Background: Funding organisations and research ethics committees should play a part in strengthening attention to gender equality in clinical research. In the research policy of European Union , funding measures have been taken to realise this, but such measures are lacking in the EU policy regarding RECs.Objective: To explore how RECs in Austria, Germany, Ireland, The Netherlands and Sweden deal with gender equality issues by asking two questions: Do existing procedures promote representation of women and gender expertise in the committee? (...) How are sex and gender issues dealt with in protocol evaluation?Methods: Two RECs were selected from each country. Data were obtained through interviews with key informants and content analysis of relevant documents .Results: All countries have rules to ensure the presence of women on RECs; gender expertise is not required. Drug study protocols are carefully evaluated, sometimes on a formal basis, as regards the inclusion of women of childbearing age. The reason for excluding either one of the sexes or including specific groups of women or making a gender-specific risk–benefit analysis are investigated by some RECs. Such measures are, however, neither defined in the regulations nor integrated in review tools.Conclusions: The RECs investigated in five European member states are found to pay limited attention to gender equality in their working methods and, in particular in protocol evaluation. Policy and regulations of EU are needed to strengthen attention to gender equality in the work of RECs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Discussions :REFLECTIONS ON THE HISTORY OF SCIENCE Every discipline worthy of a name deserves to be criticized periodically, asked to explain its objects and assess its march. The history of science is no exception. Indeed, criticism at this juncture should be all the more welcomed since the subjcct has now won its place in the curriculum of Anglo-Saxon educational institutions, particularly in the United States where Ph.D. (...) program offerings are multiplying almost faster than students. 1 The pioneering days of the 1930's and 1940's are past--if not totally forgotten--and men of the "second generation" like myself who received their training in the 1950's will gain much from having their methodological presuppositions questioned. Curiously enough, there has been little discussion of this kind in print for the last decade, with the exception of articles published in Poland and Russia, where the discipline is passing through its own pioneering crisis.2 In the West, the older debates stirred up largely by British Marxists are nowadays generally disregarded and have had surprisingly little productive effect upon the field. Within the last few years, the most effective methodological discussions have stemmed from Karl Popper and his generally brilliant lot of disciples. Dr. Joseph Ag~ssi, now Associate Professor of Philosophy at the University of Illinois and a member of this group, recently wrote a deliberately provocative essay entitled "Towards an historiography of science." a Agassi begins it with the arresting statement that the study of the history of science is "in a lamentable state" and ends with the implicit suggestion that an examination of the historiography of science is one of the most revealing ways to discover the discipline's failings. For Agassi, it is clear that the root of the historian's problems has been a false set of philosophical premises about the nature of science, and of its history as well. He finds that the discipline has suffered from two diseases named "inductive philosophy " and "conventionalist philosophy," for which there is a major new panacea, Popper's "critical philosophy of science." This refreshingly straightforward argument provides the essay with a ready-made structure, at the same time as it infuses it throughout with a polemical tone. Because of this tone and because of the importance of Agassi's message, he deserves to be answered. On one subject, I cannot agree more with Agassi--the need for a critical examination of the hisComell, Harvard, and the University of Wisconsin have a long-standing tradition of graduate study in the history of science. In the last few years, they have been joined by: the Case IImtitute of Technology; Indiana; Johns Hopkins; M.I.T.; Princeton ; the Universities of California (Berkeley and U.C.L.A.), Kansas, Oklahoma, Pennsylvania, and Washington; and Yale. Profeasor Duane Roller of Oklahoma has prepared a report on the present state of teaching of the history of science in the United States. 2Abstracts of the discussions can be found in the Bulletin signalgtique : Philosophie. Sciences humaines of the French Centre National de la Recherche Scientifique. See especially Kwartalnik Historii Nauki i Techniki u (1962), special issue; and Organon (1964), no. 1. 8History and Theory. Studies in the philosophy o] history, Beiheft 2 (The Hague: Mouton & Co., 1963),117pp. [235] 236 HISTORY OF PHILOSOPHY toriography of science. On the other hand, his interpretation of the way history of science has and is being written seems more like a misinformed caricature than a sincere effort to understand the past in all its complexity. But let us first examine his discussion of "inductivism," "conventionalism," and "Popperianism." Inductivists or Baconians---he uses the terms interchangeably--write history the way they insist science itself has developed. Just as they assume scientific theories to have emerged from the collection of evidence, they expect that the piling up of historical facts strung along a time-axis adds up to history. As Agassi sagely observes, historians of science, like other induetivists, delude themselves into the belief that such an approach guards them from subjectivity and prejudice. To be sure, philosophers since Kant have known that such naive empiricism is in fact fundamentally misleading, for even the most ardent Baconian has... (shrink)

Auch die subtilsten geistigen Kompetenzen haben eine organische Basis. Mag es auch zunächst überraschen, so besteht daher doch eine entscheidende Verbindung zwischen Gedächtnis und Körper. Es geht also darum, Gedächtnis und Erinnerung nicht als bloßes Wissen misszuverstehen. Vor allem als soziale Tatsache bedarf Erinnerung stets wiederholter Beschwörungen, um nicht zu verschwinden. Spricht man vom individuellen Gedächtnis und der persönlichen Erinnerung, denkt man im Allgemeinen an bewusste Prozesse, dabei ist es häufig viel eher so, dass bestimmte Lernerfahrungen gar nicht mehr bewusst, (...) sondern gleichsam zum weitestgehend unbewussten Moment geistiger und vor allem auch körperlicher Prägungen geworden sind. Diese Verbindung zwischen Körper und Gedächtnis faltet der vorliegende Band systematisch aus. (shrink)

In this analysis of one of the most difficult and neglected topics in Hegelian studies, Songsuk Susan Hahn tackles the status of contradiction in Hegel's ...

The Chairman of Volkswagen's Board of Management made the following presentation in London last November at a Conference on‘Business and Moral Standards in Post‐Communist Europe’, held under the auspices of the Cardinal Archbishop of Westminster and sponsored by the Sedgwick Group and KPMG Peat Marwick. Dr Hahn's lecture is reproduced with permission.

Conditionals pervade every aspect of our thinking, from the mundane and everyday such as ‘if you eat too much cheese, you will have nightmares’ to the most fundamental concerns as in ‘if global warming isn’t halted, sea levels will rise dramatically’. Many decades of research have focussed on the semantics of conditionals and how people reason from conditionals in everyday life. Here it has been rather overlooked how we come to such conditionals in the first place. In many cases, they (...) are learned through testimony: someone warns us about the ill-effects of cheese. Any full account of the conditional must consequently incorporate such learning. Here, we provide a new formal account of belief change in response to a testimonial conditional. (shrink)

A common view in both philosophy and the vision sciences is that, in human vision, wavelength information is primarily ‘for’ colouring: for seeing surfaces and various media as having colours. In this article we examine this assumption of ‘colour-for-colouring’. To motivate the need for an alternative theory, we begin with three major puzzles from neurophysiology, puzzles that are not explained by the standard theory. We then ask about the role of wavelength information in vision writ large. How might wavelength information (...) be used by any monochromat or dichromat and, finally, by a trichromatic primate with object vision? We suggest that there is no single ‘advantage’ to trichromaticity but a multiplicity, only one of which is the ability to see surfaces and so on as having categorical colours. Instead, the human trichromatic retina exemplifies a scheme for a general encoding of wavelength information given the constraints imposed by high spatial resolution object vision. Chromatic vision, like its partner, luminance vision, is primarily for seeing. Viewed this way, the ‘puzzles’ presented at the outset make perfect sense. 1 Reframing the Problem1.1 Introduction1.2 Three puzzles1.2.1 Why is trichromatic vision an anomaly in diurnal mammals?1.2.2 Why does the colour system occupy such a large and central part in human vision?1.2.3 Why are the blue cones so rare?1.3 Recasting the question2 The Costs and Benefits of Spectral Vision2.1 Spectral information and object vision2.2 Encoding the spectral dimension of light2.2.1 ‘General’ versus ‘specific’ encoding2.2.2 Spectral encoding and the monochromat2.2.3 Spectral encoding and the dichromat2.2.4 Spectral encoding and the human trichromat2.3 Three puzzles revisited2.3.1 Why is trichromatic vision an anomaly in diurnal mammals?2.3.2 Why does the colour system occupy such a large and central part in human vision?2.3.3 Why are the blue cones so rare3 Conclusion. (shrink)

Shape and locomotion of tissue cells depend on the interaction of elements of the cytoskeleton, adhesion to the substrate and an intracellular hydrostatic pressure. The existence of this pressure becomes obvious from increase in cell volume on cessation of contractile forces and from observations with ultrasound acoustic microscopy. Wherever such an internal pressure is established, it is involved in generation of shape and driving force of cell locomotion. Therefore each hypothesis on cell shape and locomotion must consider this property of (...) a living cell. Apparently different types of locomotion depend on differences in substrate adhesion and/or cytoskeleton organisation. (shrink)

The debate over environmental, health, and safety regulation has reached a new crescendo in the 104th Congress. So impassioned is the debate on occasion, and so high the feelings, that even the tools of regulatory analysis have become part of the combat.To some, the term cost-benefit analysis, for example, is virtually a swearword, a nefarious tool used by big business to undermine regulations aimed at benefiting the people at large. To others, it is the mechanism for achieving more effective regulation (...) at less cost.This new book on the subject of reforming regulation is aimed at increasing the light and turning down the heat. It consists of an introduction and nine chapters written by scientists, public policy analysts, and economists on various aspects of regulation and regulatory analysis.The book advances the latest knowledge and evidence on risk analysis, cost-benefit analysis, and related techniques for improving regulation--all based on experience and data accumulated over the quarter century since regulation in the areas of environment, health, and safety became a major player on the governmental stage. The strengths and limitations of those analytical tools are an important part of the portrait that is painted, but a common thesis is that, properly used, the tools can be helpful in getting better regulatory results. (shrink)

It is virtuous for individual and collective agents to be tolerant. However, toleration is difficult, both in practice and in conceptualization. Firstly, given that toleration can be understood in various ways (Walzer 1997, Forst 2007), it seems that to determine what is the proper conception of toleration would be controversially difficult. Here I shall suggest one particular conception of toleration is more suitable than others. This conception allows, as I shall explain, us to better understandthe difficulties of toleration. Thus, this (...) particular conception of toleration should lead us to see what is more adequate for dealing with the difficulties of toleration. To be more precise, I shall argue for a political conception of toleration, which different from the attitudinal conception of toleration as being indifferent, or the ethical conception of toleration as respect. There is the suggestion of toleration as recognition (Galeotti 2002). These alternative understandings of toleration do not provide better diagnoses of the difficulties of toleration. The political conception of toleration is intended to be grounded on some moral considerations, notpragmatic purpose. It is political in that it recognizes the fact that toleration is essentially practiced to deal with a power relationship among the parties of toleration. Where these is no such power relationship, as I shall argue, there is no issue of toleration. Secondly, this proposed conception of toleration is political in the sense that it shall not deal with differences coming from, to use John Rawls’s phrase, the fact of pluralism by adopting any comprehensive doctrine such as an ethics of respect or recognition. (shrink)

Norms—that is, specifications of what we ought to do—play a critical role in the study of informal argumentation, as they do in studies of judgment, decision-making and reasoning more generally. Specifically, they guide a recurring theme: are people rational? Though rules and standards have been central to the study of reasoning, and behavior more generally, there has been little discussion within psychology about why (or indeed if) they should be considered normative despite the considerable philosophical literature that bears on this (...) topic. In the current paper, we ask what makes something a norm, with consideration both of norms in general and a specific example: norms for informal argumentation. We conclude that it is both possible and desirable to invoke norms for rational argument, and that a Bayesian approach provides solid normative principles with which to do so. (shrink)

In der Einleitung in den Schwerpunkt „Ethik der Globalisierung und kollektive Verantwortung“ machen wir uns für ein Verständnis von globaler Ethik als einer neuen Disziplin innerhalb der angewandten Ethik stark. Darin geht es wesentlich um Probleme, die sich aus der globalen Kooperation und Konkurrenz in wirtschaftlicher, politischer, sozialer und kultureller Hinsicht ergeben. Nach dieser Auffassung hat es globale Ethik grundsätzlich mit der Bestimmung globaler kollektiver Verantwortlichkeiten zu tun, da sich das Handeln individueller und kollektiver Akteure heute vor dem Hintergrund einer (...) globalisierten Struktur von Handlungspfaden, Anreizen und Regeln vollzieht. In allen Bereichsethiken der globalen Ethik ist daher die Frage, wie sich kollektive Verantwortung unstrukturierten Gruppen zuschreiben lässt, zentral geworden. Worin besteht die kollektive Verantwortung von Unternehmen und Konsument*innen für globale Ausbeutung, Weltarmut oder die Folgen der Klimawandels? Die Antworten der fünf in dieser Einleitung vorgestellten Beiträge greifen dazu in erhellender Weise auf die handlungstheoretischen Debatten zu kollektiver Verantwortung zurück. Es zeigt sich, dass das Verantwortungsprinzip durch seinen prospektiven, Kollektive in den Blick nehmenden, die moralische, politische und juridische Dimension verbindenden sowie auf Strukturen scharf stellenden Charakter besonders geeignet ist, diese Probleme zu behandeln. (shrink)

Much of what we believe we know, we know through the testimony of others. While there has been long-standing evidence that people are sensitive to the characteristics of the sources of testimony, for example in the context of persuasion, researchers have only recently begun to explore the wider implications of source reliability considerations for the nature of our beliefs. Likewise, much remains to be established concerning what factors influence source reliability. In this paper, we examine, both theoretically and empirically, the (...) implications of using message content as a cue to source reliability. We present a set of experiments examining the relationship between source information and message content in people's responses to simple communications. The results show that people spontaneously revise their beliefs in the reliability of the source on the basis of the expectedness of a source's claim and, conversely, adjust message impact by perceived reliability; hence source reliability and message content have a bi-directional relationship. The implications are discussed for a variety of psychological, philosophical and political issues such as belief polarization and dual-route models of persuasion. (shrink)

Autour du Manifeste de Vienne se trouvent reunis des textes fondateurs ecrits autour de 1929. Leurs auteurs: Carnap, Hahn, Neurath, Schlick l'ame du Cercle de Vienne, et Waismann plus proche de Wittgenstein, temoignent d'un courant philosophique constituant aujourd'hui la tradition analytique de source continentale a la fois empiriste et logique. Forme de maniere informelle a Vienne, au coeur de l'Europe, le Cercle reunissait des savants de differentes branches qui voulaient se donner une philosophie susceptible d' unifier leurs vues. Echo (...) aux reves d'unite de la science, cette philosophie en exprime aussi le renversement complet. Veritable Discours de la methode, mais d'esprit anti-cartesien, elle entend reconstruire la science de maniere a evincer la speculation metaphysique, le but etant qu'aucun enonce ne soit laisse a l'exterieur de cette grande architecture de symboles s'il etait pourvu de sens. La declaration de guerre contre la metaphysique est un geste de militance a une epoque riche en differents manifestes. Incomprehensible en dehors du contexte socio-politique viennois de ces annees, elle porte aussi un programme de reconstruction rationnelle qui, au dela du langage de la science, devait toucher tous les secteurs de la vie. Plus complexe qu'il n'y parait, ce programme contient, en reference a Wittgenstein, son prestigieux representant a cote d'Einstein et Russell, une mise en garde contre differentes formes d'irrationalismes, qui est d'actualite. (shrink)

There has been much interest in group judgment and the so-called 'wisdom of crowds'. In many real world contexts, members of groups not only share a dependence on external sources of information, but they also communicate with one another, thus introducing correlations among their responses that can diminish collective accuracy. This has long been known, but it has-to date-not been examined to what extent different kinds of communication networks may give rise to systematically different effects on accuracy. We argue that (...) equations that relate group accuracy, individual accuracy, and group diversity are useful theoretical tools for understanding group performance in the context of research on group structure. In particular, these equations may serve to identify the kind of group structures that improve individual accuracy without thereby excessively diminishing diversity so that the net positive effect is an improvement even on the level of collective accuracy. Two experiments are reported where two structures are investigated from this perspective. It is demonstrated that the more constrained network outperforms the network with a free flow of information. (shrink)

Globalization arguably generated a governance gap that is being filled by transnational rule-making involving private actors among others. The democratic legitimacy of such new forms of governance beyond nation states is sometimes questioned. Apart from nation-centered democracies, such governance cannot build, for example, on representation and voting procedures to convey legitimacy to the generated rules. Instead, alternative elements of democracy such as deliberation and inclusion require discussion to assess new instruments of governance. The recently published standard ISO 26000 is an (...) interesting example of transnational governance. ISO 26000 was developed in a lengthy multiorganizational process for the purpose of giving guidance on the social responsibility of organizations. By assessing the specific case of ISO 26000, this study sheds light on the question of how legitimacy beyond nation-state democracy is ensured or constricted. Centering on the idea of deliberate democracy and democratic legitimacy, the study offers in-depth insights on the normative legitimacy of the development process of ISO 26000. Positioned on the interface of business studies and public policy, this article contributes to the academic literature on transnational governance and on the role of multistakeholder processes in shaping the role of business in society. (shrink)

Many groups of closely related species have reticulate phylogenies. Recent genomic analyses are showing this in many insects and vertebrates, as well as in microbes and plants. In microbes, lateral gene transfer is the dominant process that spoils strictly tree‐like phylogenies, but in multicellular eukaryotes hybridization and introgression among related species is probably more important. Because many species, including the ancestors of ancient major lineages, seem to evolve rapidly in adaptive radiations, some sexual compatibility may exist among them. Introgression and (...) reticulation can thereby affect all parts of the tree of life, not just the recent species at the tips. Our understanding of adaptive evolution, speciation, phylogenetics, and comparative biology must adapt to these mostly recent findings. Introgression has important practical implications as well, not least for the management of genetically modified organisms in pest and disease control. (shrink)

Information generally comes from less than fully reliable sources. Rationality, it seems, requires that one take source reliability into account when reasoning on the basis of such information. Recently, Bovens and Hartmann (2003) proposed an account of the conjunction fallacy based on this idea. They show that, when statements in conjunction fallacy scenarios are perceived as coming from such sources, probability theory prescribes that the “fallacy” be committed in certain situations. Here, the empirical validity of their model was assessed. The (...) model predicts that statements added to standard conjunction problems will change the incidence of the fallacy. It also predicts that statements from reliable sources should yield an increase in fallacy rates (relative to unreliable sources). Neither the former (Experiment 1) nor the latter prediction (Experiment 3) was confirmed, although Experiment 2 showed that people can derive source reliability estimates from the likelihood of statements in a manner consistent with the tested model. In line with the experimental results, model fits and sensitivity analyses also provided very little evidence in favor of the model. This suggests that Bovens and Hartmann’s present model fails to explain fully people’s judgements in standard conjunction fallacy tasks. (shrink)