A transnational capitalist class has emerged as that segment of the world bourgeoisie that represents transnational capital, the owners of the leading worldwide means of production as embodied in the transnational corporations and private financial institutions. The spread of TNCs, the sharp increase in foreign direct investment, the proliferation of mergers and acquisitions across national borders, the rise of a global financial system, and the increased interlocking of positions within the global corporate structure, are some empirical indicators of the transnational (...) integration of capitalists. The TCC manages global rather than national circuits of accumulation. This gives it an objective class existence and identity spatially and politically in the global system above any local territories and polities. The TCC became politicized from the 1970s into the 1990s and has pursued a class project of capitalist globalization institutionalized in an emergent transnational state apparatus and in a "Third Way" political program. The emergent global capitalist historic bloc is divided over strategic issues of class rule and how to achieve regulatory order in the global economy. Contradictions within the ruling bloc open up new opportunities for emancipatory projects from global labor. (shrink)

The potential for the occurrence of multiple-role relationships is increased when professors also consult with athletic teams on their campuses. Such multiple-role relationships have potential ethical implications that are unclear and largely unexplored, and consultants may find multiple-role relationships both difficult to deal with and unavoidable. Therefore, the purpose of this study was to explore the nature of teacher-practitioner multiple-role relationships. Participants (N = 35) were recruited from Association for the Advancement of Applied Sport Psychology (AAASP) certified consultants (CCs) who (...) were also affiliated with a university (N = 68). All participants completed a 28-item survey exploring the incidence and relevant issues pertaining to multiple-role relationships. Chi-square analyses revealed that licensed mental health practitioners (i.e., psychologists and counselors) were more likely than nonlicensed AAASP CCs to believe that multiple-role relationships were never appropriate in sport psychology, 2(1, N = 30) = 12.80, p < .001, and to have never taken part in a multiple-role relationship, 2(1, N = 33) = 12.44, p < .001. Independent samples t tests revealed that mental health practitioners also reported that they would have higher levels of concern for both the practitioner, t(30) = -2.77, p = .009, and the client, t(30) = -2.50, p = .018, in such a relationship. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...) to first-in-human clinical trials involving novel technologies, the question arises as to whether it is appropriate to advocate for a new model that prioritizes efficacy over safety across all phase 1 clinical research trials involving irreversible interventions in the brain. -/- . (shrink)

Nietzsche values intellectual honesty, but is dubious about what he calls the will to truth. This is puzzling since intellectual honesty is a component of the will to truth. In this paper, I show that this puzzle tells us something important about how Nietzsche conceives of our pursuit of truth. For Nietzsche, those who pursue truth occupy unstable ground, since being honest about the ultimate reasons for that pursuit would mean that truth could no longer satisfy the important human needs (...) it satisfies at present. We can pursue truth, or be honest about what in us is served by such a pursuit, but not both. Nietzsche aims to show that understanding and owning up to this instability is the sort of affirmation of human life to which we ought to aspire, and is the price we pay for being free from otherworldly morality. (shrink)

In response to its current crisis, scholars call for the revitalisation of democracy through democratic innovations. While they make ample use of life metaphors describing democracy as a living organism, no comprehensive understanding of ‘life’ has been established within democratic theory. The Black Lives Matter (BLM) movement articulates the urgency of refocusing on life and its meaning through radical democratic practice. This article employs a grounded theory approach, enriched with participatory methods, to develop a radical democratic concept of life in (...) conversation with BLM. It conceptualises life as the existence of a perspective that constantly transforms through its fundamental interconnectedness. Building on this concept, the article outlines four principles of a living democracy that go beyond the revitalisation discourse. A living democracy (1) safeguards the existence of all humans and nonhumans, (2) nurtures a diversity of perspectives, (3) fosters social and planetary connectivity, and (4) enables self- and collective transformation. (shrink)

Nietzsche is famously a critic of Mitleid, compassion or pity. He claims that because it must condemn all suffering, a morality of compassion is unable to recognize the ennobling aspects of suffering, and so is unable to recognize what is good and noble about those aspects of the human condition susceptible to suffering. Compassion thus robs our finitude of significance. Alongside his criticisms of compassion, however, at numerous places we see Nietzsche distinguishing between conceptions of compassion made different by the (...) different forms of life in which they are implicated. “Compassion,” for Nietzsche, is too broad a term, capturing a range of moral phenomena and their attendant eliciting conditions, deep... (shrink)

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

Nietzsche criticizes the shared suffering of compassion as a basis for ethics, yet his challenge to overcome compassion seeks not to extinguish all fellow feeling but instead urges us to transform the way we relate to others, to learn to share not suffering but joy. For Schopenhauer, we act morally when we respond to another’s suffering, while we are mistrustful of the joys of others. Nietzsche turns to the type of relationality exempli!ied by friendship, understood as shared joy, in order (...) to help him to articulate his ethical ideal for human beings. (shrink)

The slogans of social movements are often put forward as simple truths, so that advocacy has consisted in changing social conditions such that these new truth claims are accepted as true: that women’s rights are human rights, that Black lives matter. Social movements critical of the political ascendance of Donald Trump, however, have been concerned not merely with this or that truth claim, but with the status—epistemological, social, and political—of truth itself. Those examining this post-truth moment have often turned to (...) Friedrich Nietzsche, who for many is synonymous with the kind of postmodern conception of truth at the center of post-truth politics. However, while it is true that Nietzsche offers valuable... (shrink)

A critic of metaphysically robust accounts of the human self, Nietzsche means not to do away with the self entirely, but to reimagine it. He pursues an account according to which the unity of the self is born out of a coherent organization of drives and yet is not something other than that organization. Readers of Nietzsche have pointed to a so-called “lack of fit” between this theoretical account of the self, according to which the self is nothing apart from (...) the organization of drives, and Nietzsche’s practical account of human agency, which often seems to require that the self be something more than mere drives. I suggest Nietzsche’s interest in Greek agonistic norms of contest sheds light on this apparent incongruity. Agonistic relationships, insofar as they cultivate contest among diverse forces, are for Nietzsche one appropriate model for the subjectivity of beings whose psychology is similarly characterized by contest among diverse forces—that is, beings like us. (shrink)

Representing a variety of interpretive strategies, and looking closely at a wide range of Nietzsche’s works, the papers in this issue are nevertheless united by a common concern to make clear whether and how our understanding of Nietzsche is improved by paying closer attention to his treatment of virtue. For Nietzsche’s overlapping projects of interrogating inherited values and of envisioning forms of human life outside of the present moral economy of guilt and retribution both grow out of concerns central to (...) virtue ethics. That is, Nietzsche is asking whether morality in its present state is good for human beings, where what counts as good has to do with the kind of creatures we are, and so what it takes for us to flourish. (shrink)

Nietzsche, Foucault, and Rorty are each ethical thinkers in that widest sense that concerns questions of who we ought to be, and each seeks to answer those questions through accounts of self-creation that are distinguished by the style and scope of embeddedness in some community they rely on. Nietzsche’s is a middle-ground position between Rorty and Foucault since he offers an affirmation of community, on grounds that Rorty might accept, without acquiescence to the status quo, a concern for Foucault. Nietzsche (...) aims to place himself in a community, but one in part defined by its vigilance in identifying its blind spots, in knowing that it does not always know itself. In particular, I would like to say that Rorty misses the force of Nietzsche’s views on self-creation and the affirmation of community because Rorty mischaracterizes Nietzsche’s perspectivism by construing it along narrative rather than affective or physiological lines. (shrink)

If we think of political progress as indexed to some permanent standard, and then agree that it is Nietzsche who dispels the authority of any such standard, then we may perhaps conclude that after Nietzsche, progress is ruled out. I want to show, however, that we find in Nietzsche comfort for a continued vision of human progress through engaged political action. I suggest that we look to Derrida and Rorty as offering a view of a post-Nietzschean democracy the engine of (...) which is an account of ameliorative progress that is at home in the Enlightenment tradition while avoiding its universalist pretensions. (shrink)

Throughout his writings, Nietzsche problematizes self-knowledge, trying to displace rather than satisfy our drive for it. Describing self-knowledge as an ideal only for a certain kind of human being, he writes that it is the community that says, “‘you shall be knowable, express your inner nature by clear and constant signs—otherwise you are dangerous [...]. We despise the secret and unrecognizable.—Consequently, you must consider yourself knowable, you may not be concealed from yourself, you may not believe that you change’”.1 And (...) he argues that what we call self-knowledge develops in the first instance not in order that we might know ourselves, but only in response to our need to... (shrink)

We think the present moment is a timely one for debating the relation between evidentiary protocols and academic disciplines. Since academic practices for constituting and deploying evidence tend to be discipline-specific, the much-discussed crisis of the disciplines in recent years has given rise to a series of controversies about the status of evidence in current modes of investigation and argument: deconstruction, gender studies, new historicism, cultural studies, new approaches to the history and philosophy of science, the critical legal studies movement, (...) and so on. Unfortunately, these controversies too often devolve into oversimplified debates about who has the evidence and who does not, who did their homework and who did not, or about the dangers of an ill-defined academic relativism. Attention needs to be better and otherwise directed: at the configuration of the fact-evidence distinction in different disciplines and historical moments, for example; or at the relative function of such notions as “self-evidence,” “experience,” “test,” “testimony,” and “textuality” in various academic discourses; or at the ways in which the invoked “rules of evidence” are themselves the products of historical developments, and themselves undergo redifferentiation and reformulation. James Chandler, professor of English at the University of Chicago, is the author of Wordsworth’s Second Nature . He is currently completing England in 1819, studies in and of romantic case history. Arnold I. Davidson, executive editor of Critical Inquiry, teaches philosophy and the history of science at the University of Chicago. He is currently working on the history of horror as it relates to the epistemology of norms and deviations and is editing a collection of essays on Heidegger, philosophy, and National Socialism. Harry Harootunian, a coeditor of Critical Inquiry and professor of history and East Asian languages and civilizations at the University of Chicago, is the author of Things Seen and Unseen: Discourse and Ideology in Tokigawa and editor, with Masao Miyoshi, of Postmodernism and Japan. (shrink)

It is my view that one essential difference between persons and other creatures is to be found in the structure of a person's will. Besides wanting and choosing and being moved to do this or that, men may also want to have certain desires and motives. They are capable of wanting to be different, in their preferences and purposes, from what they are. Many animals appear to have the capacity for what I shall call "first-order desires" or "desires of the (...) first order," which are simply desires to do or not to do one thing or another. No animal other than man, however, appears to have the capacity for reflective self-evaluation that is manifested in the formation of second-order desires. (shrink)