ObjectiveProcessing Speed, the ability to perceive and react fast to stimuli in the environment, has been shown to be impaired in children with attention deficit hyperactivity disorder. However, it is unclear whether PS can be improved following targeted treatments for ADHD. Here we examined potential changes in PS following application of transcranial electric stimulation combined with cognitive training in children with ADHD. Specifically, we examined changes in PS in the presence of different conditions of mental fatigue.MethodsWe used a randomized double-blind (...) active-controlled crossover study of 19 unmedicated children with ADHD. Participants received either anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex or transcranial random noise stimulation, while completing CT, and the administration order was counterbalanced. PS was assessed before and after treatment using the MOXO-CPT, which measures PS in the presence of various conditions of mental fatigue and cognitive load.ResultstRNS combined with CT yielded larger improvements in PS compared to tDCS combined with CT, mainly under condition of increased mental fatigue. Further improvements in PS were also seen in a 1-week follow up testing.ConclusionThis study provides initial support for the efficacy of tRNS combined with CT in improving PS in the presence of mental fatigue in pediatric ADHD. (shrink)

Children diagnosed with type 1 diabetes mellitus (T1DM) are at risk for neurocognitive sequelae, including impaired attention functioning. The specific nature of the cognitive deficit varies; current literature underscores early age of diabetes diagnosis and increased disease duration as primary risk factors for this neurocognitive decline. Forty-three children with T1DM were evaluated for Attention Deficit/Hyperactivity Disorder (ADHD) symptomatology using the MOXO continuous performance test (MOXO-CPT) performed during a routine outpatient evaluation. The study cohort demonstrated a significant decline in all four (...) domains of attention functioning. The effect was most pronounced with early age at T1DM diagnosis, a longer disease duration and with poorer glycemic control (represented by higher HbA1c values). With increased disease duration (of 5 plus years), acute hyperglycemia was associated with inattention in the real-time setting. These findings highlight the need for routine screening of neurocognitive function in children with T1DM so that early intervention can be employed during this crucial period of cognitive development. (shrink)

Intuition is frequently used in medicine. Along with the use of existing medical rules, there is a separate channel that physicians rely on when making decisions: their intuition. To cope with the epistemic problem of using intuition, I use some clues from Wittgenstein's philosophy to illuminate the decision-making process in medicine. First, I point to a connection between intuition as functioning in medicine and Wittgenstein's notions of "seeing as" or noticing "aspects". Secondly, I use Wittgenstein notion of empirical regularities hardened (...) into rules to suggest that there are two stages that should be addressed in the analysis of medical practice: the first concerns the accumulation of cases and the second pertains to the setting a rule based on these cases. I argue further that the medical context is exceptional in that the two stages are intertwined and, and explain the consequences of this fact for the physician's work. Finally, inspired by Wittgenstein's rule-following conundrum, I argue that medicine is particularly prone to difficulties in applying a general rule to a specific case represented by an individual patient. Recourse to intuition is reflects the physicians' efforts to bridge this gap. (shrink)

Asymmetrical convergence is the increasing overlap between academic and industrial sectors, but with academia moving closer toward for-profit industrial norms than vice versa. Although this concept, developed by Kleinman and Vallas, is useful, processes of asymmetrical convergence in daily laboratory life are largely unexplored. Here, observations of three lab groups of chemical scientists in academic and industry contexts illustrate variation in interactions with ethics-related policies. Findings show more tension for academic science with business-based practices, such as the move toward greater (...) accountability, than for industrial science with academic practices. This asymmetry is evident in the process of purposive decoupling: for example, where academic scientists use humor to distance themselves from the performance of compliance in required reporting and top-down ethics training requirements. This distancing from meaningless requirements contrasts with mentoring around practices of professional behavior that are thought to matter. Convergence is evident in how safety policies seem more engaging than other kinds of policies. Yet, power structures shape engagement. Academic engagement often means rule following, and flows vertically from professor’s authority to student apprenticeship. Industry engagement includes collaborative problem solving and flows along a more horizontal peer structure where informal power is less visible. (shrink)

Grammatical theories of Scalar Implicatures make use of an exhaustivity operator exh, which asserts the conjunction of the prejacent with the negation of excludable alternatives. We present a new Grammatical theory of Scalar Implicatures according to which exh is replaced with pex, an operator that contributes its prejacent as asserted content, but the negation of scalar alternatives at a non-at-issue level of meaning. We show that by treating this non-at-issue level as a presupposition, this theory resolves a number of empirical (...) challenges faced by the old formulation of exh (as well as by standard neo-Gricean theories). The empirical challenges include projection of scalar implicatures from certain embedded environments (‘some under some’ sentences, some under negative factives), their restricted distribution under negation, and the existence of common ground-mismatching and oddness-inducing implicatures. We argue that these puzzles have a uniform solution given a pex-based Grammatical theory of implicatures and some independently motivated principles concerning presupposition projection, cancellation and accommodation. (shrink)

:One view of practical reasoning is that it involves the weighing of reasons. It is not clear, however, how the weights of reasons combine, especially given the logical and substantive relations among different reasons. Nor is it clear how the weighing of reasons relates to decision theoretic maximization of expected value. This paper constructs a formal model of reasons and their weight in order to shed light on these issues. The model informs philosophical debates about reasons, such as the question (...) of whether reasons or values are more fundamental and the opposing doctrines of atomism and holism about reasons. (shrink)

We describe the design and evaluation of a sub-clinical digital assessment tool that integrates digital biomarkers of depression. Based on three standard cognitive tasks on which people with depression have been known to perform differently than a control group, we iteratively designed a digital assessment tool that could be deployed outside of laboratory contexts, in uncontrolled home environments on computer systems with widely varying system characteristics. We conducted two online studies, in which participants used the assessment tool in their own (...) homes, and completed subjective questionnaires including the Patient Health Questionnaire —a standard self-report tool for assessing depression in clinical contexts. In a first study, we demonstrate that each task can be used in isolation to significantly predict PHQ-9 scores. In a second study, we replicate these results and further demonstrate that when used in combination, behavioral metrics from the three tasks significantly predicted PHQ-9 scores, even when taking into account demographic factors known to influence depression such as age and gender. A multiple regression model explained 34.4% of variance in PHQ-9 scores with behavioral metrics from each task providing unique and significant contributions to the prediction. (shrink)

Objective: The purpose of this study was to demonstrate how educators involved in the teaching of bioethics to healthcare university students in Japan would cope with ethical disagreement in the classroom, and to identify factors influencing them.Methods: A cross sectional survey was conducted using self administered questionnaires mailed to a sample of university faculty in charge of bioethics curriculum for university healthcare students.Results: A total of 107 usable questionnaires were returned: a response rate of 61.5%. When facing ethical disagreement in (...) the classroom, coping behaviour differed depending on the topic of discussion, was influenced by educators’ individual clear ethical attitudes regarding the topic of discussion, and was independent of many respondents’ individual and social backgrounds. Among educators, it was commonly recognised that the purpose of bioethics education was to raise the level of awareness of ethical problems, to provide information about and knowledge of those issues, to raise students’ sensitivity to ethical problems, and to teach students methods of reasoning and logical argument. Yet, despite this, several respondents considered the purpose of bioethics education to be to influence students about normative ethical judgments. There was no clear relationship, however, between ways of coping with ethical disagreement and educators’ sense of the purpose of bioethics education.Conclusions: This descriptive study suggests that educators involved in bioethics education for healthcare university students in Japan coped in various ways with ethical disagreement. Further research concerning ethical disagreement in educational settings is needed to provide better bioethics education for healthcare students. (shrink)

We develop several aspects of local and global stability in continuous first order logic. In particular, we study type-definable groups and genericity.

We study the following conjecture. Conjecture. Let $T$ be an $\omega$-stable theory with continuum many countable models. Then either i) $T$ has continuum many complete extensions in $L_1$, or ii) some complete extension of $T$ in $L_1$ has continuum many $L_1$-types without parameters. By Shelah's proof of Vaught's conjecture for $\omega$-stable theories, we know that there are seven types of $\omega$-stable theory with continuum many countable models. We show that the conjecture is true for all but one of these seven (...) cases. In the last case we show the existence of continuum many $L_2$-types. (shrink)

We prove that for every simple theory $T$ (or even simple thick compact abstract theory) there is a (unique) compact abstract theory $T^fP$ whose saturated models are the lovely pairs of $T$. Independence-theoretic results that were proved in [Ben Yaacov, Pillay, Vassiliev - Lovely pairs of models] when $T^fP$ is a first order theory are proved for the general case: in particular $T^fP$ is simple and we characterise independence.

We represent continuous functions on compact intervals by sequences of functions defined on finite sets of rational numbers. We call this an exact representation. This enables us to calculate the values of the function arbitrarily exactly, without roundoff errors. As an application we develop a procedure to transfer an exact representation of an increasing function into an exact representation of the corresponding inverse function.

We study the following conjecture. Conjecture. Let T be an ω-stable theory with continuum many countable models. Then either i) T has continuum many complete extensions in L1(T), or ii) some complete extension of T in L1 has continuum many L1-types without parameters. By Shelah's proof of Vaught's conjecture for ω-stable theories, we know that there are seven types of ω-stable theory with continuum many countable models. We show that the conjecture is true for all but one of these seven (...) cases. In the last case we show the existence of continuum many L2-types. (shrink)

We prove that the definition of supersimplicity in metric structures from [Ben Yaacov, Uncountable dense categoricity in cats] is equivalent to an textit{a priori} stronger variant. This stronger variant is then used to prove that if $T$ is a supersimple Hausdorff cat then so is its theory of lovely pairs.

Clinical ethics support, including ethics consultation, has become established in the field of medical practice throughout the world. This practice has been regarded as useful, most notably in the UK and the USA, in solving ethical problems encountered by both medical practitioners and those who receive medical treatment. In Japan, however, few services are available to respond to everyday clinical ethical issues, although a variety of difficult ethical problems arise daily in the medical field: termination of life support, euthanasia and (...) questions about patient autonomy. In light of these conditions, a group of 17 volunteer educators and researchers from the area of biomedical ethics, including the authors, have formed the Clinical Ethics Support and Education Project, and began providing Japan’s first small team clinical ethics consultation service in October, 2006. Members include scholars of biomedical ethics, scholars of philosophy and ethics, legal professionals and legal scholars, nurses and doctors, consisting of five women and 12 men. Consultation teams, made up of a small number of members, were organised each time a request for consultation was received. Over approximately 15 months (October 2006–December 2007), the programme received 22 consultation requests from medical practitioners and medical institutions, and three from the families of patients. In this paper, we will discuss the status of our consultation service and examples of consultation cases we have handled. In addition, we will examine the process of evaluating small team clinical ethics consultation services, as well as the strengths and weakness of such programmes. (shrink)

The Pareto principle is a normative principle about preferences that advocates concordance with unanimous preference. However, people have perspectives not just preferences. Evaluating preferences...

We give a general framework for the treatment of perturbations of types and structures in continuous logic, allowing to specify which parts of the logic may be perturbed. We prove that separable, elementarily equivalent structures which are approximately $aleph_0$-saturated up to arbitrarily small perturbations are isomorphic up to arbitrarily small perturbations. As a corollary, we obtain a Ryll-Nardzewski style characterisation of complete theories all of whose separable models are isomorphic up to arbitrarily small perturbations.

Continuous first-order logic has found interest among model theorists who wish to extend the classical analysis of “algebraic” structures to various natural classes of complete metric structures. With research in continuous first-order logic preoccupied with studying the model theory of this framework, we find a natural question calls for attention. Is there an interesting set of axioms yielding a completeness result?The primary purpose of this article is to show that a certain, interesting set of axioms does indeed yield a completeness (...) result for continuous first-order logic. In particular, we show that in continuous first-order logic a set of formulae is satisfiable if it is consistent. From this result it follows that continuous first-order logic also satisfies an approximated form of strong completeness, whereby Σ⊨φ only if Σ⊢φ∸ 2-n for all n < ω. This approximated form of strong completeness asserts that if Σ⊨φ, then proofs from Σ, being finite, can provide arbitrarily better approximations of the truth of φ.Additionally, we consider a different kind of question traditionally arising in model theory—that of decidability. When is the set of all consequences of a theory recursive? Say that a complete theory T is decidable if for every sentence φ, the value φT is a recursive real, and moreover, uniformly computable from φ. If T is incomplete, we say it is decidable if for every sentence φ the real number φT∘ is uniformly recursive from φ, where φT∘is the maximal value of φ consistent with T. As in classical first-order logic, it follows from the completeness theorem of continuous first-order logic that if a complete theory admits a recursive axiomatization then it is decidable. (shrink)

BACKGROUND: Little is known about how hospitalized patients share decisions with physicians. METHODS: We conducted an observational study of patient-doctor communication on an inpatient medicine service among 18 hospitalized patients and 9 physicians. A research assistant (RA) approached newly hospitalized patients and their physicians before morning rounds and obtained consent. The RA audio recorded morning rounds, and then separately interviewed both patient and physician. Coding was done using integrated analysis. RESULTS: Most patients were white (61%) and half were female. Most (...) physicians were male (66%) and of Southeast Asian descent (66%). All physicians explained the plan of care to the patients; most believed that their patient understood. However, many patients did not. Physicians rarely asked the patient for their opinion. In all those cases, the decision had been made previously by the doctors. No decisions were made with the patient. Patients sometimes disagreed. CONCLUSIONS: Shared decision-making may not be the norm in hospital care. Although physicians do explain treatment plans, many hospitalized patients do not understand enough to share in decisions. When patients do assert their opinion, it can result in conflict. PRACTICE IMPLICATIONS: Some hospitalized patients are interested in discussing treatment. Improving hospital communication can foster patient autonomy. (shrink)

Sentences such as Olivia can take Logic or Algebra (‘♢∨-sentences’) are typically interpreted as entailing that Olivia can take Logic and can take Algebra. Given a standard semantics for modals and disjunction, those ‘Free choice’ (FC) readings are not predicted from the surface form of ♢∨-sentences. Yet the standard semantics is appropriate for the ‘double prohibition’ reading typically assigned to ¬♢∨-sentences like Olivia can’t take Logic or Algebra. Several extant approaches to FC can account for those two cases, but face (...) challenges when ♢∨, ¬♢∨ and related sentences appear embedded in certain environments. In this paper, we present a novel account of FC that builds on a ‘grammatical’ theory of scalar implicatures — proposed by Bassi et al. (2021) and Del Pinal (2021) — according to which covert exhaustification is a presupposition trigger such that the prejacent forms the assertive content while any excludable or includable alternatives are incorporated at the non-at issue, presuppositional level. Applied to ♢∨, ¬♢∨, and similar sentences, ‘presuppositional exhaustification’ predicts that their default interpretations have an assertive component (roughly, the classical interpretation of the prejacent) and a homogeneity presupposition which projects in standard ways. Those predictions, we then show, support a uniform account of the puzzling behavior of ♢∨, ¬♢∨, and related sentences when embedded under (negative) factives (Marty & Romoli 2020), disjunctions (Romoli & Santorio 2019), and in the scope of universal, existential (Bar-Lev & Fox 2020) and non-monotonic quantifiers (Gotzner et al. 2020). (shrink)

Artificial intelligence (AI) technologies in medicine are gradually changing biomedical research and patient care. High expectations and promises from novel AI applications aiming to positively impact society raise new ethical considerations for patients and caregivers who use these technologies. Based on a qualitative content analysis of semi-structured interviews and focus groups with healthcare professionals (HCPs), patients, and family members of patients with Parkinson’s Disease (PD), the present study investigates participant views on the comparative benefits and problems of using human versus (...) AI predictive computer vision health monitoring, as well as participants’ ethical concerns regarding these technologies. Participants presumed that AI monitoring would enhance information sharing and treatment, but voiced concerns about data ownership, data protection, commercialization of patient data, and privacy at home. They highlighted that privacy issues at home and data security issues are often linked and should be investigated together. Findings may help technologists, HCPs, and policymakers determine how to incorporate stakeholders’ intersecting but divergent concerns into developing and implementing AI PD monitoring tools. (shrink)

We present an adaptation of continuous first order logic to unbounded metric structures. This has the advantage of being closer in spirit to C. Ward Henson's logic for Banach space structures than the unit ball approach, as well as of applying in situations where the unit ball approach does not apply. We also introduce the process of single point emph{emboundment}, allowing to bring unbounded structures back into the setting of bounded continuous first order logic. Together with results from cite{BenYaacov:Perturbations} regarding (...) perturbations of bounded metric structures, we prove a Ryll-Nardzewski style characterisation of theories of Banach spaces which are separably categorical up to small perturbation of the norm. This last result is motivated by an unpublished result of Henson. (shrink)

Text-generative AI-systems have become important semantic agents with ChatGPT. We conducted a series of experiments to learn what teachers’ conceptions of text-generative AI are in relation to philosophical texts. In our main experiment, using mixed methods, we had twenty-four high school students write philosophical essays, which we then randomized to essays with the same command from ChatGPT. We had ten prospective teachers assess these essays. They were able to tell whether it was an AI or student essay with 78.7 percent (...) accuracy, which is better than the Open AI Classifier. Interestingly, however, they used criteria like argumentative and logical flawlessness and neutrality. We concluded from this that they are using an inverted Turing test and are no longer looking for rationality in machines but for irrationality in humans. (shrink)

-/- Continuous first-order logic has found interest among model theorists who wish to extend the classical analysis of “algebraic” structures (such as fields, group, and graphs) to various natural classes of complete metric structures (such as probability algebras, Hilbert spaces, and Banach spaces). With research in continuous first-order logic preoccupied with studying the model theory of this framework, we find a natural question calls for attention. Is there an interesting set of axioms yielding a completeness result? -/- The primary purpose (...) of this article is to show that a certain, interesting set of axioms does indeed yield a completeness result for continuous first-order logic. In particular, we show that in continuous first-order logic a set of formulae is (completely) satisfiable if (and only if) it is consistent. From this result it follows that continuous first-order logic also satisfies an approximated form of strong completeness, whereby Σ⊧φ (if and) only if Σ⊢φ ∸2−n for all n < ω. This approximated form of strong completeness asserts that if Σ⊧φ, then proofs from Σ, being finite, can provide arbitrarily better approximations of the truth of φ. -/- Additionally, we consider a different kind of question traditionally arising in model theory—that of decidability. When is the set of all consequences of a theory (in a countable, recursive language) recursive? Say that a complete theory T is decidable if for every sentence φ, the value φ T is a recursive real, and moreover, uniformly computable from φ. If T is incomplete, we say it is decidable if for every sentence φ the real number φ T o is uniformly recursive from φ, where φ T o is the maximal value of φ consistent with T. As in classical first-order logic, it follows from the completeness theorem of continuous first-order logic that if a complete theory admits a recursive (or even recursively enumerable) axiomatization then it is decidable. (shrink)

We point out how the "Fundamental Theorem of Stability Theory", namely the equivalence between the "non order property" and definability of types, proved by Shelah in the 1970s, is in fact an immediate consequence of Grothendieck's "Criteres de compacite" from 1952. The familiar forms for the defining formulae then follow using Mazur's Lemma regarding weak convergence in Banach spaces.

The argument from inductive risk claims that judgments about the moral severity of errors are relevant to decisions about what should count as sufficient evidence for accepting claims. While this idea has been explored in connection with evidence required for the approval of pharmaceuticals, the role of inductive risk in the post-approval process has been largely neglected. In this article, we examine the ethics of inductive risk in connection with revisions to the product monograph for OxyContin in Canada, which understates (...) the risks of addiction and abuse associated with this drug. Using the concept of inductive risk, we consider what evidence should have been sufficient for Health Canada to revise the product monograph for OxyContin. Given the stakes involved, we argue that a less strict standard of evidence would have been appropriate, yet HC in fact took the opposite course, insisting upon a higher standard of evidence than it normally requires. In addition to providing a novel perspective on the opioid crisis in Canada, this article contributes to existing philosophical work by demonstrating that inductive risks in the post-approval stage are important and linked to pre-approval inductive risks. (shrink)

A variety of crucial and still most relevant ideas about nothingness or emptiness have gained profound philosophical prominence in the history and development of a number of South and East Asian traditions--including in Buddhism, Daoism, Neo-Confucianism, Hinduism, Korean philosophy, and the Japanese Kyoto School. These traditions share the insight that in order to explain both the great mysteries and mundane facts about our experience, ideas of "nothingness" must play a primary role. This collection of essays brings together the work of (...) twenty of the world's prominent scholars of Hindu, Buddhist, Daoist, Neo-Confucian, Japanese and Korean thought to illuminate fascinating philosophical conceptualizations of "nothingness" in both classical and modern Asian traditions. The unique collection offers new work from accomplished scholars and provides a coherent, panoramic view of the most significant ways that "nothingness" plays crucial roles in Asian philosophy. It includes both traditional and contemporary formulations, sometimes putting Asian traditions into dialogue with one another and sometimes with classical and modern Western thought. The result is a book of immense value for students and researchers in Asian and comparative philosophy. (shrink)

Studies of public health decisions that have had harmful effects tend to disagree about what constitutes a public health error. Debates exist about whether public health errors must be culpable or not, as well as about what the criteria for judging public health errors should be.

In the history of philosophy as well as in most recent discussions, empathy is held to be a key concept that enables a basic understanding of the other while at the same time acting as the foundation of our moral emotionality. In this paper I want to show why empathy is the wrong candidate for both of these tasks. If we understand empathy as projection, i.e. a process of imaginary self-transposition, we are bound to presuppose a fully established interpersonal sphere. (...) If we consider empathy as synonymous with compassion it is highly questionable if we ever reach the other person in his or her otherness. Max Scheler and other early phenomenologists offer very fruitful approaches to both problems without resorting to empathy. I will present some of their thoughts and focus especially on Scheler’s claim about the connection between the experience of the real other and the intentionality of compassion. (shrink)

The article deals with the polemical procedures in the constitution of the bourgeois-literary public sphere in the mid-18th century, exemplified by the work of the philosopher, literary critic and Lessing’s successor at the Berliner Literaturbriefe Thomas Abbt. His public-constitutive polemical practice is realized as theological polemics, as polemical classicism, as considerations about publicity and with a constant reflexive shift from strategic or ethical points of view. The theoretical basis of the study is a concept of polemics as a variable, non-dialogical (...) and public mode of speech with epistemic, aesthetic and political productivity and a strong reflexive tendency. (shrink)

Editors’ Note: As a matter of policy, the editors believe that publishing several reviews of selected texts is a valuable exercise which will enable a cross-section of views to be aired.Copies of this report can be obtained from the Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3EG, U.K.. The report publishes the recommendation of a Working Party set up in January 1995. Following a wide public consultation, the Working Party prepared its report on xenotransplantation which has been endorsed (...) by the Nuffield Council on Bioethics. (shrink)