İbn Sînâ, Yeter Sebep İlkesi’ni (YSİ), yani her şeyin bir sebebi olduğu ve sebepsiz hiçbir varlığın var olamayacağı iddiasını savunan modern dönem öncesi filozoflarından biridir. YSİ’nin sonuçlarından biri de zorunlulukçuluktur (necessitarianism); yani gerçekte var olan her şeyin aynı zamanda zorunlu olarak var olduğu iddiasıdır. Bu fikre göre sebepler zincirinin her bir üyesi kendinden önceki sebepler tarafından belirlenir. Dolayısıyla YSİ, olayların başka türlü de olabileceğini telkin eden insan sezgisine karşı çıkmaktadır. Bu çalışmadaki amacım, İbn Sînâ sonrası yazarların insan iradesini dışlamak suretiyle (...) YSİ’nin zorunlulukçu sonuçlarını hafifletmeye çalışıp çalışmadıklarını araştırmaktır. Nasîrüddin Tûsî’nin (ö. 672/1274) Cebr ve Kader adlı Farsça risalesi ile Tecrîdü’l-i‘tikâd adlı kelâm kitabı arasında bir karşılaştırma yapmaya odaklanacağım. Bu konuyu seçmemin öncelikli sebebi, insanların eylemlerinin bağımsız fâilleri olduklarını sezgisel olarak bildiklerine dair Tûsî’nin iddialarıdır ki bu, YSİ‘nin evrensel uygulanabilirliği ile çelişiyor gibi görünmektedir. Tûsî’nin özgür irade konusunda, metinlerin karakterine ve yazıldıkları döneme bağlı olarak, bazen İbn Sînâ ile tutarlılık arzeden bazen de Mu‘tezile’ye angaje olan farklı görüşler benimsediğini savunacağım. Tûsî’nin, bazen nedensel olarak etkin olmamasına rağmen insan özgürlüğüne nasıl yer bıraktığını göstereceğim. O, insan özgürlüğünü, insanın karşı karşıya kaldığı fiziksel veya ilahî diğer belirlenim türlerinden bağımsız olarak hareket edebilen farklı bir belirlenim türü olarak anlar. Genel olarak bu mesele, Tûsî’nin İbn Sînâ felsefesine ya da Şiî kelâmına bağlılığını test etmekte ve hatta onu bazı eserlerinde İbn Sînâ’nın bilgi görüşüne karşı bir duruş sergilemeye zorlamaktadır. (shrink)

Recreational Drugs European Network (ReDNet) project aims to use the Psychonaut Web Mapping Project database (Psychonaut Web Mapping Group, 2009) containing novel psychoactive compounds usually not mentioned in the scientific literature and thus unknown to clinicians as a unique source of information. The database will be used to develop an integrated ICT prevention approach targeted at vulnerable individuals and focused on novel synthetic and herbal compounds and combinations. Particular care will be taken in keeping the health professionals working directly with (...) young people showing problematic behaviors regularly updated in terms of novel compounds and combinations as well. A user-friendly project website will be developed aimed primarily at delivering the information/prevention approaches, but will also be a way of communicating with project partners and relevant stakeholders (e.g. thematic forum facilities, instant messages, blogs, video chat, wikiblog, newsletters distributed via mailing list). The website will support various ICT prevention tools, including an SMS alert service. Different areas and sections will be aimed specifically at the different target groups. -/- . (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

This article proposes a theoretical reflection on the articulation between teachers’ conceptions of particular knowledge objects on the one hand, and their professional action about these objects on the other. We will illustrate our point through two studies carried out in France and in Quebec in the field of the teaching of socially acute questions (SAQs). The first study focuses on the link between the social representations (Abric, 1994) of sustainable development (SD) among future teachers of humanities and natural sciences (...) and their practices with regard to education for sustainable development (ESD).The second study focuses on the relationship between a science teacher’s knowledge about the natural sciences (NS) as an object of knowledge and as an object of instruction. In order to enrich our reflection, we present an original operationalization of the concept of teaching practices, whose different dimensions (finalized, technical, interactive, affective) are put in relation with the concepts of social representations and relationships to knowledges. This perspective and theoretical reflection allows us to identify crossings and tensions between beliefs and teaching practices with regard to the SAQs in reference to the transformative-sociocritical and transmissive-positivist approaches of ESD. (shrink)

L’article est consacré à la conception de processio et d’explicatio dans un contexte historique et doctrinal du néoplatonisme de l’école d’Athènes et puis dans le néoplatonisme chrétien médiéval. C’est à Thierry de Chartres que le Cusain a emprunté les termes-clefs : complicatio-explicatio décrivant la relation de la Cause Première et de la multitude de ce qui en procède, aussi bien que expliquant la relation parmi l’immanence et la transcendance Divine.

By the late 1920s in Europe new art directions were regarded as already completed phenomena, a part of “avant-garde tradition.” Such views were expressed by Jean Arp and El Lissitzky’s in their book Kuntismen, and by Amédée Ozenfant’s in Art. Bilan des arts modernes en France. Similar opinions were also voiced by Jan Brzękowski, a Polish poet and critic, who regarded this time as a period of “establishing certain values” rather than new breakthroughs. In this article I discuss Brzękowski’s strategies (...) as a spokesman of modern art, an intermediary between the Parisian artworld and Polish avant-garde, an author connected with constructivism, and also with surrealist circles in Paris. My main focus is his magazine “Sztuka Współczesna – L’Art Contemporain” and his series of articles “Mileages,” in which he summarizes the developments of modern art. Conscious of the “wearing up” of avant-garde ideas and critical about seeking “novelty” for its own sake, Brzękowski tried to establish a progressive position based on the idea of formal discipline and creative construction. While rejecting a mimetic conception of art, he argued for abstract artistic form that would be “anchored to the bottom of life,” thus emphasizing the interplay of abstract and figurative elements and their dialectic. (shrink)

SUBJECTIVITY AND DIFFERENCE: BUTLER AND BRAIDOTTI Judith Butler and Rosi Braidotti are recognized as the inheritors of postmodern tradition, in their ideas deconstruct the myth of a stable and an unequivocally characterized identity. Both, Butler and Braidotti express the belief, that human being cannot get rid of defining her/his own subjectivity. Therefore, Braidotti and Butler have created original concepts of the subjectivity. Both, Judith Butler and Rosi Braidotii, represent the third wave of feminism, therefore they begin the discussion on the (...) subjectivity from similar initial assumptions: the end of "I/self" understood in a metaphysical way, the definition of a new subjectivity of women. Judith Butler drawing on J.L. Austin’s philosophical achievements and the theory of performative acts of speech (performative utterance), creates an innovative concept of the subjectivity, which is established by/through performative acts. Rosi Braidotti is focused on the revision of the idea of the woman and the constitution of new women’s subjectivity. Braidotti conceives woman as a nomadic entity, who is ambiguous, embodied, cultural, etc. (shrink)

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...) with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers (...) such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies. We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology. (shrink)

Psychotherapy with the use of psychedelic substances, including psilocybin, lysergic acid diethylamide (LSD), ketamine, and 3,4-methylenedioxymethamphetamine (MDMA), has demonstrated promise in treatment of post-traumatic stress disorder (PTSD), anxiety, addiction, and treatment-resistant depression. Psychedelic-assisted psychotherapy (PP) represents a unique psychopharmacological model that leverages the profound effects of the psychedelic experience. That experience is characterized by strong dependency on two key factors: participant mindset and the therapeutic environment. As such, therapeutic models that utilize psychedelics reflect the need for careful design that promotes (...) an open, flexible, trusting mindset and a supportive setting. To meet this need, the PP model is increasingly supplemented by auxiliary methods, including meditation, relaxation, visualization or spiritual practices. We suggest virtual reality (VR) as a full-spectrum tool able to capitalize on and catalyze the innately therapeutic aspects of the psychedelic experience, such as detachment from familiar reality, alteration of self-experience, augmentation of sensory perception and induction of mystical-type experiences. This is facilitated by VR’s evidenced capacity to: aid relaxation and reduce anxiety; buffer from external stimuli; promote a mindful presence; train the mind to achieve altered states of consciousness (ASC); evoke mystical states; enhance therapeutic alliance and encourage self-efficacy. While these unique VR features appear promising, VR’s potential role in PP remains speculative due to lack of empirical evidence on the combined use of VR and PP. Given the increased commercial interest in this synergy there is an urgent need to evaluate this approach. We suggest specific VR models and their role within PP protocols to inspire future direction in scientific research, and provide a list of potential disadvantages, side effects and limitations that need to be carefully considered. These include sensory overstimulation, cyber-sickness, triggering memories of past traumatic events as well as distracting from the inner experience or strongly influencing its contents. A balanced, evidence-based approach may provide continuity across all phases of treatment, support transition into and out of an ASC, deepen acute ASC experiences including mystical states and enrich the psychotherapeutic process of integration. We conclude that the potential application of VR in modulating psychedelic-assisted psychotherapy demands further exploration and an evidence-based approach to both design and implementation. (shrink)

I explore some of the ways that assumptions about the nature of substance shape metaphysical debates about the structure of Reality. Assumptions about the priority of substance play a role in an argument for monism, are embedded in certain pluralist metaphysical treatments of laws of nature, and are central to discussions of substantivalism and relationalism. I will then argue that we should reject such assumptions and collapse the categorical distinction between substance and property.

1. Falsafat al-rūḥ -- 2. Falsafat al-ʻaqūl -- 3. Raḥīq al-nafs -- 4. al-Qadāʼ wa-al-qadar.

Since the 1980s, there has been an increasing acknowledgement of the importance of recognising the ethical dimension of clinical decision-making. Medical professional regulatory authorities in some countries now include ethical knowledge and practice in their required competencies for undergraduate and post graduate medical training. Educational interventions and clinical ethics support services have been developed to support and improve ethical decision making in clinical practice, but research evaluating the effectiveness of these interventions has been limited. We undertook a systematic review of (...) the published literature on measures or models of evaluation used to assess the impact of interventions to improve ethical decision making in clinical care. We identified a range of measures to evaluate educational interventions, and one tool used to evaluate a clinical ethics support intervention. Most measures did not evaluate the key impact of interest, that is the quality of ethical decision making in real-world clinical practice. We describe the results of our review and reflect on the challenges of assessing ethical decision making in clinical practice that face both developers of educational and support interventions and the regulatory organisations that set and assess competency standards. (shrink)

We discuss applications of our account of moral status grounded in person-rearing relationships: which individuals have higher moral status or not, and why? We cover three classes of cases: (1) cases involving incomplete realization of the capacity to care, including whether infants or fetuses have this incomplete capacity; (2) cases in which higher moral status rests in part on what is required for the being to flourish; (3) hypothetical cases in which cognitive enhancements could, e.g., help dogs achieve human-like cognitive (...) capacities. We thereby show that our account does not have the counterintuitive implications alleged by DeGrazia and other critics. (shrink)

While issues of efficacy and specificity are crucial for the future of neurofeedback training, there may be alternative designs and control analyses to circumvent the methodological and ethical problems associated with double-blind placebo studies. Surprisingly, most NF studies do not report the most immediate result of their NF training, i.e. whether or not children with ADHD gain control over their brain activity during the training sessions. For the investigation of specificity, however, it seems essential to analyze the learning and adaptation (...) processes that take place in the course of the training and to relate improvements in self-regulated brain activity across training sessions to behavioral, neuropsychological and electrophysiological outcomes. To this aim, a review of studies on neurofeedback training with ADHD patients, which include the analysis of learning across training sessions or relate training performance to outcome, is presented. Methods on how to evaluate and quantify learning of EEG regulation over time are discussed. “Non-learning” has been reported in a small number of ADHD-studies, but has not been a focus of general methodological discussion so far. For this reason, selected results from the brain-computer interface (BCI) research on the so-called “brain-computer illiteracy”, the inability to gain control over one’s brain activity, are also included. It is concluded that in the discussion on specificity, more attention should be devoted to the analysis of EEG regulation performance in the course of the training and its impact on clinical outcome. It is necessary to improve the knowledge on characteristic cross-session and within-session learning trajectories in ADHD and to provide the best conditions for learning. (shrink)

Although there is much research on the relationships of corporate social responsibility and employee-related outcomes, a systematic and quantitative integration of research findings is needed to substantiate and broaden our knowledge. A meta-analysis allows the comparison of the relations of different types of CSR on several different outcomes, for example to learn what type of CSR is most important to employees. From a theoretical perspective, social identity theory is the most prominent theoretical approach in CSR research, so we aim to (...) investigate identification as a mediator of the relationship between CSR and employee-related outcomes in a meta-analytical mediation model. This meta-analysis synthesizes research findings on the relationship between employees' perception of CSR (people, planet, and profit) and employee-related outcomes (identification, engagement, organizational attractiveness, turnover (intentions), OCB, commitment, and job satisfaction), thereby distinguishing attitudes and behavior. A total of 143 studies (N= 89,396) were included in the meta-analysis which was conducted according to the methods by Schmidt and Hunter (except of the meta-analytical structural equation model). Mean effect sizes for the relationship between CSR and employee-related attitudes and behaviors were medium-sized to large. For attitudes, the relationships were stronger than for behavior. For specific types of CSR, average effect sizes were large. Identification mediated the relation between CSR and commitment, job satisfaction, and OCB, respectively. Based on our results, we give recommendations concerning the design of CSR initiatives in a way that benefits employees. (shrink)

Tributes to Professor Andrzej Kopcewicz - Agnieszka Salska New Media Effects on Traditional News Sources: A Review of the State of American Newspapers - Richard Profozich Review of The Body, ed. by Ilona Dobosiewicz and Jacek Gutorow - Grzegorz Kość “Taste good iny?”: Images of and from Australian Indigenous Literature - Jared Thomas Speaks with Teresa Podemska-Abt Engaging the “Forbidden Texts” of Philosophy - Pamela Sue Anderson Talks to Alison Jasper.

Axiological Character of Egotic Sphere in Tischner’s ThoughtThe paper presents the conception of egotic consciousness understood from the axiological and phenomenological perspective. In the work Fenomenologia świadomości egotycznej Tischner presents phenomenological considerations about self-consciousness. In the light of the results of analyses conducted by Tischner, egotic consciousness is understood as axiological sphere. In the perspective of the phenomenology of egotic consciousness, being a result of revealing Tischner’s original thought, in its beginning, Husserl’s conception of transcendental consciousness is one of the (...) possibilities. (shrink)

[A] man does not consist of memory alone. He has feeling, will, sensibilities, moral being…. And it is here … that you may find ways to touch him.—A. R. Luria1.

In his work on internality, identification, and caring, Harry Frankfurt attempts to delineate the organization of agency peculiar to human beings, while avoiding the traditional overintellectualized emphasis on the human capacity to reason about action. The focal point of Frankfurt’s alternative picture is our capacity to make our own motivation the object of reflection. Building upon the observation that marginal agents (such as young children and Alzheimer’s patients) are capable of caring, I show that neither caring nor internality need to (...) depend on the phenomena of reflectiveness. I develop alternative interlocking accounts of caring and internality that are independent of both reflectiveness and evaluation, but that can still do justice to the central role of carings in the organization of agency characteristic of human persons. (shrink)

Le philosophe Jean Baudrillard (1929-2007) a-t-il vraiment existé? Que reste-t-il de lui? "Une élégance certaine de la pensée", affirme l'un de ses meilleurs interprètes, François L'Yvonnet. Le philosophe de La Société de consommation, des Stratégies fatales et des Cool Memories s'attachait à l'idée du fragment comme mode de pensée : car dans le détail, tout est parfait, c'est dans sa reproduction que tout se complique. François L'Yvonnet explore cinq fragments de la philosophie de Jean Baudrillard et de sa biographie pour (...) mieux saisir l'éclat et la jubilation d'une pensée toujours vivante et contemporaine. (shrink)

A being has moral standing if it or its interests matter intrinsically, to at least some degree, in the moral assessment of actions and events. For instance, animals can be said to have moral standing if, other things being equal, it is morally bad to intentionally cause their suffering. This essay focuses on a special kind of moral standing, what I will call “full moral standing” (FMS), associated with persons. In contrast to the var- ious accounts of what ultimately grounds (...) FMS in use in the philosophical literature, I will propose that the emotional capacity to care is a sufficient condition of an individual’s FMS as a person. In developing this account, I will appeal to a set of intuitions not previously mined for this purpose: those generated by conflicts of interests between different life phases of a single individual. (shrink)

RésuméLa notion de «rationalité de l'Univers » a varié au cours du temps, le long dialogue de l'esprit et de la nature ayant toujours abouti à ce que Le Roy appelait « l'évolution de l'évidence et la plasticité de la raison ».L'échec de l'explication mécanique de l'Univers a conduit James Jeans à déclarer que le monde ressemble plutôt « à une grande pensée » qu'à une grande machine », car on ne peut en donner qu'une description mathématique. En réalité, la (...) physique moderne n'est ni plus ni moins mathématique que l'ancienne; elle est seulement plus générale. James Jeans confond les mathématiques pures et les mathématiques appliquées.Eddington prétend déduire les lois générales et les constantes physiques de la nature de considérations épistémologiques a priori. C'est un retour à Kant. Malheureusement les postulate dont il part comme évidents n'ont point paru tels au XVIIe siècle et n'ont été admis que sous la contrainte de l'expérience. Sa théorie ne prévoit ni les neutrons ni les mésons. Elle est vouée à l'échec.La possibilité de trouver un formalisme mathématique applicable à un domaine expérimental ne préjuge en rien la rationalité de l'Univers, car un mathématicien habile sera toujours capable de faire rentrer même un monde « erratique » dans un vêtement mathématique approprié. (shrink)