In clinical trials, it is common practice to follow up significant interactions between the factors under investigation with subgroup analyses. Such analyses pose at least two analytical and interpretational challenges. The first challenge is that performing multiple subgroup analyses increases the likelihood of obtaining spuriously significant results. This has been acknowledged and relevant guidance exists in the medical literature. The second challenge is that the effects that are obtained at the level of subgroup are composite. This has yet to be (...) fully acknowledged and discussed in the context of medical research. This paper aims to fill this lacuna. Using a simple additive model, we use recent findings from the CHARISMA trial on the efficacy of clopidogrel in addition to aspirin in the treatment of patients at risk for atherothrombotic events to demonstrate quantitatively the composition of effects at the level of subgroups. In the simplest case of a design involving an interaction (two crossed factors, with two levels each, i.e. a 2 x 2 design), effects at the level of subgroup consist of influences that stem (i) from the incidence of the measured outcome in the study population as a whole; (ii) from the factor of interest (e.g. treatment vs. placebo); (iii) from the second factor (e.g. patient group membership); (iv) from the interaction between the two factors; and (v) from random error in the measured outcome. The value of the approach illustrated here is that it is generalizable to any research design irrespective of its complexity and that it prompts clinicians to consider the multiple causality underlying medical research findings. (shrink)

Despite the growing profile of ‘implementation science’, its status as a field of study remains ambiguous. Implementation science originates in the evidence-based movement and attempts to broaden the scope of evidence-based medicine to improve ‘clinical effectiveness’ and close the ‘implementation gap’. To achieve this agenda, implementation science draws on methodologies from the social sciences to emphasise coherence between qualitative and quantitative approaches. In so doing, we ask if this is at the expense of ignoring the dominating tendencies of the evidence-based (...) movement and consider if some of the methodologies being drawn on should be considered irreconcilable with evidence-based methodologies. (shrink)

Trait emotional intelligence concerns people’s perceptions of their emotional functioning. Two studies investigated this construct in surgeons and comparison occupations. We hypothesized that trait EI profiles would differ both within surgical specialties as well as between them and other professions. Study 1 compared the trait EI profiles of four different surgical specialties. There were no significant differences amongst these specialties or between consultant surgeons and trainees in these specialties. Accordingly, the surgical data were combined into a single target sample that (...) was compared against samples of engineers, executives and senior managers, lawyers, junior military managers, nurses, and salespeople. Surgeons scored significantly higher on global trait EI than junior military managers, but lower than executives and senior managers, salespeople, and nurses. There were no significant differences vis-à-vis engineers or lawyers. A MANOVA confirmed a similar pattern of differences in the four trait EI factors. Global trait EI scores correlated strongly with single-question measures of job satisfaction and job performance in the surgical sample. These findings suggest that interventions to optimize the trait EI profiles of surgeons can be helpful in relation to job satisfaction, job performance, and overall psychological wellbeing. (shrink)

What is the purpose of art? What drives us to make it? Why do we value it? Nick Zangwill argues that the function of art is to have certain aesthetic properties in virtue of its non-aesthetic properties, and this function arises because of the artist's insight into the nature of these dependence relations and her intention to bring them about.

A dizzying trip through the mind(s) of the provocative and influential thinker Nick Land. During the 1990s British philosopher Nick Land's unique work, variously described as “rabid nihilism,” “mad black deleuzianism,” and “cybergothic,” developed perhaps the only rigorous and culturally-engaged escape route out of the malaise of “continental philosophy” —a route that was implacably blocked by the academy. However, Land's work has continued to exert an influence, both through the British “speculative realist” philosophers who studied with him, and (...) through the many cultural producers—writers, artists, musicians, filmmakers—who have been invigorated by his uncompromising and abrasive philosophical vision. Beginning with Land's early radical rereadings of Heidegger, Nietzsche, Kant and Bataille, the volume collects together the papers, talks and articles of the mid-90s—long the subject of rumour and vague legend (including some work which has never previously appeared in print)—in which Land developed his futuristic theory-fiction of cybercapitalism gone amok; and ends with his enigmatic later writings in which Ballardian fictions, poetics, cryptography, anthropology, grammatology and the occult are smeared into unrecognisable hybrids. Fanged Noumena gives a dizzying perspective on the entire trajectory of this provocative and influential thinker's work, and has introduced his unique voice to a new generation of readers. (shrink)

Philosophers often characterize discourse in general as aiming at some sort of convergence (in beliefs, plans, dispositions, feelings, etc.), and many views about aesthetic discourse in particular affirm this thought. I argue that a convergence norm does not govern aesthetic discourse. The conversational dynamics of aesthetic discourse suggest that typical aesthetic claims have directive force. I distinguish between dynamic and illocutionary force and develop related theories of each for aesthetic discourse. I argue that the illocutionary force of aesthetic utterances is (...) typically invitational because its dynamic force is influenced by a ‘communal’ norm. I draw on dynamic pragmatics to develop a formal account of this dynamic force that explains why invitation has pride of place in aesthetic conversation. It turns out that the end of aesthetic discourse is not convergence but a distinctive form of community, a kind of harmony of individuality, that is compatible with aesthetic disagreement. If this is right, then convergence theories of aesthetic and normative discourse, and of conversation in general, need to be revised. (shrink)

The problem of free will has fascinated philosophers since ancient times: Do we have free will, or at least the kind of free will that seems necessary for moral responsibility? Does determinism - the idea that everything that happens is necessitated to happen, given the past and the laws of nature - threaten the commonly held assumption that we are indeed free and morally responsible? Although these questions have been widely discussed in the past, the present volume offers a variety (...) of new perspectives from philosophers who have made significant contributions to this debate over recent years, including Derk Pereboom, Robert Kane, Ishtiyaque Haji, Michael McKenna, John Martin Fischer, David Widerker and Saul Smilansky. The emphasis in these essays is not merely on free will, but on allied notions such as moral responsibility, moral obligation, fairness and meaningfulness, and on whether any room can be made for these notions in a deterministic or an indeterministic universe. (shrink)

I argue that an evaluational conception of love collides with the way we value love. That way allows that love has causes, but not reasons, and it recognizes and celebrates a love that refuses to justify itself. Love has unjustified selectivity, due to its arbitrary causes. That imposes a non-tradability norm. A love for reasons, rational love or evaluational love would be propositional, and it therefore allows that the people we love are tradable commodities. A moralized conception of love is (...) no less committed to treating those we love as tradable commodities; it is just that they are tradable moral commodities. An evaluative criterion of adequacy, I suggest, encourages the opposite view ? a non-rational and non-evaluational concept of love. Such a love can set up partial obligations, which may even demand that one sacrifice one's life. Only a love that has causes but not reasons can have the kind of value that we think love has, and thus it would only be rational to pursue and foster such a love. (shrink)

"Ethical thought has no chance of being everything it seems." Bernard Williams offered this cryptic remark in Ethics and the Limits of Philosophy, and in this chapter I argue that understanding it is the key to understanding Williams' skepticism about moral theory and about systematization in ethics. The difficulty for moral philosophy, Williams believed, is that ethics looks one way to embodied, active agents, but looks entirely different when considered from the standpoint of theory. This, in turn, means that following (...) a moral theory is a sure route to practical alienation. I argue that once we see it for what it is, we can see that Williams own skepticism undermines his later attempts to vindicate Truthfulness. Moreover, given the pervasiveness of reflective practical alienation in ordinary life, it leaves us with a difficult question: what would a non-alienated ethical existence even look like for us? (shrink)

In the Aristotelian tradition, the psychological difference between virtue and continence is commonly understood in terms of inner harmony versus inner conflict. Virtuous agents experience inner harmony between feeling and action because they do not care to do other than what their circumstances call for, whereas continent agents feel conflicted about doing what is called for because of competing concerns. Critics of this view argue, however, that when the circumstances require sacrificing something of genuine value, virtuous agents can indeed feel (...) conflicted about acting well. But if this is so, what differentiates virtuous from merely continent agency? This essay argues that the traditional distinction conflates two aspects of virtue as well as two species of continence. And distinguishing between them provides resources for making sense of the complex relationship between inner conflict and good moral agency. (shrink)

Analytic moral philosophers have generally failed to engage in any substantial way with the cultural history of morality. This is a shame, because a genealogy of morals can help us accomplish two important tasks. First, a genealogy can form the basis of an epistemological project, one that seeks to establish the epistemic status of our beliefs or values. Second, a genealogy can provide us with functional understanding, since a history of our beliefs, values or institutions can reveal some inherent dynamic (...) or pattern which may be problematically obscured from our view. In this paper, I try to make good on these claims by offering a sketchy genealogy of emancipatory values, or values which call for the liberation of persons from systems of dominance and oppression. The real history of these values, I argue, is both epistemologically vindicatory and functionally enlightening. (shrink)

Tasler teaches readers how to thrive when faced with difficult choices, provides a clear understanding of why you make the choices you do, and suggests the tools to make those decision change your business and your life.

We begin by showing that every theory of the value of uncertain prospects must have one of three unpalatable properties. _Reckless_ theories recommend giving up a sure thing, no matter how good, for an arbitrarily tiny chance of enormous gain; _timid_ theories permit passing up an arbitrarily large potential gain to prevent a tiny increase in risk; _non-transitive_ theories deny the principle that, if A is better than B and B is better than C, then A must be better than (...) C. Having set up this trilemma, we study its horns. Non-transitivity has been much discussed; we focus on drawing out the costs and benefits of recklessness and timidity when it comes to axiology, decision theory, and normative uncertainty. (shrink)

To what extent should we use technological advances to try to make better human beings? Leading philosophers debate the possibility of enhancing human cognition, mood, personality, and physical performance, and controlling aging. Would this take us beyond the bounds of human nature? These are questions that need to be answered now.

Self–other discrimination was investigated with point-light displays in which actions were presented with or without additional auditory information. Participants first executed different actions in time with music. In two subsequent experiments, they watched point-light displays of their own or another participant’s recorded actions, and were asked to identify the agent . Manipulations were applied to the visual information and to the auditory information . Results indicate that self-recognition was better than chance in all conditions and was highest when observing relatively (...) unconstrained patterns of movement. Auditory information did not increase accuracy even with the most ambiguous visual displays, suggesting that judgments of agent identity depend much more on motor cues than on auditory or audiovisual information. (shrink)

This article responds to recent debates in critical algorithm studies about the significance of the term “algorithm.” Where some have suggested that critical scholars should align their use of the term with its common definition in professional computer science, I argue that we should instead approach algorithms as “multiples”—unstable objects that are enacted through the varied practices that people use to engage with them, including the practices of “outsider” researchers. This approach builds on the work of Laura Devendorf, Elizabeth Goodman, (...) and Annemarie Mol. Different ways of enacting algorithms foreground certain issues while occluding others: computer scientists enact algorithms as conceptual objects indifferent to implementation details, while calls for accountability enact algorithms as closed boxes to be opened. I propose that critical researchers might seek to enact algorithms ethnographically, seeing them as heterogeneous and diffuse sociotechnical systems, rather than rigidly constrained and procedural formulas. To do so, I suggest thinking of algorithms not “in” culture, as the event occasioning this essay was titled, but “as” culture: part of broad patterns of meaning and practice that can be engaged with empirically. I offer a set of practical tactics for the ethnographic enactment of algorithmic systems, which do not depend on pinning down a singular “algorithm” or achieving “access,” but which rather work from the partial and mobile position of an outsider. (shrink)

Tasler teaches readers how to thrive when faced with difficult choices, provides a clear understanding of why you make the choices you do, and suggests the tools to make those decision change your business and your life.

Our paradigms of aesthetic value condition the philosophical questions we pose and hope to answer about it. Theories of aesthetic value are typically individualistic, in the sense that the paradigms they are designed to capture, and the questions to which they are offered as answers, center the individual’s engagement with aesthetic value. Here I offer some considerations that suggest that such individualism is a mistake and sketch a communitarian way of posing and answering questions about the nature of aesthetic value.

The clash between atheism and religion has become the defining battle of the 21st century. Books on and about atheism retain high profile and popularity, and atheist movements on both sides of the Atlantic capture headlines with high-profile campaigns and adverts. However, very little has been written on the history of atheism, and this book fills that conspicuous gap. Instead of treating atheism just as a philosophical or scientific idea about the non-existence of God, Atheists: The Origin of the Species (...) places the movement in its proper social and political context. Because atheism in Europe developed in reaction to the Christianity that dominated the continent's intellectual, social and political life, it adopted, adapted and reacted against its institutions as well as its ideas. Accordingly, the history of atheism is as much about social and political movements as it is scientific or philosophical ideas."--book jacket. (shrink)

A theory of aesthetic value should explain what makes aesthetic value good. Current views about what makes aesthetic value good privilege the individual’s encounter with aesthetic value—listening to music, reading a novel, writing a poem, or viewing a painting. What makes aesthetic value good is its benefit to the individual appreciator. But engagement with aesthetic value is often a social, participatory matter: sharing and discussing aesthetic goods, imitating aesthetic agents, dancing, cooking, dining, or making music together. This article argues that (...) we should understand aesthetic value in a way that centers these social forms of aesthetic engagement. To this end, the article argues that there is a social practice of aesthetic valuing, characterized as a participatory practice governed by the value of aesthetic community, which engages us in the social development of our capacities for discretionary valuing and volitional openness. Current theories of aesthetic value have trouble capturing the character of the practice of aesthetic valuing, and this motivates a novel communitarian theory of aesthetic value: aesthetic value is what is worthy of engagement in the social practice of aesthetic valuing. (shrink)

Li Da (1890–1966) was one of China’s most important Marxist intellectuals and a founding member of the Chinese Communist Party. He played a major role in the introduction of Marxist philosophy and theory to China and in its dissemination among Chinese revolutionaries. His works are now regarded in China as classics of Marxist philosophy, and he is numbered among the ten most influential Chinese intellectuals of this century. Yet, almost nothing has been written about Li Da in English.In this seminal (...) study, Knight analyzes Li Da’s contribution to the flowering of Marxist philosophy and theory in China, examining Li’s writings and placing them in the context of the Marxist tradition. Knight also explores Li Da’s philosophical relationship with Mao Zedong, who was heavily influenced by Li’s works. Through the lens of Li’s life and thought, this book provides a detailed assessment of the introduction and dissemination of Marxist philosophy and social theory in China. (shrink)

Prior research found correlations between reflection test performance and philosophical tendencies among laypeople. In two large studies (total N = 1299)—one pre-registered—many of these correlations were replicated in a sample that included both laypeople and philosophers. For example, reflection test performance predicted preferring atheism over theism and instrumental harm over harm avoidance on the trolley problem. However, most reflection-philosophy correlations were undetected when controlling for other factors such as numeracy, preferences for open-minded thinking, personality, philosophical training, age, and gender. Nonetheless, (...) some correlations between reflection and philosophical views survived this multivariate analysis and were only partially confounded with either education or self-reported reasoning preferences. Unreflective thinking still predicted believing in God whereas reflective thinking still predicted believing that (a) proper names like ‘Santa’ do not necessarily refer to entities that actually exist and (b) science does reveal the fundamental nature of the world. So some robust relationships between reflection and philosophical tendencies were detected even among philosophers, and yet there was clearly more to the link between reflection and philosophy. To this end, demographic and metaphilosophical hypotheses are considered. (shrink)

§1.1 What m otivated the perpetrators of the holocaust? Christopher Browning and Daniel Goldhagen differ in their analysis of Reserve Police Battalion 101 (Browning 1992, Goldhagen 1996). The battalion consisted of around 500 ‘ordinary’ Germ ans who, during the period 1942-44, killed around 40,000 Jews and who deported as m any to the death cam ps. Browning and Goldhagen differ over the m otivation wit h which the m en killed. I want to com m ent on a central aspect (...) of this debate. (shrink)

A brief overview of work on street art and graffiti.

Views on addiction are often polarised - either addiction is a matter of choice, or addicts simply can't help themselves. But perhaps addiction falls between the two? This book contains views from philosophy, neuroscience, psychiatry, psychology, and the law exploring this middle ground between free choice and no choice.

Why the West is different -- Religiously secular: the making of America -- Trouble with the law: Magna Carta and the limits of the law -- christianity and democracy: friend and foe -- Saving humanism from the humanists -- Christianity and atheism: a family affair -- The accidental midwife: the emergence of a scientific culture -- No doubts as to how one ought to act: Darwin's doubts and his faith -- The religion of Christianity and the religion of human rights (...) -- The secular self -- Always with you: capital, inequality and the absence of war -- The rise of Christian populism -- Not just mere rhetoric: the word in U.S. politics. (shrink)