Crutchfield and Redinger argue that consciousness-altering chemical restraints are less “liberty-intrusive” (or as we will sometimes put it, just less “intrusive”) than physical restraints. Physica...

Widespread tax evasion and avoidance have recently led to both significant reforms of international tax governance and increased attention from theorists of global tax justice. Against the background of an analysis of the double challenge of effectiveness and distribution facing the taxation of multinational enterprises, this paper puts forward a taxonomy of recent contributions of the tax justice literature. This taxonomy not only opens up an original angle of interpretation on global tax justice, but also provides a vantage point from (...) which to evaluate recent reforms by the Organisation for Economic Co-operation and Development. (shrink)

Industrial emissions of greenhouse gases are significant contributors to climate change, which poses a grave threat to social and economic systems. Our understanding of what might drive firms to reduce their emissions of these gases, however, is incomplete, and it is not clear that the knowledge gained from other environmental issues will readily apply to these emissions. We argue and find that indicators of environmental injustice previously shown to relate to toxic pollutants, for example, are poor predictors of greenhouse gas (...) emissions. Instead, we show that the degree of belief in and concern about climate change in a local community is a significant predictor of the facility’s rate of emission improvements. Furthermore, we find that beliefs at both the facility and headquarter communities influence emission reduction, and that those effects are substitutes for each other. (shrink)

Since the 19th century, innocence has been a hallmark of childhood. The innocence of children is seen as both a sanctity worth defending and a feature that excuses the unavoidable mistakes of adolescence. While beneficial in many settings, notions of childhood innocence are often entangled with values judgements. Inherent in innocence is the notion that that which we are innocent of is undesirable. Further, attributing innocence to some implies the tolerability of blame for others. This has unique implications in a (...) medical setting. This essay explores the implications of espousing the innocence of paediatric patients. Ultimately, because attribution of innocence is both prone to bias and rooted in the same framework as blame, it degrades patient-centred care and compromises the patient–provider relationship. I argue that avoiding such characterisations may allow providers to more effectively promote paediatric health. (shrink)

This article describes the development, implementation, and evaluation of a complex methotrexate ethics case used in teaching a Pharmacy Law and Ethics course. Qualitative analysis of student reflective writings provided useful insight into the students’ experience and comfort level with the final ethics case in the course. These data demonstrate a greater student appreciation of different perspectives, the potential for conflict in communicating about such cases, and the importance of patient autonomy. Faculty lessons learned are also described, facilitating adoption of (...) this methotrexate ethics case by other healthcare profession educators. (shrink)

David Hilbert sought to secure the epistemic foundations of mathematics by providing consistency proofs of axiomatized mathematical theories from within the finite standpoint. This standpoint requires concrete constructions without reference to completed infinities. In 1938, Gerhardt Gentzen proved the consistency of first-order Peano Arithmetic relying on the well-ordering of certain ordinal notations. This was thought by Gentzen and Paul Bernays to be finitistically acceptable. However, a finitistically acceptable proof of the relevant well-ordering was not available until Gaisi Takeuti’s proof in (...) 1978. Beginning with the proposition that Takeuti’s proof conforms to the finite standpoint, this chapter explores the limits of a finitism based on the methods of Gentzen and Takeuti. It is argued that the upper limit is the Feferman-Schütte ordinal, and thus that finitism may be extended to strong subsystems of second-order arithmetic-systems strong enough to provide a theory of the ordinals for which Gentzen employed notations. (shrink)

Abstract:This essay explores key values of John Lachs's work, especially freedom, diversity, and human flourishing, when applied to the history of the philosophy of education as well as to the practical problems of policy and implementation today in American schools. I consider the importance and tensions involved in these values in the thinking of Plato, Jean-Jacques Rousseau, and John Dewey. Next, I examine necessary and then avoidable challenges of operationalizing freedom and diversity in schools, especially in tensions with recent policy (...) initiatives that threaten freedom and diversity for human flourishing. The aim here is to note the central importance of the values that Lachs has long championed, while attending also to the risks and dangers that misunderstanding and narrow thinking pose about them when applied to American public schools. Ultimately, I argue that while advocacy for liberty sometimes raises profound problems in the sphere of public education, democratic education is enriched immeasurably when it enables and empowers freedom to pursue diverse forms of flourishing. (shrink)

This edited collection includes contributions from expert philosophers of law and considers the work of one of the most important legal philosophers of our time, Professor Gerald J Postema. The chapters dig deep into important camps of Postema's rich theoretical project including: - the value of the rule of law; - the ideal of integrity in adjudication; - his works on analogical reasoning; - the methodology of jurisprudence; - dialogues with Ronald Dworkin, Joseph Raz, Frederick Schauer and HLA Hart. It (...) includes an original article by Professor Postema, in which he develops his conception of the rule of law and replies to some objections to previous works, and an interview in which he provides a fascinating and unique insight into his philosophy of law. (shrink)

The Darwinian theory of evolution is itself evolving and this book presents the details of the core of modern Darwinism and its latest developmental directions. The authors present current scientific work addressing theoretical problems and challenges in four sections, beginning with the concepts of evolution theory, its processes of variation, heredity, selection, adaptation and function, and its patterns of character, species, descent and life. The second part of this book scrutinizes Darwinism in the philosophy of science and its usefulness in (...) understanding ecosystems, whilst the third section deals with its application in disciplines beyond the biological sciences, including evolutionary psychology and evolutionary economics, Darwinian morality and phylolinguistics. The final section addresses anti-Darwinism, the creationist view and issues around teaching evolution in secondary schools. The reader learns how current experimental biology is opening important perspectives on the sources of variation, and thus of the very power of natural selection. This work examines numerous examples of the extension of the principle of natural selection and provides the opportunity to critically reflect on a rich theory, on the methodological rigour that presides in its extensions and exportations, and on the necessity to measure its advantages and also its limits. Scholars interested in modern Darwinism and scientific research, its concepts, research programs and controversies will find this book an excellent read, and those considering how Darwinism might evolve, how it can apply to the human sciences and other disciplines beyond its origins will find it particularly valuable. Originally produced in French (Les Mondes Darwiniens), the scope and usefulness of the book have led to the production of this English text, to reach a wider audience. This book is a milestone in the impressive penetration by Francophone scholars into the world of Darwinian science, its historiography and philosophy over the last two decades. Alex Rosenberg, R. Taylor Cole Professor of Philosophy, Duke University Until now this useful and comprehensive handbook has only been available to francophones. Thanks to this invaluable new translation, this collection of insightful and original essays can reach the global audience it deserves. Tim Lewens, University of Cambridge. (shrink)

Socrates' moral psychology is widely thought to be 'intellectualist' in the sense that, for Socrates, every ethical failure to do what is best is exclusively the result of some cognitive failure to apprehend what is best. Until publication of this book, the view that, for Socrates, emotions and desires have no role to play in causing such failure went unchallenged. This book argues against the orthodox view of Socratic intellectualism and offers in its place a comprehensive alternative account that explains (...) why Socrates believed that emotions, desires and appetites can influence human motivation and lead to error. Thomas C. Brickhouse and Nicholas D. Smith defend the study of Socrates' philosophy and offer an alternative interpretation of Socratic moral psychology. Their novel account of Socrates' conception of virtue and how it is acquired shows that Socratic moral psychology is considerably more sophisticated than scholars have supposed. (shrink)

When do people say that they are moved, and does this experience constitute a unique emotion? We review theory and empirical research on being moved across psychology and philosophy. We examine feeling labels, elicitors, valence, bodily sensations, and motivations. We find that the English lexeme being moved typically (but not always) refers to a distinct and potent emotion that results in social bonding; often includes tears, piloerection, chills, or a warm feeling in the chest; and is often described as pleasurable, (...) though sometimes as a mixed emotion. While we conclude that it is a distinct emotion, we also recommend studying it in a more comprehensive emotion framework, instead of using the ambiguous vernacular term being moved as a scientific term. (shrink)

Thomas Brickhouse and Nicholas Smith offer a comprehensive historical and philosophical interpretation of, and commentary on, one of Plato's most widely read works, the Apology of Socrates. Virtually every modern interpretation characterizes some part of what Socrates says in the Apology as purposefully irrelevant or even antithetical to convincing the jury to acquit him at his trial. This book, by contrast, argues persuasively that Socrates offers a sincere and well-reasoned defense against the charges he faces. First, the authors establish (...) a consensus of ancient reports about Socrates ' moral and religious principles and show that these prohibit him from needlessly risking the condemnation of the jury. Second, they consider each specific claim made by Socrates in the Apology and show how each can be construed as an honest effort to inform the jurors of the truth and to convince them of his blamelessness. The arguments of this book are informed by a critical review of the scholarly literature and careful attention to the philosophy expressed in Plato's other early dialogues. (shrink)

Hydra are remarkable because they are immortal. Much of immortality can be ascribed to the asexual mode of reproduction by budding, which requires a tissue consisting of stem cells with continuous self‐renewal capacity. Emerging novel technologies and the availability of genomic resources enable for the first time to analyse these cells in vivo. Stem cell differentiation in Hydra is governed through the coordinated actions of conserved signaling pathways. Studies of stem cells in Hydra, therefore, promise critical insights of general relevance (...) into stem cell biology including cellular senescence, lineage programming and reprogramming, the role of extrinsic signals in fate determination and tissue homeostasis, and the evolutionary origin of these cells. With these new facts as a backdrop, this review traces the history of studying stem cells in Hydra and offers a view of what the future may hold. (shrink)

Cover Photograph: Transgenic Hydra provide insights of general relevance into stem cell biology. The image shows a mass culture of transgenic Hydra expressing EGFP in all of their ectodermal epithelial cells. See article by Thomas C. G. Bosch pp. 478–486.

Current work in experimental biology revolves around a handful of animal species. Studying only a few organisms limits science to the answers that those organisms can provide. Nature has given us an overwhelming diversity of animals to study, and recent technological advances have greatly accelerated the ability to generate genetic and genomic tools to develop model organisms for research on host–microbe interactions. With the help of such models the authors therefore hope to construct a more complete picture of the mechanisms (...) that underlie crucial interactions in a given metaorganism (entity consisting of a eukaryotic host with all its associated microbial partners). As reviewed here, new knowledge of the diversity of host–microbe interactions found across the animal kingdom will provide new insights into how animals develop, evolve, and succumb to the disease. (shrink)

Codes of ethics exist in many, if not the majority, of all large U.S. companies today. But how the impact of these written codes affect managerial attitudes and behavior is still not clearly documented or explained. This study takes a step in that direction by proposing that attention should shift from the codes themselves as the sources of ethical behavior to the persons whose behavior is the focus of these codes. In particular, this study investigates the role of code familiarity (...) as a factor impacting the influence of an ethics code on manager behavior. Data collected from 286 executives from companies in the direct selling industry are used to test hypotheses (1) that the perceived usefulness of ethics codes is positively related to the degree of familiarity with the code, and (2) that ethical climate as assessed by managers is positively related to the code''s perceived usefulness. Both hypotheses are supported, and their implications and further research directions are discussed. (shrink)

Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...) Hydra raises the question of whether, in early metazoan evolution, cell–cell communication was based mainly on these small molecules rather than on the growth‐factor‐like cytokines that control differentiation and development in higher animals. BioEssays 23:420–427, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This article argues that Carol Gilligan's research in moral development psychology, work which claims that women speak about ethics in a "different voice" than men do, is applicable to business ethics. This essay claims that Gilligan's "ethic of care" provides a plausible explanation for the results of two studies that found men and women handling ethical dilemmas in business differently. This paper also speculates briefly about the management implications of Gilligan's ideas.

Ecological developmental biology (eco‐devo) explores the mechanistic relationships between the processes of individual development and environmental factors. Recent studies imply that some of these relationships have deep evolutionary origins, and may even pre‐date the divergences of the simplest extant animals, including cnidarians and sponges. Development of these early diverging metazoans is often sensitive to environmental factors, and these interactions occur in the context of conserved signaling pathways and mechanisms of tissue homeostasis whose detailed molecular logic remain elusive. Efficient methods for (...) transgenesis in cnidarians together with the ease of experimental manipulation in cnidarians and sponges make them ideal models for understanding causal relationships between environmental factors and developmental mechanisms. Here, we identify major questions at the interface between animal evolution and development and outline a road map for research aimed at identifying the mechanisms that link environmental factors to developmental mechanisms in early diverging metazoans.Also watch the Video Abstract. (shrink)

Over 300 years ago the father of microscopy, Antonie van Leeuwenhoek, observed dried rotifers “coming back to life” upon rehydration. Since then, scientists have been fascinated by the enduring mystery of how certain organisms survive losing essentially drying out completely. Historically sugars, such as the disaccharide trehalose, have been viewed as major functional mediators of desiccation tolerance. However, some desiccation tolerant organisms do not produce this sugar, hinting that additional mediators, and potentially novel mechanisms exist. It has become apparent that (...) a common theme among such organisms is the production and use of intrinsically disordered proteins to mediate survival in this dry state. However, the basic biology of these proteins – which unlike globular proteins lack persistent three-dimensional structure – is poorly understood, as are the functional mechanisms utilized by these enigmatic proteins that allow them to mediate desiccation tolerance. We purpose that probing the biochemical and biophysical nature of stress-related IDPs will provide mechanistic insights into these fascinating proteins. Remarkably, organisms from every kingdom of life can survive losing nearly all their intracellular water. A hallmark of desiccation tolerance is the use of intrinsically disordered proteins, but how IDPs contribute to tolerance is poorly understood. Here, we discuss possible mechanisms and avenues for studying these enigmatic proteins. (shrink)

Motive des Todes und der Vanitas kennzeichnen den Italo-Western auf markante Art, was ihn sowohl vom klassischen Hollywood-Western als auch von den deutschen Karl May-Verfilmungen deutlich unterscheidet. Das Genre erfährt in den italienischen Western eine umfassende Adaptation an die katholisch-mediterrane Kultur Italiens. Neben ihrer spezifischen Ikonographie betrifft dies auch die Hervorhebung der Zeitlichkeit als filmisches Darstellungsmittel und eine spezifische negative Anthropologie und Naturauffassung mit quasi-barocken Zügen. Die Zitation und Verwendung dieser traditionellen Elemente dient aber nicht nur der Kritik des amerikanischen (...) Westernmythos und der Anpassung an das Ethos der eigenen Kultur. Sie steht zugleich im Dienst der kulturellen Erneuerungsprozesse der 1960er-Jahre, des Individualismus und Hedonismus der Popkultur, der ‚Coolness‘ ihrer neuartigen Heldenfiguren und dem spielerischen Traditionsverhältnis ihrer postmodernen künstlerischen Darstellungsweisen. (shrink)

Motive des Todes und der Vanitas kennzeichnen den Italo-Western auf markante Art, was ihn sowohl vom klassischen Hollywood-Western als auch von den deutschen Karl May-Verfilmungen deutlich unterscheidet. Das Genre erfährt in den italienischen Western eine umfassende Adaptation an die katholisch-mediterrane Kultur Italiens. Neben ihrer spezifischen Ikonographie betrifft dies auch die Hervorhebung der Zeitlichkeit als filmisches Darstellungsmittel und eine spezifische negative Anthropologie und Naturauffassung mit quasi-barocken Zügen. Die Zitation und Verwendung dieser traditionellen Elemente dient aber nicht nur der Kritik des amerikanischen (...) Westernmythos und der Anpassung an das Ethos der eigenen Kultur. Sie steht zugleich im Dienst der kulturellen Erneuerungsprozesse der 1960er-Jahre, des Individualismus und Hedonismus der Popkultur, der ‚Coolness‘ ihrer neuartigen Heldenfiguren und dem spielerischen Traditionsverhältnis ihrer postmodernen künstlerischen Darstellungsweisen. (shrink)

The study combines a general theory of the history of literary genres with a history of the sonnet from the Middle Ages to the Romantic period. It demonstrates the adaptability of artistic genres, paying special attention to media and communication theoryand social and historico-cultural aspects. For the sonnet, it proposes models for its genesis in the Middle Ages and its various historical manifestations. This is a fundamental work on genre theory and the history of the German and European sonnet.

Graphical AbstractCIFAR's Humans & the Microbiome program is a multidisciplinary group of biological, clinical, and social scientists who explore the links between microbiome biology and sociocultural, historical, evolutionary, and environmental aspects of human existence that may impact the microbiome or be impacted by it. In this focus issue, members of the program focus on topics ranging from decoding the link between nutrition, the microbiome and human developmental, metabolic, and immune health and aging, to understanding past changes in the environment and (...) microbiome. The image depicts a population of bacteria (green) in association with the epithelia tissues (magenta and blue), perhaps the most common type of symbiosis in humans and other animals. Image contribution: Tara Essock-Burns. DOI: 10.1002/bies.201900130. (shrink)

Cells in the basal metazoan phylum Cnidaria are characterized by remarkable plasticity in their differentiation capacity. The mechanism controlling asymmetric cell divisions is not understood in cnidarians or in any other animal group. PIWI proteins recently have been shown to be involved in maintaining the self‐renewal capacity of stem cells in organisms as diverse as ciliates, flies, worms and mammals. Seipel et al.1 find that, in the cnidarian Podocoryne carnea, the Piwi homolog Cniwi is transcriptionally upregulated when the polyp generates (...) buds, which will develop into medusae. Since transdifferentiation of striated muscle cells to smooth muscle cells also activated Cniwi expression, Cniwi appears to play a crucial role in differentiation events. The discovery should facilitate elucidation of the poorly understood factors that control asymmetric cell divisions at the beginning of animal evolution. BioEssays 26:929–931, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

In ‘Field Experiments and Methodological Intolerance,’ Glenn Harrison develops a criticism of randomized field experiments and denounces ‘intolerance’ for lab experiments and a ‘disconnect from theory.’ We argue that lab experiments and RCTs are based on different methodological approaches and therefore fulfill different scientific objectives; key features of the RCT methodology make it highly relevant for policy-making, which accounts for a large part of its uptake; RCTs foster a convergence of interests between policy-makers and researchers around the study of economic (...) mechanisms, which makes it possible to challenge and improve economic theory based on real-world facts; and hybrid forms of experimentation are being increasingly used and open promising avenues. In sum, economic research based on RCTs is more and more connected to theory and other forms of experiment, while also helping policy-makers tackle daunting problems of poverty and exclusion. (shrink)

ABSTRACT This article examines the Fourierist reception of Owenism. In challenging the established historiography on Owen’s reception in France, the article draws on a wide range of Fourierist material – letters, unpublished draft manuscripts, and neglected articles in Fourierist and non-Fourierist periodicals – that previously not accessible to twentieth-century historians in order to reassess the Fourierist response to Owen and Owenism. The article pays special attention to the work of Fourier’s leading disciple, Victor Considerant. It contrasts Fourier’s highly critical evaluation (...) of Owen’s work, with Considerant’s more considered reading of Owen and conciliatory approach in dealing with other socialists, such as the Saint-Simonians and Owen’s French disciples. The article also examines the work of some of Fourier’s other followers, including Jules Lechevalier, Adrien Berbrugger, Alexandre Baudet-Dulary, and Amédée Paget and their evaluations of Owen and Owenism. (shrink)

La politique de « réformes et ouverture » vers l’étranger, initiée par Deng Xiaoping au sortir de la Révolution culturelle en 1978 s’est avérée, d’un point de vue économique, une véritable réussite qui a amené la Chine au rang des grandes puissances mondiales en à peine trente ans. D’un point de vue social par contre, le résultat est tout autre : transfigurée par ces réformes qui ont acté le basculement d’une économie planifiée vers une économie de marché, la société chinoise (...) s’est retrouvée bouleversée par la disparition de l’État-providence et la restructuration du secteur de production étatique, autant de dommages collatéraux qui vont brutalement vulnérabiliser et « précariser » des millions d’individus. Dès la fin des années 1980, vont se constituer de nouvelles « classes dangereuses » de paysans sans terres, de chômeurs et de pauvres, des « masses dangereuses » que l’État-parti chinois va devoir discipliner, puisque c’est sur leur exploitation que va se construire le miracle chinois. C’est donc un véritable arsenal discursif, une langue de bois élaborée et complétée sur trois décennies, que les dirigeants du Parti communiste chinois vont mettre en place pour formuler les perceptions et « corriger les consciences erronées » de ces populations vers une acceptation d’un ordre social qui leur est foncièrement défavorable.From the economic point of view, the policy for « reform and openness » to other countries initiated by Deng Xiaoping as the Cultural Revolution ended in 1978 was a genuine success that made China a top-ranking world power in the space of barely thirty years. The outcome was very different from the social point of view, however: the reforms that turned a planned economy into a market economy caused radical upheaval in Chinese society as collateral damage from the demise of the welfare state and the restructuring of the State-controlled production sector plunged millions into precariousness and insecurity. The late 1980s saw the emergence of a new « dangerous class » of landless peasants, unemployed workers and poverty-stricken individuals: the « dangerous masses » that the Chinese party-state would have to discipline so that the « Chinese miracle » could be built by exploiting their labour. Thus did China’s Communist party leadership deploy a whole arsenal of political doublespeak, developed and honed over three decades, designed to formulate perceptions and « correct » the « erroneous conceptions » of these populations to lead them to acceptance of a social order which is fundamentally opposed to their interests. (shrink)

The major point of contention among the philosophers and mathematicians who have written about the independence results for the continuum hypothesis (CH) and related questions in set theory has been the question of whether these results give reason to doubt that the independent statements have definite truth values. This paper concerns the views of G. Kreisel, who gives arguments based on second order logic that the CH does have a truth value. The view defended here is that although Kreisel's conclusion (...) is correct, his arguments are unsatisfactory. Later sections of the paper advance a different argument that the independence results do not show lack of truth values. (shrink)