Here, we used event-related potentials to test the predictions of two prominent accounts of code-switching in bilinguals: The Matrix Language Framework (MLF; Myers-Scotton, 1993) and an application of the Minimalist Program (MP; Cantone & MacSwan, 2009). We focused on the relative order of the noun with respect to the adjective in mixed Welsh-English nominal constructions given the clear contrast between pre- and post-nominal adjective position between Welsh and English. MP would predict that the language of the adjective should determine felicitous (...) word order (i.e., English adjectives should appear pre-nominally and Welsh adjectives post-nominally). In contrast, MLF contends that it is the language of the finite verb inflection rather than that of a particular word that governs felicitous word order. To assess the predictions of the two models, we constructed sentences featuring a code-switch between the adjective and the noun, that complied with either English or Welsh word-order. Highly proficient Welsh-English bilinguals made semantic acceptability judgements upon reading the last word of sentences which could violate MP assumptions, MLF assumptions, both assumptions, or neither. Behaviourally, MP violations had no significant effect, whereas MLF violations induced an average drop of 11% in acceptability judgements. Neurophysiologically, MP violations elicited a significant Left Anterior Negativity (LAN) modulation, whereas MLF violations modulated both P600 and LAN mean amplitudes. In addition, there was a significant interaction between MP and MLF status in the P600 range: When MP was violated, MLF status did not matter, and when MP criteria were met, MLF violations resulted in a P600 modulation. This interaction possibly reflects a general preference for noun over adjective insertions, and may provide support for MLF over MP at a global sentence processing level. Model predictions also manifested differently in each of the matrix languages: When the matrix language was Welsh, MP and MLF violations elicited greater P600 mean amplitudes than MP and MLF adherences, however this pattern was not observed when the matrix language was English. We discuss methodological considerations relating to the neuroscientific study of code-switching, and the extent to which our results shed light on adjective-noun code-switching beyond findings from production and experimental-behavioural studies. (shrink)

Is there only one bioethics? Is a global bioethics possible? Or, instead, does one encounter a plurality of bioethical approaches shaped by local cultural and national traditions? Some thirty years ago a field of applied ethics emerged under the rubric `bioethics'. Little thought was given at the time to the possibility that this field bore the imprint of a particular American set of moral commitments. This volume explores the plurality of moral perspectives shaping bioethics. It is inspired by Kazumasa (...) class='Hi'>Hoshino's critical reflections on the differences in moral perspectives separating Japanese and American bioethics. The essays include contributions from Hong Kong, China, Japan, Texas, the United States, Germany, Switzerland, and Italy. The volume offers a rich perspective of the range of approaches to bioethics. It brings into question whether there is unambiguously one ethics for bioethics to apply. (shrink)

Resolution and cut-free LK are the most popular propositional systems used for logical automated reasoning. The question whether or not resolution and cut-free LK have the same efficiency on the system of CNF formulas has been asked and studied since 1960 425–467). It was shown in Cook and Reckhow, J. Symbolic Logic 44 36–50 that tree resolution has super-polynomial speed-up over cut-free LK. Naturally, the current issue is whether or not resolution and cut-free LK expressed as directed acyclic graphs have (...) the same efficiency. In this paper, we introduce a new algorithm to eliminate atomic cuts and show that cut-free LK polynomially simulates resolution when the input formula is expressed as a k-CNF formula. As a corollary, we show that regular resolution does not polynomially simulate cut-free LK . We also show that cut-free LK polynomially simulates regular resolution. (shrink)

The Pragmatics of Multi-Verb Sequences: The Case of the Verb Go This paper is an empirical investigation into the nature of multi-verb sequences in English. Multi-verb sequences such as V-to-VP and V-and-VP present a natural construction type of investigating recurring patterns of event sequences as conceived situations. This paper focuses on the image-schematic properties of both the go-to-VP construction and the go-and-VP construction to which previous accounts have paid little attention, and it demonstrates that the interpretation of the image-schemas has (...) enhanced research. The go-to-VP and the go-and-VP constructions require different image schemas. With respect to the go-to-VP construction, the SOURCE-PATH-GOAL schema plays an important role; sometimes a compound image schema of that type are necessary. Specifically, the image-schematic properties of the first verb go are incorporated into the event structure of the second verb to allow the speaker to construe the event denoted by the second verb in accordance with the image-schematic meaning of the first verb go. Consequently, this paper offers a pragmatic and cognitive account of the two constructions respectively. Some results in a data-driven analysis in this paper also reinforce selected convincing explanations. (shrink)

BackgroundFew comparative studies of clinical ethics consultation practices have been reported. The objective of this study was to explore how American and Japanese experts analyze an Alzheimer's case regarding ethics consultation.MethodsWe presented the case to physicians and ethicists from the US and Japan (one expert from each field from both countries; total = 4) and obtained their responses through a questionnaire and in-depth interviews.ResultsEstablishing a consensus was a common goal among American and Japanese participants. In attempting to achieve consensus, the (...) most significant similarity between Japanese and American ethics consultants was that they both appeared to adopt an "ethics facilitation" approach. Differences were found in recommendation and assessment between the American and Japanese participants. In selecting a surrogate, the American participants chose to contact the grandson before designating the daughter-in-law as the surrogate decision-maker. Conversely the Japanese experts assumed that the daughter-in-law was the surrogate.ConclusionOur findings suggest that consensus building through an "ethics facilitation" approach may be a commonality to the practice of ethics consultation in the US and Japan, while differences emerged in terms of recommendations, surrogate assessment, and assessing treatments. Further research is needed to appreciate differences not only among different nations including, but not limited to, countries in Europe, Asia and the Americas, but also within each country. (shrink)

Healthcare professionals must make decisions for patients based on ethical considerations. However, they rely on clinical ethics consultations (CEC) to review ethical justifications of their decisions. CEC consultants support the cases reviewed and guide medical care. When both healthcare professionals and CEC consultants face ethical problems in medical care, how is their judgment derived? How do medical judgments differ from the ethical considerations of CECs? This study examines CECs in Japan to identify differences in the ethical judgment of clients and (...) CEC consultants. (shrink)

Crucial problems exist in understanding Japanese traditional customs with regard to autonomous decision making by patients in Japan. These problems are difficult to comprehend because they seem, by western standards, to defy logic. Questions that baffle those outside the Japanese tradition, include: Why do many Japanese patients hesitate to make medical treatment and care decisions for themselves without consulting family, close friends, or someone viewed as being in a superior position? Why do many Japanese physicians fail to disclose the truth (...) directly to the patient, instead customarily conveying information to family members, despite the doctors' awareness of their legal obligation to protect the patient's privacy? Why do many Japanese physicians continue to question whether patients should be told the truth at all? What perpetuates Japan's widespread, but often unnoticed, neglect of the individual's right to self-determination in healthcare decision making? (shrink)

The mechanism of chromosome condensation is one of the classic mysteries of mitosis. A number of years ago, it was suggested that nonhistone proteins of the chromosome scaffold fraction might help chromosomes to condense, possibly by constructing a framework for the condensed structure. Recent results have shown that topoisomerase II and the SMC proteins, two abundant members of the scaffold fraction, are required for chromosome condensation and segregation during mitosis. Topoisomerase II is a well‐characterized enzyme. In contrast, nothing is yet (...) known about the function of the SMC proteins. We summarize evidence suggesting that these proteins may be enzymes whose activity is somehow involved in the establishment and maintenance of mitotic chromosome morphology. (shrink)

This research examines the current status of clinical ethics consultation (CEC) in Japan through a nationwide study conducted with chairs of ethics committees and clinical ethics committees among 1028 post-graduate clinical teaching hospitals. We also qualitatively analyzed their viewpoints of the CEC’s benefits and problems related to hospital consultation services to identify the critical points for CEC and inform the development of a correctly functioning system. The questionnaire included structured questions about hospital CEC organization and service purpose and operation and (...) open-ended questions about the benefits and problems of initiating CEC. The questionnaire comprised the presence/absence of an ethics committee, CEC services and membership when services were implemented, users, and the number of cases handled since inception. In addition, the respondents also provided their impressions of the CEC system’s impact on their hospital by describing (a) the benefits of CEC services and (b) the ineffectual or harmful aspects of the CEC system. Qualitative data were examined using qualitative content analysis to determine the impact of establishing a CEC and the difficulties of practice. One hundred twenty-five questionnaires were returned from either the chair of the ethics committee or clinical ethics committee in teaching hospitals. Of these, 90 (72%) reported they provided CEC services. Additionally, 36 respondents (34.6%) reported that their existing research and clinical ethics committees had conducted CEC services, and 35 (33.7%) reported having a newly established clinical ethics committee conducting CEC services. Three positive effects of establishing and four challenges in managing CEC were also identified. (shrink)

Approximately 30 years ago, a son prepared a cup of milk mixed with insecticide and arranged for his mother to unknowingly administer the poison to his father, who had been suffering severe pain after a cerebral apoplectic attack and demanding that his son assist him. in dying. After drinking the mixture, the father died, and the son was charged with homicide.

The Japanese government took significant steps in making decisions about a newly developing clinical application of gene therapy when, on April 15, 1993, the Government officially accepted the Guidelines for Clinical Research on Gene Therapy submitted by the Health Science Council of the Ministry of Health and Welfare of Japan to the Minister.

The method of analytic tableaux is employed in many introductory texts and has also been used quite extensively as a basis for automated theorem proving. In this paper, we discuss the complexity of the system as a method for refuting contradictory sets of clauses, and resolve several open questions. We discuss the three forms of analytic tableaux: clausal tableaux, generalized clausal tableaux, and binary tableaux. We resolve the relative complexity of these three forms of tableaux proofs and also resolve the (...) relative complexity of analytic tableaux versus resolution. We show that there is a quasi-polynomial simulation of tree resolution by analytic tableaux; this simulation is close to optimal, since we give a matching lower bound that is tight to within a polynomial. (shrink)

インフォームド・コンセント、脳死と臓器移植、生体肝移植、終末医療と尊厳死、体外受精...。これら医療の新しい問題をどう考えたらいいのか。バイオエシックスが生まれ育った北米で二十年を過ごし、日本の医療倫 理の確立のために活躍してきた著者が、患者中心の医療の倫理とは何か、わが国になじむ倫理とは何かを、情熱をこめて語る。.

In the past few years, a second phase of biomedical ethics in Japan has begun to surface with a succession of governmental guidelines and laws regulating biomedical technology. Although this rush of guidelines exemplifies a heightened awareness concerning ethical standards for healthcare research, it also invites several practical, political, and procedural problems.

In the circular sphere around the Pacific Ocean many volcanos have erupted, and, because of tectonic plates, numerous earthquakes have occurred. In Tonga, especially, the resulting devastation has been beyond our wildest imagination. Regarding such natural phenomena, we could not predict anything. Likewise, the Covid-19 pandemic appeared suddenly, and no one can say when its destruction will end. Protective measures against infection have affected the nature of our social interactions: masking has changed our spatial consciousness; observing social distancing has made (...) us less dependent on one another and has influenced us to seek solitude. As a result, inter-subjectivity—the foundation of ethics—has been broken. All of these effects on our interpersonal relationships have instilled in us a new attitude towards nature, because the human being is a part of nature. This new attitude with nature opens up a new paradigm: dialogues with nature and their co-operative activities must be demanded, and we must wait for nature’s movement and ask for its help. It is, in a way, the traditional artistic attitude toward nature. (shrink)