Cell and tissue-based products, such as autologous adult stem cells, are being prescribed by physicians across the world for diseases and illnesses that they have neither been approved for or been demonstrated as safe and effective in formal clinical trials. These doctors often form part of informal transnational networks that exploit differences and similarities in the regulatory systems across geographical contexts. In this paper, we examine the regulatory infrastructure of five geographically diverse but socio-economically comparable countries with the aim of (...) identifying similarities and differences in how these products are regulated and governed within clinical contexts. We find that while there are many subtle technical differences in how these regulations are implemented, they are sufficiently similar that it is difficult to explain why these practices appear more prevalent in some countries and not in others. We conclude with suggestions for how international governance frameworks might be improved to discourage the exploitation of vulnerable patient populations while enabling innovation in the clinical application of cellular therapies. (shrink)

At the very beginning of Lavallee’s article on addictive craving, they note that they will avoid using the term addict in an attempt to avoid essentializing the identities of people who experience addiction. Neuroscientific approaches to the study of mental disorders could benefit from a similar level of caution with regard to discouraging essentialism. Zachar characterized psychological essentialism as the “cognitive predisposition to view entities as possessing underlying natures that make them be the kind of things that they are”. The (...) view that the brain is the underlying “essence” of the person has been dubbed neuroessentialism. Neuroessentialism entails that mental disorders have an inherent... (shrink)

Important philosophical work has gone into debunking thoroughly entrenched positivist notions that objective science proceeds in a value neutral manner. Dr. Tamara Kayali Browne's article "A Role for Philosophers, Sociologists, and Bioethicists in Revising the DSM" admirably takes the next step. Given the evaluative elements that permeate, in this case, the science of nosology—how do we deal responsibly with those evaluative elements? She correctly, in my opinion, concludes that dealing with evaluative issues responsibly is tantamount to dealing with them ethically. (...) But, as her concrete example of the ethics of premenstrual dysphoric disorder demonstrates, dealing with the ethics of the science of... (shrink)

I would like to thank Scott Waterman for sharing what must have been very challenging personal circumstances. Waterman's reflections touched upon many complex issues. For my part, I would like to explore how Waterman's experience underscores the importance of epistemic humility regarding the limits of scientific knowledge and our sense of the meaning of scientific knowledge while still recognizing the significance and power of scientific knowledge. The first epistemic challenge presented by Scott Waterman's experience of "patienthood" that demonstrates the limits (...) of scientific knowledge is the ability to know pain. Of course, we have all known pain, but such firstperson knowledge would not qualify as scientific... (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further (...) questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article will take up the first two questions. With the first question, invited commentators express a range of opinion regarding the nature of psychiatric disorders, loosely divided into a realist position that the diagnostic categories represent real diseases that we can accurately name and know with our perceptual abilities, a middle, nominalist position that psychiatric disorders do exist in the real world but that our diagnostic categories are constructs that may or may not accurately represent the disorders out there, and finally a purely constructivist position that the diagnostic categories are simply constructs with no evidence of psychiatric disorders in the real world. The second question again offers a range of opinion as to how we should define a mental or psychiatric disorder, including the possibility that we should not try to formulate a definition. The general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article took up the first two questions. Part II will take up the second two questions. Question 3 deals with the question as to whether DSM-V should assume a conservative or assertive posture in making changes from DSM-IV. That question in turn breaks down into discussion of diagnoses that depend on, and aim toward, empirical, scientific validation, and diagnoses that are more value-laden and less amenable to scientific validation. Question 4 takes up the role of pragmatic consideration in a psychiatric nosology, whether the purely empirical considerations need to be tempered by considerations of practical consequence. As in Part 1 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Blame is multifarious. It can be passionate or dispassionate. It can be expressed or kept private. We blame both the living and the dead. And we blame ourselves as well as others. What’s more, we blame ourselves, not only for our moral failings, but also for our non-moral failings: for our aesthetic bad taste, gustatory self-indulgence, or poor athletic performance. And we blame ourselves both for things over which we exerted agential control (e.g., our voluntary acts) and for things over (...) which we lacked such control (e.g., our desires, beliefs, and intentions). I argue that, despite this manifest diversity in our blaming practices, it’s possible to provide comprehensive account of blame. Indeed, I propose a set of necessary and sufficient conditions that aims to specify blame’s extension in terms of its constitution as opposed to its function. And I argue that this proposal has a number of advantages beyond accounting for blame in all its disparate forms. For one, it can account for the fact that one’s having had control over whether one was to φ is a necessary condition for one’s being fittingly blamed for having φ-ed. For another, it can account for why, unlike fitting shame, fitting blame is always deserved, which in turn explains why there is something morally problematic about ridding oneself of one’s fitting self-blame (e.g., one’s fitting guilt). (shrink)

In this paper I argue that luck and fortune are distinct concepts that apply to different sets of events. I do so by suggesting that lucky events are best understood as significant events that are either modally fragile or improbable (depending on whether you accept a modal account or a probability account of luck), whereas fortunate events are best understood as significant events that are outside of our control. I call this the Pure Control Account of Fortune. I show that (...) this account of fortune forces control theorists about luck to be fortune reductionists but allows those who endorse a modal or probability account of luck to be fortune realists. Additionally, I argue that this account of fortune helps us overcome prominent counterexamples and challenges found in the luck literature. (shrink)

Argumentation, which can be abstractly defined as the interaction of different arguments for and against some conclusion, is an important skill to learn for everyday life, law, science, politics and business. The best way to learn it is to try it out on real instances of arguments found in everyday conversational exchanges and legal argumentation. The introductory chapter of this book gives a clear general idea of what the methods of argumentation are and how they work as tools that can (...) be used to analyze arguments. Each subsequent chapter then applies these methods to a leading problem of argumentation. Today the field of computing has embraced argumentation as a paradigm for research in artificial intelligence and multi-agent systems. Another purpose of this book is to present and refine tools and techniques from computing as components of the methods that can be handily used by scholars in other fields. (shrink)

Abstract: There are epistemic manipulators in the world. These people are actively attempting to sacrifice epistemic goods for personal gain. In doing so, manipulators have led many competent epistemic agents into believing contrarian theories that go against well-established knowledge. In this paper, I explore one mechanism by which manipulators get epistemic agents to believe contrarian theories. I do so by looking at a prominent empirical model of trustworthiness. This model identifies three major factors that epistemic agents look for when trying (...) to determine who is trustworthy. These are (i) ability, (ii) benevolence, and (iii) moral integrity. I then show how manipulators can manufacture the illusion that they possess these factors. This leads epistemic agents to view manipulators as trustworthy sources of information. Additionally, I argue that fact-checking will be an ineffective – or even harmful – practice when correcting the beliefs of epistemic agents who have been tricked by this illusion of epistemic trustworthiness. I suggest that in such cases we should use an alternative correction, which I call trust undercutting. (shrink)

What accounts for the prestige of quantitative methods? The usual answer is that quantification is desirable in social investigation as a result of its successes in science. Trust in Numbers questions whether such success in the study of stars, molecules, or cells should be an attractive model for research on human societies, and examines why the natural sciences are highly quantitative in the first place. Theodore Porter argues that a better understanding of the attractions of quantification in business, government, (...) and social research brings a fresh perspective to its role in psychology, physics, and medicine. Quantitative rigor is not inherent in science but arises from political and social pressures, and objectivity derives its impetus from cultural contexts. In a new preface, the author sheds light on the current infatuation with quantitative methods, particularly at the intersection of science and bureaucracy. (shrink)

I argue that a common philosophical approach to the interpretation of physical theories—particularly quantum field theories—has led philosophers astray. It has driven many to declare the quantum field theories employed by practicing physicists, so-called ‘effective field theories’, to be unfit for philosophical interpretation. In particular, such theories have been deemed unable to support a realist interpretation. I argue that these claims are mistaken: attending to the manner in which these theories are employed in physical practice, I show that interpreting effective (...) field theories yields a robust foundation for a more refined approach to scientific realism in the context of quantum field theory. The paper concludes by briefly sketching some general morals for interpretive practice in the philosophy of physics. (shrink)

Agents often face a choice of what to do. And it seems that, in most of these choice situations, the relevant reasons do not require performing some particular act, but instead permit performing any of numerous act alternatives. This is known as the basic belief. Below, I argue that the best explanation for the basic belief is not that the relevant reasons are incommensurable (Raz) or that their justifying strength exceeds the requiring strength of opposing reasons (Gert), but that they (...) are imperfect reasons—reasons that do not support performing any particular act, but instead support choosing any of the numerous alternatives that would each achieve the same worthy end. In the process, I develop and defend a novel theory of objective rationality, arguing that it is superior to its two most notable rivals. (shrink)

This book provides an argumentation model for means-end reasoning, a distinctive type of reasoning used for problem-solving gand decision-making. Means-end reasoning is modeled as goal-directed argumentation from an agent's goals and known circumstances, and from an action selected as a means, to a decision to carry out the action. Goal-based reasoning for argumentation provides an argumentation model for this kind of reasoning, showing how it is employed in settings of intelligent deliberation where agents try to collectively arrive at a conclusion (...) on what they should do to move forward in a set of circumstances. The book explains how this argumentation model can help build more realistic computational systems of deliberation and decision-making and shows how such systems can be applied to solve problems posed by goal-based reasoning in numerous fields, from social psychology and sociology, to law, political science, anthropology, cognitive science, artificial intelligence, multi-agent systems, and robotics." -- Back cover. (shrink)

Occupying a space in-between conventional scholarship and imaginative storytelling, The University in Crumbs: A Register of Things Seen and Heard is an experimental work that dramatizes the everyday life of the academy.

6. Jürgen Habermas's Critical Hermeneutics Introduction Habermas and Critical Hermeneutics Life and Influences 132 Habermas's Place in Contemporary Thought ...

This monograph poses a series of key problems of evidential reasoning and argumentation. It then offers solutions achieved by applying recently developed computational models of argumentation made available in artificial intelligence. Each problem is posed in such a way that the solution is easily understood. The book progresses from confronting these problems and offering solutions to them, building a useful general method for evaluating arguments along the way. It provides a hands-on survey explaining to the reader how to use current (...) argumentation methods and concepts that are increasingly being implemented in more precise ways for the application of software tools in computational argumentation systems. It shows how the use of these tools and methods requires a new approach to the concepts of knowledge and explanation suitable for diverse settings, such as issues of public safety and health, debate, legal argumentation, forensic evidence, science education, and the use of expert opinion evidence in personal and public deliberations. (shrink)

This reader-friendly book examines philosophies and philosophers using an engaging, non-condescending approach that speaks to you at your level.

I explain what teleological reasons are, distinguish between direct and indirect teleological reasons, and discuss both whether all practical reasons are teleological and whether all teleological reasons are direct.

_Discusses philosophers Mencius and Aristotle as socio-ecological thinkers._ Mencius (385–303/302 BCE) and Aristotle (384–322 BCE) were contemporaries, but are often understood to represent opposite ends of the philosophical spectrum. Mencius is associated with the ecological, emergent, flowing, and connected; Artistotle with the rational, static, abstract, and binary. Douglas Robinson argues that in their conceptions of rhetoric, at least, Mencius and Aristotle are much more similar than different: both are powerfully socio-ecological, espousing and exploring collectivist thinking about the circulation of (...) energy and social value through groups. The agent performing the actions of _pistis_, “persuading-and-being-persuaded,” in Aristotle and _zhi_, “governing-and-being-governed,” in Mencius is, Robinson demonstrates, not so much the rhetor as an individual as it is the whole group. Robinson tracks this collectivistic thinking through a series of comparative considerations using a theory that draws impetus from Arne Naess’s “ecosophical” deep ecology and from work on rhetoric powered by affective ecologies, but with details of the theory drawn equally from Mencius and Aristotle. (shrink)

This book examines the concept of "forbidden knowledge" in religion, science, government, and psychology. From the tree of knowledge in the Garden of Eden (forbidden fruit), to world altering scientific research (nuclear power, stem-cells, cloning) to damning government secrets (Abu Ghraib, domestic spying), to traumatic experiences that individuals want to repress (sexual abuse), humanity has encountered knowledge that has been hidden and suppressed. We experience this denial as a loss of control and respect, and we want to know exactly what (...) knowledge has been prohibited and why we cannot have access to it. The author takes the general position that too much material is prohibited, especially today, even while business and government invade individual privacy more and more. A primary assumption in a democracy is that we can have confidence in the people, so information should not be forbidden unless there is a vital and compelling reason to withhold it. (shrink)

This chapter contains sections titled: “Claims to Power” The Rhetoric of the Will to Power “The world viewed from inside”: Nietzsche's Later Atomism “The Logic of Feeling”.

T'Challa, seemingly risen from the dead after having suffered grievous wounds and a fall from a high cliff, openly challenges Erik Killmonger's right to be called King of Wakanda. With T'Challa's return, Killmonger orders W'Kabi to "kill this clown," but Okoye decides to follow tradition, not Killmonger, saying to her husband W'Kabi that "the challenge is not complete." The same principle is at work when, earlier in the film, T'Challa engages in ritual combat against M'Baku, leader of the Jabari Tribe. (...) T'Challa, occupying the most privileged position, can smile bemusedly and shake his head at Shuri's outburst, and a child in the crowd can innocently slap his hand to his forehead in disbelief; but the adults present are not amused at Shuri's transgressions. Shuri may be the most visible gadfly, but the harshest – and, ultimately, most effective – critics of Wakanda's kings are Killmonger, Nakia, and T'Challa himself. (shrink)

Douglas Wadle celebrates the juxtaposition of art and science while examining music's influence on humanity's understanding of our place in the universe. Tracing the millennia-old love affair between music and science, Wadle chronicles the surprising ubiquity of musical training among history's greatest thinkers. He shines a spotlight on the intertwining stories of pattern and form and how they complement one another in our search for creativity and insight. Einstein's Violin relies on extensive research to tell the story of how (...) music impacts the pattern recognition software in our brains, facilitating more creative problem solving. Without digression into technical treatise, it focuses on the historical stories that best display music's beautiful interaction with mind and universe"--Back cover. (shrink)

In this concentrated, intelligible, and useful introductory volume Stanley Porter and Jason Robinson give a splendid overview of hermeneutical and interpretive thought. Neither an all-inclusive survey that moves too quickly over the surface of complex issues nor a specialized volume on a single, narrow topic, Porter and Robinson's Hermeneutics provides critical analysis of major movements and figures in hermeneutics and interpretive theory in the modern era -- from Schleiermacher and Heidegger to Thiselton and Culpepper -- showing especially how (...) these interpreters and their movements have impacted biblical and theological study. (shrink)

This is an introduction to the agent-relative/agent-neutral distinction as it pertains to utilitarianism.

This is a general introduction to supererogation in relation to utilitarianism.

Landscape and brandingexplores the way landscape is conceptualised, conceived, represented and designed by professionals in a brand-driven age. Landscape - incorporating tangible physical space as well as intangible concepts, narratives, images, and experiences of place - is constructed by a number of creative industries. This book tests the hypothesis that place branding, a powerful marketing and management practice, increasingly blurs the distinction between the promotionof landscape and its production in design terms. Place branding involves the strategic and systematic composition of (...) single-minded, experiential and market-friendly place identities which are consistently communicated across various media, including physical space. How does this implicate or transform notions of place, nature, landscape experience, and the qualitative value of landscape itself? How does this affect the role of landscape architecture? To answer these questions, place branding theory and practice is critically examined alongside an in depth case study of one specific landscape - the Blue Mountains (Australia). Projects undertaken between 1995 and 2015, including a branding strategy for the region, media campaigns, television, cinema, and several landscape architectural works in the public and private domain are comparatively analysed, focusing on the discourse, conventions and values informing their production, and the landscape narratives they convey. (shrink)

Excerpt from Epictetus and the New Testament I gladly accept the opportunity of offering a foreword to my old pupil's study of contracts between Epictetus and the New Testament. It was on my suggestion that he took up this subject for linguistic research; but the arrival of the proofs of a book was a surprise to me. A very rapid glance over the pages has made the surprise a welcome one. In grammatical as well as lexical questions, as this book (...) well shows, Epictetus has much to teach us. I might remark in this connexion that Mr. Sharp (p. 61) remembers my obiter dicta better than I do. I do not now feel so sure about the use ws suggested there, but I must look into it further. A wider circle than those who study New Testament Greek will find much interest in the few pages which present parallels in Epictetus' thought. They should send some English readers to the accessible discourses of a very noble 'heathen, ' whose 'feeling after God' was assuredly not without reward. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

An award-winning author explores how the world works in our age of "continuous now" Back in the 1970s, futurism was all the rage. But looking forward is becoming a thing of the past. According to Douglas Rushkoff, "presentism" is the new ethos of a society that's always on, in real time, updating live. Guided by neither history nor long term goals, we navigate a sea of media that blend the past and future into a mash-up of instantaneous experience. Rushkoff (...) shows how this trend is both disorienting and exhilarating. Without linear narrative we get both the humiliations of reality TV and the associative brilliance of The Simpsons. With no time for long term investing, we invent dangerously compressed derivatives yet also revive sustainable local businesses. In politics, presentism drives both the Tea Party and the Occupy movement. In many ways, this was the goal of digital technology--outsourcing our memory was supposed to free us up to focus on the present. But we are in danger of squandering this cognitive surplus on trivia. Rushkoff shows how we can instead ground ourselves in the reality of the present tense. (shrink)

Introduction: The spectrum and the poles -- Seeking truth or pursuing happiness -- Just deserts or divine forgiveness -- Our conduct as forced or free -- Religious faith and rational doubt -- Individual rights and the common good -- Human I.Q. and animal feeling -- Asceticism and sensuality -- The populist and elitist perspectives -- Self-interest and self-sacrifice -- Truth as invented or discovered -- Men and women : categories or constructs -- Trusting our senses or being rational -- Northern (...) efficiency and Southern charm. (shrink)