activates PGC1α (peroxisome proliferator‐activated receptor γ coactivator‐1α), a master regulator of mitochondrial content. These results raise intriguing possibilities for a role of NO in modulating mitochondrial content in response to physiological stimuli such as exercise or cold exposure. However, whether this signaling cascade represents a widespread mechanism (...) by which mammalian tissues regulate mitochondrial content, and how it might integrate with other pathways that control PGC1α expression, remain unclear. BioEssays 25:538–541, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

_Parages_ brings together four essays by Derrida on the fictions of Maurice Blanchot. Three of the essays—"Living On," "Title To Be Specified," and "The Law of Genre," are by now canonical. The fourth, "_Pa_ce Not" as well as Derrida's 1986 introduction to the French edition of the book, appear here in English for the first time. This was a breakthrough publication in the analysis of Blanchot, a notoriously difficult writer. It is safe to say Derrida contributed much to that writer's (...) reputation in both French and English, always insisting on the philosophical pertinence of Blanchot's work to any discussion of the relationship between literature and critical thought. Through patient citation, and an ample collocation and readings of Blanchot's various motifs, Derrida explores a variety of questions, including the limits of genre, the procedure of crossing out, and the evocation of a non-dialectical and non-privative negativity. The book marks a crucial stage in Derrida's itinerary and provides a context for his later writings on apophatics in such works as _On the Name_ and his response to Heidegger on death in _Aporias_. (shrink)

In a world where economies have no moral conscience, biblical theologians can challenge local cultures with ancient wisdom about generosity and equity. Systemic solutions require changes in the habits of virtue, and this study focuses on the habit of generosity. Building on the work of Stephan Joubert’s Paul as Benefactor, this study concentrates on Paul’s collection in one notable instance: what he says about generosity in 2 Corinthians 8-9 and, in particular, what he means by isotēs in 2 Cor 8:13–15. (...) Does it mean “equality” or “equity”? Beginning with a reinvigorated interest in the economic vision of the apostle Paul about what is meant by “weak” and “good works” and what the Pastoral Epistles communicate with eusebeia (not “godliness” but “social respectability and civility”), we reconsider the collection as an act on the part of the Pauline mission churches to express more than ecclesial unity. This act embodied a theology of grace in mutual reciprocity and in equitable provision on the part of the wealthy for the poor, not least and not limited to those in their own Christian assemblies. The term isotēs is too easily glossed over when translated as “fair balance”, “fairness”, and so the translation of the term with “equity” or “equality” comes closest to the vision of the apostle. Too few studies on this term baptize it sufficiently in the economics of the ancient world and the early Christian radical vision of siblingship and family. Contribution: From the perspective of the Historical Thought and Source Interpretation of the work of Paul, the question of systemic equality or equity is as crucial to navigating the current economic climate as it has ever been. Equality or equity is not limited to Christian communities but following the early church in embodying a theology of grace. (shrink)

Pacifism, as well as just war theory, are expressions of one’s general hermeneutic of reading the Bible. In recent New Testament hermeneutics, while the so-called old perspective might have more resonance with just war theory, both the new perspective and apocalyptic open the door to a hermeneutically based pacifism. I examine the case of Dietrich Bonhoeffer’s under the category of a “Christoform hermeneutic,” namely, an approach to Christian ethics and the Christian and state that takes the suffering and cross of (...) Christ as the chief orientation point. (shrink)

The standard version of the psychological criterion or theory of personal identity takes it that psychological connectedness is not necessary for personal identity, or for what matters in survival. That is, a future person can be you, and/or have what matters in survival for you, even though there is no psychological connectedness between you and that future person. David Lewis, however, holds that psychological connectedness is necessary to both identity and what matters (which he takes to coincide). This entails, Lewis (...) acknowledges, that if a human body were to live longer than connectedness lasts, then that body would ‘embody’ or ‘constitute’ a different person later on than it did to begin with. Moreover, Lewis accepts, a body may embody more than one person at any one time. Lewis claims that this can be reconciled to some degree with common sense if we count by person stages rather than by persons. I show, though, that Lewis' view cannot be salvaged in this way, and, moreover, that it leads to further absurdities. I conclude that as an account of identity and of what matters in survival, it is highly implausible, and most unsatisfactory. (shrink)

"Using hundreds of examples from newsrooms large and small, author Ron F. Smith challenges readers to determine how they would face moral dilemmas on the job. Chapters evaluate the search for principles, accountability, truth and objectivity, errors and corrections, diversity, "faking" the news, reporters and their sources, privacy, the government watch, deception, compassion, the business of news, journalists and their communities, and financial concerns. New to this edition: a chapter on improving coverage of minorities, expanded discussion of broadcast journalism and (...) reporting on the Internet, and stories from recent front pages and TV news programs."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved. (shrink)

A common strategy in philosophical debate is to limit the alternative positions available in order to increase the appeal of one's own position. Unfortunately, this has too often been true in debates regarding the justification of religious faith. Both defenders and critics of religious faith have tried to rule out agnosticism as a viable alternative in order to support their own arguments for or against religious faith. Unfortunately, this strategy only encourages what is already the problematic polarization of religious discourse. (...) My goal in writing this paper is to lessen this polarization by making space for agnosticism between atheism and religious faith. I do this by critiquing two arguments against .. (shrink)

In this paper, I argue that self-awareness is intertwined with one's awareness of possibilities for action. I show this by critically examining Dan Zahavi's multidimensional account of the self. I argue that the distinction Zahavi makes among 'pre-reflective minimal', 'interpersonal', and 'normative' dimensions of selfhood needs to be refined in order to accommodate what I call 'pre-reflective self-understanding'. The latter is a normative dimension of selfhood manifest not in reflection and deliberation, but in the habits and style of a person’s (...) pre-reflective absorption in the world. After reviewing Zahavi's multidimensional account and revealing this gap in his explanatory taxonomy, I draw upon Heidegger, Merleau-Ponty, and Frankfurt in order to sketch an account of pre-reflective self-understanding. I end by raising an objection to Zahavi’s claim for the primitive and foundational status of pre-reflective self-awareness. To carve off self-awareness from the self’s practical immersion in a situation where things and possibilities already matter and draw one to act is to distort the phenomena. A more careful phenomenology of pre-reflective action shows that pre-reflective self-awareness and pre-reflective self-understanding are co-constitutive, both mutually for each other and jointly for everyday experience. (shrink)

In 'Een handvol filosofen' staan de filosofen centraal die sinds de oprichting van de Vrije Universiteit in 1880 aan deze instelling verbonden zijn geweest. Het gaat hierbij niet alleen om de inhoud van hun werk, maar ook om de personen zelf. Er waren filosofiedocenten die zich met de universiteit identificeerden en zich volledig konden ontplooien. Er waren er echter ook voor wie dit niet gold, die geïsoleerd of in gewetensnood raakten. Veel filosofiestudenten waren actief betrokken bij wat er in hun (...) faculteit gebeurde. Zij namen initiatieven, protesteerden soms tegen de gang van zaken en kozen partij in conflictsituaties. Sinds het eind van de jaren zestig van de twintigste eeuw verloor de Vrije Universiteit geleidelijk haar christelijk karakter. Tegenwoordig werken alle stafleden vanuit hun eigen motivatie mee aan een hoofdzakelijk seculier geworden universiteit, die ruimte biedt voor religieuze en levensbeschouwelijke diversiteit. (shrink)

While the topics of emergentism and religious naturalism have both received renewed attention in the past two decades, the recent publication of several books and numerous articles arguing for emergentism and its religious significance suggests that they are converging in interesting ways. Indeed, religious naturalists such as cell biologist Ursula Goodenough, complexity theorist Stuart Kauffman, and philosopher Loyal Rue have been important voices in this conversation. While they cannot be easily classified as religious naturalists, biological anthropologist Terrence Deacon and theologian (...) and philosopher Philip Clayton have also made significant contributions. (shrink)

In Black Lives and Sacred Humanity: Toward an African American Religious Naturalism, Carol Wayne White sets out to develop a new religious ideal for African American culture by bringing two unlikely partners, African American religiosity and religious naturalism, into conversation. This is an ambitious project given the prominent role that supernaturalistic theism plays in African American religiosity and the paucity of attention that contemporary religious naturalism has given to cultural issues such as race. She attempts to bridge the two through (...) the concept of “sacred humanity,” a radical version of religious humanism, which, she argues, is foreshadowed in African American religious tradition on the one hand... (shrink)