If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

M. Tulli Ciceronis libri qui ad rem publicam et ad philosophiam spectant; vol. ix. Cato Maior de Senectute, Laelius de Amicitia; 50 Pf. vol. x. De Officiis; 80 Pf. ed. Th. Schiche, Leipzig, Freytag.M. Tulli Ciceronis Orationes Selectae; vol. i. Oratio pro Sex. Roscio Arnerino; 30 Pf. vol. ii. In Q. Caecilium Diuinatio, in C. Verrem Accusationis, Lib. iv. v.; ed. H. Nohl; 80 Pf. Leipzig, Freytag.M. Tulli Ciceronis Scripta quae remanserunt omnia. Recognovit C. F. W. Mueller. Partis ii. vol. (...) iii. Leipzig, Teubner, 1886. 2 Mk. 10. (shrink)

Originally published: London: Allen & Unwin, 1936.

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

The long-term persistence of neurotic symptoms, such as anxiety, poses difficult problems for any psychological theory. An attempt is made to revive the Watson-Mowrer conditioning theory and to avoid the many criticisms directed against it in the past. It is suggested that recent research has produced changes in learning theory that can be used to render this possible. In the first place, the doctrine of equipotentiality has been shown to be wrong, and some such concept as Seligman's “preparedness” is required, (...) that is the notion that certain CS are biologically prepared to be more readily connected with anxiety responses than others. In the second place, the law of extinction has to be amended, and the law of incubation or enhancement added, according to which the exposure of the CS-only may, under certain specified conditions, have the effect of increasing the strength of the CR, rather than reducing it. The major conditions favouring incubation are Pavlovian B conditioning, that is a type of conditioning in which the CR is a drive; a strong UCS, and short exposure of the CS-only. (shrink)

Although the view that punishment is to be justified on utilitarian grounds has obvious appeal, an examination of utilitarianism reveals that, consistently and accurately interpreted, it dictates unjust punishments which are unacceptable to the common moral consciousness. In this rule?utilitarianism is no more satisfactory than is act?utilitarianism. Although the production of the greatest good, or the greatest happiness, of the greatest number is obviously a relevant consideration when determining which punishments may properly be inflicted, the question as to which punishment (...) is just is a distinct and more basic question and one which must be answered before we can determine which punishments are morally permissible. That a retributivist theory, which is a particular application of a general principle of justice, can account more satisfactorily for our notion of justice in punishment is a positive reason in its support. (shrink)

The present volume contains the lectures and papers given at the 1994 international conference on hermeneutics in Halle (Germany). The conference aimed at a state of the art in the light of recent developments in science and humanities. The place in which the conference was held is renowned for its centuries-old tradition in hermeneutics and among the lectures there are indeed some devoted to this history. For the most part, however, the papers concentrate on present-day problems in fields as different (...) as comparative literature, religious studies, bible exegesis, esthetics, social sciences, intercultural dialogue. The theme of the conference, "strangeness and familiarity", reflects the tension in which any interpretation process is situated and that any theory of interpretation has to account for. The contributions to the volume are in German and French. (shrink)

A classic exposition of Kant's ethical thought.

summaryThis paper discusses objections against the idea that the meaning of a word is its use. Sct. 1 accepts Rundle's point that ‘meaning’ and ‘use’ are used differently, but insists that this is compatible with holding that use determines meaning, an therefore holds the key to conceptual analysis. Scts. 2–4 rebut three lines of argument which claim that linguistic philosophy goes astray by reading into the meaning of words non‐semantic features of its use: Searle's general speech act fallacy charge, Hacker's (...) use of the Frege‐point against Wittgenstein's account of avowals, and Grice's attack on Wittgenstein's discussion of ‘trying’. Sct. 5 argues that Grice's doctrine of conversational implicature fails to show that the features he disregards are pragmatic rather than semantic. Sct. 6 ends with some suggestions about how use can be related to meaning without being abused. (shrink)

CHAPTER INTRODUCTION At first sight Plotinus' philosophy is full of contradictions. The same entity will appear with different characteristics in different ...