The mechanisms responsible for the fine tuning of development, where the wildtype phenotype is reproduced with high fidelity, are not well understood. The difficulty in approaching this problem is the identification of mutant phenotypes indicative of a defect in these fine‐tuning control mechanisms. Evolutionary biologists have used asymmetry as a measure of developmental homeostasis. The rationale for this was that, since the same genome controls the development of the left and right sides of a bilaterally symmetrical organism, departures from symmetry (...) can be used to measure genetic or environmental perturbations. This paper examines the relationship between asymmtry and resistance to organophosphorous insecticides in the Australian sheep blowfly, Lucilia cuprina. A resistance gene, Rop‐1, which encodes a carboxylesterase enzyme, also confers a significant increase in asymmetry. Continued exposure of resistant populations to insecticide has selected a dominant suppressor of the asymmetry phenotype. Genetic evidence indicates that the modifier is the L. cuprina Notch homologue. (shrink)

This new edition of the classic Contemporary Theories of Knowledge has been significantly updated to include analyses of the recent literature in epistemology.

The objective of this book is to produce a theory of rational decision making for realistically resource-bounded agents. My interest is not in “What should I do if I were an ideal agent?”, but rather, “What should I do given that I am who I am, with all my actual cognitive limitations?” The book has three parts. Part One addresses the question of where the values come from that agents use in rational decision making. The most comon view among philosophers (...) is that they are based on preferences, but I argue that this is computationally impossible. I propose an alternative theory somewhat reminiscent of Bentham, and explore how human beings actually arrive at values and how they use them in decision making. Part Two investigates the knowledge of probability that is required for decision-theoretic reasoning. I argue that subjective probability makes no sense as applied to realistic agents. I sketch a theory of objective probability to put in its place. Then I use that to define a variety of causal probability and argue that this is the kind of probability presupposed by rational decision making. So what is to be defended is a variety of causal decision theory. Part Three explores how these values and probabilities are to be used in decision making. In chapter eight, it is argued first that actions cannot be evaluated in terms of their expected values as ordinarily defined, because that does not take account of the fact that a cognizer may be unable to perform an action, and may even be unable to try to perform it. An alternative notion of “expected utility” is defined to be used in place of expected values. In chapter nine it is argued that individual actions cannot be the proper objects of decision-theoretic evaluation. We must instead choose plans, and select actions indirectly on the grounds that they are prescribed by the plans we adopt. However, our objective cannot be to find plans with maximal expected utilities. Plans cannot be meaningfully compared in that way. (shrink)

"A sequel to Pollock's How to Build a Person, this volume builds upon that theoretical groundwork for the implementation of rationality through artificial ...

Now in a new edition, this exceptionally successful survey text introduces the faith, belief, and practice of Islam from its earliest origins up to its contemporary resurgence. John L. Esposito, an internationally renowned expert on Islam, traces the development of this dynamic faith and its impact on world history and politics. The fourth edition features updated and expanded coverage of Islam and politics; more extensive treatment of early Islam; an enhanced art program; a new appendix; and a free 6-month (...) subscription to Oxford Islamic Studies Online edited by John L. Esposito. (shrink)

This exceptionally successful survey text introduces the teachings and practice of Islam from its earliest origins up to its contemporary practice. John L. Esposito, an internationally renowned expert on Islam, traces the development of Islam and its impact on world history and politics.Lucidly written and expansive in scope, Islam: The Straight Path, Updated Fifth Edition, provides keen insight into one of the world's least understood religions. It is ideally suited for use in courses on Islam, world religions, comparative religions, (...) and Middle East history and culture.A FREE 6-month subscription to Oxford Islamic Studies Online, edited by John L. Esposito, is included with the purchase of every new copy of this text. (shrink)

There was a long tradition in philosophy according to which good reasoning had to be deductively valid. However, that tradition began to be questioned in the 1960’s, and is now thoroughly discredited. What caused its downfall was the recognition that many familiar kinds of reasoning are not deductively valid, but clearly confer justification on their conclusions. Here are some simple examples.

Princeton University Press, 1974. This book is out of print, but can be downloaded as a pdf file (5 MB).

This exceptionally successful survey text introduces the teachings and practice of Islam from its earliest origins up to its contemporary practice. John L. Esposito, an internationally renowned expert on Islam, traces the development of Islam and its impact on world history and politics.Lucidly written and expansive in scope, Islam: The Straight Path, Fifth Edition, provides keen insight into one of the world's least understood religions. It is ideally suited for use in courses on Islam, world religions, comparative religions, and (...) Middle East history and culture.A FREE 6-month subscription to Oxford Islamic Studies Online, edited by John L. Esposito, is included with the purchase of every new copy of this text. (shrink)

Presenting an analytical and critical study of the contemporary adult educator, Paulo Freire, this book deals with all aspects of his thought, placing at the centre of consideration his educational philosophy.

Mucins are a family of high molecular weight, highly glycosylated glycoproteins found in the apical cell membrane of human epithelial cells from the mammary gland, salivary gland, digestive tract, respiratory tract, kidney, bladder, prostate, uterus and rete testis. Increased synthesis of the core protein and alterations in the carbohydrates attached to these glycoproteins are believed to play important roles in the function and proliferation of tumour cells. Aberrant glycosylation leads not only to the production of novel carbohydrate structures, but also (...) to the exposure of the core peptide. These novel epitopes may be candidates for diagnosis or therapy, by using either synthetic mucin fragments as vaccines, or monoclonal antibody‐based reagents which detect these structures. (shrink)

Pollock argues that theories of ideal rationality are largely irrelevant to the decision making of real agents. Thinking about Acting aims to provide a theory of "real rationality.".

In this book Pollock deals with the subject of probabilistic reasoning, making general philosophical sense of objective probabilities and exploring their ...

Princeton University Press, 984. This book is out of print, but can be downloaded as a pdf file (3.9 MB).

Pollock describes an exciting theory of rationality and its partial implementation in OSCAR, a computer system whose descendants will literally be persons.

This third edition, now available in paperback, is a follow up to the author's classic Boolean-Valued Models and Independence Proofs in Set Theory. It provides an exposition of some of the most important results in set theory obtained in the 20th century: the independence of the continuum hypothesis and the axiom of choice.

"There is no attempt here to lay down as inviolable or to legislate certain ways of looking at things or ways of proceeding for philosophers of religion, only proposals for how to deal with a range of basic issues-proposals that I hope will ignite much fruitful discussion and which, in any case, I shall take as a basis for my own ongoing work in the field."-from the Preface Providing an original and systematic treatment of foundational issues in philosophy of religion, (...) J. L. Schellenberg's new book addresses the structure of religious and irreligious belief, the varieties of religious skepticism, and the nature of religion itself. From the author's searching analysis of faith emerges a novel understanding of propositional faith as requiring the absence of belief. Schellenberg asks what the aims of the field should be, setting out a series of principles for carrying out some of the most important of these aims. His account of justification considers not only belief but also other responses to religious claims and distinguishes the justification of responses, propositions, and persons. Throughout Prolegomena to a Philosophy of Religion, Schellenberg is laying the groundwork for an elaboration of his own vision while at the same time suggesting how philosophers might rethink assumptions guiding most of today's work in analytic philosophy of religion. (shrink)

When your word processor or email program is running on your computer, this creates a “virtual machine” that manipulates windows, files, text, etc. What is this virtual machine, and what are the virtual objects it manipulates? Many standard arguments in the philosophy of mind have exact analogues for virtual machines and virtual objects, but we do not want to draw the wild metaphysical conclusions that have sometimes tempted philosophers in the philosophy of mind. A computer file is not made of (...) epiphenomenal ectoplasm. I argue instead that virtual objects are “supervenient objects.” The stereotypical example of supervenient objects is the statue and the lump of clay. To this end I propose a theory of supervenient objects. Then I turn to persons and mental states. I argue that my mental states are virtual states of a cognitive virtual machine implemented on my body, and a person is a supervenient object supervening on this cognitive virtual machine. (shrink)

"The Third Edition of Philosophical Foundations of Adult Education presents seven theoretical approaches to adult education: liberal, progressive, behaviorist, humanist, radical/critical, analytic, and postmodem. The book gives the historical grounding as well as the basic principles for each approach. In this edition each chapter has been revised and brought up to date. The chapter on radical adult education incorporates recent developments in radical education, phenomenology, feminist educational theory, and critical social theory. The book contains an entirely new chapter on postmodem (...) adult education.". (shrink)

Princeton University Press, 1982. This book is out of print, but can be downloaded as a pdf file (5 MB).

The usual meaning of the word continuous is “unbroken” or “uninterrupted”: thus a continuous entity —a continuum—has no “gaps.” We commonly suppose that space and time are continuous, and certain philosophers have maintained that all natural processes occur continuously: witness, for example, Leibniz's famous apothegm natura non facit saltus—“nature makes no jump.” In mathematics the word is used in the same general sense, but has had to be furnished with increasingly precise definitions. So, for instance, in the later 18th century (...) continuity of a function was taken to mean that infinitesimal changes in the value of the argument induced infinitesimal changes in the value of the function. With the abandonment of infinitesimals in the 19th century this definition came to be replaced by one employing the more precise concept of limit. (shrink)

A theory of rational choice is a theory of how an agent should, rationally, go about deciding what actions to perform at any given time. For example, I may want to decide whether to go to a movie this evening or stay home and read a book. The actions between which we want to choose are perfectly ordinary actions, and the presumption is that to make such a decision we should attend to the likely consequences of our decision. It is (...) assumed that these decisions must be made in the face of uncertainty regarding both the agent’s initial situation and the consequences of his actions. (shrink)