Socrates: the philosopher whose questioning gave birth to the foundations of Western thought, and whose execution marked the end of the Athenian Golden Age. Yet despite his pre-eminence among the great thinkers of history, little of his life story is known. What we know tends to begin in his middle age and end with his trial and death. Our conception of Socrates has relied upon Plato and Xenophon--men who met him when he was in his fifties, a well-known figure in (...) war-torn Athens. There is mystery at the heart of Socrates's story: what turned the young Socrates into a philosopher? What drove him to pursue with such persistence, at the cost of social acceptance and ultimately his life, a whole new way of thinking about the meaning of existence? In this revisionist biography, classicist Armand D'Angour draws on neglected sources to explore the passions and motivations of young Socrates, showing how love transformed him into the philosopher he was to become. What emerges is the figure of Socrates as never previously portrayed: a heroic warrior, an athletic wrestler and dancer--and a passionate lover. Socrates in Love sheds new light on the formative journey of the philosopher, finally revealing the identity of the woman who Socrates claimed inspired him to develop ideas that have captivated thinkers for 2,500 years."--Publisher's description. (shrink)

Pindar's Dithyramb 2opens with a reference to the historical development of the genre it exemplifies, the celebrated circular chorus of classical Greece. The first two lines were long known from various citations, notably in Athenaeus, whose sources included the fourth-century authors Heraclides of Pontus and Aristotle's pupil Clearchus of Soli. The third line appears, only partly legible, on a papyrus fragment published in 1919, which preserves some thirty lines of the dithyramb including most of the first antistrophe.

The Greeks have long been regarded as innovators across a wide range of fields in literature, culture, philosophy, politics and science. However, little attention has been paid to how they thought and felt about novelty and innovation itself, and to relating this to the forces of traditionalism and conservatism which were also present across all the various societies within ancient Greece. What inspired the Greeks to embark on their unique and enduring innovations? How did they think and feel about the (...) new? This book represents the first serious attempt to address these issues, and deals with the phenomenon across all periods and areas of classical Greek history and thought. Each chapter concentrates on a different area of culture or thought, while the book as a whole argues that much of the impulse towards innovation came from the life of the polis which provided its setting. (shrink)

What difference does music make to performance poetry, and how did the ancients understand this relationship? This volume explores the interaction of music and language in ancient Greek poetry, arguing that music crucially informs the ways in which these texts create meaning and exploring its place in contemporary critical writings.

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

It is not without a certain emotion that one opens this book devoted to the memory of a great scholar of medieval thought who worked and lived in the certainty that there cannot be a conflict between the Christian faith and science. In a significant essay, Benedict M. Ashley defends the idea of the philosophy of nature as continuous or identical with natural science. Ashley does allow, however, for so many divergences between philosophy of nature and natural science due to (...) later developments in science that this identification must be qualified. Steven E. Baldner points out some of the contradictions of Hartshorne's atomism: Hartshorne denies change and real causality. Anthony J. Celano recalls that Robert Kilwardby was very much aware that happiness as described by Aristotle is quite different from the beatitude promised by the Christian faith. The order of the divine entitative attributes in the Summa theologiae I, qq. 3-11 has baffled many a commentator. Lawrence Dewan connects it with some texts of Aristotle's Metaphysics. Jeremiah Hackett studies Roger Bacon's Moralis philosophia. Dealing with Luther's attitude toward St. Thomas, Denis R. Tanz accepts Erasmus's verdict that the weight given to Thomas in theology was an important factor in propelling Luther out of the Roman Catholic orbit. This opinion, however, confounds appearances with the real reason for leaving, namely, estrangement from several central positions of Catholic doctrine. It is a tribute to the Catholicity of Thomas that after 1519 Luther came to identify the Pope, the Church and all scholastic doctors with the Thomists and said that the Church had become the synagogue of the papists and the Thomists: Thomas had been made the arbiter of heresy. Mark F. Johnson stresses the sapiential character of the sacra doctrina. Mark D. Jordan wrestles with the question why Thomas wrote his Aristotelian commentaries. Arguing in the line of Owens's interpretation he reduces their importance with regard to Thomas's own positions. Jordan seems to think that Thomas's philosophy cannot be formulated without his theology, an explanation which is hardly satisfactory. Armand Maurer submits some reflections on St. Thomas's notion of presence. The question to what extent Albert the Great contributed to Aquinas's treatises of the morality of human acts and of natural law is examined by Ernest J. McCullough. Walter H. Principe points out how, according to Aquinas, food is assimilated into the veritas humanae naturae. Eric A. Reitan retraces Weisheipl's analysis of Aristotle's Physics and of St. Thomas' Commentary: the axiom, "whatever is moved, is moved by another" can be understood only within the context of the general science of nature. In his Liber de causis et processu universitatis Albert came to hold the same position as Thomas on the demonstrability of creation and of its beginning in time. Two final articles concern the difficulties underlying Aristotle's arguments in Physics 7 and 8, and Aquinas and Newton on causality: William Wallace connects Newton's universal gravitation with the axiom that nothing acts on itself. (shrink)

It is not without a certain emotion that one opens this book devoted to the memory of a great scholar of medieval thought who worked and lived in the certainty that there cannot be a conflict between the Christian faith and science. In a significant essay, Benedict M. Ashley defends the idea of the philosophy of nature as continuous or identical with natural science. Ashley does allow, however, for so many divergences between philosophy of nature and natural science due to (...) later developments in science that this identification must be qualified. Steven E. Baldner points out some of the contradictions of Hartshorne's atomism: Hartshorne denies change and real causality. Anthony J. Celano recalls that Robert Kilwardby was very much aware that happiness as described by Aristotle is quite different from the beatitude promised by the Christian faith. The order of the divine entitative attributes in the Summa theologiae I, qq. 3-11 has baffled many a commentator. Lawrence Dewan connects it with some texts of Aristotle's Metaphysics. Jeremiah Hackett studies Roger Bacon's Moralis philosophia. Dealing with Luther's attitude toward St. Thomas, Denis R. Tanz accepts Erasmus's verdict that the weight given to Thomas in theology was an important factor in propelling Luther out of the Roman Catholic orbit. This opinion, however, confounds appearances with the real reason for leaving, namely, estrangement from several central positions of Catholic doctrine. It is a tribute to the Catholicity of Thomas that after 1519 Luther came to identify the Pope, the Church and all scholastic doctors with the Thomists and said that the Church had become the synagogue of the papists and the Thomists: Thomas had been made the arbiter of heresy. Mark F. Johnson stresses the sapiential character of the sacra doctrina. Mark D. Jordan wrestles with the question why Thomas wrote his Aristotelian commentaries. Arguing in the line of Owens's interpretation he reduces their importance with regard to Thomas's own positions. Jordan seems to think that Thomas's philosophy cannot be formulated without his theology, an explanation which is hardly satisfactory. Armand Maurer submits some reflections on St. Thomas's notion of presence. The question to what extent Albert the Great contributed to Aquinas's treatises of the morality of human acts and of natural law is examined by Ernest J. McCullough. Walter H. Principe points out how, according to Aquinas, food is assimilated into the veritas humanae naturae. Eric A. Reitan retraces Weisheipl's analysis of Aristotle's Physics and of St. Thomas' Commentary: the axiom, "whatever is moved, is moved by another" can be understood only within the context of the general science of nature. In his Liber de causis et processu universitatis Albert came to hold the same position as Thomas on the demonstrability of creation and of its beginning in time. Two final articles concern the difficulties underlying Aristotle's arguments in Physics 7 and 8, and Aquinas and Newton on causality: William Wallace connects Newton's universal gravitation with the axiom that nothing acts on itself. (shrink)

Much of the progress in the fields constituting cognitive science has been based upon the use of explicit information processing models, almost exclusively patterned after conventional serial computers. An extension of these ideas to massively parallel, connectionist models appears to offer a number of advantages. After a preliminary discussion, this paper introduces a general connectionist model and considers how it might be used in cognitive science. Among the issues addressed are: stability and noise‐sensitivity, distributed decision‐making, time and sequence problems, and (...) the representation of complex concepts. (shrink)

Recent studies using functional magnetic resonance imaging of patients in a vegetative state have raised the possibility that such patients retain some degree of consciousness. In this paper, the ethical implications of such findings are outlined, in particular in relation to decisions about withdrawing life-sustaining treatment. It is sometimes assumed that if there is evidence of consciousness, treatment should not be withdrawn. But, paradoxically, the discovery of consciousness in very severely brain-damaged patients may provide more reason to let them die. (...) Although functional neuroimaging is likely to play an increasing role in the assessment of patients in a vegetative state, caution is needed in the interpretation of neuroimaging findings. (shrink)

There is some complementarity of models for the origin of the electroencephalogram (EEG) and neural network models for information storage in brainlike systems. From the EEG models of Freeman, of Nunez, and of the authors' group we argue that the wavelike processes revealed in the EEG exhibit linear and near-equilibrium dynamics at macroscopic scale, despite extremely nonlinear – probably chaotic – dynamics at microscopic scale. Simulations of cortical neuronal interactions at global and microscopic scales are then presented. The simulations depend (...) on anatomical and physiological estimates of synaptic densities, coupling symmetries, synaptic gain, dendritic time constants, and axonal delays. It is shown that the frequency content, wave velocities, frequency/wavenumber spectra and response to cortical activation of the electrocorticogram (ECoG) can be reproduced by a “lumped” simulation treating small cortical areas as single-function units. The corresponding cellular neural network simulation has properties that include those of attractor neural networks proposed by Amit and by Parisi. Within the simulations at both scales, sharp transitions occur between low and high cell firing rates. These transitions may form a basis for neural interactions across scale. To maintain overall cortical dynamics in the normal low firing-rate range, interactions between the cortex and the subcortical systems are required to prevent runaway global excitation. Thus, the interaction of cortex and subcortex via corticostriatal and related pathways may partly regulate global dynamics by a principle analogous to adiabatic control of artificial neural networks. (shrink)

D. J. Allan; XV—Aristotle's Criticism of Platonic Doctrine Concerning Goodness and The Good, Proceedings of the Aristotelian Society, Volume 64, Issue 1, 1 June.

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

The first student-friendly introduction to the philosophical issues surrounding torture. It is a timely and useful contribution to a highly topical and on-going debate.

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

The recent revival of scholarly interest in Suetonius provides a good occasion to emend a long-standing crux in Joannes Lydus' description of Suetonius' dedication of his Vitae Caesarum to his friend the praetorian prefect Septicius Clarus. The codex unicus Caseolinus has Τράγκυλλος τοίνυν τος τν Καισάων βίους ν γράμμασιν † ποτίνων † Σεπτικί, ς ν παρχος τν πραιτωριανν σπειρν πì ατο. The conjectures ποτείνων by J. D. Fuss and ποτείνων by I. Bekker do little to improve the sense, and although (...) W. Kroll's προτείνων gives the meaning required by the context , προ- would not easily have been misread as πο-. For ποτίνων read νατείνων. For parallels compare BGU ii , 613.3–4 'Ανέτινα βιβλ[ίδι]α τλαμπροτάτ [γεμόνι] in a papyrus from the reign of Antoninus Pius cited by LSJ, and several other passages, most of which I owe to the supplement to Preisigke and Kiessling's Wörterbuch der griechischen Papyrusurkunden and to Dr Francisco R. Adrados of the Diccionario Griego-Español: Sammelbuch x , 10527.5–7 ['Ανέτε]ινά σοι, κ[ύριε,]…ναφόρ[ιον… of a.d. 152–3, P. Fouad iii , 26.5–10 , 8252.5–10) Ο νέτινάσυ τ κυρί βιβλιδίου…ντίγραφον πέταξα of a.d. 157–9, P. Oslo. iii , 80.21 ο νέτιναν βιβλιδί[ου…written sometime after March 7, a.d. 161, Sammelbuch iv 7472.3 'Ανέτεινά [σοι, κύριε πίτροπε, βιβλείδιον of a.d. 164, Sammelbuch vi.3 9339.24–7 13.5–7) ο νετείναμεν τ [κρατίσ τρχιερε O]λπί Σερηνιαν βιβλιδίου…[…] ντίγραφον πετάξαμεν from a.d. 178 or a little later, P. Mich. xii 616.13–14 τ δίκαιά μου βιβλειδί νγράψασ νέτεινα Νεμεσιαν πωσ τα[]τα διαπέμψηται[τ ]πιτρόπ from ca. a.d. 182, P. Cornell 14.2–4 ο νέτει[να τ κρατίστ πιστρ]ατηγ Κλαυδί [Ξενοφντι βιβλδίο]υ from a.d. 180–92, Wilcken, Chrestomathie 461.3–5 О[ νέ]τεινα τ λαμπροτάτ [γεμόνΚ]υίντω[ι] Μαικίωι λαιτίωι βιβλιδίου…ντίγραφον [ποτάξασ] from the beginning of the third century, and Sammelbuch v , 8246.3–4 α συνηγερούμεναι λιβέλλον νέτιναν π τν παρχον ξουσίαν from a.d. 340. (shrink)

The recent revival of scholarly interest in Suetonius provides a good occasion to emend a long-standing crux in Joannes Lydus' description of Suetonius' dedication of his Vitae Caesarum to his friend the praetorian prefect Septicius Clarus. The codex unicus Caseolinus has Τράγκυλλος τοίνυν τος τν Καισάων βίους ν γράμμασιν † ποτίνων † Σεπτικί, ς ν παρχος τν πραιτωριανν σπειρν πì ατο. The conjectures ποτείνων by J. D. Fuss and ποτείνων by I. Bekker do little to improve the sense, and although (...) W. Kroll's προτείνων gives the meaning required by the context, προ- would not easily have been misread as πο-. For ποτίνων read νατείνων. For parallels compare BGU ii, 613.3–4 'Ανέτινα βιβλ[ίδι]α τλαμπροτάτ [γεμόνι] in a papyrus from the reign of Antoninus Pius cited by LSJ, and several other passages, most of which I owe to the supplement to Preisigke and Kiessling's Wörterbuch der griechischen Papyrusurkunden and to Dr Francisco R. Adrados of the Diccionario Griego-Español: Sammelbuch x, 10527.5–7 ['Ανέτε]ινά σοι, κ[ύριε,]…ναφόρ[ιον… of a.d. 152–3, P. Fouad iii, 26.5–10, 8252.5–10) Ο νέτινάσυ τ κυρί βιβλιδίου…ντίγραφον πέταξα of a.d. 157–9, P. Oslo. iii, 80.21 ο νέτιναν βιβλιδί[ου…written sometime after March 7, a.d. 161, Sammelbuch iv 7472.3 'Ανέτεινά [σοι, κύριε πίτροπε, βιβλείδιον of a.d. 164, Sammelbuch vi.3 9339.24–7 13.5–7) ο νετείναμεν τ [κρατίσ τρχιερε O]λπί Σερηνιαν βιβλιδίου…[…] ντίγραφον πετάξαμεν from a.d. 178 or a little later, P. Mich. xii 616.13–14 τ δίκαιά μου βιβλειδί νγράψασ νέτεινα Νεμεσιαν πωσ τα[]τα διαπέμψηται[τ ]πιτρόπ from ca. a.d. 182, P. Cornell 14.2–4 ο νέτει[να τ κρατίστ πιστρ]ατηγ Κλαυδί [Ξενοφντι βιβλδίο]υ from a.d. 180–92, Wilcken, Chrestomathie 461.3–5 О[ νέ]τεινα τ λαμπροτάτ [γεμόνΚ]υίντω[ι] Μαικίωι λαιτίωι βιβλιδίου…ντίγραφον [ποτάξασ] from the beginning of the third century, and Sammelbuch v, 8246.3–4 α συνηγερούμεναι λιβέλλον νέτιναν π τν παρχον ξουσίαν from a.d. 340. (shrink)