Vaccinia virus, the world's oldest vaccine, was used originally for the eradication of smallpox. It is now being genetically engineered to create new live vaccines for use against other infectious agents of medical and veterinary importance. Genes coding for antigens of several pathogens have been linked to vaccinia virus transcriptional regulatory signals and inserted into the vaccinia virus genome. The resultant recombinant viruses are infectious, express the foreign gene, stimulate specific immune responses in vaccinated animals and can protect against disease (...) caused by the corresponding pathogen. (shrink)

Le livre de Nadine Bernard n’aborde pas un sujet neuf et ne comble pas un vide bibliographique. Les synthèses anciennes, telle celle de Claude Mossé, et plus récentes, comme le premier volume de l’Histoire des femmes paru sous la direction de Pauline Schmitt-Pantel ou encore le livre récent de Pierre Brulé, ont déjà beaucoup donné au lecteur, spécialiste ou non, qui s’intéresse à ce champ d’étude. Mais ce livre fait pourtant oeuvre utile. Procédant d’une bonne connaissance de la bibliographie...

Questo breve scritto si propone di ripercorrere sinteticamente alcuni nodi fondamentali del dibattito filosofico tra Bernard Williams e Martha Nussbaum sul significato e sul valore etico della rappresentazione tragica non tanto all’interno del mondo greco quanto per la contemporaneità. Si cercherà di mostrare lo scarto tra le diverse concezioni dei due autori a partire dalle differenti interpretazioni che essi forniscono dell’Agamennone di Eschilo, e dei diversi giudizi che essi formulano nei confronti del protagonista e della sua vicenda. Gli obiettivi (...) delle argomentazioni che seguono sono principalmente due: innanzitutto evidenziare come in alcune delle critiche mosse dalla filosofa americana al collega britannico siano rinvenibili spunti fondamentali per quella che si ritiene una più completa comprensione della tragedia come caso limite del conflitto tra soggetto etico e mondo; in secondo luogo, attraverso una riproposizione del conflitto di valori in termini di conflitto di ruoli, produrre una giustificazione del giudizio di Nussbaum su Agamennone compatibile con l’approccio di Williams. (shrink)

Nationalism is one of modern history’s great surprises. How is it that the nation, a relatively old form of community, has risen to such prominence in an era so strongly identified with the individual? Bernard Yack argues that it is the inadequacy of our understanding of community—and especially the moral psychology that animates it—that has made this question so difficult to answer. Yack develops a broader and more flexible theory of community and shows how to use it in the (...) study of nations and nationalism. What makes nationalism such a powerful and morally problematic force in our lives is the interplay of old feelings of communal loyalty and relatively new beliefs about popular sovereignty. By uncovering this fraught relationship, Yack moves our understanding of nationalism beyond the oft-rehearsed debate between primordialists and modernists, those who exaggerate our loss of individuality and those who underestimate the depth of communal attachments. A brilliant and compelling book, _Nationalism and the Moral Psychology of Community_ sets out a revisionist conception of nationalism that cannot be ignored. (shrink)

This essay asks why Aristotle, certainly no friend to unlimited democracy, seems so much more comfortable with unconstrained rhetoric in political deliberation than current defenders of deliberative democracy. It answers this question by reconstructing and defending a distinctly Aristotelian understanding of political deliberation, one that can be pieced together out of a series of separate arguments made in the Rhetoric, the Politics, and the Nicomachean Ethics.

Abstract The idea of a purely civic nationalism has attracted Western scholars, most of whom rightly disdain the myths that sustain ethnonationalist theories of political community. Civic nationalism is particularly attractive to many Americans, whose peculiar national heritage encourages the delusion that their mutual association is based solely on consciously chosen principles. But this idea misrepresents political reality as surely as the ethnonationalist myths it is designed to combat. And propagating a new political myth is an especially inappropriate way of (...) defending the legacy of Enlightenment liberalism from the dangers posed by the growth of nationalist political passions. (shrink)

With a new foreword by Jonathan Lear 'Remarkably lively and enjoyable…It is a very rich book, containing excellent descriptions of a variety of moral theories, and innumerable and often witty observations on topics encountered on the way.' -_ Times Literary Supplement_ Bernard Williams was one of the greatest philosophers of his generation. Ethics and the Limits of Philosophy is not only widely acknowledged to be his most important book, but also hailed a contemporary classic of moral philosophy. Drawing on (...) the ideas of the Greek philosophers, Williams reorients ethics away from a preoccupation with universal moral theories towards ‘truth, truthfulness and the meaning of an individual life’. He explores and reflects upon the most difficult problems in contemporary philosophy and identifies new ideas about central issues such as relativism, objectivity and the possibility of ethical knowledge. This edition also includes a commentary on the text by A.W.Moore. At the time of his death in 2003, Bernard Williams was hailed by the Times as 'the outstanding moral philosopher of his age.' He taught at the Universities of Cambridge, Berkeley and Oxford and is the author of many influential books, including _Morality; Descartes: The Project of Pure Enquiry_ and _Truth and Truthfulness_. (shrink)

In Nietzsche's Psychology of Ressentiment, Guy Elgat develops an interpretation of some of the central themes of Nietzsche's GM, which is one of his most systematic works and a pivotal part of his critique of the modern moral outlook that grew out of Christianity. Elgat's original approach is framed by two fundamental ideas: first, Nietzsche takes the concept of "moral justice" to be central to the morality he sets out to criticize; second, Nietzsche's suspicion toward moral justice is rooted in (...) its association with the affect of ressentiment. Thus, Elgat notes that ressentiment is frequently supposed either to express a sense of justice, or to... (shrink)

In addition to this much-needed clarification of the uses and abuses of the term "modernity," Yack here provides a fresh look at familiar modern ideas and practices such as nationalism, constitutionalism, and liberal democratic politics. Our world, the author suggests, offers us far stranger and more unexpected combinations that are dreamt of in modernist and postmodernist philosophies. His critique of the tendency to treat modernity as an integrated and coherent whole will expand the reader's vision to take in the broader (...) landscape of surprising and inconsistent features in the social and political world that surrounds us. The Fetishism of Modernities will be of interest to social, political and cultural theorists, intellectual historians and philosophers, as well as anyone with a stake in current debates about modernity and postmodernity. (shrink)

What can--and what can't--philosophy do? What are its ethical risks--and its possible rewards? How does it differ from science? In Philosophy as a Humanistic Discipline , Bernard Williams addresses these questions and presents a striking vision of philosophy as fundamentally different from science in its aims and methods even though there is still in philosophy "something that counts as getting it right." Written with his distinctive combination of rigor, imagination, depth, and humanism, the book amply demonstrates why Williams was (...) one of the greatest philosophers of the twentieth century. Spanning his career from his first publication to one of his last lectures, the book's previously unpublished or uncollected essays address metaphysics, epistemology, and ethics, as well as the scope and limits of philosophy itself. The essays are unified by Williams's constant concern that philosophy maintain contact with the human problems that animate it in the first place. As the book's editor, A. W. Moore, writes in his introduction, the title essay is "a kind of manifesto for Williams's conception of his own life's work." It is where he most directly asks "what philosophy can and cannot contribute to the project of making sense of things"--answering that what philosophy can best help make sense of is "being human." Philosophy as a Humanistic Discipline is one of three posthumous books by Williams to be published by Princeton University Press. In the Beginning Was the Deed: Realism and Moralism in Political Argument was published in the fall of 2005. The Sense of the Past: Essays in the History of Philosophy is being published shortly after the present volume. (shrink)

This article attempts an organological and pharmacological re-interpretation of the later Heidegger’s understanding of modern technology as a provocative mode of revealing of beings, in particular of its central notions of Gestell [enframing] Gefahr [danger], Kehre [turning] and Ereignis [event]. Although these notions in principle allow us to think what is at stake currently in the Anthropocene as the age of total automation, generalized toxicity of the technical milieu and post-truth calling for a radical bifurcation, they need to be reframed (...) and re-imagined in terms of the process of exosomatization issuing from humanity’s original and necessary default of origin and situated within the perspective of entropy and negentropy, both unthought by Heidegger. Only thus will it become possible to really think and take care of what Heidegger called the danger of technology and its turning into the event as the destiny of enframing. This also requires a rethinking of Aristotle’s theory of four causes as it is invoked by Heidegger in his analysis of technology, in particular the efficient and final causes, in terms of what Deleuze called quasi-causality, here understood as the need and the obligation for mortals to make their fault come true, i.e., to make it truly happen or make it advene in truth, out of the experience of the danger as the ordeal of the necessary default. Thus becoming the anti-anthropic cause of anthropic toxicity, humans would restore final causality as quasi-causality and inaugurate, as neganthropos, the bifurcation into the Neganthropocene. (shrink)

This book is a philosophically sophisticated and scientifically well-informed discussion of the moral and social issues raised by genetically engineering animals, a powerful technology which has major implications for society. Unlike other books on this emotionally charged subject, the author attempts to inform, not inflame, the reader about the real problems society must address in order to manage this technology. Bernard Rollin is both a professor of philosophy, and physiology and biophysics, and writes from a uniquely well-informed perspective on (...) this topic. The style is non-technical and anecdotal and will ensure that the book can be used on a wide range of courses on bioethics, biotechnology, veterinary medicine and public policy. The book could also appeal to a general, non-academic reader with a serious interest in genetic engineering. (shrink)

Journal of Social Philosophy, EarlyView.

In Science and Ethics, Bernard Rollin examines the ideology that denies the relevance of ethics to science. Providing an introduction to basic ethical concepts, he discusses a variety of ethical issues that are relevant to science and how they are ignored, to the detriment of both science and society. These include research on human subjects, animal research, genetic engineering, biotechnology, cloning, xenotransplantation, and stem cell research. Rollin also explores the ideological agnosticism that scientists have displayed regarding subjective experience in (...) humans and animals, and its pernicious effect on pain management. Finally, he articulates the implications of the ideological denial of ethics for the practice of science itself in terms of fraud, plagiarism, and data falsification. In engaging prose and with philosophical sophistication, Rollin cogently argues in favor of making education in ethics part and parcel of scientific training. (shrink)

We tend to suppose that the ancient Greeks had primitive ideas of the self, of responsibility, freedom, and shame, and that now humanity has advanced from these to a more refined moral consciousness. Bernard Williams's original and radical book questions this picture of Western history. While we are in many ways different from the Greeks, Williams claims that the differences are not to be traced to a shift in these basic conceptions of ethical life. We are more like the (...) ancients than we are prepared to acknowledge, and only when this is understood can we properly grasp our most important differences from them, such as our rejection of slavery. The author is a philosopher, but much of his book is directed to writers such as Homer and the tragedians, whom he discusses as poets and not just as materials for philosophy. At the center of his study is the question of how we can understand Greek tragedy at all, when its world is so far from ours. Williams explains how it is that when the ancients speak, they do not merely tell us about themselves, but about ourselves. _Shame and Necessity_ gives a new account of our relations to the Greeks, and helps us to see what ethical ideas we need in order to live in the modern world. (shrink)

Journal of Social Philosophy, EarlyView.

In lieu of an abstract, here is a brief excerpt of the content:ContributorsMichael Bernard-Donals is the Nancy Hoefs Professor of English, and an affiliate member of the Mosse-Weinstein Center for Jewish Studies, at the University of Wisconsin—Madison. His most recent book is An Introduction to Holocaust Studies: History, Memory, and Representation.Oliver Marchart is a professor in the Department of Sociology, University of Lucerne, Switzerland. He is the author of books on Hannah Arendt (2005) and postfoundational political thought (2007) and (...) coeditor, with Simon Critchley, of Laclau: A Critical Reader (2004).Michèle Richman's research and publications focus primarily on the relations between Georges Bataille and other intellectuals with close ties to the French School of Sociology's founding figures, Emile Durkheim and Marcel Mauss. She is Professor of French Studies at the University of Pennsylvania.Anthony Sampson is a practicing psychoanalyst, member of the École lacanienne de psychanalyse, and teaches in the Institute of Psychology at the University del Valle, Cali, Colombia.An assistant professor of English at East Carolina University, Mikko Tuhkanen has published essays in American Literature, diacritics, African American Review, GLQ, Modern Fiction Studies, and elsewhere.Copyright © 2007 The Johns Hopkins University Press... (shrink)

In 1944 Horkheimer and Adorno warned that industrial society turns reason into rationalization, and Polanyi warned of the dangers of the self-regulating market, but today, argues Stiegler, this regression of reason has led to societies dominated by unreason, stupidity and madness. However, philosophy in the second half of the twentieth century abandoned the critique of political economy, and poststructuralism left its heirs helpless and disarmed in face of the reign of stupidity and an economic crisis of global proportions. New theories (...) and concepts are required today to think through these issues. The thinkers of poststructuralism Lyotard, Deleuze, Derrida must be re-read, as must the sources of their thought, Hegel and Marx. But we must also take account of Naomi Klein’s critique of Milton Friedman and the Chicago School and her account of the ‘shock doctrine’. In fact, argues Stiegler, a permanent ‘state of shock’ has prevailed since the beginning of the industrial revolution, intensified by the creative destruction brought about by the consumerist model. The result has been a capitalism that destroys desire and reason and in which every institution is undermined, above all those institutions that are the products par excellence of the Enlightenment the education system and universities. Through a powerful critique of thinkers from Marx to Derrida, Stiegler develops new conceptual weapons to fight this destruction. He argues that schools and universities must themselves be transformed: new educational institutions must be developed both to take account of the dangers of digitization and the internet and to enable us to take advantage of the new opportunities they make available. (shrink)

Tractatus, 5.62 famously says: ‘… what the solipsist means is quite correct; only it cannot be said but makes itself manifest. The world is my world: this is manifest in the fact that the limits of language mean the limits of my world.’ The later part of this repeats what was said in summary at 5.6: ‘the limits of my language mean the limits of my world’. And the key to the problem ‘how much truth there is in solipsism’ has (...) been provided by the reflections of TLP, 5.61. (shrink)

Public health responses to the Covid‐19 pandemic included various measures to mitigate the spread of the virus. Among these, the most restrictive was a broad category referred to as “lockdowns.” We argue that the reasoning offered in favor of extended lockdowns—those lasting several months or longer—did not adequately account for a host of countervailing considerations, including the impact on mental illness, education, employment, and marginalized communities as well as health, educational, and economic inequities. Furthermore, justifications offered for extended lockdowns set (...) aside a basic tenet of public health ethics: restrictions on liberty and autonomy should be the least intrusive means of achieving the desired end. Since it is now clear that extended lockdowns cause severe harm to many vulnerable populations, the burden of proof is on those who would advocate for them, and there must be a much higher bar to implement an extended lockdown, with high‐quality evidence that the benefit would substantially exceed its harm. (shrink)

Moral problems do not always come in the form of great social controversies. More often, the moral decisions we make are made quietly, constantly, and within the context of everyday activities and quotidian dilemmas. Indeed, these smaller decisions are based on a moral foundation that few of us ever stop to think about but which guides our every action. Here distinguished philosopher Bernard Gert presents a clear and concise introduction to what he calls "common morality" -- the moral system (...) that most thoughtful people implicitly use when making everyday, common sense moral decisions and judgments. Common Morality is useful in that -- while not resolving every disagreement on controversial issues -- it is able to distinguish between acceptable and unacceptable answers to moral problems. In the first part of the book Gert lays out the fundamental features of common morality: moral rules, moral ideals, and a two-step procedure for determining when a violation of a moral rule is justified. Written in a non-technical style, the ten general moral rules include rules on which everyone can agree, such as "do not kill," "do not deceive," and "keep your promises." The moral ideals include similarly uncontroversial precepts such as "Relieve pain" and "Aid the needy." In the second part of the book Gert examines the underlying concepts that justify common morality, such as the notions of rationality and impartiality. The distillation of over 40 years of scholarship, this book is the most accessible version of Gert's influential theory of morality as well as an eye-opening look at the moral foundations of our everyday actions. Throughout the discussion is clear enough for a reader with little or no philosophy background. (shrink)

Bernard Berofsky addresses that metaphysical picture directly.Nature's Challenge to Free Willoffers an original defense of Humean Compatibilism.

In his recent address to the Aristotelian Society, Aurel Kolnai suggests that games exhibit what he calls a “genuine paradoxy.” I do not believe that he has shown this to be the case, even on the most permissive interpretation of what it means to be a paradox. Kolnai has, however, called attention to an aspect of games which invites further investigation, and I should like to advance the following considerations not so much as a criticism of Kolnai as an attempt (...) to take the investigation along a path which Kolnai has indicated, but which he has not himself, in my opinion, followed. It is not that Kolnai does not say many interesting, indeed penetrating, things about games, for he does. That Kolnai's inquiry is an important contribution to the philosophy of games is not in question. What is questionable is whether paradox has very much to do with that contribution. (shrink)

Bernard Williams; IV*—Moral Incapacity, Proceedings of the Aristotelian Society, Volume 93, Issue 1, 1 June 1993, Pages 59–70, https://doi.org/10.1093/aristotel.

This edition includes, in addition to the most pertinent sections of The Fable's two volumes, a selection from Mandeville's An Enquiry into the Origin of Honor and selections from two of Mandeville's most important sources: Pierre Bayle and the Jansenist Pierre Nicole. Hundert's Introduction places Mandeville in a number of eighteenth-century debates--particularly that of the nature and morality of commercial modernity--and underscores the degree to which his work stood as a central problem, not only for his immediate English contemporaries, but (...) for such philosophers as Hume, Rousseau, and Kant. The selections are substantive enough to faithfully represent Mandeville the social theorist, and compact enough to be used in courses that can afford to spend no more than a week on his work. (shrink)