Alzheimer’s disease is the most common form of dementia which is estimated to impact 350,000 people over 65 years of age in Canada. The lack of effective treatment and the growing number of people who are expected to be diagnosed with Alzheimer’s disease in the near future are compelling reasons why continued research is in this area is necessary. With additional research, there needs to be greater recognition of the complexity of seeking ongoing informed consent from those with Alzheimer’s disease. (...) This complexity is because the impairment of memory and cognitive ability does not diminish in a linear manner, but rather fluctuates between periods of impairment and relatively normal cognitive lucidness. There is limited discussion in the guidelines of those progressing from early stages of Alzheimer’s disease who have intermittent cognitive function. Guidelines to research and Research Ethics Boards require further development to facilitate researcher including those with Alzheimer’s disease while protecting this growing pool of potential participants. (shrink)

This paper argues (i) that the possibility of experiencing at once pleasures and unpleasures does not threaten the contrariety of pleasure and unpleasure. (ii) That the hedonic balance calculated by adding all pleasures and displeasures of a subject at a time yields an abstract result that does not correspond to any new psychological reality. There are no resultant feelings. (iii) That there are nevertheless, in some cases, sentimental fusions: when the co-occurent pleasures and unpleasures do not have any bodily location, (...) and that their intentional object vanishes, they truly fuse with each other, giving rise to sentimental mixtures in which the initial pleasures and unpleasures are no longer discernible. (shrink)

Continental breakup between northwest Europe and Greenland was associated with widespread magmatism. Silica undersaturated alkaline porphyritic igneous rocks of a similar age have previously been dredged near the mid-Norwegian coast. These igneous rocks of the Vestbrona Formation have previously been interpreted as either igneous plugs or volcanic flows. New 3D seismic data indicate that relatively small sill complexes are abundant in the same region. In total, 36 sills with a size of [Formula: see text] have been mapped. In addition, 10 (...) seismic horizons were interpreted and tied to nearby wells to obtain a robust stratigraphic framework. The sills mainly intrude Cretaceous and Paleocene sequences; however, one sill is also identified in the pre-Cretaceous sequences. The sills locally form erosional remnants on the seabed due to massive uplifting and erosion of the continental margin. Vintage igneous and sedimentary dredge samples have been reanalyzed, including petrography, geochemistry, biostratigraphy, and Ar-Ar geochronology. The new Ar-Ar data suggest that the sills are 1–2 Ma older than breakup. Furthermore, the biostratigraphy and petrography of two sediment samples suggest that the samples were collected from near in situ subcrops and not of an ice rafted origin. The sediment samples are of Danian age and are strongly metamorphosed, most likely by contact metamorphism resulting from heating during sill emplacement. The newly identified sills have implications for the petroleum prospectivity of the study area including source rock maturation within thermal aureoles and the long-term alteration of fluid migration pathways. (shrink)

ABSTRACT: BACKGROUND: The governments and citizens of the developed nations are increasingly called upon to contribute financially to health initiatives outside their borders. Although international development assistance for health has grown rapidly over the last two decades, austerity measures related to the 2008 and 2011 global financial crises may impact negatively on aid expenditures. The competition between national priorities and foreign aid commitments raises important ethical questions for donor nations. This paper aims to foster individual reflection and public debate on (...) donor responsibilities for global health. METHODS: We undertook a critical review of contemporary accounts of justice. We selected theories that: (i) articulate important and widely held moral intuitions; (ii) have had extensive impact on debates about global justice; (iii) represent diverse approaches to moral reasoning; and (iv) present distinct stances on the normative importance of national borders. Due to space limitations we limit the discussion to four frameworks. RESULTS: Consequentialist, relational, human rights, and social contract approaches were considered. Responsibilities to provide international assistance were seen as significant by all four theories and place limits on the scope of acceptable national autonomy. Among the range of potential aid foci, interventions for health enjoyed consistent prominence. The four theories concur that there are important ethical responsibilities to support initiatives to improve the health of the worst off worldwide, but offer different rationales for intervention and suggest different implicit limits on responsibilities. CONCLUSIONS: Despite significant theoretical disagreements, four influential accounts of justice offer important reasons to support many current initiatives to promote global health. Ethical argumentation can complement pragmatic reasons to support global health interventions and provide an important foundation to strengthen collective action. (shrink)

This thesis investigates Habermas's attempt to establish a credible form of universalism in moral and political philosophy by means of the theoretical approach which he terms "discourse ethics." The central question motivating this study is whether Habermas succeeds in this ambition. Discourse ethics specifies a procedure which purports to enable all agents involved in a conflict of interest in which issues of justice are at stake to come to a rational and cooperative resolution. It proposes a position unique among contemporary (...) approaches to justice in the strength and character of its anti-relativist stance: the plurality of human cultures and the situated character of human understanding do not, according to this theory, bar the way to arriving at a minimal form of moral universalism. Although the procedure specified in communicative ethics elucidates only a narrow range of concerns--those pertaining to justice in the strict sense--it aims to do so in a way valid across all human cultures. ;Habermas's strategy for the defence of a species-wide moral universalism is, I argue, both the key feature of his position, and the least well understood. Discussion of discourse ethics to date has focussed almost exclusively on the question of its appropriateness to the context of modern, Western pluralism. An important reason for this focus has been the intricacy of Habermas's argumentative strategy, which links the recent work on discourse ethics to his longstanding project of developing a theory of communicative action. ;The principle aim of this thesis is to clarify Habermas's position by explicating his programme of justification. In so doing, I draw attention to several problems in his approach as a mechanism for cross-cultural conflict adjudication, and endeavour to provide a more perspicuous account of the relation of Habermas's theory to its main philosophical competitors, especially Rawlsian deontology, and contextualism. (shrink)

The paper depicts the blueprint of an electronic wise indicating system for demonstrating learning French to understudies to overcome the inconveniences they go up against. The fundamental idea of this structure is a proficient introduction into learning French. The system shows the purpose of learning French and coordinates thusly made issues for the understudies to clarify. The system is logically balanced at run time to the understudy’s individual progress. The system gives unequivocal help to adaptable presentation to learners.

Objective: To determine whether a moral reasoning exercise can improve response quality to surveys of healthcare priorities Methods: A randomised internet survey focussing on patient age in healthcare allocation was repeated twice. From 2574 internet panel members from the USA and Canada, 2020 (79%) completed the baseline survey and 1247 (62%) completed the follow-up. We elicited respondent preferences for age via five allocation scenarios. In each scenario, a hypothetical health planner made a decision to fund one of two programmes identical (...) except for average patient age (35 vs 65 years). Half of the respondents (intervention group) were randomly assigned to receive an additional moral reasoning exercise. Responses were elicited again 7 weeks later. Numerical scores ranging from –5 (strongest preference for younger patients) to +5 (strongest preference for older patients); 0 indicates no age preference. Response quality was assessed by propensity to choose extreme or neutral values, internal consistency, temporal stability and appeal to prejudicial factors. Results: With the exception of a scenario offering palliative care, respondents preferred offering scarce resources to younger patients in all clinical contexts. This preference for younger patients was weaker in the intervention group. Indicators of response quality favoured the intervention group. Conclusions: Although people generally prefer allocating scarce resources to young patients over older ones, these preferences are significantly reduced when participants are encouraged to reflect carefully on a wide range of moral principles. A moral reasoning exercise is a promising strategy to improve response quality to surveys of healthcare priorities. (shrink)

In a recent global survey commissioned for the Millennium Summit of the United Nations, people around the world consistently mentioned good health as what they most desired.

Companies that have joined the United Nations Global Compact are required to submit a Communication on Progress, which is an environmental, social, and governance report, to the UNGC every year. If they fail to do so, they are marked and listed as non-communicating on the UNGC website. Using the event study methodology, this study shows that a company that fails to report to the UNGC is penalized in the financial markets with an average cumulative abnormal return of −1.6% over a (...) period of 5 trading days around the event. Although a major critique against the UNGC is that the initiative’s voluntary nature and its lack of external monitoring and sanction mechanisms render it ineffective in terms of the business participants’ implementation of the UNGC principles into their operations, this result suggests that investors may be able to pressure UNGC business participants to increase their compliance with the UNGC requirements and to “walk the talk.”. (shrink)

Contrary to what is stated in Lemma 7.1 of [8], it is shown that some Boolean algebras of finitary logic admit finitely additive probabilities that are not σ-additive. Consequences of Lemma 7.1 are reconsidered. The concept of a C-σ-additive probability on B (where B and C are Boolean algebras, and $\mathscr{B} \subseteq \mathscr{C}$ ) is introduced, and a generalization of Hahn's extension theorem is proved. This and other results are employed to show that every S̄(L)-σ-additive probability on s̄(L) can be (...) extended (uniquely, under some conditions) to a σ-additive probability on S̄(L), where L belongs to a quite extensive family of first order languages, and S̄(L) and s̄(L) are, respectively, the Boolean algebras of sentences and quantifier free sentences of L. (shrink)

Radiography images are widely utilized in the health sector to recognize the patient health condition. The noise and irrelevant region information minimize the entire disease detection accuracy and computation complexity. Therefore, in this study, statistical Kolmogorov–Smirnov test has been integrated with wavelet transform to overcome the de-noising issues. Then the cat swarm-optimized deep belief network is applied to extract the features from the affected region. The optimized deep learning model reduces the feature training cost and time and improves the overall (...) disease detection accuracy. The network learning process is enhanced according to the AdaDelta learning process, which replaces the learning parameter with a delta value. This process minimizes the error rate while recognizing the disease. The efficiency of the system evaluated using image retrieval in medical application dataset. This process helps to determine the various diseases such as breast, lung, and pediatric studies. (shrink)

It is important to design digital infrastructure that can better accommodate multicultural and pluralistic views from its foundations. It is insufficient to look at only the responses and influences of culture on technology without considering how the technology can be adapted in anticipation of, and to support, pluralistic multicultural perspectives in its original design. This goes beyond the simple act of supporting multiple languages and interfaces, but should include the ability of digital and data infrastructure to capture and accommodate pluralistic (...) views, supporting multiple perspectives in the representation and processing of the data itself. In this work, we look at how rethinking the representation of data can allow us to more directly tackle domains that are typically hampered due to intercultural differences, and their inevitable losses in translation, particularly losses of valuable information like context and intention. When we refer to a loss of context and intention, we are referring to the loss of semantic information when practices such as referencing and citation are hard-coded to a particular set of cultural norms. We show that it is possible to expand the way in which we track referential data to capture richer semantic information regarding the contexts and intentions of the creators of this data, and thereby better serve the varied needs of those who consume, study, and refer to such data. We demonstrate this concept through a prototype system for a multicultural digital infrastructure, which we have named MultiVerse, and discuss its ethical implications from the perspectives of ‘multistability’, Intercultural Information Ethics framework, and poststructuralism. (shrink)

For first order languages with no individual constants, empty structures and truth values (for sentences) in them are defined. The first order theories of the empty structures and of all structures (the empty ones included) are axiomatized with modus ponens as the only rule of inference. Compactness is proved and decidability is discussed. Furthermore, some well known theorems of model theory are reconsidered under this new situation. Finally, a word is said on other approaches to the whole problem.

Consideration of reference systems for semivalues leads us to a global representation of the action of a semivalue on a game. Using this representation, we show how to modify semivalues to take account of coalition structures on the player set. The players' allocations according to a semivalue, including a modified semivalue, can be computed by means of products of matrices obtained from the multilinear extension of the game.

In this note we give an interpretation of cylindric algebras as algebras of sentences of first order logic. We show that the isomorphism types of such algebras of sentences coincide with the class of neat reducts of cylindric algebras. Also we show how this interpretation sheds light on some recent results. This is done by likening Henkin's Neat Embedding Theorem to his celebrated completeness proof.

This article explores Amartya Sen’s understanding of freedom, and performs two central functions, one classificatory and the other substantive in nature. First, I situate his reflections within canonical understandings of liberty, finding an irreducible pluralism incorporating positive liberty in ‘capability’ alongside negative and republican liberty in ‘process’, which is subsequently unified in the notion of ‘comprehensive outcomes’. Secondly, I attempt to find a normative referent for the intrinsic value of choice, and thereby indirectly that of freedom, in his account. In (...) contrast to the liberal subjectivity one might – I believe, mistakenly – attribute to Sen’s deployment of neoclassical economic frameworks, I instead argue for a re-interpretation of his account, inspired by the sociological literature on embodiment. Here, an ‘encumbered’ subject must inherit and transcend a normative totality to become an agent in the fullest sense. (shrink)

ABSTRACT he paper examines the digital practices and discourses of the Islamic State when exploiting Social Media Communication environments to propagate their jihadist ideology and mobilise specific audiences. It draws on insights from Social Media Critical Discourse Studies, observational approaches, and visual content/semiotic analysis. The paper maintains the complementary nature of technological practice and discursive content in the process of meaning-making in digital jihadist discourse. The study shows that digital practices of strategic sharing, distribution and campaigns to re-upload textual materials (...) are made possible by exploiting SMC communicative affordances. As for the analysis of discursive content, the paper focuses on YouTube and highlights strategic patterns and covert references in an IS-produced flagship video. It illustrates how IS discourse constructs its envisaged in-group/outgroup by symbolising current events within historical, political and ideological conflict scenarios, i.e. the incessant resistance and legitimacy of forces of virtue vs evil. By foregrounding symbolic references to military outgroup actors, IS legitimises its own violence and projects a powerful self-identity against a global hegemony. The paper shows how the combination of a technologically savvy operation and a resistant, anti-hegemonic narrative, embedded in a strategically framed symbolism of Islam, may resonate with global -diasporic digital consumers. (shrink)

Internet-of-Things creates a significant impact in spectrum sensing, information retrieval, medical analysis, traffic management, etc. These applications require continuous information to perform a specific task. At the time, various intermediate attacks such as jamming, priority violation attacks, and spectrum poisoning attacks affect communication because of the open nature of wireless communication. These attacks create security and privacy issues while making data communication. Therefore, a new method autoencoder deep neural network is developed by considering exploratory, evasion, causative, and priority violation attack. (...) The created method classifies the transmission outcomes used to predict the transmission state, whether it is jam data transmission or sensing data. After that, the sensing data is applied for network training that predicts the intermediate attacks. In addition to this, the channel access algorithm is used to validate the channel for every access that minimizes unauthorized access. After validating the channel according to the neural network, data have been transmitted over the network. The defined process is implemented, and the system minimizes different attacks on various levels of energy consumption. The effectiveness of the system is implemented using TensorFlow, and the system ensures the 99.02% of detection rate when compared with other techniques. (shrink)

The risk of cigarette smoking plays a pivotal role in increasing the incidence rates of lung cancer. This paper sheds new light on modeling the impact of cigarette smoking on lung cancer evolution, especially genetic instability and the number of gene mutations in the genome of stem cells. To handle this issue, we have set up stochastic multi-stage models to fit the data set of the probabilities of current and former smokers from the Nurses’ Health Study cohort of females and (...) the Health Professionals Follow up Study cohort of men. Throughout this paper, we consider both mutation rates and clonal expansion rates as parameters in each compartment. For current and former smokers, three-driver mutations are most likely to take place in the progression of lung cancer under smoking risk. For current smokers, our findings reveal that two to sixteen gene mutations are required to obtain a cancerous cell among men and women in US. Moreover, two to six cancer-mutations are available in the pathway to lung cancer among former smokers who have quit smoking for more than ten years for both male and female patients. This highlights that cigarette smoking stimulates the number of driver mutations during lung tumorigenesis in both sexes. It is very crucial to examine the role of cigarette smoking in determining whether genomic instability is an early stage or late stage in the process of lung carcinogenesis. (shrink)