New technologies coupled with high energy prices, a desire for energy independence, and cleaner energy, have led to many energy companies investing large amounts of capital into rural places. In the last decade, along with solar and wind, unconventional shale oil and gas production has risen steeply throughout the United States boosting economic growth and stimulating wealth creation in many communities. Because farmers own or operate over half of rural lands in the lower 48 states, the possibility is high (...) for shale development to contribute to the financial well-being of farmers with land in shale regions. However, by focusing on the large royalties of some landowners, environmental and social risks that farmers encounter may be overlooked. To address the gap of farmer impacts, I examine the experiences and perceptions of crop farm owners who reside in two established shale plays: the Bakken region in North Dakota and the Marcellus region in Pennsylvania and in one emerging shale play: the New Albany region in Southern Illinois. I survey farm owners of both large and small crop farms, who farm a variety of crops both by conventional and organic methods. By having such a diverse sample of farm owners in both established shale plays and emerging shale plays, I explore how farmers’ experiences differ with respect to their finances and investments, environmental degradation as well as how their perceptions of trust in oil and gas companies and community rifts differ. (shrink)

This study was designed to determine the quality of service through the evaluation of hospitalized patients. An analysis of hospitalized patients’ subjective feelings towards service quality was carried out, in the context of the application of the SERVQUAL method. The pilot study was conducted in a Silesian hospital in a group of 29 young patients diagnosed with kidney disease. The study used a standard sheet of 22 SERVQUAL statements and an analysis of the significance of the 5 areas (...) of quality material important for the patient. According to the respondents, the most important of the 5 features that influence the quality of life is the ability of the ward staff to provide adequate medical services The least important were the aesthetics and ergonomics of rooms. Service quality gaps were seen in all the five dimensions as well as in the overall service quality. Hence, the following conclusions could be made: 1. The SERVQUAL method helps to identify discrepancies between perceptions of patients’ expectations in all the dimensions of quality of medical services. 2. For patients, the least important is the material dimension, whereas the one most affecting them is the dimension associated with the reliability of medical services. 3. An improvement of the level of satisfaction with the quality of medical services requires proper planning and effectiveness of implementation of health care services. 4. Research should be conducted on a larger population of patients. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 111 A Critical History of Western Philosophy. Edited by D. J. O'Connor. (Giencoe: The Free Press, 1964. Pp. x + 604. $9.95.) Professor O'Connor and his collaborators have, in their Critical History of Western Philosophy, produced a novel and, to my mind, unusually good textbook. The volume, which is designed primarily as a text for undergraduate philosophy students, is made up of twentynine essays, each one devoted (...) to a major philosopher in the Western tradition--or, in a few instances, to a philosophical movement. The essays (29) have been written by 25 persons and each includes a sho[t biography of the philosopher under discussion followed by a fairly lengthy presentation and critical analysis of his philosophical views, with particular attention to metaphysics and epistemology. The contributors to the volume are mostly British, although they include a sprinkling of Americans and one Norwegian. This reviewer was pleased to note several representatives from the new British universities among them. The philosophers selected for study in the book have, I believe, been well chosen. The standard greats, from Plato through Hegel, are all included. In going beyond this repertory, the editor has used good judgment in his selections. It is always possible to question individual choices, but this proves only that different editors would produce different books. In the present ease, it might be argued that in making his selections from the seco~td rank the editor showed some partiality in favor of the insular over the continental tradition. There is, however, a quite reasonable reply to such an objection: that the selection of philosophers was determined by the purpose for which the book was designed--namely, to serve as a text for students in British and American universities. One of the problems in a book of this type, containing essays by more than two dozen writers, is to maintain a measure of uniformity--of style, of method, of complexity, and so on. Once again, the result seems to me to be on the whole successful. The essays in general are clearly written; they approach their subjects at a level that avoids oversimplification on the one hand, yet should almost always be intelligible to the average, studious undergraduate on the other. One notes an occasional idiosyneracy of interpretation; however, because the essays are written by different people, such peculiarities do not repeat themselves long enough to become an annoyance. Indeed, if I have any criticism to make on this point, it would be that the editor has been too successful in achieving uniformity in his essays. The result is writing that strikes me as being somewhat on the bland side, as though each of the contributors had made a conscious effort to produce an essay indistinguishable in anything but its content from all the others. I shall not attempt in this review to discuss critically the separate essays contained in the book. That would be an endless task, of dubious value. Instead I should like to raise two quite general issues that seem pertinent to the book as a whole. The first concerns the editor's statement, in the Preface, of the purposes of the book: In his words: "The writers have tried to do two things: (1) to explain the principal philosophical concepts and theories in the order in which they were developed; and (2) to evaluate and criticize them in the light of contemporary knowledge and to bring out whatever may be in them that is of permanent philosophical interest." The first of these two aims raises no questions; the second, however, is a different matter. I am puzzled, specifically, by its first clause, that the essays will evaluate and criticize past philosophical theories in the light of contemporary knowledge. Is this really a meaningful task? If the book were a history of science rather than of philosophy, I could understand how the writers might go about criticizing earlier theories in the light of contemporary knowledge. In philosophy, however, the situation is quite different. On what contemporary knowledge can one base his criticisms? Most of us recognize the prodigious advances that have been made during our century in the accumulation of empirical knowledge. If by contemporary... (shrink)

Alcohol and other drug-related stigma is a growing concern. Many organizations have called for a reduction in such stigma through law reform, but there is little sense of how, precisely, this might be achieved. This paper reports on a new method to examine the relationship between stigma and the law and establish a framework that can guide and inform future law reform efforts.

Next SectionObjectives To evaluate the adequacy of paediatric informed consent and its augmentation by a supplemental computer-based module in paediatric endoscopy. Methods The Consent-20 instrument was developed and piloted on 47 subjects. Subsequently, parents of 101 children undergoing first-time, diagnostic upper endoscopy performed under moderate IV sedation were prospectively and consecutively, blinded, randomised and enrolled into two groups that received either standard form-based informed consent or standard form-based informed consent plus a commercial (Emmi Solutions, Inc, Chicago, Il), sixth grade level, (...) interactive learning module (electronic assisted consent). Anonymously and electronically, the subjects' anxiety (State Trait Anxiety Inventory), satisfaction (Modified Group Health Association of America), number of questions asked, and attainment of informed consent were assessed (Consent-20). Statistics were calculated using t test, paired t test, and Mann Whitney tests. Results The ability to achieve informed consent, as measured by the new instrument, was 10% in the control form-based consent group and 33% in the electronic assisted consent group (p<0.0001). Electronically assisting form-based informed consent did not alter secondary outcome measures of subject satisfaction, anxiety or number of questions asked in a paediatric endoscopy unit. Conclusions This study demonstrates the limitations of form-based informed consent methods for paediatric endoscopy. It also shows that even when necessary information was repeated electronically in a comprehensive and standardised video, informed consent as measured by our instrument was incompletely achieved. The supplemental information did, however, significantly improve understanding in a manner that did not negatively impact workflow, subject anxiety or subject satisfaction. Additional study of informed consent is required. Clinical trial registration number ClinicalTrials.gov Identifier NCT00899392. (shrink)

We have achieved a residue‐level resolution of genetic interaction mapping – a technique that measures how the function of one gene is affected by the alteration of a second gene – by analyzing point mutations. Here, we describe how to interpret point mutant genetic interactions, and outline key applications for the approach, including interrogation of protein interaction interfaces and active sites, and examination of post‐translational modifications. Genetic interaction analysis has proven effective for characterizing cellular processes; however, to date, systematic high‐throughput (...) genetic interaction screens have relied on gene deletions or knockdowns, which limits the resolution of gene function analysis and poses problems for multifunctional genes. Our point mutant approach addresses these issues, and further provides a tool for in vivo structure‐function analysis that complements traditional biophysical methods. We also discuss the potential for genetic interaction mapping of point mutations in human cells and its application to personalized medicine. (shrink)

Anna J Dare,1 Anthony RJ Phillips,1–3 Michael Chu,1 Anthony JR Hickey,2 Adam SJR Bartlett1–31Department of Surgery, 2Maurice Wilkins Centre for Biodiscovery, University of Auckland, Auckland, New Zealand; 3New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New ZealandBackground: Hepatic steatosis is increasingly encountered among organ donors. Currently, there is no consensus guideline as to the type or degree of donor steatosis considered acceptable for liver transplantation, and little is known about local practices in this area. The aim of this survey (...) was to evaluate current clinical practices amongst liver transplant surgeons in Australia and New Zealand in the evaluation and use of steatotic donor livers in LT.Methods: An anonymous online twelve-question survey was emailed to all practicing LT surgeons in ANZ in January 2010.Results: The response rate was 83%. Estimated prevalence of steatosis in donor livers was between 40% and 60%. In determining suitability for LT, 90% of respondents reported rejecting organs with "severe" steatosis based on visual and palpation grounds alone. A total of 68% sought further histological assessment if the donor liver looked bad and there were risk factors for steatosis. The majority of respondents performed only one biopsy of the liver, using hematoxylin and eosin staining for fat assessment. There was wide variation in the upper limit of steatosis considered to be acceptable for LT. A total of 21% of respondents still considered microvesicular steatosis a risk factor for primary graft nonfunction.Conclusion: This survey highlights the significant variation in the appraisal and use of steatotic grafts by LT surgeons in ANZ. Accurate evaluation and judicious use of mild and moderately steatotic grafts is required if we are to utilize the available donor pool best.Keywords: liver transplantation, steatosis, fatty liver, organ donors. (shrink)

This essay aims to show how feminist theoretical and practical perspectives have enriched and deepened debate about moral and social issues generated by the proliferation and commodification of new reproductive techniques. It evaluates alternative feminist appraisals beginning with the first group to organize a collective response to the medicalization of infertility and explores several weaknesses working within their assessment: objectification of infertile women, naturalizing constructions of motherhood, hostility to technology, and an overly simplistic conception of power relations. Next, it shows (...) how subsequent feminists have reframed the issues to overcome these weaknesses, drawing on themes prominent in recent theoretical debates: the need to reclaim women's agency, to revalue mothering, and to reappraise power relations. Lastly, it weighs the prospects for a collaborative politics that is sensitive to the social marginalization of vulnerable women and suggests practical strategies for responding to mounting pressures to procreate at any price. (shrink)

This forward-thinking collection presents new work that looks beyond the division between the analytic and continental philosophical traditions—one that has long caused dissension, mutual distrust, and institutional barriers to the development of common concerns and problems. Rather than rehearsing the causes of the divide, contributors draw upon the problems, methods, and results of both traditions to show what post-divide philosophical work looks like in practice. Ranging from metaphysics and philosophy of mind to political philosophy and ethics, the papers gathered (...) here bring into mutual dialogue a wide range of recent and contemporary thinkers, and confront leading problems common to both traditions, including methodology, ontology, meaning, truth, values, and personhood. Collectively, these essays show that it is already possible to foresee a future for philosophical thought and practice no longer determined neither as "analytic" nor as "continental," but, instead, as a pluralistic synthesis of what is best in both traditions. The new work assembled here shows how the problems, projects, and ambitions of twentieth-century philosophy are already being taken up and productively transformed to produce new insights, questions, and methods for philosophy today. (shrink)

Besides sensory characteristics of food, food-evoked emotion is a crucial factor in predicting consumer’s food preference and therefore in developing new products. Many measures have been developed to assess food-evoked emotions. The aim of this literature review is (i) to give an exhaustive overview of measures used in current research and (ii) to categorize these methods along measurement level (physiological, behavioral, and cognitive) and emotional processing level (unconscious sensory, perceptual / early cognitive, and conscious / decision making) level. This 3x3 (...) categorization may help researchers to compile a set of complementary measures (‘toolbox’) for their studies. We included 101 peer-reviewed articles that evaluate consumer’s emotions and were published between 1997 to 2016, providing us with 59 different measures. More than 60% of these measures are based on self-reported, subjective ratings and questionnaires (cognitive measurement level) and assess the conscious / decision-making level of emotional processing. This multitude of measures and their overrepresentation in a single category hinders the comparison of results across studies and building a complete multi-faceted picture of food-evoked emotions. We recommend (1) to use widely applied, validated measures only, (2) to refrain from using (highly correlated) measures from the same category but use measures from different categories instead, preferably covering all three emotional processing levels, and (3) to acquire and share simultaneously collected physiological, behavioral, and cognitive datasets to improve the predictive power of food choice and other models. (shrink)

This forward-thinking collection presents new work that looks beyond the division between the analytic and continental philosophical traditions—one that has long caused dissension, mutual distrust, and institutional barriers to the development of common concerns and problems. Rather than rehearsing the causes of the divide, contributors draw upon the problems, methods, and results of both traditions to show what post-divide philosophical work looks like in practice. Ranging from metaphysics and philosophy of mind to political philosophy and ethics, the papers gathered (...) here bring into mutual dialogue a wide range of recent and contemporary thinkers, and confront leading problems common to both traditions, including methodology, ontology, meaning, truth, values, and personhood. Collectively, these essays show that it is already possible to foresee a future for philosophical thought and practice no longer determined neither as "analytic" nor as "continental," but, instead, as a pluralistic synthesis of what is best in both traditions. The new work assembled here shows how the problems, projects, and ambitions of twentieth-century philosophy are already being taken up and productively transformed to produce new insights, questions, and methods for philosophy today. (shrink)

Objective We conducted a process evaluation to (a) assess the effectiveness of a new problem-based learning curriculum designed to teach professionalism and scientific integrity to biomedical graduate students and (b) modify the course to enhance its relevance and effectiveness. The content presented realistic cases and issues in the practice of science, to promote skill development and to acculturate students to professional norms of science. Method We used 5-step Likert-scaled questions, open-ended questions, and interviews of students and facilitators to (...) assess curricular effectiveness. Results Both facilitators and students perceived course objectives were achieved. For example, respondents preferred active learning over lectures; both faculty and students perceived that the curriculum increased their understanding of norms, role obligations and responsibilities of professional scientists. They also reported an increased ability to identify ethical situations and felt that they had developed skills in moral reasoning and effective group work. Conclusions These data helped to improve course implementation and instructional material. For example, to correct a negative perception that this was an ‘ethics’ course, we redesigned case debriefing activities to reinforce learning objectives and important skills. We refined cases to be more engaging and relevant for students, and gave facilitators more specific training and resources for each case. The problem-based learning small group strategy can stimulate an environment whereby participants are more aware of ethical implications of science, and increase their socialisation and open communication about professional behaviour. (shrink)

Performative methods have been part of history of science research and education for at least three decades. Understood broadly, they cover every methodology in which a historian or philosopher of science engages in embodied interaction with sources, tools and materials that do not traditionally belong to historical research, with the aim of answering a historical research question. The question no longer appears to be whether performative methods have a place within history and philosophy of science research, but what their place (...) is, could, or should be; when and how they can and cannot be used. Because although performative methods are seen as an enrichment of the field by many, their growing popularity also raises questions: what new insights and challenges has the increased use of performative methods in the history of science brought us? How has it changed the field? Should performative research methods become a mandatory part of the training of new generations of historians of science? In this special issue, historians and philosophers of science for whom performative methods play an important role in their work reflect on these questions from their own research and teaching practices. (shrink)

Our paper contributes to the rapidly expanding body of experimental research on transformative decision making, and in the process, marks out a novel empirical interpretation for assessments of subjective value in transformative contexts. We start with a discussion of the role of subjective value in transformative decisions, and then critique extant experimental work that explores this role, with special attention to Reuter and Messerli (2018). We argue that current empirical treatments miss a crucial feature of practical deliberation manifesting across a (...) variety of everyday decisions: often, people attach more weight to decision criteria that they can know—a phenomenon known as the “evaluability bias.” In transformative contexts, if people cannot know the subjective value of an option, they are unlikely to attach it much weight. Despite this, people may care very much about such value. We then use this point to develop and present new empirical results that, in addition to supporting our concerns about evaluability bias, support the hypothesis that people care about subjective value. Our work enriches the current philosophical understanding of transformative decisions and helps to frame the emerging experimental paradigm for the empirical dimensions of the debate. (shrink)

BackgroundParent-mediated intervention has been studied in promoting skill acquisition or behavior change in the children with autism spectrum disorder. Most studies emphasize on the improvement of child’s core symptoms or maladaptive behaviors, making parental perceived competence and self-efficacy secondary. Yet, the evaluations of intervention implementation are under-reported, especially when translating such interventions into a new population or context. This research investigated the intervention implementation of a 12-week parent coaching intervention which was delivered through telehealth and tailored to Chinese population. The (...) intervention was based on the Parent-mediated Early Start Denver Model with culturally adapted lectures, manuals, and demonstration and commentary videos. This study aimed to evaluate the intervention implementation by assessing parents’ satisfaction, acceptability, appropriateness, and feasibility.MethodA randomized controlled trial was conducted with two telehealth conditions: self-directed and web+group therapy. Parents in the self-directed condition received intervention individually through the online learning platform. The web+group therapy condition navigated the same program with weekly 1.5-h group coaching sessions via videoconferencing. This mixed-methods study used a concurrent convergent design to evaluate the intervention implementation at post-intervention. The quantitative data was collected from the Program Evaluation Survey and the qualitative data was collected from five focus groups.ResultsParents in self-directed group reported significantly lower scores in total perceived competence than parents in web+group therapy condition, while there was no group difference on the total self-efficacy. Tailored feedback, demonstration and commentary videos, peer commenting, live coaching, and guided reflection were the top-five acceptable telehealth strategies that were strongly endorsed by parents. Family centered care, home-based intervention, strategies relative to daily activities, the remote learning platform, and the program-based community were elements that parents considered when evaluating the program’s appropriateness. Parent modeling, step-by-step instructions, and tailored feedback were key components in making intervention strategies feasible for parents to implement at home.ConclusionFindings indicate the application of telehealth was acceptable, appropriate, and feasible for Chinese parents. Group-based parent coaching intervention via videoconferencing could be a promising home-based service model to increase parental perceived competence. A large-scale RCT is needed to investigate the effectiveness of group-based PMI via telehealth. (shrink)

BackgroundThere are limited sensitive evaluation methods to distinguish people’s symptoms of peripheral fatigue and central fatigue simultaneously. The purpose of this study is to identify and evaluate them after acute exercise with a simple and practical scale.MethodsThe initial scale was built through a literature review, experts and athlete population survey, and a small sample pre-survey. Randomly selected 1,506 students were evaluated with the initial scale after exercise. Subjective fatigue self-assessments were completed at the same time.ResultsThe Acute Exercise-Induced Fatigue Scale (...) was determined after performing a factor analysis. In the exploratory factor analysis, the cumulative variance contribution rate was 65.464%. The factor loadings of the total 8 questions were 0.661–0.816. In the confirmatory factor analysis, χ2/df = 2.529, GFI = 0.985, AGFI = 0.967, NFI = 0.982, IFI = 0.989, CFI = 0.989, and RMSEA = 0.048. The Cronbach’s alpha coefficient for the scale was 0.872, and it was 0.833 for peripheral fatigue and 0.818 for central fatigue. The intra-class correlation coefficient for the scale was 0.536, and the intra-class correlation coefficients for peripheral fatigue and central fatigue were 0.421 and 0.548, respectively. The correlation coefficient between the total score of the AEIFS and the SFSA score was 0.592.ConclusionOur results demonstrate that the AEIFS can distinguish peripheral fatigue and central fatigue and can also reflect their correlation. This scale can be a useful evaluation tool not only for measuring fatigue after acute exercise but also for guiding reasonable exercise, choosing objective testing indicators, and preventing sports injuries resulting from acute exercise-induced fatigue. (shrink)

Context: There is a growing recognition in consciousness science of the need for rigorous methods for obtaining accurate and detailed phenomenological reports of lived experience, i.e., descriptions of experience provided by the subject living them in the “first-person.” Problem: At the moment although introspection and debriefing interviews are sometimes used to guide the design of scientific studies of the mind, explicit description and evaluation of these methods and their results rarely appear in formal scientific discourse. Method: The recent (...) publication of an edited book of papers dedicated to the exploration of first-and second-person methods, Ten Years of Viewing from Within: The Legacy of Francisco Varela, serves as a starting point for a discussion of how these methods could be integrated into the growing discipline of consciousness science. We complement a brief review of the book with a critical analysis of the major pilot studies in Varela’s neurophenomenology, a research program that was explicitly devised to integrate disciplined experiential methods with the latest advances in neuroscience. Results: The book is a valuable resource for those who are interested in impressive recent advances in first- and second-person methods, as applied to the phenomenology of lived experience. However, our review of the neurophenomenology literature concludes that there is as yet no convincing example of these specialized techniques being used in combination with standard behavioral and neuroscientific approaches in consciousness science to produce results that could not have also been achieved by simpler methods of introspective reporting. Implications: The end of behaviorism and the acceptance of verbal reports of conscious experience have already enabled the beginning of a science of consciousness. It can only be of benefit if new first- and second-person methods become well-known across disciplines. Constructivist content: Constructivism has long been interested in the role of the observer in the constitution of our sense of reality, so these developments in the science of consciousness may open new avenues of constructivist research. More specifically, one of the ways in which the insights from first- and second-person methods are being validated is by recursively applying the methods to themselves; a practical application of an epistemological move that will be familiar to constructivists from the second-order cybernetics tradition. (shrink)

IntroductionThe National Institute for Health and Care Excellence guidelines acknowledge the importance of the parent–infant relationship for child development but highlight the need for further research to establish reliable tools for assessment, particularly for parents of children under 1 year. This study explores the acceptability and psychometric properties of a co-developed tool, ‘Me and My Baby’.Study designA cross-sectional design was applied. The MaMB was administered universally with mothers during routine 6–8-week Health Visitor contacts. The sample comprised 467 mothers. Dimensionality of (...) instrument responses were evaluated via exploratory and confirmatory ordinal factor analyses. Item response modeling was conducted via a Rasch calibration to evaluate how the tool conformed to principles of ‘fundamental measurement’. Tool acceptability was evaluated via completion rates and comparing ‘completers’ and ‘non-completers’ demographic differences on age, parity, ethnicity, and English as an additional language. Free-text comments were summarized. Data sharing agreements and data management were compliant with the General Data Protection Regulation, and University of York data management policies.ResultsHigh completion rates suggested the MaMB was acceptable. Psychometric analyses showed the response data to be an excellent fit to a unidimensional confirmatory factor analytic model. All items loaded statistically significantly and substantially on a single underlying factor. The item response modeling showed that most MaMB items fitted the Rasch model. item reliability was high yet the test yielded little information on each respondent, as highlighted by the relatively low ‘person separation index’ of 0.1.Conclusion and next stepsMaMB reliably measures a single construct, likely to be infant bonding. However, further validation work is needed, preferably with ‘enriched population samples’ to include higher-need/risk families. The MaMB tool may benefit from reduced response categories and some modest item wording amendments. Following further validation and reliability appraisal the MaMB may ultimately be used with fathers/other primary caregivers and be potentially useful in research, universal health settings as part of a referral pathway, and clinical practice, to identify dyads in need of additional support/interventions. (shrink)

Context: Ernst von Glasersfeld introduced radical constructivism in 1974 as a new interpretation of Jean Piaget’s constructivism to give new meanings to the notions of knowledge, communication, and reality. He also claimed that RC would affect traditional theories of education. Problem: After 40 years it has become necessary to review and evaluate von Glasersfeld’s claim. Also, has RC been successful in taking the “social turn” in educational research, or is it unable to go beyond “private worlds? Method: We provide (...) an overview of contributed articles that were written with the aim of showing whether RC has an impact on educational research, and we discuss three core issues: Can RC account for inter-individual aspects? Is RC a theory of learning? And should Piaget be regarded as a radical constructivist? Results: We argue that the contributed papers demonstrate the efficiency of the application of RC to educational research and practice. Our argumentation also shows that in RC it would be misleading to claim a dichotomy between cognition and social interaction (rather, social constructivism is a radical constructivism), that RC does not contain a theory of mathematics learning any more or less than it contains a theory of mathematics teaching, and that Piaget should not be considered a mere trivial constructivist. Implications: Still one of the most challenging influences on educational research and practice, RC is ready to embark on many further questions, including its relationship with other constructivist paradigms, and to make progress in the social dimension. (shrink)

This paper discusses the ethical and regulatory issues raised by ‘‘intragenics’’ – organisms that have been genetically modified using gene technologies, but that do not contain DNA from another species. Considering the rapid development of knowledge about gene regulation and genomics, we anticipate rapid advances in intragenic methods. Of regulatory systems developed to govern genetically modified organisms (GMOs) in North America, Europe, Australia, and New Zealand, the Australian system stands out in explicitly excluding intragenics from regulation. European systems are also (...) under pressure to exclude intragenics from regulation. We evaluate recent arguments that intragenics are safer and more morally acceptable than transgenic organisms, and more acceptable to the public, which might be thought to justify a lower standard of regulation. We argue that the exemption of intragenics from regulation is not justified, and that there may be significant environmental risks associated with them. We conclude that intragenics should be subject to the same standard of regulation as other GMOs. (shrink)

In order to reduce the misoperation of submersible pilots in the complex environment of deep sea and improve human reliability, it is a very important method to optimize the cabin space of manned submersible. In this paper, manned submersible Jiaolong is taken as an example to describe the breakthrough of traditional modes for optimizing the cabin layout of manned submersible with an aesthetic perspective of deconstruction and reconstruction thinking; the layout is optimized based on deconstruction and reconstruction from the (...) cultural perspective of interdisciplinary. The experimental results show that the layout of manned submersible cabin is optimized by combining the theory of deconstruction and reconstruction aesthetics and human factors engineering, and the feasibility and effectiveness of this method are verified by multiobjective genetic algorithm. Deconstruction and reconfiguration layout optimization improves the human reliability of divers. It is a new method for the optimization of manned submersible cabin layout and also provides a reference for studies on the layout of similar small space. (shrink)

Scholars have thoroughly discussed the visual aspects of Foucault’s archaeological and genealogical methods, as well as his own emphasis on how sight functions and what contexts and conditions shape how we see and what we can see. Yet while some of the images and visual devices he uses are frequently discussed, like Las Meninas and the panopticon, his diagrams in The Order of Things have received little attention. Why does Foucault diagram historical ways of thinking? What are we supposed to (...) see and understand through these diagrams? To examine the role of the diagram in Foucault’s archaeological method, this paper provides a close reading of how the classical quadrilateral visualizes the structure, function, content, principles, and underlying assumptions of language and thought. In analyzing the diagram as a way for visualizing history, this paper demonstrates how Foucault enacts a new visual language that emphasizes the contingency of thought. (shrink)

Transgenic plants are now being used to develop pharmaceutical and industrial products in addition to their use in crop improvement. Using confinement requirements, these transgenic plants are grown and processed under conditions that prevent intermixing with commodity crops. Regulatory agencies in the United States have provided guidance of zero tolerance of these new industrial crops with commodity crops. While this is a worthy goal, it is theoretically unattainable. In spite of the best containment practices, there is a potential risk using (...) any system of production due to unforeseen incidences including natural disasters or exposure to workers. The precautionary principle has been used for numerous regulated articles in addressing the potential risks of new products and technology based on a risk assessment in similar situations. We present here a risk assessment model that could be used as a start to develop an accepted model for the industry. The model is based on current risk models used for other regulated articles, but adapted for these types of products. This could be used to determine action levels in the event of an unintended exposure or to ensure that detection or confinement methods are adequate to avoid risks. As an example, aprotinin, a therapeutic protein now being produced in maize, was evaluated for potential risk to humans using this model. (shrink)

Existing methods for evaluating manufacturing process chain complexity consider the number of machines, state of machines, number of parts, operation time, and processing sequence of parts. However, such evaluation methods ignore human factors. To consider human factors, human cognitive decision-making process factors are considered in the complexity evaluation of production processes. Accordingly, a new objective evaluation method of the human factor complexity is proposed. In the proposed method, sewing operations are taken as an example, and (...) the human factor complexity is classified into perceived and cognitive complexity. Information entropy is used to measure cognitive complexity according to the type and quantity of sewing workers’ cognitive activities. The results show that various methods have significant differences in the evaluation of the complexity level of the production process chain. Specifically, the calculation results of the proposed evaluation method are much greater than those of other methods. This indicates that human cognitive and perceived complexities account for a large proportion. Therefore, human factor complexity cannot be omitted. (shrink)

Reason and World, a collection of lectures and essays, ranges in terms of the date of authorship from a lecture on Heidegger published while Marx was at the New School for Social Research to his Inaugural Lecture upon succession to Heidegger’s chair in Freiburg/br. to the Woodward Lecture at Yale in 1970. Although some of the papers were delivered in English, others are appearing here in English translation for the first time. The papers are reflections on German Idealism, Husserl, and (...) Heidegger. They are not arranged chronologically but rather in terms of the history of philosophy, yet their order is not meant merely to reflect this history. What is at issue is rather what Marx, playing on Hegel’s phrase, believes to be the contemporary Bedürfnis der Philosophie. The subject of the initial paper is what constitutes this requirement or need for Hegel and how the Differenzschrift is crucial for an understanding of German Idealism. In a similar fashion, Marx holds that contemporary philosophy must come to terms with the requirement of its time. Through reflection of philosophy since Hegel, the contemporary period is depicted as one of transition. The need is to secure "the older thought in its domain" and to legitimize that thought in terms of the questions it asked while still remaining open for a new and different type of philosophy. The fact that the contemporary period is to be understood as one of transition finds expression in the sub-title of the book itself: Between Tradition and Another Beginning. Those two philosophical issues which Marx believes respectively to be the basis for the tradition and the other beginning are reflected by the title: Reason and World. This new beginning and the emergence of the world as a focal philosophical concern represent none other than the overcoming of tradition with its presuppositions of telos and logos. In his analyses of Heidegger, Marx discloses the world to be, in the last instance, the crucial problem of contemporary philosophy in its turn towards ateleological and pre-logical experience. Implicitly, the tradition was for him already called into question by Husserl insofar as the lifeworld together with its possible salutary effect on Western man became the subject of Husserl’s later philosophy. In this book Marx pursues the theme he first enunciated in Heidegger and the Tradition. In my opinion, however, the title of the present work might have been more accurately Reason, Language, and World. For, as Marx seeks to establish, the transition from traditional philosophy is characterized simultaneously by a change in our understanding of language. According to his interpretation of Hegel, Hegel thought of language as a "servant of logos"; on the other hand, contemporary philosophy "attributes power to language in the same measure as it denies it to logos." The question is, then, about the role of language in the emergence of world. In place of reason is the problem of the world and of the possibility of a poetic dwelling in it. The purpose of historical studies is to show via negativa the difference between the tradition and the other beginning proclaimed by Heidegger. In the latter regard, Marx contents himself with an immanent critique and asks simply whether Heidegger’s thought "has been conceived consistently and whether it has been thought through to the end." To be sure, this work is a significant contribution to the literature on Heidegger and its importance in this respect cannot be overlooked. On the other hand, the difficulty of the book lies precisely in its method. Heidegger’s claim for another beginning is itself never evaluated. Marx underscores the point that, if Heidegger is correct, traditional criteria are not applicable to the thought required by another beginning. We are left in the dilemma of simply being or not being Heideggerians. For those who are not, the only insight we gain is through a via negativa. Even if Heidegger’s thought should prove to be consistent and consequential, this fact would not suffice to establish its validity. And what are these if not traditional criteria?—A. G. (shrink)

Background Knowing the opinions of patients with Progressive Neurological Diseases and their family members on end-of-life care can help initiate communication and the drawing up of a care plan. The aim of this paper is to describe the creation and psychometric properties of the newly developed APND-EoLC questionnaire. Methods Following focus group discussion, four main areas of interest were identified: patients’ and family members’ attitudes towards end-of-life care, factors influencing decisions about treatment to prolong patients’ life, concerns and fears regarding (...) dying, and opinions on the system of care. The created questions were divided into domains based on factor analysis and psychometric properties were evaluated by sample of 209 patients with PND and 118 their family members. Results The final version of the scale contains a total of 28 questions divided into six domains and five individual questions determining views of the care system with specified response options. Construct validity was verified by confirmatory factor analysis for each evaluated area individually. Appropriate psychometric properties were identified in the questionnaire. Conclusions The APND-EoLC questionnaire can be recommended for use in both research and clinical practice. (shrink)

The New Testament Church was born for mission and by it the gospel has reached different parts of the world today. Through the activities of the CMS, the gospel reached the shores of Nigeria and the Anglican Church of Nigeria was subsequently born. The Church in Nigeria has also employed various methods in furthering the mission of the Church. However, a critical evaluation suggests that unless the church carefully reviews its strategy, it risks abandoning NT mission for structural growth (...) and expansionism which could have negative impact on the mission it sets out to promote. As well as reflect on biblical missions we shall reflect on the development of mission work in Nigeria with appropriate references to available materials while some will also include first- hand knowledge and information with no written document. (shrink)

Introduction The goal of this project was to develop and validate a new tool to evaluate learners' knowledge and skills related to research ethics. Methods A core set of 50 questions from existing computer-based online teaching modules were identified, refined and supplemented to create a set of 74 multiple-choice, true/false and short answer questions. The questions were pilot-tested and item discrimination was calculated for each question. Poorly performing items were eliminated or refined. Two comparable assessment tools were created. These assessment (...) tools were administered as a pre-test and post-test to a cohort of 58 Indian junior health research investigators before and after exposure to a new course on research ethics. Half of the investigators were exposed to the course online, the other half in person. Item discrimination was calculated for each question and Cronbach's α for each assessment tool. A final version of the assessment tool that incorporated the best questions from the pre-/post-test phase was used to assess retention of research ethics knowledge and skills 3 months after course delivery. Results The final version of the REKASA includes 41 items and had a Cronbach's α of 0.837. Conclusion The results illustrate, in one sample of learners, the successful, systematic development and use of a knowledge and skills assessment tool in research ethics capable of not only measuring basic knowledge in research ethics and oversight but also assessing learners' ability to apply ethics knowledge to the analytical task of reasoning through research ethics cases, without reliance on essay or discussion-based examination. These promising preliminary findings should be confirmed with additional groups of learners. (shrink)

A thoroughly updated introduction to the concepts, methods, and standards of critical thinking, _A Practical Guide to Critical Thinking: Deciding What to Do and Believe, Second Edition_ is a unique presentation of the formal strategies used when thinking through reasons and arguments in many areas of expertise. Pursuing an interdisciplinary approach to critical thinking, the book offers a broad conception of critical thinking and explores the practical relevance to conducting research across fields such as, business, education, and the biological sciences. (...) Applying rigor when necessary, the _Second Edition_ maintains an informal approach to the fundamental core concepts of critical thinking. With practical strategies for defining, analyzing, and evaluating reasons and arguments, the book illustrates how the concept of an argument extends beyond philosophical roots into experimentation, testing, measurement, and policy development and assessment. Featuring plenty of updated exercises for a wide range of subject areas, _A Practical Guide to Critical Thinking Deciding What to Do and Believe, Second Edition_ also includes: Numerous real-world examples from many fields of research, which reflect the applicability of critical thinking in everyday life New topical coverage, including the nature of reasons, assertion and supposing, narrow and broad definitions, circumstantial reasons, and reasoning about causal claims Selected answers to various exercises to provide readers with instantaneous feedback to support and extend the lessons _A Practical Guide to Critical Thinking Deciding What to Do and Believe, Second Edition_ is an excellent textbook for courses on critical thinking and logic at the undergraduate and graduate levels as well as an appropriate reference for anyone with a general interest in critical thinking skills. (shrink)

Objective: To evaluate whether ethics rounds stimulated ethical reflection. Methods: Philosopher-ethicist-led interprofessional team ethics rounds concerning dialysis patient care problems were applied at three Swedish hospitals. The philosophers were instructed to stimulate ethical reflection and promote mutual understanding between professions but not to offer solutions. Questionnaires directly before and after rounds were answered by 194 respondents. The analyses were primarily content analysis with Boyd’s framework but were also statistical in nature. Findings: Seventy-six per cent of the respondents reported a moderate (...) to high rating regarding new insights on ethical problem identification, but the ethics rounds did not seem to stimulate the ethical reflection that the respondents had expected (p<0.001). Dominant new insights did not seem to fit into traditional normative ethics but were instead interpreted as hermeneutic ethics. This was illustrated in the extended perspective on the patient and increased awareness of relations to other professions. Regarding insights into how to solve ethical problems, the request for further interprofessional dialogue dominated both before and after rounds. Conclusion: The findings show the need for interprofessional reflective ethical practice but a balance between ethical reflection and problem solving is suggested if known patients are discussed. Further research is needed to explore the most effective leadership for reflective ethical practice. (shrink)

Measuring perceived similarity is an important issue in visual perception of faces, since a measure of the perceived similarity between faces may be used to investigate fundamental tasks like face categorization and recognition. Despite its fundamental role, measuring perceived similarity between faces is not trivial from both a theoretical and methodological point of view. In this paper we present theoretical arguments that undermine the method currently most used to measure perceived similarity between faces in visual perception, and we propose (...) an alternative method. We finally compare the two methods and find some empirical evidence that the proposed method can provide a more reliable evaluation of the perceived similarity between faces. (shrink)

Contemporary Russian philosophical traditions cannot be reduced to Marxist works and research in religious philosophy. Russian philosophers developed philosophy and methodology of social sciences and humanities as early as at the end of the nineteenth century and in the beginning of the twentieth century. In particular, S.N. Bulgakov’s social philosophy of science is closely related to European thinkers’ works and ideas. Problems of social determinism in scientific cognition are among them. These problems are topical now as seen in the well-known (...) discussion about the nature and meaning of various forms of determinism in which different stands are taken by R. Thomas, E. Morin and I. Prigogine. A new level of research of social determinism is presented in Russia in the second-half of the twentieth century. The identification of determination with causality is overcome. Necessary and contingent, dynamic and statistical determination, self-determination, and so on, come under examination. In the 1970s mechanistic and objectivistic determination is overcome and human factors, such as the will and systems of values, are taken into account. S.L. Frank turns to the methodology of social sciences in 1922 and continues his studies in 1930 in Europe. Frank creates a holistic, fully secular doctrine of social philosophy, sociology, philosophy of law and history. The changing situation in Russia at the end of the twentieth century and the beginning of the twenty first century allows us to re-evaluate ideas and works of Russian thinkers who studied mainly rationalist themes, including philosophy and methodology of science, its hermeneutic and semiotic aspects. Russian and European philosophies are used and essentially enriched. G.G. Shpet’s ideas are examined. Studying the sphere of language and meaning, recognizing the essential importance of hermeneutics for knowledge in the humanities, he brings forward a semiotic conception of ethnic psychology to precede, in particular, American anthropologist and ethnographer C. Geertz’s theory of culture. Russian philosophers are quite aware that any reconstruction of real cognition cannot limit itself to the transcendental epistemological agent or “consciousness in general”. It is necessary to change the level of abstraction of the subject matter of the non-classical—social, cultural and historical—epistemology to draw closer to the real manifestations of cognitive activity. (shrink)

Use of argumentation methods applied to legal reasoning is a relatively new field of study. The book provides a survey of the leading problems, and outlines how future research using argumentation-based methods show great promise of leading to useful solutions. The problems studied include not only these of argument evaluation and argument invention, but also analysis of specific kinds of evidence commonly used in law, like witness testimony, circumstantial evidence, forensic evidence and character evidence. New tools for analyzing these (...) kinds of evidence are introduced. (shrink)

Biomolecules and particularly proteins and DNA exhibit some mysterious features that cannot find satisfactory explanation by quantum mechanical modes of atoms. One of them, known as a Levinthal’s paradox, is the ability to preserve their complex three-dimensional structure in appropriate environments. Another one is that they possess some unknown energy mechanism. The Basic Structures of Matter Supergravitation Unified Theory (BSM-SG) allows uncovering the real physical structures of the elementary particles and their spatial arrangement in atomic nuclei. The resulting physical models (...) of the atoms are characterized by the same interaction energies as the quantum mechanical models, while the structure of the elementary particles influence their spatial arrangement in the nuclei. The resulting atomic models with fully identifiable parameters and angular positions of the quantum orbits permit studying the physical conditions behind the structural and bonding restrictions of the atoms connected in molecules. A new method for a theoretical analysis of biomolecules is proposed. The analysis of a DNA molecule leads to formulation of hypotheses about the energy storage mechanism in DNA and its role in the cell cycle synchronization. This permits shedding a light on the DNA feature known as a C-value paradox. The analysis of a tRNA molecule leads to formulation of a hypothesis about a binary decoding mechanism behind the 20 flavors of the complex aminoacyle-tRNA synthetases - tRNA, known as a paradox. (shrink)

BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in (...) a standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials (CONSORT) statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data.MethodsThe development of this CONSORT extension will consist of five phases. Phase 1 (completed) consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications (1) that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or (2) that are protocols or report results from such RCTs. An initial “long list” of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the “long list” and generate a “short list” of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline.DiscussionDevelopment of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data. (shrink)

Drawing on Pennock’s theory of scientific virtues, we are developing an alternative curriculum for training scientists in the responsible conduct of research that emphasizes internal values rather than externally imposed rules. This approach focuses on the virtuous characteristics of scientists that lead to responsible and exemplary behavior. We have been pilot-testing one element of such a virtue-based approach to RCR training by conducting dialogue sessions, modeled upon the approach developed by Toolbox Dialogue Initiative, that focus on a specific virtue, e.g., (...) curiosity and objectivity. During these structured discussions, small groups of scientists explore the roles they think the focus virtue plays and should play in the practice of science. Preliminary results have shown that participants strongly prefer this virtue-based model over traditional methods of RCR training. While we cannot yet definitively say that participation in these RCR sessions contributes to responsible conduct, these pilot results are encouraging and warrant continued development of this virtue-based approach to RCR training. (shrink)

The aims of this study were to examine the effectiveness of a range of smartphone apps for managing symptoms of anxiety and depression and to assess the utility of a single-case research design for enhancing the evidence base for this mode of treatment delivery. The study was serendipitously impacted by the COVID-19 pandemic, which allowed for effectiveness to be additionally observed in the context of significant community distress. A pilot study was initially conducted using theSuperBetter app to evaluate the proposed (...) methodology, which proved successful with the four finishing participants. In the main study, 39 participants commenced, with 29 finishing the intervention phase and completing post-intervention measures. At 6-month follow-up, a further three participants could not be contacted. This study used a digitally enhanced, multiple baseline across-individuals single-case research design. Participants were randomly assigned to the following apps:SuperBetter,Smiling Mind,MoodMission,MindShift, andDestressify. Symptomatology and life functioning were measured at five different time points: pre-baseline/screening, baseline, intervention, 3-week post-intervention, and 6-month follow-up. Detailed individual perceptions and subjective ratings of the apps were also obtained from participants following the study’s completion. Data were analyzed using visual inspection, time-series analysis, and methods of statistical and clinical significance. Positive results were observed for all apps. Overall, more favorable outcomes were achieved by younger participants, those concurrently undertaking psychotherapy and/or psychotropic medication, those with anxiety and mixed anxiety and depression rather than stand-alone depression, and those with a shorter history of mental illness. Outcomes were generally maintained at 6-month follow-up. It was concluded that a diverse range of evidence-based therapies offered via apps can be effective in managing mental health and improving life functioning even during times of significant global unrest and, like all psychotherapies, are influenced by client features. Additionally, this single-case research design is a low-cost/high value means of assessing the effectiveness of mental health apps.Clinical Trial Registration: The study is registered with the Australian and New Zealand Clinical Trials Registry, which is a primary registry in the World Health Organization Registry Network, registration number ACTRN12619001302145p. (shrink)

I would like to stress Vadim Mikhailovich's [Mezhuev's] position and clarify our conversation about culturology. It is constantly repeated that culturology is a science. It is my profound conviction that culturology is not a science. Culturology is a distinctive phenomenon of Russian culture and represents a certain intellectual movement. If one briefly surveys the history of its emergence, its philosophical origin becomes obvious. This intellectual movement consists of three levels, if one takes into account the "-logy" ending. First, the philosophical (...) level, from which in the 1970s culture began to be conceived as a special field of knowledge in our country. Then, humanistic knowledge: a great many representatives of the humanities in Russia-historians, art specialists, art critics, essayists-studied culture. Finally, there is the socioscientific tendency, which is just beginning to form in Russia and carries the internationally accepted name of social and cultural anthropology. All of us are synergistically attracted to these three tendencies, which comprise what is called culturology. The question of how these three tendencies of knowledge are correlated in the framework of the given intellectual movement is, in my view, extremely important. For quite some time now, there has been no reflection in Russia on the foundations of scientific and philosophical knowledge, but such reflection is necessary. To advance along the road of rational knowledge it is important to reflect in what cognitive space we find ourselves, what we are doing within its boundaries, and for what reason. From this point of view, neither philosophers nor representatives of the humanities or the social sciences will renounce their positions of observer. Moreover, I agree with Mezhuev that there is no single philosophy, humanistic conception, or theory of culture. Anyone who is engaged professionally in the study of cultural phenomena can choose his initial foundations. As Vadim Mezhuev correctly notes, the significance of philosophy for other types of knowledge lies in the fact that there are borderline areas of man's existence in the world. However, they are identified in different ways by different philosophies: positivism, phenomenology, classical Platonism, Aristotelianism, Kantianism, and so forth. Representatives of humanistic and socioscientific knowledge are free to choose any metaphysics. Philosophers will continue to attend to their business in their subject area, and scientists in theirs. But it is important periodically to determine rationally when there must be close and complementary relations between the three components of this intellectual movement and when they must exist in parallel. Then questions such as who has priority and who is the guardian of truth will not arise. If the tendencies have diverged in parallel, then the representatives of each of them are occupied within their domains with questions which are irrelevant in other fields of knowledge or for other theoretical models. At the end of the twentieth century, to pose the question of scientism or antiscientism is senseless because today we know that there are different forms of rationality and that science is not the only, and is quite a narrow, form of rationality. Myth too is rational. It is expressed in categories and has a particular inner logic. We recognize myth as a rational cultural entity, because it is represented in symbolic form as an ordered sequence of judgments, as an artifact. But it differs from scientific theory. That is why it is fruitful to reflect on what forms of rationality are relevant to what levels of knowledge. I agree with Ogurtsov, who says that these forms penetrate in one way or another into every culturally institutionalized form of knowledge. Indeed, in philosophical knowledge there are elements of everyday, mythological, and scientific knowledge, but this does not negate the distinctive nature of the philosophical form of knowledge. In science there are elements of metaphysics, mythology, and everyday knowledge, but this does not cancel the particularities of the scientific form of knowledge. The same is true of the humanistic form, which is in principle irremovable from the framework of institutionalized knowledge, at least for now. I do not agree with Ogurtsov that I give the humanistic form of knowledge a negative evaluation. Humanistic knowledge begins to be significant in a period of a cognitive paradigm shift. This, we can say, is apparent today, at a time of transition from the grand style of modernism in its postmodern mode to the building of the foundations for a new whole. The point is that the humanistic form of knowledge enables us to isolate at the outset those areas of the unknown at which we arrive because of the limitations inherent in other forms of rationality. It is closest to everyday and empirical categories of knowledge and forms of ideas; hence, particularism, image syncretism, and mobility are its distinctive features. But without this humanistic level no further step is possible in either scientific or philosophical knowledge. The breakdown into these forms of knowledge- philosophical, humanistic, and scientific-may be primitive, but we have to start our reflection on the foundations of our cognitive relationship to our surroundings somewhere. The identification of the forms of knowledge makes it possible to draw the conclusion that, unlike philosophical and humanistic knowledge, socioscientific knowledge is modeled on the natural sciences. From this it becomes obvious that the distinctive features of the object of social sciences determine also the special nature of the categorial apparatus, operationalization, selection method, and information analysis. I do not insist that the model I suggest must be accepted. Other models can be constructed. But let us start with a simpler comparison of types of knowledge and later we shall differentiate them. I started from this level because in our culture such a division is apparent and generally accepted. There are the philosophical, humanistic, and scientific forms of knowledge. They are irreducible to one another, they perform entirely different functions in the knowledge of man's relationship to the environment, and express different views about how man lives in culture. I agree that philosophy is exactly existence in culture with a singling out of the limits of this existence. But representatives of humanistic and socioscientific knowledge also deal with existence in culture. What is important for the philosopher is the direction of knowledge from within to the outside; for the representative of humanistic knowledge it is the description of how he exists among a multitude of seemingly diverse and divergent artifacts and processes; and for the scientist it is the order of the philosophically and humanistically defined reality in order to control it the better. (shrink)

Cost-benefit analysis is a widely used governmental evaluation tool, though academics remain skeptical. This volume gathers prominent contributors from law, economics, and philosophy for discussion of cost-benefit analysis, specifically its moral foundations, applications and limitations. This new scholarly debate includes not only economists, but also contributors from philosophy, cognitive psychology, legal studies, and public policy who can further illuminate the justification and moral implications of this method and specify alternative measures. These articles originally appeared in the Journal of (...) Legal Studies. Contributors: - Matthew D. Adler - Gary S. Becker - John Broome - Robert H. Frank - Robert W. Hahn - Lewis A. Kornhauser - Martha C. Nussbaum - Eric A. Posner - Richard A. Posner - Henry S. Richardson - Amartya Sen - Cass R. Sunstein - W. Kip Viscusi. (shrink)

The rapid advancement of artificial intelligence has brought about significant positive changes across various sectors. However, it has also created new opportunities for cybercrime. Nigeria, in particular, has witnessed a surge in cybercriminal activities, which have had severe economic and social consequences. The paper explored the relationship between AI, cybercrime, and the underground business economy in Nigeria, focusing on the rise of fraud, identity theft, and hacking. It discussed the ethical implications of AI, cybercrime, and the underground business economy, highlighting (...) potential risks to privacy, security, and social trust, while emphasizing the ethical responsibilities of AI developers, policymakers, and stakeholders in mitigating these risks and promoting responsible AI use. The Igwebuike ethical theoretical framework was employed for the evaluation of cybercrime, and the thematic and analytical methods of inquiry were used. The paper submits that there is need for an ethical response to the challenges posed by cybercrime in Nigeria. (shrink)

Today, the earth is an interconnected globe humming with electronic transmissions-a chattering planet nestled in the provident silence of space. The ethical question is whether this is contributing to authentic human development and helping individuals and peoples to be true to their transcendent destiny. The new media are powerful tools for education, cultural enrichment, commercial activity, political participation, intercultural dialogue and understanding. They also can serve the cause of religion. Yet the new information technology needs to be informed and (...) guided by solidarity in the service of the common good bridging the digital divide within and among nations. The value-laden message of Western secular culture to people and traditional societies in many cases ill-prepared to evaluate it leads to widespread crisis, for example, in regard to marriage and family life. This technology can be a means for solving human problems, promoting the integral development of persons, creating a world governed by justice, peace, and love. It also can help men and women in their age-old search for self-understanding. Like today's world itself, the world of media, including the Internet, has been brought by Christ, inchoately yet truly, within the boundaries of the kingdom of God and placed in service to the word of salvation. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Much research effort has been directed in different physiological contexts towards describing realistic behaviors with differential equations. One observes obviously that more state-variables give the model more accuracy. Unfortunately, the computational cost involved is higher. A new algorithm is presented for simulating a model described by a system of differential equations in which efficiency may not be altered by its size. In order to do this, the method is based on a polynomial description of the state-variables' evolution and on (...) a computation distributed control. Evaluations and results performed with classical models like Fitzhugh Nagumo or Hodgkin Huxley, allow validation of the method and exhibits its potential to decrease the computational costs. (shrink)

The traditional organizational boundaries between healthcare, social work, police and other non-profit organizations are fading and being replaced by new relational patterns among a variety of disciplines. Professionals work from their own history, role, values and relationships. It is often unclear who is responsible for what because this new network structure requires rules and procedures to be re-interpreted and re-negotiated. A new moral climate needs to be developed, particularly in the early stages of integrated services. Who should do what, with (...) whom and why? Departing from a relational and hermeneutic perspective, this article shows that professionals in integrated service networks embark upon a moral learning process when starting to work together for the client’s benefit. In this context, instrumental ways of thinking about responsibilities are actually counterproductive. Instead, professionals need to find out who they are in relation to other professionals, what core values they share and what responsibilities derive from these aspects. This article demonstrates moral learning by examining the case of an integrated social service network. The network’s development and implementation were supported by responsive evaluation, enriched by insights of care ethics and hermeneutic ethics. (shrink)

SETTING: Medical ethics education has become common, and the integrated ethics curriculum has been recommended in Western countries. It should be questioned whether there is one, universal method of teaching ethics applicable worldwide to medical schools, especially those in non-Western developing countries. OBJECTIVE: To characterise the medical ethics curricula at Asian medical schools. DESIGN: Mailed survey of 206 medical schools in China, Hong Kong, Taiwan, Korea, Mongolia, Philippines, Thailand, Malaysia, Singapore, Indonesia, Sri Lanka, Australia and New Zealand. PARTICIPANTS: A (...) total of 100 medical schools responded, a response rate of 49%, ranging from 23%-100% by country. MAIN OUTCOME MEASURES: The degree of integration of the ethics programme into the formal medical curriculum was measured by lecture time; whether compulsory or elective; whether separate courses or unit of other courses; number of courses; schedule; total length, and diversity of teachers' specialties. RESULTS: A total of 89 medical schools (89%) reported offering some courses in which ethical topics were taught. Separate medical ethics courses were mostly offered in all countries, and the structure of vertical integration was divided into four patterns. Most deans reported that physicians' obligations and patients' rights were the most important topics for their students. However, the evaluation was diverse for more concrete topics. CONCLUSION: Offering formal medical ethics education is a widespread feature of medical curricula throughout the study area. However, the kinds of programmes, especially with regard to integration into clinical teaching, were greatly diverse. (shrink)

It is a commonplace of modern criticism that every text is to be located within a complex network of cultural practices and material. Students of the ancient world may sometimes feel at a disadvantage; we simply do not have as much information as we would like in order to contextualize thoroughly. This has been especially true in the study of Platonic dialogues. The meagre remains of the writings of the sophists against whom Plato measured himself and of the art to (...) which he refers entail that analysis of Plato is often confined to the structure of his philosophy. Of course, the requirements of Plato's arguments must always be assigned primary importance; the relative lack of information about Plato's cultural context has not prevented detailed exposition of his method and achievements. Occasionally, however, a kindly fate allows us to set a dialogue, or part of it, in its appropriate material and ideological context and to create an interface between literary, philosophical, and archaeological evidence. Such evidence may not alter our evaluation of Plato's arguments on the analytic level, but it can enrich our appreciation of his literary artistry and recapture for us some of the resonance that his work would have had for a contemporary audience. (shrink)