It is widely assumed that selection history accounts of function can support a fully reductive naturalization of functional properties. I argue that this assumption is false. A problem with the alternative causal role account of function in this context is that it invokes the teleological notion of a goal in analysing real function. The selection history account, if it is to have reductive status, must not do the same. But attention to certain cases of selection history in biology, specifically those (...) involving meiotic drive, shows that selection historical explanations are available in the case of items without any plausible function. Making contributions to goals, here fitness, must be introduced as an additional constraint in the analysis, either explicitly, or implicitly by appeal to individual functions or the selection-of/selection-for distinction. (shrink)

From the neurophysiological perspective, thinking in dreaming and the quality of dream thought have been considered hallucinatory, bizarre, illogical, improbable, or even impossible. This empirical phenomenological research concentrates on testing whether dream thought can be defined as rational in the sense of an intervening mental process between sensory perception and the creation of meaning, leading to a conclusion or to taking action. From 10 individual dream journals of male participants aged 22–59 years and female participants aged 25–49 years, we delimited (...) four dreams per journal and randomly selected five thought units from each dream for scoring. The units provided a base for testing a hypothesis that the thought processes of dream construction are rational. The results support the hypothesis and demonstrate that eight fundamental rational thought processes can be applied to the dreaming process. (shrink)

In this book, Della Rocca traces out the conceptual links between key concepts and principles of Spinoza's system bearing on representation and the mind-body problem. In the course of doing so, he presents and defends a number of new, interesting theses about Spinoza's thought on these matters. The arguments are presented with impressive clarity and in great detail. All in all, the book is a significant contribution to the literature on Spinoza's metaphysics and epistemology, and should be read by anyone (...) with a serious interest in its historical subject or in the two perennial philosophical problems on which it focuses. (shrink)

A set of amino acid side chains that confer specificity for the coenzyme NADPH and the substrate glutathione in the flavoprotein disulphide oxidoreductase, glutathione reductase, has been identified. Systematic replacement of these amino acid residues in the coenzyme‐binding site switches the specificity of the enzyme from its natural strong preference for NADPH to a marked preference For NADH. The amino acids replaced all lie in a structural motif within the dinucleotide‐binding domain of the protein. Since this domain is a feature (...) common to most dehydrogenases (reductases) that use nicotinamide coenzymes, it may be that the coenzyme specificities of all such enzymes can be manipulated in this way. Similarly, amino acid residues involved in the selective recognition of trypanothione by trypanothione reductase, an enzyme related to glutathione reductase and exclusive to trypanosomatids, were identified. Suitable mutation of the corresponding residues in E. coli glutathione reductase switched its substrate specificity towards trypanothione. A better understanding of the substrate specificity of these enzymes could open up a route to the chemotherapy of trypanosomal infections. (shrink)

Reviews in allegory the approaches taken to the problem of agency by contemporary perspectives in psychology and broader intellectual tradition. The author argues that agency can only be rendered sensible or possible where there is freedom from traditional determinisms and where there is real moral content. It is argued that agency will only be possible when moral relativity is overcome. 2012 APA, all rights reserved).

PLATO'S UNIVERSE by Gregory Vlastos. Clarendon Press: O.U.P., 1975. xiii+130 pp. £3.75.

This essay contends that Jonathan Bennett gave a passive reading of conatus, and that he misunderstood Spinoza’s conception of mental representation, mistakenly attributing to Spinoza the common, contemporary view that representational content does not supervene on the intrinsic features of representations. A reading of the conatus as an active, motive principle of opposition is presented. It is argued that Spinoza’s notion of representation is best understood as grounded in a conception of causation on which effects bear intrinsic, distinctive structural marks (...) of their causes. (shrink)

Through personal testimony, the author details the experience of fathering a baby with a poor prenatal diagnosis. The author invites the reader to follow his journey, from learning his wife is pregnant, through their experiences as a family with their unborn daughter’s poor prenatal diagnosis, welcoming their baby girl at her birth, and ultimately finding peace in her early passing. Perinatal peer support is discussed and encouraged, drawing attention to the needs and concerns of the babies, women, and families who (...) may not know to seek help in a similar situation. Great honor is given to the beauty and sanctity of life from the perspective of a father with a sick unborn child. National Catholic Bioethics Quarterly 14.1 : 31–37. (shrink)

Argues that the historical concept of agency ultimately fails since such weighing and choosing always require grounds that reach beyond private consciousness. Agency is bound inherently with morality; the modernist understanding of agency removes it from morality. It is suggested that agency is only possible on inherently moral, rather than metaphysical, grounds. An alternative conceptualization of agency as living truthfully is proposed that does not posit the existence of Cartesian ego and does not surrender to moral relativism. This concept of (...) agency is exemplified and distinguished from volition, which is much closer to the more traditional view of agency as the capacity to choose from among alternatives. A grounding for agency in ethics is offered, suggesting that neither traditional notions, which are grounded in traditional metaphysics, nor postmodern notions, which accept ethical relativity, can render satisfactory accounts of human agency. 2012 APA, all rights reserved). (shrink)

This paper argues that Donald Davidson’s infamous denial in “A Nice Derangement of Epitaphs” that there is any such thing as a language, though it may not be fully supported by the arguments given for it in that paper, is nonetheless entailed by his semantic views generally, according to which the literal, linguistic meaning of a speaker’s words on an occasion is determined by how the speaker intended to be understood. In favor of this view, and thus against conventional languages, (...) the paper then argues that this understanding of linguistic meaning promises, in a way the conventional view of meaning does not, to make sense of linguistic normativity. (shrink)

I examine the arguments Donald Davidson has offered through the years concerning the ontological bona fides of facts. In “Truth and Meaning”, Davidson uses the so-called “slingshot” argument to the effect that if true sentences refer, then they are all coreferential. Through a detailed examination of the assumptions underlying this argument, I show that, while it is effective as part of a reductio of bottom-up, reference based semantics, it has no tendency to establish the truth of its negative conclusion concerning (...) the existence of facts. Davidson also argues against facts by claiming they are of no help in the explication of truth. I claim that his repeated invocation of the slingshot in this context, as well as of arguments from other authors employing assumptions similar to the slingshot's, is inappropriate, especially in light of his own commitment to a top-down semantics — a committment inspired, ironically, by the reductio offered in “Truth and Meaning”. Davidson's other argument against truth as correspondence, namely that our grasp of facts is no better than our grasp of truths, is sound. But this argument does not show that there are no facts; it shows only that no theory of truth in terms of corre- pondence to facts can genuinely illuminate its explanandum. (shrink)

Donald Davidson infamously claims that belief is in its nature veridical, and that skepticism is for this reason fundamentally incoherent. To those who take the issue of external world skepticism seriously, Davidson's arguments may seem to involve a conjuring trick. In particular, his invocation of an ‘omniscient interpreter’, whose intelligibility supposedly ensures that our beliefs must be largely true, has the air of incense and lantern-rubbing about it. Davidson's claim has received considerable critical response in the literature, almost all of (...) it negative. In my view, some commentators have indeed lit on a critical and controversial lemma in Davidson's argument, but this basic result has been obscured by being presented amidst an array of other criticisms that simply make no sense from a Davidsonian point of view. The aim of this paper is to clear away some of the confusion that stands in the way of a more productive evaluation of Davidson's important claim. (shrink)

Kant distinguishes “natural ends” as exhibiting a part-whole reciprocal causal structure in virtue of which we can only conceive them as having been caused through a conception, as if by intelligent design. Here, I put pressure on Kant’s position by arguing that his view of what individuates and makes cognizable material bodies of any kind is inadequate and needs supplementation. Drawing on Spinoza, I further urge that the needed supplement is precisely the whole-part reciprocal causal structure that Kant takes to (...) be distinctive of natural ends alone. (shrink)

Donald Davidson argues that his interpretivist approach to meaning shows that accounting for the intentionality and objectivity of thought does not require an appeal, as John McDowell has urged it does, to a specifically rational relation between mind and world. Moreover, Davidson claims that the idea of such a relation is unintelligible. This paper takes issue with these claims. It shows, first, that interpretivism, contra Davidson's express view, does not depend essentially upon an appeal to a causal relation between events (...) in the world and speakers' beliefs. Second, it shows that interpretivism essentially, if implicitly, depends upon interpreters' appealing to facts taken in in perception, and that such facts are suited to provide a rational connection between mind and world. The paper then argues that none of Davidson's legitimate epistemological arguments tell against the idea that experience, in the form of the propositional contents of perception, can play a role in doxastic economy. Finally, it argues that granting experience such a role is consistent with Davidson's coherentist slogan that nothing can count as a reason for holding a belief except another belief. (shrink)

This paper is a result of remarks delivered at the 2014 conference of the Florida Philosophical Association during a book symposium on Elijah Chudnoff's Intuition.

This chapter contains sections titled: Introduction Rationalism and the Analytic/Synthetic Distinction A priori Principles I: Davidson on Causation and the Mental Constitutive Principles and Classical Rationalism Classical Rationalism or Kantian Transcendentalism? The Refutation of (Transcendental) Idealism Rationalism Full‐Blown.

The topic of the present essay is the proper understanding of Donald Davidson’s version of the publicity requirement for the determinants of linguistic meaning. On the understanding I promote, the requirement is very strict indeed. My narrow aim is to show how such a strict conception of the publicity requirement can be maintained despite the evident need for interpreters to go beyond what is public on that conception in the process of constructing Davidsonian theories of meaning. Towards that aim, I (...) engage dialectically with treatments of Davidson’s principle of charity owing to Lepore and Ludwig and to Bar-On and Risjord, each of which, in different ways, recommend a more permissive approach to the publicity requirement than the one I recommended here. A broader aim is to shed some light on what would be required to take seriously the larger ambitions of Davidson’s semantic program. (shrink)