There is a lack of consensus on whether the derivation and use of human embryonic stem cells (hESCs) from embryos remaining after infertility treatment morally require the informed consent of third-party gamete donors who contributed to the creation of the embryos. The principal guidelines for oversight and funding of hESC research in the United States make minimal or no demands for consent from gamete donors. In this article, I consider the arguments supporting and opposing gamete donor consent for hESC research (...) and embryo research more broadly. I argue that it is not morally permissible to use leftover embryos in research without the informed consent of gamete donors, and that we should place restrictions on the use of existing hESC lines that may have been derived without informed consent. While the standard argument for this position relies on an appeal to gamete donors’ interest in controlling what happens with their genetic material, I identify shortcomings with the standard approach and seek instead to locate the deeper moral foundations for gamete donor consent in rights to bodily integrity. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)

Detailed studies of people who have experienced the Capgras delusion (the delusion that certain other people, usually close relatives, have been replaced by impostors) have led to advances in constructing an account which can deal with the basic symptomatology, testing alternative possibilities, generating and testing non‐trivial predictions, and broadening the scope of the basic account to encompass other delusions. This paper outlines these developments. It uses them to explore implications for understanding the formation and maintenance of beliefs, and to discuss (...) basic principles of what has come to be known as cognitive neuropsychiatry. (shrink)

What is the function of cognition? On one influential account, cognition evolved to co-ordinate behaviour with environmental change or complexity. Liberal interpretations of this view ascribe cognition to an extraordinarily broad set of biological systems—even bacteria, which modulate their activity in response to salient external cues, would seem to qualify as cognitive agents. However, equating cognition with adaptive flexibility per se glosses over important distinctions in the way biological organisms deal with environmental complexity. Drawing on contemporary advances in theoretical biology (...) and computational neuroscience, we cash these distinctions out in terms of different kinds of generative models, and the representational and uncertainty-resolving capacities they afford. This analysis leads us to propose a formal criterion for delineating cognition from other, more pervasive forms of adaptive plasticity. On this view, biological cognition is rooted in a particular kind of functional organisation; namely, that which enables the agent to detach from the present and engage in counterfactual inference. (shrink)

The God of Israel in the theology of Robert Jenson -- Jenson's hermeneutics -- Godd in Israel's life -- The God of Israel and Jesus -- The God of Israel and the Trinity -- The God of Israel, the People of God, and the Eschaton -- The identity of the one and triune God of Israel -- Jenson, the God of Israel, and non-supersessionist theology.

Charles Sanders Peirce famously claimed that ‘The opinion which is fated to be ultimately agreed to by all who investigate is what we mean by the truth’ (W3: 273). Christopher Hookway has argued for a highly distinctive interpretation of this claim in terms of speech-acts and the normative commitments we incur in performing them. So-construed, Peirce’s conception of truth is difficult to compare with standard theories of the concept, which tend to focus instead upon some property or feature that is (...) shared by all and only true propositions, and with whether or not that property is substantive or metaphysically significant. This paper examines Hookway’s interpretation of Peirce’s conception of truth in an effort to clarify its position in logical space. It then raises some difficulties for the way Hookway tries to accommodate Peirce’s remarks about the special status of assertion and belief in science. (shrink)

Circumscribed delusional beliefs can follow brain injury. We suggest that these involve anomalous perceptual experiences created by a deficit to the person's perceptual system, and misinterpretation of these experiences due to biased reasoning. We use the Capgras delusion (the claim that one or more of one's close relatives has been replaced by an exact replica or impostor) to illustrate this argument. Our account maintains that people voicing this delusion suffer an impairment that leads to faces being perceived as drained of (...) their normal affective significance, and an additional reasoning bias that leads them to put greater weight on forming beliefs that are observationally adequate rather than beliefs that are a conservative extension of their existing stock. We show how this position can integrate issues involved in the philosophy and psychology of belief, and examine the scope for mutually beneficial interaction. (shrink)

In his influential book Truth, Paul Horwich deploys a philosophical method focused on linguistic usage, that is, on the function(s) the concept of truth serves in actual discourse. In doing so Horwich eschews abstract metaphysics, arguing that metaphysical or ontological conceptions of truth rest on basic misconceptions. From this description, one might reasonably expect Horwich's book to have drawn inspiration from, or even embodied philosophical pragmatism of some kind. Unfortunately Horwich relies upon Russell's tired caricature of pragmatism about truth (''p' (...) is true if and only if it is useful to believe p' (Ibid., p. 34, p. 47)), and as a result underestimates the challenge it poses to Minimalism. This paper develops a pragmatist critique of minimalism that focuses on the seemingly central, plausibly constitutive role played by the concept of truth in the speech-act of assertion. The critique suggests that Horwich's Minimalism does not and cannot accomplish its stated goal of explaining all of the facts involving truth. Indeed, the kind of thorough-going deflationism sought by Horwich and others (including pragmatist sympathizer Bob Brandom) is incompatible with an adequate account of assertion, and perhaps other concepts (like belief, judgement and inquiry) as well. (shrink)

On June 13, 2013, the Supreme Court placed its imprimatur on a principle that has been gathering force within patent law for several decades: human beings constitute unpatentable subject matter. In Association for Molecular Pathology v. Myriad Genetics, Inc., the court answered the question it had posed itself–“Are human genes patentable?”–decisively in the negative. This legal result was predictable, given a careful reading of the entrails of judicial decisions, congressional bills, executive branch pronouncements, and decisions in other countries about patents (...) claiming human‐related inventions, all of which have echoed the spirit of the Thirteenth Amendment by proscribing property rights‐including intellectual property rights‐in human beings. To understand how patent law has evolved toward this result, one may trace the legal treatment of patents claiming human embryonic stem cells, chemical products of human physiology, human thought, and now, human genes. Woven together, these strands of evidence led inexorably toward the ultimate rejection of human gene patents by the Supreme Court. (shrink)

Some cases of prosopagnosia involve a highly circumscribed loss of A-consciousness. When seen in this way they offer further support for the arguments made in Block's target article.

This study focuses on concepts and, ultimately, their possible implementation in brains. Especially salient is analysis of Jerry Fodor's work. The view of concepts found therein is one where many of both are "simple": to be ascribed or to token most concepts doesn't require being ascribed or tokening any other concepts, and most symbols lack "parts" which are themselves symbols. This is, I think, a very popular, and mistaken, view. ;In chapter 1, I argue that Fodor's theory of content is, (...) contra its goals, neither naturalistic nor atomistic. A deep mistake undermines both, viz. that there's no way to individuate a mental symbol non-semantically. This leads to chapter 2, where I explore the much neglected notion of Mentalese syntax. I argue that there are three possible principles of syntactic type individuation, and that these turn out not only to be incompatible but also inadequate for a "language of thought." I conclude that the idea of simple mental symbols is in trouble. ;This then allows me to argue in chapter 3 that we don't have to fear intentional holism , which sanctions the prevalence of complex concepts. I next sketch, in chapter 4, the sort of complex symbols needed to implement complex concepts. The chapter's bulk consists in an empirical argument for the complexity view via seven domains of current cognitive science, including concept context dependency, typicality effects, association, and reasoning. ;Chapter 5 concludes by exploring connectionism. I argue that, despite problems, connectionism seems on the right track in a way that Fodor's computationalism isn't. For example, it's more explicitly brain-like; in dropping the idea of mental computation over symbols it's free from the syntax problems of chapter 2; and, most important, it's highly compatible with the complexity view, which best characterized the cognitive processes of chapter 4. (shrink)

In Act 1 scene iv of Macbeth, Duncan reflects that: 'There's no art to find the mind's construction in the face'. In contrast, the claim that Andy Young sets out in this book is that we are now developing a science of face perception which can indeed shed light on certain aspects of mentallife. Face and Mind consists of a series of seminal research and review papers on face perception published by the author and his colleagues over the last 12 (...) years. A comprehensive introductory chapter, written especially for this volume, serves to draw together the various themes explored in thedifferent contributions. The book examines the question of how faces are special, in terms of their social, biological, and theoretical roles. In particular, Face and Mind seeks to determine what our understanding of the face can tell us about the human brain. It discusses the evidence for anevolved neural substrate for face perception, and the question of whether we are innately predisposed to recognise faces, to find them attractive, and to decode the many social signals they give us. The ability of the human brain to process and remember the many different faces that we see andsubsequently recall is analysed. Young includes detailed studies of the types of impairment to face perception which can follow brain injury or psychiatric illness, and uses them to address these questions, as well as other issues of high intrinsic and interdisciplinary interest. These include theextent to which our mental lives result from the operation of discrete components devoted to different purposes, the differences between conscious and non-conscious processes, and how we use evidence to support our beliefs about the world. Because of the huge variety of social signals read from theface, it can offer unique theoretical and philosophical insights into these questions. This fascinating book will be of interest not only to psychologists and neuropsychologists working in the field of visual perception, but to cognitive scientists generally. It provides an excellent summary ofthe most important theorietical and empirical work done on face perception in recent years, and as such will be of interest to advanced undergraduate and post-graduate students in psychology, philosophy, and cognitive science. (shrink)

Between inventing the concept of a universal computer in 1936 and breaking the German Enigma code during World War II, Alan Turing, the British founder of computer science and artificial intelligence, came to Princeton University to study mathematical logic. Some of the greatest logicians in the world--including Alonzo Church, Kurt Gödel, John von Neumann, and Stephen Kleene--were at Princeton in the 1930s, and they were working on ideas that would lay the groundwork for what would become known as computer science. (...) Though less well known than his other work, Turing's 1938 Princeton PhD thesis, "Systems of Logic Based on Ordinals," which includes his notion of an oracle machine, has had a lasting influence on computer science and mathematics. This book presents a facsimile of the original typescript of the thesis along with essays by Andrew Appel and Solomon Feferman that explain its still-unfolding significance. A work of philosophy as well as mathematics, Turing's thesis envisions a practical goal--a logical system to formalize mathematical proofs so they can be checked mechanically. If every step of a theorem could be verified mechanically, the burden on intuition would be limited to the axioms. Turing's point, as Appel writes, is that "mathematical reasoning can be done, and should be done, in mechanizable formal logic." Turing's vision of "constructive systems of logic for practical use" has become reality: in the twenty-first century, automated "formal methods" are now routine. Presented here in its original form, this fascinating thesis is one of the key documents in the history of mathematics and computer science. (shrink)

Constructive theories usually have interesting metamathematical properties where explicit witnesses can be extracted from proofs of existential sentences. For relational theories, probably the most natural of these is the existence property, EP, sometimes referred to as the set existence property. This states that whenever ϕϕ is provable, there is a formula χχ such that ϕ∧χϕ∧χ is provable. It has been known since the 80s that EP holds for some intuitionistic set theories and yet fails for IZF. Despite this, it has (...) remained open until now whether EP holds for the most well known constructive set theory, CZF. In this paper we show that EP fails for CZF. (shrink)

This article gives an overview of what we can learn about face perception from studying its disorders. The term “disorders” is broadly interpreted to include acquired brain injury and disease, neurodevelopmental differences, and neuropsychiatric problems. The article examines the reasons for various opinions about what can be learnt from disorders, ranging from the entire spectrum from “nothing that isn't misleading” to “everything worth knowing.” Cognitive neuropsychology typically operates in a unique way, in which the emphasis is on detailed analysis of (...) individual patients with theoretically interesting impairments. The article then highlights a number of the assumptions that get made, explains why things are often complicated, and emphasizes the value of a pragmatic “converging operations” approach in which evidence from disorders of face perception is brought together with other sources of data and theory. (shrink)

Introduction: The aim of this study was to investigate time-trial (TT) performance in the presence of one competitor and in a group with competitors of various abilities. Methods: In a randomized order, 24 participants performed a 5-km cycling TT individually (IND), with one similarly matched participant (1v1), and in a group of four participants (GRP). For the GRP session, two pairs of matched participants from the 1v1 session were used. Pairs were selected so that TT duration was considered either inferior (...) (INF) or superior (SUP) compared to the other pair of participants. Results: Overall, TT duration (P = 0.86, ηp2 < 0.01) was not different between conditions, whilst heart rate (HR) was significantly greater in GRP compared to IND (P < 0.01, ηp2 = 0.16). For INF, a large effect size for both mean power (P = 0.07, ηp2 = 0.15) and HR (P = 0.05, ηp2 = 0.16), indicates greatest effort in GRP. Pacing behaviour was affected by competition but similar in 1v1 and GRP for SUP, whilst large effect sizes indicate an increased power output in the initial 750-m for INF in GRP. Additionally, for INF, there was a significant correlation with ego orientation for an increase in TT duration between the GRP session and both the IND (r = 0.43, P = 0.04) and 1v1 (r = 0.54, P = 0.01) sessions. Conclusion: For INF participants, intensity was increased when competing in GRP. Yet, the presence of the SUP competitors resulted in lesser performance improvements for ego oriented INF participants. These findings demonstrate that consideration should be given to the ability of competitors in a group setting to provide adequate motivation. (shrink)

This article aims to supplement our understanding of later developments within European universities, that is, Scholastic thought, by attending to how certain pre-Scholastics, namely, Peter Abelard and other twelfth-century philosophers, thought about artifacts and social constructions more generally. It focuses on the treatment of artifacts that can be cobbled together out of Abelard’s Dialectica. The article argues that Abelard attempts to sharply distinguish the world of things from the world of human-made objects. This is most apparent in his treatment of (...) creation and human acts of making. Yet there are places in his thought where we see some hesitancy. Many of Abelard’s peers seem to have drawn on the reasons why Abelard hesitates, and they blur the line between human-made objects such as houses and substances such as rocks and humans. Others seem to go further than Abelard—perhaps inspired by some of the thoughts that Abelard also entertains about social constructions such as days and speeches—and assert that even houses are merely convenient fictions. (shrink)

Anne Conway (1631–1679) is sometimes said to be a Monist. I present several kinds of Monism and then investigate whether any of these adequately capture Conway’s theory of substance and individuals. I outline Conway’s reasons for postulating that there are three irreducibly distinct kinds of essence or substance, which by itself demonstrates that she is not an unrestricted Token Monist. I then examine her various remarks about created substance, which she sometimes refers to as “a creature” and other times as (...) “creatures.” Here I argue that, while the texts are ambiguous, there are compelling reasons—especially given her views about salvation and justice—to believe that she is merely a Type Monist at the level of created substances. I then examine two theses that result from her relativized Type Monism. First, there are no substantial barriers between, say, horses and humans, and thus all created things can convert into one another as they improve or regress morally. Second, there is no substantial difference between minds and bodies. I suggest that Conway’s arguments against Descartes’ Type Pluralism could easily be included as part of a more inclusive philosophy syllabus. (shrink)

Paracelsus was a transmutational alchemist: For most of his career, he believed that one metal could be turned into another. In an alchemical text, the De renovatione et restauratione, he explored the theoretical foundations of transmutation and hinted at recipes for bringing it about. He proposed that from plants, gems, metals, and minerals might be prepared a class of marvelous medicaments, which he called prima entia (first entities). Each primum ens had particular uses, but the entia were all supposed to (...) be able to revitalize the human body and cleanse it of disease. Certain entia could also transmute metals. The De renovatione et restauratione affirmed the metaphysical centrality, in goldmaking and medicine alike, not just of purification or alteration but of renewal and transformation. It expressed the author’s eschatological excitement at God’s works of wonder, whether within or above nature. (shrink)

Majority-Minority electoral districts, while increasing the number of minorities in legislatures, work to deepen divisions among racial groups, to exacerbate the systematic disadvantages of some individuals, and to impede effective representation. I examine another form of race-conscious districting that will increase marginalized minority presence in legislatures while avoiding these problems.

Many philosophers who support a four-dimensionalist metaphysics of things also conceive of experience as a state of a mind having temporal extension or existing as a momentary feature of the dimension of time. This essay shows that such a strict four-dimensionalism — suggested in works by D. M. Armstrong, Mark Heller, and David Lewis — cannot be correct, since it cannot allow for the passing of time that is essential to awareness. The argument demonstrates that the positing of any temporal (...) process at all must compromise the strict four-dimensionalist view of the temporality of experience. This is not to say that the traditional endurantist view is left wholeheartedly endorsed. As I point out, this traditional view makes several questionable claims of its own that must be carefully scrutinized. Still, the criticism of the strict four-dimensionalist ontology indicates a direction to be followed in developing a successful metaphysics of experience. (shrink)