The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

Achieving space situational awareness requires, at a minimum, the identification, characterization, and tracking of space objects. Leveraging the resultant space object data for purposes such as hostile threat assessment, object identification, and conjunction assessment presents major challenges. This is in part because in characterizing space objects we reference a variety of identifiers, components, subsystems, capabilities, vulnerabilities, origins, missions, orbital elements, patterns of life, operational processes, operational statuses, and so forth, which tend to be defined in highly heterogeneous and sometimes inconsistent (...) ways. The Space Domain Ontologies are designed to provide a consensus-based realist framework for formulating such characterizations in a way that is both consistent and computable. Space object data are aligned with classes and relations in a suite of ontologies built around the existing Space Object Ontology. They are stored in a dynamically updated Resource Description Framework triple store, which can be queried to support space situational awareness and the needs of spacecraft operators and analysts. This paper provides an overview of the Space Domain Ontologies and their development and use. It presents the motivation for and advantages of the Space Domain Ontologies, including the benefits they provide for enhancing and maintaining long-term space situational awareness. (shrink)

Several cases which have been considered by the courts in recent years have highlighted the legal dilemmas facing doctors whose decisions result in the ending of a patient's life. This paper considers the case of Dr Cox, who was convicted of attempting to murder one of his patients, and explores the roles of motive, diminished responsibility and consent in cases of "mercy killing". The Cox decision is compared to that of Tony Bland and Janet Johnstone, in which the patients were (...) in a persistent vegetative state. In all three cases, the doctors believed that their patients' quality of life was so poor that their continued existence was of no benefit to them, and decided that their lives should not be unduly prolonged, yet the doctor who was prosecuted was the one whose dying patient had requested that her death be hastened. The paper examines the law's seemingly contradictory approaches to such cases. (shrink)

This paper provides a method for characterizing space events using the framework of conceptual spaces. We focus specifically on estimating and ranking the likelihood of collisions between space objects. The objective is to design an approach for anticipatory decision support for space operators who can take preventive actions on the basis of assessments of relative risk. To make this possible our approach draws on the fusion of both hard and soft data within a single decision support framework. Contextual data is (...) also taken into account, for example data about space weather effects, by drawing on the Space Domain Ontologies, a large system of ontologies designed to support all aspects of space situational awareness. The framework is coupled with a mathematical programming scheme that frames a mathematically optimal approach for decision support, providing a quantitative basis for ranking potential for collision across multiple satellite pairs. The goal is to provide the broadest possible information foundation for critical assessments of collision likelihood. (shrink)

The overall goal of the approach developed in this paper is to estimate the likelihood of a given kinetic kill scenario between hostile spacebased adversaries using the mathematical framework of Complex Conceptual Spaces Single Observation. Conceptual spaces are a cognitive model that provide a method for systematically and automatically mimicking human decision making. For accurate decisions to be made, the fusion of both hard and soft data into a single decision framework is required. This presents several challenges to this data (...) fusion framework. The first is the challenge involved in handling multiple complex terminologies, which is addressed by drawing on a set of Space Domain Ontologies. Another challenge is the complex combinatorics involved when considering all possible feature combinations. This can be mitigated by using integer linear programming optimization that is outlined by the Complex Conceptual Spaces Single Observation mathematical model framework. A third challenge is the complicated physics that is involved in a spacecraft collision that must be addressed to obtain a better understanding of threat assessment. Overcoming these various challenges allows for a quantitative ranking for the potential of a kinetic kill collision across multiple spacecraft pairs. In addition to overcoming these challenges this paper will break down threat assessment into four domains and identify a ranking of threat both for each individual domain and for the four domains combined. Simulation results are shown to verify the developed concepts. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

Computer-based logic proofs are a form of unnatural language in which the process and structure of proof generation can be observed in considerable detail. We have been studying how students respond to multimodal logic teaching, and performance measures have already indicated that students' pre-existing cognitive styles have a significant impact on teaching outcome. Furthermore, a large corpus of proofs has been gathered via automatic logging of proof development. This paper applies a series of techniques, including corpus statistical methods, to the (...) proof logs. The results indicate that students' cognitive styles influence the structure of their logical discourse, via their differing methods of handling abstract information in diagrams, and transferring information between modalities. (shrink)

A woman and a man desire to come together stirred by the primal fire of Kama and the man deposits his egg in the womb of the woman. This egg develops into a human undergoing nine or ten months of evolution. This process is the microscopic replication of the method evolved by God to create the universe. Rigveda (10.121) mentions Hiranyagarbha, the Golden Egg as the source of the creation of the universe. It is said that God, wishing to create (...) the world, produced an egg as big as the cosmos. God meditated for a thousand years sitting inside the egg and when the egg burst, the Lord himself was born out of the egg as the Progenitor of the universe (“He made Himself by Himself.”, Taitiriya Upanishad: 2.7.1). The Rishis called the Egg Brahmanda (the Cosmic Egg), and the Progenitor Manu. Scientists have discovered that the universe has an oval shape. Like the nine months of the evolution of the human egg, the Cosmic Egg also undergoes nine stages of evolution before it gets dissolved during what we call ‘Maha Pralaya’. The Puranas mention that Brahmanda has 14 biospheres, seven nether and seven upper inhabited by different types of souls. If we count from the human world, there are ten dimensions of consciousness. Rishis called these astral biospheres Mandalas/Lokas with different wavelengths and colours. Sri Karunakara Guru referred to them as Avasthas, or spiritual stages. The Buddhists and Hindu esoteric sects such as the Theosophical Society explain these levels of the Absolute in terms of Physical plane, Astral plane, Mental plane, Buddhic plane, Atmic plane, Anupadaka plane, Adi plane and Shiv and Shakti. These Avasthas are related to the expanding consciousness reaching up to the core of the Cosmic Egg, the Paramatma. Like a spider which creates a web around it sitting in the centre, and withdraws it in the end, Paramatma creates and withdraws webbed multi-dimensional universes. Nobody can say when it started and when it will end as it is a beginningless and endless process. (shrink)

India has produced several drafts of data policies. In this work, they are referred to [1] JBNSCR 2018, [2] DPDPR 2018, [3] NSAI 2018, [4] RAITF 2018, [5] PDPB 2019, [6] PRAI 2021, [7] JPCR 2021, [8] IDAUP 2022, [9] IDABNUP 2022. All of them consider Artificial Intelligence (AI) a social problem solver at the societal level, let alone an incentive for economic growth. However, these policy drafts warn of the social disruptions caused by algorithms and encourage the careful use (...) of computational technologies in various social contexts. Hence, the emerging data society and its implications in India's social contexts demand immense social science attention, which needs to be improved in the policy drafts, primarily because they are creations of industry stakeholders, technocrats, bureaucrats, and experts from tech schools. In the larger social milieu of digital infrastructure emerging, the fundamental question is whether India's national philosophy envisioned in the Indian constitution is reflected in the policy papers. The paper enquires whether the national data policy upholds the core values dispersed through the philosophy of the Indian constitution, which, among other things, is not confined only to inclusion, diversity, rights, liberty, justice and equality. By focusing on constitutional values, the paper seeks to offer a broader and more critical understanding of India's approach to AI policy by bringing together analyses of a wide array of policy documents available in the public realm. (shrink)

Aim To explore the views in non-Western cultures about ending the lives of damaged newborns.Method 254 university students from India and 150 from Kuwait rated the acceptability of ending the lives of newborns with genetic defects in 54 vignettes consisting of all combinations of four factors: gestational age ; severity of genetic defect ; the parents’ attitude about prolonging care ; and the procedure used .Results Four clusters were identified by cluster analysis and subjected to analysis of variance. Cluster I, (...) labelled ‘Never Acceptable’, included 4% of the Indians and 59% of the Kuwaitis. Cluster II, ‘No Firm Opinion’, had little variation in rating from one scenario to the next; it included 38% of the Indians and 18% of the Kuwaitis. In Cluster III, ‘Parents’ Attitude+Severity+Procedure’, all three factors affected the ratings; it was composed of 18% of the Indians and 16% of the Kuwaitis. Cluster IV was called ‘Severity+Parents’ Attitude’ because these had the strongest impact; it was composed of 40% of the Indians and 7% of the Kuwaitis.Conclusions In accordance with the teachings of Islam versus Hinduism, Kuwaiti students were more likely to oppose ending a newborn's life under all conditions, Indian students more likely to favour it and to judge its acceptability in light of the different circumstances. (shrink)

I. Einleitung: Prinzipien einer konstruktivistischen Rekonstruktion des Aufbaus von Wissenschaften. Die Stelle der Protophysik der Zeit in einem solchen Aufbau der Physik. Skizze der Ziele und der Struktur von Janichs Protophysik der Zeit und der wichtigsten immanenten Kriterien ihrer Beurteilung. II. Referat und immanente Kritik seiner grundlegenden Definition . III. Ein konstruktivistischer Vorschlag zur Verbesserung von und zu einem akzeptablen Realisationsverfahren für sie. Eigentümlichkeiten dieses Realisationsverfahrens lassen bereits erwarten, daß Janichs 'Eindeutigkeitsbeweis' einen Fehler haben muß. IV. Skizze des Weges von (...) bis zu den Forderungen für Uhren und dem angeblichen Eindeutigkeitsbeweis für diese. Untersuchung und Widerlegung dieses Beweises, mit dessen Haltbarkeit das ganze Unternehmen Janichs steht und fällt. (shrink)

We introduce a linear analogue of Läuchli's semantics for intuitionistic logic. In fact, our result is a strengthening of Läuchli's work to the level of proofs, rather than provability. This is obtained by considering continuous actions of the additive group of integers on a category of topological vector spaces. The semantics, based on functorial polymorphism, consists of dinatural transformations which are equivariant with respect to all such actions. Such dinatural transformations are called uniform. To any sequent in Multiplicative Linear Logic (...) , we associate a vector space of“diadditive” uniform transformations. We then show that this space is generated by denotations of cut-free proofs of the sequent in the theory MLL + MIX. Thus we obtain a full completeness theorem in the sense of Abramsky and Jagadeesan, although our result differs from theirs in the use of dinatural transformations.As corollaries, we show that these dinatural transformations compose, and obtain a conservativity result: diadditive dinatural transformations which are uniform with respect to actions of the additive group of integers are also uniform with respect to the actions of arbitrary cocommutative Hopf algebras. Finally, we discuss several possible extensions of this work to noncommutative logic.It is well known that the intuitionistic version of Läuchli's semantics is a special case of the theory of logical relations, due to Plotkin and Statman. Thus, our work can also be viewed as a first step towards developing a theory of logical relations for linear logic and concurrency. (shrink)

One of the gains to be reckoned from the study of nomenclature in the sepulchral inscriptions of the early empire is the gradual abandonment of attempts to distinguish between slave and freeborn on the basis of personal name or cognomen alone, especially when this is of Latin derivation. Nevertheless, one still finds personal cognomina in undated inscriptions adduced as sole evidence for the origin or status of individuals below senatorial rank. Thus in a standard work on freedmen in the early (...) empire, recently reprinted, names such as Agilis, Amandus, Auctus, Communis, Donatus, Faustus, Felix, etc., are said to be commonly servile, but others such as Aquila, Bassus, Capito, Cams, Celer, Crescens, etc., are taken as ingenuous. The criteria used in making such a distinction are subjective and arbitrary and the statistics based on them are largely valueless. It is the purpose of this note to consider briefly on this question the evidence of the personal nomenclature of the Imperial slaves and freedmen. In this group, the Familia Caesaris, no problem of status arises, and the fact that the majority of their inscriptions can be dated, at least approximately, makes it possible to trace the chronological development of the use of cognomina ingenua by one important group of servile origin from the first to the early third century A.D. Moreover, such a development is useful evidence for change in the social structure of the early empire. (shrink)

Lily Ross Taylor in an interesting recent article on the proportion of freedmen to freeborn in the sepulchral inscriptions of Imperial Rome discusses the increasing omission of status nomenclature by freedmen in the first and second centuries A.D. and the consequent difficulty of determining the status of persons whose names appear in the epitaphs. One contributory factor to this decline in the traditional nomenclature which she mentions is the growing numbers and importance of the freedmen of the emperor, the Augusti (...) liberti. While non-imperial freedmen were anxious to record their acquisition of citizenship, but not their inferior status in the citizen body, the emperor's freedmen, on the other hand, increasingly formalized their status nomenclature so that the formula ‘Aug. lib.’ proclaimed not only the fact of their manumission within the Familia Caesaris but also the higher social status which they enjoyed. An examination of the nomenclature of the Imperial freedmen might help to throw some light on this process, particularly on the problem of dating. (shrink)