The label ‘Translational Research’ (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the lab bench and its use at the clinical bedside. This is claimed to help society harvest the benefits of its investments in scientific research. The rhetorical as well as moral force of the label TR obscure, however, that it is actually used in very different ways. In (...) this paper, we analyse the scientific discourse on TR, with the aim to disentangle and critically evaluate the different meanings of the label. We start with a brief reconstruction of the history of the concept. Subsequently, we unravel how the label is actually used in a sample of scientific publications on TR and examine the presuppositions implied by different views of TR. We argue that it is useful to distinguish different views of TR on the basis of three dimensions, related to (1) the construction of the ‘translational gap’; (2) the model of the translational process; and (3) the cause of the perceived translational gap. We conclude that the motive to make society benefit from its investments in biomedical science may be laudable, but that it is doubtful whether the dominant views of TR will contribute to this end. (shrink)

The label ‘Translational Research’ (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the lab bench and its use at the clinical bedside. This is claimed to help society harvest the benefits of its investments in scientific research. The rhetorical as well as moral force of the label TR obscure, however, that it is actually used in very different ways. In (...) this paper, we analyse the scientific discourse on TR, with the aim to disentangle and critically evaluate the different meanings of the label. We start with a brief reconstruction of the history of the concept. Subsequently, we unravel how the label is actually used in a sample of scientific publications on TR and examine the presuppositions implied by different views of TR. We argue that it is useful to distinguish different views of TR on the basis of three dimensions, related to (1) the construction of the ‘translational gap’; (2) the model of the translational process; and (3) the cause of the perceived translational gap. We conclude that the motive to make society benefit from its investments in biomedical science may be laudable, but that it is doubtful whether the dominant views of TR will contribute to this end. (shrink)

The question we raise in this paper is, whether patient involvement might be a beneficial way to help determine and achieve the aims of translational research and, if so, how to proceed. TR is said to ensure a more effective movement of basic scientific findings to relevant and useful clinical applications. In view of the fact that patients are supposed to be the primary beneficiaries of such translation and also have relevant knowledge based on their experience, listening to their voice (...) early on in the innovation process might very well increase the effectiveness of the translation. After explaining how the concept of TR emerged and what it entails, this paper shows through a literature review which arguments have been put forward to promote patient involvement in health care research in a more general sense. We examine whether, and if so how, these arguments are relevant for the discourse on TR and we identify pitfalls and dilemmas. Ultimately, we conclude that it may be worthwhile to experiment with patient involvement in TR but that the design of such involvement requires careful consideration. (shrink)

The question we raise in this paper is, whether patient involvement might be a beneficial way to help determine and achieve the aims of translational research and, if so, how to proceed. TR is said to ensure a more effective movement of basic scientific findings to relevant and useful clinical applications. In view of the fact that patients are supposed to be the primary beneficiaries of such translation and also have relevant knowledge based on their experience, listening to their voice (...) early on in the innovation process might very well increase the effectiveness of the translation. After explaining how the concept of TR emerged and what it entails, this paper shows through a literature review which arguments have been put forward to promote patient involvement in health care research in a more general sense. We examine whether, and if so how, these arguments are relevant for the discourse on TR and we identify pitfalls and dilemmas. Ultimately, we conclude that it may be worthwhile to experiment with patient involvement in TR but that the design of such involvement requires careful consideration. (shrink)

Many political theorists today deny that citizenship can be defended on liberal grounds alone. Cosmopolitans claim that loyalty to a particular state is incompatible with universal liberal principles, which hold that we have equal duties of justice to persons everywhere, while nationalist theorists justify civic obligations only by reaching beyond liberal principles and invoking the importance of national culture. In Liberal Loyalty, Anna Stilz challenges both views by defending a distinctively liberal understanding of citizenship. Drawing on Kant, Rousseau, and (...) Habermas, Stilz argues that we owe civic obligations to the state if it is sufficiently just, and that constitutionally enshrined principles of justice in themselves--rather than territory, common language, or shared culture--are grounds for obedience to our particular state and for democratic solidarity with our fellow citizens. She demonstrates that specifying what freedom and equality mean among a particular people requires their democratic participation together as a group. Justice, therefore, depends on the authority of the democratic state because there is no way equal freedom can be defined or guaranteed without it. Yet, as Stilz shows, this does not mean that each of us should entertain some vague loyalty to democracy in general. Citizens are politically obligated to their own state and to each other, because within their particular democracy they define and ultimately guarantee their own civil rights. Liberal Loyalty is a persuasive defense of citizenship on purely liberal grounds. (shrink)

Positive polarity items (PPIs) are generally thought to have the boring property that they cannot scope below negation. The starting point of the paper is the observation that their distribution is significantly more complex; specifically, someone/something-type PPIs share properties with negative polarity items (NPIs). First, these PPIs are disallowed in the same environments that license yet type NPIs; second, adding any NPI-licenser rescues the illegitimate constellation. This leads to the conclusion that these PPIs have the combined properties of yet-type and (...) ever-type NPIs: what appears to be a prohibition is nothing but “halfway licensing”. The paper goes on to propose a unification of the analyses of rescuable PPIs, NPIs, and negative concord, and questions the grounding of polarity sensitivity in the scalar or the referential semantics of the items involved. (shrink)

Can social phenomena be understood by analyzing their parts? Contemporary economic theory often assumes that they can. The methodology of constructing models which trace the behavior of perfectly rational agents in idealized environments rests on the premise that such models, while restricted, help us isolate tendencies, that is, the stable separate effects of economic causes that can be used to explain and predict economic phenomena. In this paper, I question both the claim that models in economics supply claims about tendencies (...) and also the view that economics, when successful, necessarily follows this method. When economics licenses successful policy interventions, as it did in the case of the Federal Communications Commission spectrum auctions, its method is not to study tendencies but rather to study the phenomenon as a whole. Key Words: economic models • tendencies • economic experiments • policy making • John Stuart Mill. (shrink)

This article describes a survey among Finnish business students to find answers to the following questions: How do business students define a well-run company? What are their attitudes on the responsibilities of business in society? Do the attitudes of women students differ from those of men? What is the influence of business education on these attitudes? Our sample comprised 217 students pursuing a master’s degree in business studies at two Finnish universities. The results show that, as a whole, students valued (...) the stakeholder model of the company more than the shareholder model. However, attitudes differed according to gender: women students were more in favor of the stakeholder model and placed more weight on corporate ethical, environmental, and societal responsibilities than their men counterparts – both at the beginning and at the end of their studies. Thus, no gender socialization effect of business school education could be observed in this sense. Business school education was found to shape women and men students’ attitudes in two ways. Firstly, valuation of the shareholder model increased and, secondly, the importance of equal-opportunity employment decreased in the course of education. This raises the question whether the educational context is creating an undesirable tendency among future business professionals. The results further suggest that the sociocultural context can make a difference in how corporate social responsibility is perceived. The article also discusses possible ways to influence the attitudes of business students. (shrink)

In this paper I argue that the infinite regress of resemblance is vicious in the guise it is given by Russell but that it is virtuous if generated in a (contemporary) trope theoretical framework. To explain why this is so I investigate the infinite regress argument. I find that there is but one interesting and substantial way in which the distinction between vicious and virtuous regresses can be understood: The Dependence Understanding. I argue, furthermore, that to be able to decide (...) whether an infinite regress exhibits a dependence pattern of a vicious or a virtuous kind, facts about the theoretical context in which it is generated become essential. It is precisely because of differences in context that he Russellian resemblance regress is vicious whereas its trope theoretical counterpart is not. (shrink)

In his article “Research Priorities and the Future of Pregnancy” in this issue of CQ, Timothy Murphy evaluates some of the arguments I advanced in an earlier publication, “The Moral Imperative for Ectogenesis.

How do we talk about events we perceive? And how tight is the connection between linguistic and non-linguistic representations of events? To address these questions, we experimentally compared motion descriptions produced by children and adults in two typologically distinct languages, Greek and English. Our findings confirm a well-known asymmetry between the two languages, such that English speakers are overall more likely to include manner of motion information than Greek speakers. However, mention of manner of motion in Greek speakers' descriptions increases (...) significantly when manner is not inferable; by contrast, inferability of manner has no measurable effect on motion descriptions in English, where manner is already preferentially encoded. These results show that speakers actively monitor aspects of event structure, which do not find their way into linguistic descriptions. We conclude that, in regard to the differential encoding of path and manner, which has sometimes been offered as a prime example of the effects of language encoding on non-linguistic thought, surface linguistic encoding neither faithfully represents nor strongly constrains our mental representation of events. (shrink)

Recent research has demonstrated an asymmetry between the origins and endpoints of motion events, with preferential attention given to endpoints rather than beginnings of motion in both language and memory. Two experiments explore this asymmetry further and test its implications for language production and comprehension. Experiment 1 shows that both adults and 4-year-old children detect fewer within-category changes in source than goal objects when tested for memory of motion events; furthermore, these groups produce fewer references to source than goal objects (...) when describing the same motion events. Experiment 2 asks whether the specificity of encoding source/goal relations differs in both spatial memory and the comprehension of novel spatial vocabulary. Results show that endpoint configuration changes are detected more accurately than source configuration changes by both adults and young children. Furthermore, when interpreting novel motion verbs, both age groups expect more fine-grained lexical distinctions in the domain of endpoint configurations compared to that of source configurations. These studies demonstrate that a cognitive-attentional bias in spatial representation and memory affects both the detail of linguistic encoding during the use of spatial language and the specificity of hypotheses about spatial referents that learners build during the acquisition of the spatial lexicon. (shrink)

This volume introduces readers to a selected number of core issues in metaphysics that have been central in the history of philosophy and remain foundational to contemporary debates, that is: substances; properties; modality and essence; causality; determinism and free will. Anna Marmodoro and Erasmus Mayr take a neo-Aristotelian approach both in the selection and presentation of the topics. But Marmodoro and Mayr's discussion is not narrowly partisan-it consistently presents opposing sides of the debate and addresses issues from different philosophical (...) traditions, and encourages readers to draw their own conclusions about them. (shrink)

Laclau and Mouffe: The Radical Democratic Imaginary is the first full-length overview of the important work of Ernesto Laclau and Chantal Mouffe. Anna Marie Smith clearly shows how Laclau and Mouffe's work has brought Gramscian, poststructuralist and psychoanalytic perspectives to revitalize traditional political theory. With clarity and insight, she shows how they have constructed a highly effective theory of identity formation and power relations that carefully draws from the criticism of political theory from postmodern anti-foundationalist political theory.

In this paper, we develop a theoretical framework for understanding women leaders in working life. Our starting point is in statistics and earlier women-in-management literature, which show that women leaders represent a minority of the managerial population. We assume such underlying mechanisms causing discriminatory practices towards women leaders to exist which have become naturalized and invisible. Our concern is that everyone irrespective of gender should have a fair chance in career progression. This is both a moral and also an economic (...) challenge. The framework we develop in this paper is an alternative approach to studying women leaders compared to traditional women-in-management literature. It aims at revealing the "natural and taken-for-granted" cultural mechanisms behind discriminatory practices. Our framework is based on a critical discursive approach, which draws on ideas of how women''s leadership becomes symbolically represented and constructed in discursive practices. These symbolic constructions, which are mediated through language, often have an ideological loading which positions women leaders and builds their identities in ways that can help to legitimize unequal relations between the genders. However, our framework emphasizes the possibility of multiple discourses and a dynamic view of culture. The cultural constructions of women leaders are, thus, open to change. (shrink)

_Laclau and Mouffe: The Radical Democratic Imaginary_ is the first full-length overview of the important work of Ernesto Laclau and Chantal Mouffe. Anna Marie Smith clearly shows how Laclau and Mouffe's work has brought Gramscian, poststructuralist and psychoanalytic perspectives to revitalize traditional political theory. With clarity and insight, she shows how they have constructed a highly effective theory of identity formation and power relations that carefully draws from the criticism of political theory from postmodern anti-foundationalist political theory.

The first part of this article (Sections 1–5) focuses on the classical notions of scope and binding and their formal foundations. It argues that once their semantic core is properly understood, it can be implemented in various different ways: with or without movement, with or without variables. The second part (Sections 6–12) takes up the empirical issues that have redrawn the map in the past two decades. It turns out that scope is not a primitive. Existential scope and distributive scope (...) have to be distinguished, leaving few if any run-of-the-mill quantifiers. Scope behavior is also not uniform. At least three classes of expressions emerge: indefinites, distributive universals, and counters. Likewise, the bound variable interpretation of pronouns is joined by co-variation with situations. As a result, the classical notions of scope and binding are likely to end up as building blocks in the varied mechanisms at work in “scope phenomena” and “binding phenomena”, and not as self-contained analyses of those phenomena. (shrink)

This paper considers the relationship between institutions and the “sexual imaginary,” understood as the set of affective and imaginative resources that produce certain forms of sexual subjectivity. Drawing on the work of Cornelius Castoriadis and Moira Gatens, I argue that institutions play an important role in shaping sexual imaginaries. Historically, institutions have been sites in which unjust sexual norms have been reinforced and legitimized. I analyse the growing trend of consent education at Australian universities to explore how institutions may also (...) represent potential sites for contesting and reimagining these norms. Feminist critiques of consent suggest that consent education may in fact reproduce a narrow and conservative vision of sexuality, one that aligns with the neoliberal politics of the contemporary university. This paper contributes to these critiques by exploring how both the neoliberal university and consent theory are premised on a distorted vision of the subject as a rational, disembodied being. I argue that transforming dominant sexual imaginaries requires recognizing and interrogating both how desire permeates institutional spaces and the role of desire in ethical sexual relations. (shrink)

I argue that we are subject to ‘aesthetic luck’ in four senses: constitutive, upbringing, sociogeographic, and circumstantial. I review evidence from our practices, philosophy, and science. I then consider what challenges aesthetic luck raises to the communicability of aesthetic judgments, the formation of one’s aesthetic character, and the goal of a life well lived, as well as possible answers to those challenges.

The Canadian Truth and Reconciliation Commission has been mandated to collect testimonies from survivors of the Indian Residential Schools system. The TRC demands survivors of the residential school system to share their personal narratives under the assumption that the sharing of narratives will inform the Canadian public of the residential school legacy and will motivate a transformation of settler identity. I contend, however, that the TRC provides a concrete example of how a politics of recognition fails to transform relationships between (...) Native and settler Canadians not only because it enacts an internalization of colonial recognition, but because it fails to account for what I call “settler ignorance.” Work in epistemologies of ignorance and epistemic oppression gives language to explain sustained denial and provide tools to further understand how settler denial is sustained, and how it can be made visible, and so challenged. For this task, Mills’s articulation of white ignorance should be expanded to a consideration of white settler ignorance. Over and above an account of white ignorance, such an account will have to consider the underlying logics of settler colonialism. This characterization of settler ignorance will show that the denial of past and ongoing violence against Indigenous peoples, through the reconstruction of the past to assert the primacy of settlers, is not explainable in terms of a lack of recognition but is rather structural ignorance. (shrink)

Self-deception, that is the distortion of reality against the available evidence and according to one's wishes, represents a distinctive component in the wide realm of political deception. It has received relatively little attention but is well worth examining for its explanatory and normative dimensions. In this book Anna Elisabetta Galeotti shows how self-deception can explain political occurrences where public deception intertwines with political failure - from bad decisions based on false beliefs, through the self-serving nature of those beliefs, to (...) the deception of the public as a by-product of a leader's self-deception. Her discussion uses close analysis of three well-known case studies: John F. Kennedy and the Cuba Crisis, Lyndon B. Johnson and the Gulf of Tonkin Resolution, and George W. Bush and the weapons of mass destruction. Her book will appeal to a range of readers in political philosophy, political theory, and international relations. (shrink)

There seems to be a perfectly ordinary sense in which different speakers can use an empty name to talk about the same thing. Call this fictional coreference. It is a constraint on an adequate theory of empty names that it provide a satisfactory account of fictional coreference. The main claim of this paper is that the pretense theory of empty names does not respect this constraint.

Our ability to attend selectively to our surroundings - noticing things that matter, ignoring those that don't - is crucial if we are to negotiate the world around us. This is the first book in years to explore just how our attention can be influenced by time, and how our own perception of time can be influenced by what we attend to.

There are two main ways of understanding the function of surrogate decision making in a legal context: the Best Interests Standard and the Substituted Judgment Standard. First, we will argue that the Best Interests Standard is difficult to apply to unconscious patients. Application is difficult regardless of whether they have ever been conscious. Second, we will argue that if we accept the least problematic explanation of how unconscious patients can have interests, we are also obliged to accept that the Substituted (...) Judgment Standard can be coherently applied to patients who have never been conscious at the same extent as the Best Interests Standard. We then argue that acknowledging this result is important in order to show patients respect. (shrink)

For most people, animals are the most significant aspects of the nonhuman world. They symbolize nature in our imaginations, in popular media and culture, and in campaigns to preserve wilderness, yet scholars habitually treat animals and the environment as mutually exclusive objects of concern. Conducting the first examination of animals' place in popular and scholarly thinking about nature, Anna L. Peterson builds a nature ethic that conceives of nonhuman animals as active subjects who are simultaneously parts of both nature (...) and human society. Peterson explores the tensions between humans and animals, nature and culture, animals and nature, and domesticity and wildness. She uses our intimate connections with companion animals to examine nature more broadly. Companion animals are liminal creatures straddling the boundary between human society and wilderness, revealing much about the mutually constitutive relationships binding humans and nature together. Through her paradigm-shifting reflections, Peterson disrupts the artificial boundaries between two seemingly distinct categories, underscoring their fluid and continuous character. (shrink)

[...] I will only investigate [Austin's] claims as challenges to present-day model theoretic semantics. My main point will be to draw a sharp line between the semantic and pragmatic aspects of performatives and thereby discover a gap in Austin’s treatment. This will in my view naturally lead to the proposal in Section 2, that is, to treating performatives as denoting changes in intensional models. The rest of Section 2 will be concerned with the status of felicity conditions and a tentative (...) extension of Montague’s PTQ. (shrink)

Char et al. question the extent and degree to which machine learning applications should be treated as exceptional by ethicists. It is clear that of the suite of ethical issues raised by mac...

This conversation between two scholars of international law focuses on the contemporary realities of feminist analysis of international law and on current and future spaces of resistance. It notes that feminism has moved from the margin towards the centre, but that this has also come at a cost. As the language of women’s rights and gender equality has travelled into the international policy worlds of crisis management and peace and security, feminist scholars need to become more careful in their analysis (...) and find new ways of resistance. While noting that we live in dangerous times, this is also a hopeful discussion. (shrink)

This article is devoted to theexploration of some trends in gender studies incontemporary Russia and is based on ourresearch and teaching in the field over thecourse of seven years. The main concepts ofgender research – gender, feminism,women's subjectivity – were introduced to theRussian public early in 1990s; Russian genderstudies began to develop as a whole due to theapplication of Western concepts and theories.The article examines the growth of genderstudies over the last 10 years, contextualdifferences as well as theoretical approachesin Russian (...) gender studies as these have arisenin the context of the `Russia – West'dichotomy. (shrink)

The set of English modal verbs is widely recognised to communicate two broad clusters of meanings: epistemic and root modal meanings. A number of researchers have claimed that root meanings are acquired earlier than epistemic ones; this claim has subsequently been employed in the linguistics literature as an argument for the position that English modal verbs are polysemous (Sweetser 1990). In this paper I offer an alternative explanation for the later emergence of epistemic interpretations by liniking them to the development (...) of the child's theory of mind (Wellman 1990). If correct, this hypothesis might have important implications for the shape of the semantics of modal verbs. (shrink)

I believe that the validity of [the Fregean principle of compositionality] is beyond doubt and thus any grammar, whether organized to reflect [it] directly or not, may ultimately be required to satisfy it. One of the systems that are precisely designed to reflect [it] is Montague Grammar, where, technical details aside, it is realized as follows: (2) a. Sentences are composed by putting their constituents together step by step, with no subsequent rearrangement; b. Not only each lexical item but also (...) each rule of composition is assigned an explicit interpretation; c. Interpretation is given in terms of model theory: the denotation conditions of expressions are defined relative to a mathematical construct which, loosely speaking, models the relevant aspects of the world talked about. (shrink)

Judgments of well-being across different circumstances and spheres of life exhibit a staggering diversity. Depending on the situation, we use different standards of well-being and even treat it as being constituted by different things. This is true of scientific studies as well as of everyday life. How should we interpret this diversity? I consider three ways of doing so: first, denying the legitimacy of this diversity, second, treating well-being as semantically invariant but differentially realizable, and, third, adopting contextualist semantics for (...) well-being expressions. I reject the first option on the grounds that it is unable to make sense of much of everyday and scientific linguistic practices, and also because it makes the category of well-being insignificant or even otiose for practical purposes. We should thus pick between the second and the third options. I argue that contextualism about well-being is more plausible and faces fewer objections than the differential realization view. I conclude with a discussion of other features of contextualism: it does not imply that well-being is relative to individual taste, it need not result in eliminativism about well-being, nor in scepticism about a general theory of well-being. It does not commit us to an “anything goes” approach, nor does it threaten anarchy and miscommunication. (shrink)

Feminist Ethics and Narrative Ethics This article defines feminist ethics and narrative ethics and then explores the intersection of the two. A narrative approach to ethics focuses on how stories that are told, written, or otherwise expressed by individuals and groups help to define and structure our moral universe. Specifically, narrative ethicists take the practices … Continue reading Feminist Ethics and Narrative Ethics →.