(2013). Informed Consent, Big Data, and the Oxymoron of Research That Is Not Research. The American Journal of Bioethics: Vol. 13, No. 4, pp. 40-42. doi: 10.1080/15265161.2013.768864.

Medical necessity (claiming that a medical intervention or care is – at minimum – reasonable, appropriate and acceptable) depends on empirical evidence and on the interpretation of that evidence. Evidence and its interpretation define the standard of care. This commentary argues that both the evidence base and its interpretation are currently weak gatekeepers. Empirical meta-research suggests that very few medical interventions have high quality evidence in support of their effectiveness and very few of them also have relatively thorough assessments of (...) their potential harms. Therefore, evidence on the risk-benefit ratios carries almost always very large uncertainty. Arbitration about medical necessity is thus left to the interpretation process. Professional guidelines are notoriously unreliable and biased in this regard. Regulatory approval ends up being the key arbitrator, but over the years the regulatory process has been subverted. Regulatory approval currently does not mean that an intervention has a favourable risk-benefit ratio, but simply that it can be marketed, sold and made profit from. The process leads to a tragedy of commons where the final victim is society at large: medical necessity is invoked as an alibi for medicine to absorb societal resources. (shrink)

Neurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

Antidepressants, in particular newer agents, are among the most widely prescribed medications worldwide with annual sales of billions of dollars. The introduction of these agents in the market has passed through seemingly strict regulatory control. Over a thousand randomized trials have been conducted with antidepressants. Statistically significant benefits have been repeatedly demonstrated and the medical literature is flooded with several hundreds of.

In this issue of the Hastings Center Report, Jonathan Kimmelman and Alex London argue that in assessing the success of clinical translation, it is narrow‐minded to focus only on how many new drugs get licensed and how quickly they achieve licensure. Kimmelman and London show that clinical translation should be judged on its ability to generate as comprehensive an intervention ensemble as possible for the tested interventions. I would like to extend Kimmelman and London's position in two ways. First, I (...) would argue that in the current environment, failures should be seen not just as acceptable, but probably as the most useful outcomes that translational research efforts can offer. Second, an intervention ensemble probably cannot be generated with information only about the drug or drugs produced by a single company. For most conditions and diseases, there are already a large number of other interventions whose use is supported or contradicted by various levels of evidence. (shrink)

Overstated generalizability is common in research. It may coexist with inflation of the magnitude and statistical support for effects and dismissal of internal validity problems. Generalizability may be secured before attempting replication of proposed discoveries or replication may precede efforts to generalize. These opposite approaches may decrease or increase, respectively, the use of inferential statistics with advantages and disadvantages.

Biomedical innovation and translation are increasingly emphasizing research using “big data.” The hope is that big data methods will both speed up research and make its results more applicable to “real-world” patients and health services. While big data research has been embraced by scientists, politicians, industry, and the public, numerous ethical, organizational, and technical/methodological concerns have also been raised. With respect to technical and methodological concerns, there is a view that these will be resolved through sophisticated information technologies, predictive algorithms, (...) and data analysis techniques. While such advances will likely go some way towards resolving technical and methodological issues, we believe that the epistemological issues raised by big data research have important ethical implications and raise questions about the very possibility of big data research achieving its goals. (shrink)

The linguistic foundations of science and technology include many terms that have been borrowed from ancient languages. In the case of terms with origins in the Greek language, the modern meaning can often differ significantly from the original one. Here we use the PubMed database to demonstrate the prevalence of words of Greek origin in the language of modern science, and call for scientists to exercise care when coining new terms.

As the expansion of the Internet and the digital formatting of all kinds of creative works move us further into the information age, intellectual property issues have become paramount. Computer programs costing thousands of research dollars are now copied in an instant. People who would recoil at the thought of stealing cars, computers, or VCRs regularly steal software or copy their favorite music from a friend's CD. Since the Web has no national boundaries, these issues are international concerns. The contributors-philosophers, (...) legal theorists, and business scholars, among others-address questions such as: Can abstract ideas be owned? How does the violation of intellectual property rights compare to the violation of physical property rights? Can computer software and other digital information be protected? And how should legal systems accommodate the ownership of intellectual property in an information age? Intellectual Property is a lively examination of these and other issues, and an invaluable resource for librarians, lawyers, businesspeople, and scholars. (shrink)

Aristotle said that induction (epagōgē) is a proceeding from particulars to a universal, and the definition has been conventional ever since. But there is an ambiguity here. Induction in the Scholastic and the (so-called) Humean tradition has presumed that Aristotle meant going from particular statements to universal statements. But the alternate view, namely that Aristotle meant going from particular things to universal ideas, prevailed all through antiquity and then again from the time of Francis Bacon until the mid-nineteenth century. Recent (...) scholarship is so steeped in the first-mentioned tradition that we have virtually forgotten the other. In this essay McCaskey seeks to recover that alternate tradition, a tradition whose leading theoreticians were William Whewell, Francis Bacon, Socrates, and in fact Aristotle himself. The examination is both historical and philosophical. The first part of the essay fills out the history. The latter part examines the most mature of the philosophies in the Socratic tradition, specifically Bacon’s and Whewell’s. After tracing out this tradition, McCaskey shows how this alternate view of induction is indeed employed in science, as exemplified by several instances taken from actual scientific practice. In this manner, McCaskey proposes to us that the Humean problem of induction is merely an artifact of a bad conception of induction and that a return to the Socratic conception might be warranted. (shrink)

This rich volume is sure to attract scholarly attention in a variety of fields. There is nothing else like it in print.

After a summary of earlier work it is shown that elementary or Kalmar arithmetic can be interpreted within the system of Russell's Principia Mathematica with the axiom of infinity but without the axiom of reducibility.

While we are commonly told that the distinctive method of mathematics is rigorous proof, and that the special topic of mathematics is abstract structure, there has been no agreement among mathematicians, logicians, or philosophers as to just what either of these assertions means. John P. Burgess clarifies the nature of mathematical rigor and of mathematical structure, and above all of the relation between the two, taking into account some of the latest developments in mathematics, including the rise of experimental (...) mathematics on the one hand and computerized formal proofs on the other hand. Along the way, a great many historical developments in mathematics, philosophy, and logic are surveyed. Yet very little in the way of background knowledge on the part of the reader is presupposed. (shrink)

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

By utilizing new information from both clinical and experimental (lesion, electrophysiological, and gene-activation) studies with animals, the anatomy underlying anterograde amnesia has been reformulated. The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part of an comprising the hippocampus, the fornix, the mamillary bodies, and the anterior thalamic nuclei. This view, which can be traced back to Delay and Brion (1969), differs from other recent models in (...) placing critical importance on the efferents from the hippocampus via the fornix to the diencephalon. These are necessary for the encoding and, hence, the effective subsequent recall of episodic memory. An additional feature of this hippocampalanterior thalamic and the perirhinal–medial dorsal thalamic systems are compromised, leading to severe deficits in both recall and recognition. (shrink)

Philosophical Logic is a clear and concise critical survey of nonclassical logics of philosophical interest written by one of the world's leading authorities on the subject. After giving an overview of classical logic, John Burgess introduces five central branches of nonclassical logic, focusing on the sometimes problematic relationship between formal apparatus and intuitive motivation. Requiring minimal background and arranged to make the more technical material optional, the book offers a choice between an overview and in-depth study, and it balances (...) the philosophical and technical aspects of the subject.The book emphasizes the relationship between models and the traditional goal of logic, the evaluation of arguments, and critically examines apparatus and assumptions that often are taken for granted. Philosophical Logic provides an unusually thorough treatment of conditional logic, unifying probabilistic and model-theoretic approaches. It underscores the variety of approaches that have been taken to relevantistic and related logics, and it stresses the problem of connecting formal systems to the motivating ideas behind intuitionistic mathematics. Each chapter ends with a brief guide to further reading.Philosophical Logic addresses students new to logic, philosophers working in other areas, and specialists in logic, providing both a sophisticated introduction and a new synthesis. (shrink)

The great logician Gottlob Frege attempted to provide a purely logical foundation for mathematics. His system collapsed when Bertrand Russell discovered a contradiction in it. Thereafter, mathematicians and logicians, beginning with Russell himself, turned in other directions to look for a framework for modern abstract mathematics. Over the past couple of decades, however, logicians and philosophers have discovered that much more is salvageable from the rubble of Frege's system than had previously been assumed. A variety of repaired systems have been (...) proposed, each a consistent theory permitting the development of a significant portion of mathematics. This book surveys the assortment of methods put forth for fixing Frege's system, in an attempt to determine just how much of mathematics can be reconstructed in each. John Burgess considers every proposed fix, each with its distinctive philosophical advantages and drawbacks. These systems range from those barely able to reconstruct the rudiments of arithmetic to those that go well beyond the generally accepted axioms of set theory into the speculative realm of large cardinals. For the most part, Burgess finds that attempts to fix Frege do less than advertised to revive his system. This book will be the benchmark against which future analyses of the revival of Frege will be measured. (shrink)

The source, status, and significance of the derivation of the necessity of identity at the beginning of Kripke’s lecture “Identity and Necessity” is discussed from a logical, philosophical, and historical point of view.

How induction was understood took a substantial turn during the Renaissance. At the beginning, induction was understood as it had been throughout the medieval period, as a kind of propositional inference that is stronger the more it approximates deduction. During the Renaissance, an older understanding, one prevalent in antiquity, was rediscovered and adopted. By this understanding, induction identifies defining characteristics using a process of comparing and contrasting. Important participants in the change were Jean Buridan, humanists such as Lorenzo Valla and (...) Rudolph Agricola, Paduan Aristotelians such as Agostino Nifo, Jacopo Zabarella, and members of the medical faculty, writers on philosophy of mind such as the Englishman John Case, writers of reasoning handbooks, and Francis Bacon. (shrink)

This volume reprints a dozen of the author’s papers, most with substantial postscripts, and adds one new one. The bulk of the material is on topics in philosophy of language, but there are also two papers on philosophy of mathematics written after the appearance of the author’s collected papers on that subject, and one on epistemology. As to the substance of Field’s contributions, limitations of space preclude doing much more below than indicating the range of issues addressed, and the general (...) orientation taken towards them. As to the style of his writing, it well exhibits the first of the two virtues, clarity and conciseness, that one looks for in philosophical prose. (shrink)

Computability and Logic has become a classic because of its accessibility to students without a mathematical background and because it covers not simply the staple topics of an intermediate logic course, such as Godel's incompleteness theorems, but also a large number of optional topics, from Turing's theory of computability to Ramsey's theorem. This 2007 fifth edition has been thoroughly revised by John Burgess. Including a selection of exercises, adjusted for this edition, at the end of each chapter, it offers (...) a simpler treatment of the representability of recursive functions, a traditional stumbling block for students on the way to the Godel incompleteness theorems. This updated edition is also accompanied by a website as well as an instructor's manual. (shrink)

Numbers and other mathematical objects are exceptional in having no locations in space or time or relations of cause and effect. This makes it difficult to account for the possibility of the knowledge of such objects, leading many philosophers to embrace nominalism, the doctrine that there are no such objects, and to embark on ambitious projects for interpreting mathematics so as to preserve the subject while eliminating its objects. This book cuts through a host of technicalities that have obscured previous (...) discussions of these projects, and presents clear, concise accounts of a dozen strategies for nominalistic interpretation of mathematics, thus equipping the reader to evaluate each and to compare different ones. The authors also offer critical discussion, rare in the literature, of the aims and claims of nominalistic interpretation, suggesting that it is significant in a very different way from that usually assumed. (shrink)

The increasingly pervasive practice of veiling among Muslim women has stimulated a great deal of scholarly investigation and debate. This study brings empirical evidence to bear on current debates about the meaning of the veil in Islam. This article first examines the conflicting meanings of the veil among Muslim religious elites and Islamic feminists. Although the dominant gender discourse among Muslim elites strongly favors this cultural practice, an antiveiling discourse promulgated by Islamic feminists has gained ground within recent years. This (...) study then examines how these discursive disputes affect gender identity negotiation among veiled and unveiled Muslim women living in Austin, Texas. Interviews with these women highlight how their gender identities reproduce and reformulate existing Muslim gender discourses. Special attention is paid to the subjective disparities and points of congruence between both groups of respondents. This study concludes by suggesting avenues for future research on the intersection of gender, religion, and cultural difference. (shrink)

A new axiomatization of set theory, to be called Bernays-Boolos set theory, is introduced. Its background logic is the plural logic of Boolos, and its only positive set-theoretic existence axiom is a reflection principle of Bernays. It is a very simple system of axioms sufficient to obtain the usual axioms of ZFC, plus some large cardinals, and to reduce every question of plural logic to a question of set theory.

IN examining Herodotos' account of the Samian tyranny, historians have long been disturbed by two considerations. First, it seems strange that the period of settled tyranny should have begun no earlier than the rise of Polykrates and his two brothers c. 533 B.C., even though Samos was among the most advanced cities in Ionia. Yet it seems equally impossible to revise this accession date in an upward direction, at least by any significant margin. Furthermore, there had been at work in (...) Samos from c. 600 or earlier many of the factors which elsewhere in Ionia did in fact lead to a comparatively stable period of tyranny at that date, for instance at Miletos and Ephesos. Secondly, though Herodotos knows of no tyrant before Polykrates, it has been observed that the policies ascribed to him as characteristic were very largely the continuation of policies initiated a generation or more previously. (shrink)

This fourth edition of one of the classic logic textbooks has been thoroughly revised by John Burgess. The aim is to increase the pedagogical value of the book for the core market of students of philosophy and for students of mathematics and computer science as well. This book has become a classic because of its accessibility to students without a mathematical background, and because it covers not simply the staple topics of an intermediate logic course such as Godel's Incompleteness (...) Theorems, but also a large number of optional topics from Turing's theory of computability to Ramsey's theorem. John Burgess has now enhanced the book by adding a selection of problems at the end of each chapter, and by reorganising and rewriting chapters to make them more independent of each other and thus to increase the range of options available to instructors as to what to cover and what to defer. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the dynamics of (...) prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

Leaders and managers of today's multinational corporations face a plethora of problems and issues directly attributable to the fact that they are operating in an international context. With work-sites, plants and/or customers based in another country, or even several countries, representing a vast spectrum of cultural differences, international trade and offshore operations, coupled with increased globalisation in respect to political, social and economic realities, contribute to new dilemmas that these leaders must deal with. Not the least of these being a (...) Code of Ethics and ethical decision making.This paper examines the differences in culture between a group of managers from the United States and similar group from Croatia using Hofstede's theory of International Cultures. The study explores how these cultural dimensions may help in our understanding of the differences in reported whistleblowing. The authors then postulate four hypotheses regarding various aspects of whistleblowing. These Hypotheses were than tested using a survey administered to a sample of U.S.A. and Croatian managers. Finally, the paper discusses the findings and practical implications for contemporary managers in the international arena. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the dynamics of (...) prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

Perhaps if the future existed, concretely and individually, as something that could be discerned by a better brain, the past would not be so seductive: its demands would he balanced by those of the future. Persons might then straddle the middle stretch of the seesaw when considering this or that object. It might be fun. But the future has no such reality (as the pictured past and the perceived present possess); the future is but a figure of speech, a specter (...) of thought. (shrink)

Crowdfunding platforms have revolutionized entrepreneurial finance, with 200 billion dollars expected to be dispersed annually to entrepreneurs and small business owners by 2020. Despite the importance of this growing phenomenon, our knowledge of the dynamics of successful lending-based prosocial crowdfunding and its implications for the business ethics literature remain limited. We use a social responsibility lens to examine whether crowdfunders on a lending-based prosocial platform lend their money based on altruistic or strategic motives. Our results indicate that the dynamics of (...) prosocial lending-based crowdfunding are somewhat consistent with traditional forms of financing. Specifically, despite a prosocial setting in nature, crowdfunders tend to act strategically, positively responding to signals of quality and low risk. Notably, we also find that projects that are high on both financial and social appeal receive the highest average amount of funding. Furthermore, language on the lender’s profile indicating ability to pay is positively related to both funding success and funding amount. Our study contributes to filling the gap in the business ethics literature about the dynamics of lending-based prosocial crowdfunding, and the strategic and altruistic ethical motives that drive lenders in such endeavors. (shrink)

Saul Kripke has been a major influence on analytic philosophy and allied fields for a half-century and more. His early masterpiece, _Naming and Necessity_, reversed the pattern of two centuries of philosophizing about the necessary and the contingent. Although much of his work remains unpublished, several major essays have now appeared in print, most recently in his long-awaited collection _Philosophical Troubles_. In this book Kripke’s long-time colleague, the logician and philosopher John P. Burgess, offers a thorough and self-contained guide (...) to all of Kripke’s published books and his most important philosophical papers, old and new. It also provides an authoritative but non-technical account of Kripke’s influential contributions to the study of modal logic and logical paradoxes. Although Kripke has been anything but a system-builder, Burgess expertly uncovers the connections between different parts of his oeuvre. Kripke is shown grappling, often in opposition to existing traditions, with mysteries surrounding the nature of necessity, rule-following, and the conscious mind, as well as with intricate and intriguing puzzles about identity, belief and self-reference. Clearly contextualizing the full range of Kripke’s work, Burgess outlines, summarizes and surveys the issues raised by each of the philosopher’s major publications. _Kripke_ will be essential reading for anyone interested in the work of one of analytic philosophy’s greatest living thinkers. (shrink)

David Lewis in the short monograph Parts of Classes (PC) undertakes a fundamental re‐examination of the relationship between mereology, the general theory of parts, and set theory, the general theory of collections. Given Lewis's theses, to be an element of a set or member of class is just to have a singleton that is a part thereof. Lewis in PC adds a claim of kind of ontological innocence, comparable to that of first‐order logic, for mereology. The only substantive assumption of (...) plethynticology is that for any condition there are some things such that they are precisely the things for which the conditions hold. All the alternatives, making do with a single domain of individuals, have in common that they involve the axiom of choice. Restated in Hazen's terminology rather than Frege's, the fallback assumption is that there are no more small species than individuals. (shrink)

John Burgess is the author of a rich and creative body of work which seeks to defend classical logic and mathematics through counter-criticism of their nominalist, intuitionist, relevantist, and other critics. This selection of his essays, which spans twenty-five years, addresses key topics including nominalism, neo-logicism, intuitionism, modal logic, analyticity, and translation. An introduction sets the essays in context and offers a retrospective appraisal of their aims. The volume will be of interest to a wide range of readers across (...) philosophy of mathematics, logic, and philosophy of language. (shrink)

The results of a survey of 272 practicing accountants and 374 accounting students enrolled in six universities are analyzed. Differences and similarities between the two groups with regard to their attitudes toward corporate social responsibility are examined. The results indicate that the students exhibit greater concern about the ethical and discretionary components of corporate responsibility and a weaker orientation toward economic performance. No significant differences between the two groups were observed with respect to the legal dimension of corporate social responsibility. (...) Some explanations as well as limited generalizations and implications are developed. (shrink)

What is the simplest and most natural axiomatic replacement for the set-theoretic definition of the minimal fixed point on the Kleene scheme in Kripke’s theory of truth? What is the simplest and most natural set of axioms and rules for truth whose adoption by a subject who had never heard the word "true" before would give that subject an understanding of truth for which the minimal fixed point on the Kleene scheme would be a good model? Several axiomatic systems, old (...) and new, are examined and evaluated as candidate answers to these questions, with results of Harvey Friedman playing a significant role in the examination. (shrink)