Medical research involving human subjects can be risky and burdensome. Therefore, such research must be reviewed and approved by a Research Ethics Committee (REC). To guarantee the safety of the subjects, it is very important that these studies be conducted in accordance with the approved protocol. An important issue in this respect is whether studies include the requisite number of subjects based on the research question. The research question is unlikely to be answered reliably if the requisite number of subjects (...) is not met. In such cases, subjects are exposed to unnecessary risks and burdens. In this descriptive study, the authors evaluated how frequently studies are completed with the required number of subjects. Moreover, the authors identified the characteristics of research that does and does not include the required number of subjects. The results of this study show that a considerable proportion of studies (41/107) were terminated although they failed to recruit a sufficient number of subjects. Furthermore, the authors found that investigator-initiated studies have significantly (p=0.028) more problems in recruiting the requisite number of subjects than studies initiated by pharmaceutical companies. Potential solutions are discussed to reduce the number of studies that do not include a sufficient number of subjects. (shrink)

In this book two of the leading figures in argumentation theory present a view of argumentation as a means of resolving differences of opinion by testing the acceptability of the disputed positions. Their model of a 'critical discussion' serves as a theoretical tool for analysing, evaluating and producing argumentative discourse. They develop a method for the reconstruction of argumentative discourse that takes into account all aspects that are relevant to a critical assessment. They also propose a practical code of behaviour (...) for discussants who want to resolve their differences in a reasonable way. This is a major contribution to the study of argumentation and will be of particular value to professionals and graduate students in speech communication, informal logic, rhetoric, critical thinking, linguistics, and philosophy. (shrink)

Is guidance by social norms compatible with rationality? Jon Elster has argued inThe Cement of Societythat there is a fundamental contrast between rationality and conformity to social norms. The context of study is the problem of collective action, with special emphasis on collective wage bargaining. In such negotiations, the appeal to social norms rather than to self-interest can block agreement. Suppose one union is committed to the norm of equal pay for equal work; another one appeals to the norm of (...) equal pay for everybody, regardless of the type of work. ‘In the presence of competing norms that favor different groups, the self-righteousness conferred by belief in a norm can lead to a bargaining impasse.'In confrontations between individuals, codes of honor can produce similar problems. It is in no one's interest to face a colleague over the barrel of a gun because one has made a nasty remark about his latest book, but if the code demands that one fight it out, the challenge must be accepted. (shrink)

The issues addressed in philosophical papers on quotation generally concern only a particular type of quotation, which I call 'closed quotation'. The other main type, 'open quotation', is ignored, and this neglect leads to bad theorizing. Not only is a general theory of quotation out of reach: the specific phenomenon of closed quotation itself cannot be properly understood if it is not appropriately situated within the kind to which it belongs. Once the distinction between open and closed quotation has been (...) drawn and properly appreciated, it is tempting to consider that only closed quotation is relevant to semantics. Open quotation is more a matter of pragmatics: it is a matter of what people do with words, rather than a matter of content and truth-conditions. In this way one can provide the beginning of a justification for the neglect of open quotation in current semantic theorizing. There is some truth in this view, yet the phenomenon of 'mixed quotation', investigated at length in this paper, is interesting precisely because it shows that things are not so simple. Important issues concerning the interface between semantics and pragmatics will thus be raised. (shrink)

BackgroundThe emphasis on impact factors and the quantity of publications intensifies competition between researchers. This competition was traditionally considered an incentive to produce high-quality work, but there are unwanted side-effects of this competition like publication pressure. To measure the effect of publication pressure on researchers, the Publication Pressure Questionnaire (PPQ) was developed. Upon using the PPQ, some issues came to light that motivated a revision.MethodWe constructed two new subscales based on work stress models using the facet method. We administered the (...) revised PPQ (PPQr) to a convenience sample together with the Maslach Burnout Inventory (MBI) and the Work Design Questionnaire (WDQ). To assess which items best measured publication pressure, we carried out a principal component analysis (PCA). Reliability was sufficient when Cronbach’s alpha > 0.7. Finally, we administered the PPQr in a larger, independent sample of researchers to check the reliability of the revised version.ResultsThree components were identified as ‘stress’, ‘attitude’, and ‘resources’. We selected 3 × 6 = 18 items with high loadings in the three-component solution. Based on the convenience sample, Cronbach’s alphas were 0.83 for stress, 0.80 for attitude, and 0.76 for resources. We checked the validity of the PPQr by inspecting the correlations with the MBI and the WDQ. Stress correlated 0.62 with MBI’s emotional exhaustion. Resources correlated 0.50 with relevant WDQ subscales. To assess the internal structure of the PPQr in the independent reliability sample, we conducted the principal component analysis. The three-component solution explains 50% of the variance. Cronbach’s alphas were 0.80, 0.78, and 0.75 for stress, attitude, and resources, respectively.ConclusionWe conclude that the PPQr is a valid and reliable instrument to measure publication pressure in academic researchers from all disciplinary fields. The PPQr strongly relates to burnout and could also be beneficial for policy makers and research institutions to assess the degree of publication pressure in their institute. (shrink)

Leading scholars address the ethical and practical dimensions of Heidegger's thought.

The Hox genes play a role in anteroposterior axis specification of bilaterian animals that has been conserved for more than 600 million years. However, some of these genes have occasionally changed their roles in evolution. For example, the insect gene fushi tarazu (ftz), although localised in the Hox cluster, no longer acts as a Hox gene, but is involved in segmentation and nervous system development. Recent data of Mouchel‐Vielh et al.,1 and Hughes and Kaufman2 on ftz homologues in a crustacean (...) and a myriapod, respectively, shed new light onto the evolution of this gene. BioEssays 24:992–995, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

This article will discuss anatheist imagination in Kearney’s work. With the help of a poem by Sharon Olds, it will make a case for the sacramental – or anatheist – play between immanence and transcendence as a crucial motif to interpreting Kearney’s philosophy. Firstly, illustrating that the sacramental opens the door to a more embodied and carnal understanding of Kearney’s hermeneutics. Secondly, drawing on insights from my research, I’ll argue in a short history of anatheist imagination that there’s a continuity (...) between the sacramental and Kearney’s early work on the hermeneutics of the possible. Finally, the article concludes with some considerations on the philosophical and/or theological character of Kearney’s emphasis on the sacramental imagination as a hermeneutic stance. (shrink)

What is the highest good? In the ethics of René Descartes, we can distinguish between at least seven different answers to this question: God; the sum of all the different goods that “we either possess... or have the power to acquire” ; free will; virtue; love of God; wisdom; and supernatural beatitude. In this paper, I argue that each of these answers, in Descartes’s view, provides the correct particular conception, relative to a distinct sense or concept of the highest good. (...) Just as there are seven different conceptions of the highest good, according to Descartes, there are thus also seven different senses or concepts of the highest good. (shrink)

Conceived of as a contender to other theories in substantive ethics, virtue ethics is often associated with, in essence, the following account or criterion of right action: VR: An action A is right for S in circumstances C if and only if a fully virtuous agent would characteristically do A in C. There are serious objections to VR, which take the form of counter-examples. They present us with different scenarios in which less than fully virtuous persons would be acting rightly (...) in doing what no fully virtuous agent would characteristically do in the circumstances. In this paper, various proposals for how to revise VR in order to avoid these counter-examples are considered. I will argue that in so far as the revised accounts really do manage to steer clear of the counter-examples to VR, something which it turns out is not quite true for all of them, they instead fall prey to other damaging objections. I end by discussing the future of virtue ethics, given what has come to light in the previous sections of the paper. In particular, I sketch the outlines of a virtue ethical account of rightness that is structurally different from VR. This account also faces important problems. Still, I suggest that further scrutiny is required before we are in a position to make a definitive decision about its fate. (shrink)

In the pragma-dialectical approach, fallacies are considered incorrect moves in a discussion for which the goal is successful resolution of a dispute. Ten rules are given for effective conduct at the various stages of such a critical discussion (confrontation, opening, argumentation, concluding). Fallacies are discussed as violations of these rules, taking into account all speech acts which are traditionally recognized as fallacies. Special attention is paid to the role played by implicitness in fallacies in everyday language use. It is stressed (...) that identifying and acknowledging fallacies in ordinary discussions always has a conditional character. Differences between the pragma-dialectical perspective, the Standard Treatment, and the formal logic approach to fallacy analysis are discussed. (shrink)

BackgroundConcerns about research misbehavior in academic science have sparked interest in the factors that may explain research misbehavior. Often three clusters of factors are distinguished: individual factors, climate factors and publication factors. Our research question was: to what extent can individual, climate and publication factors explain the variance in frequently perceived research misbehaviors?MethodsFrom May 2017 until July 2017, we conducted a survey study among academic researchers in Amsterdam. The survey included three measurement instruments that we previously reported individual results of (...) and here we integrate these findings.ResultsOne thousand two hundred ninety-eight researchers completed the survey. Results showed that individual, climate and publication factors combined explained 34% of variance in perceived frequency of research misbehavior. Individual factors explained 7%, climate factors explained 22% and publication factors 16%.ConclusionsOur results suggest that the perceptions of the research climate play a substantial role in explaining variance in research misbehavior. This suggests that efforts to improve departmental norms might have a salutary effect on behavior. (shrink)

This theoretical expose explores the complex notion of argumentative style, which has so far been largely neglected in argumentation theory. After an introduction of the problems involved, the theoretical tools for identifying the properties of the discourse in which an argumentative style manifests itself are explained from a pragma-dialectical perspective and a theoretical definition of argumentative style is provided that does full justice to its role in argumentative discourse. The article concludes with a short reflection upon the next steps that (...) need to be taken in argumentation theory in further substantiating the notion of argumentative style. (shrink)

I argue that epistemic injustice manifests not only in the content of our concepts, but in the spaces between them. Others have shown that epistemic injustice arises in the form of “testimonial injustice,” where an agent is harmed because her credibility is undervalued, and “hermeneutical injustice,” where an agent is harmed because some community lacks the conceptual resources that would allow her to render her experience intelligible. I think that epistemic injustice also arises as a result of prejudiced and harmful (...) defects in the inferential architecture of both scientific practice and everyday thinking. Drawing on lessons from the philosophy of science, I argue that the inferential architecture of our epistemic practices can be prejudiced and wrongful, leading to a variety of epistemic injustice that I am calling “inferential injustice.” This type of injustice is fully structural; it inheres in our epistemic practices themselves rather than as a direct result of an individual’s action. For this reason, cases of inferential injustice are importantly different from extant cases of epistemic injustice and are especially hard to track. We need a better understanding of inferential injustice so that we can avoid and ameliorate cases such as the ones I present here. (shrink)

Attention is given to a background idea that is often invoked in discussions about reasonable partiality: the idea of a moral division of labour. It is not only a right, but also a duty for professionals to attend (almost) exclusively to the interests of their own clients, because their partial activities are part of an impartial scheme providing for an allocation of professional help to all clients. To clarify that idea, a difference is made between two kinds of division of (...) labour, a technical one and a social one. In order to assess the applicability of the idea of a moral division of labour to professional ethics, journalism is contrasted with other professions. (shrink)

In Waartoe Wetenschap? onderzoekt Frans W. Saris de wetenschap in evolutionair perspectief en hij bepleit een radical enlightenment in een dertiental essays en een toneeltekst waarin zulke uiteenlopende wetenschappers verschijnen als ...

ABSTRACT We outline a number of ethical objections to genetic technologies aimed at enhancing human capacities and traits. We then argue that, despite the persuasiveness of some of these objections, they are insufficient to stop the development and use of genetic enhancement technologies. We contend that the inevitability of the technologies results from a particular guiding worldview of humans as masters of the human evolutionary future, and conclude that recognising this worldview points to new directions for ethical thinking about genetic (...) enhancement technologies. (shrink)

This commentator has no argument with the explanations given by Soltis. Yet a different approach to the phenomenon of crying might be fruitful. Neonates elicit care. It is hypothesized that non-neonates evolved to mimic, when in need, the appearance of the neonate by crying and by shedding tears, thus inducing helping behavior by the spectator.

Ideas formulated by Paul Ewald about the “evolution of virulence” are used to explain why bats, more often than other mammals, are a reservoir of virulent viruses, and why many of these viruses severely affect other mammals, including humans, but are apparently less pathogenic for bats. Potential factors contributing to bat viruses often being zoonotic are briefly discussed.

This study examines the shame that drives the rite of confession of guilt and sin in the Toraja tradition and then dialogues with the Christian faith. In this study, a qualitative research method was used with an ethnographic approach. Observations and interviews were conducted with figures who knew the topic. The results show that Toraja people experience collective shame when community members commit moral violations. A sense of shame before others or social shame is felt. However, spiritual shame is an (...) aspect that cannot be ignored. Behind the social violations, there are efforts to interpret the relationship with God (Toraja language, Puang Matua), which needs to be brought back to lead people to repentance. Contribution: This article combines tradition and theology, particularly missional and contextual theology. The results of this study are expected to increase the efforts of each respondent to interpret God in every social violation committed to lead people to repentance. (shrink)

In his reflections on ethics, Descartes distances himself from the eudaimonistic tradition in moral philosophy by introducing a distinction between happiness and the highest good. While happiness, in Descartes’s view, consists in an inner state of complete harmony and satisfaction, the highest good instead consists in virtue, i.e. in ‘a firm and constant resolution' to always use our free will well or correctly. In Section 1 of this paper, I pursue the Cartesian distinction between happiness and the highest good in (...) some detail. In Section 2, I discuss the question of how the motivation to virtue should be accounted for within Descartes’s ethical framework. In Section 3, I turn to Descartes’s defence of the view that virtue, while fundamentally distinct from happiness, is nevertheless sufficient for obtaining it. In the final section of the paper , my concern is instead with a second and sometimes neglected distinction that Descartes makes between two different senses o.. (shrink)

It is often claimed that the exceptional severity of the Spanish flu, one of the most deadly events in recorded human history, is an unsolved mystery. However, even detailed aspects such as its W-shaped mortality curve are well explained by Paul Ewald’s theory of the evolution of virulence. Understanding the causes of the Spanish flu will help to prevent future epidemics.

The Belief‐Desire model (the B‐D model) of reasons for action has been subject to much criticism lately. Two of the most elaborate and trenchant expositions of such criticisms are found in recent works by Jonathan Dancy (2000) and Fred Stoutland (2002). In this paper we set out to respond to the central pieces of their criticisms. For this purpose it is essential to sort out and regiment different senses in which the term ‘reason’ may be used. It is necessary to (...) go beyond common philosophical practice and distinguish not merely between two such different uses but to make a tripartite distinction. Our aim is largely conciliatory: we grant the main parts of the points made by Stoutland and Dancy but argue that once the B‐D model has been properly stated, and different uses of the term ‘reason’ sufficiently regimented, the B‐D proponent is able to accommodate their respective criticisms within the framework of the B‐D model and thereby undermine their case against the model. (shrink)

Michael Dummett has shown that the fragment ‘17 Kernsätze zur Logik’ is evidence that Frege knew Lotze's Logik Dummett’s dating of this fragment prior to 1879, however, must be rejected.The present paper shows that there are other articles of Frege’s which bear clear traces of Lotze's LogikFirst of all, the expressions Vorstellungsverlauf from ‘Über die wissenschaftliche Berechtigung einer Begriffsschrift’, and veranlassenden Ursachen, from ‘Logik’, certainly are borrowed from Lotze.Second, there are links between ‘Booles rechnende Logik und die Begriffsschrift’ and Lotze's (...) Logik. Furthermore, it is shown that Frege’s ‘Kernsätze’, the ‘Dialog mit Pünjer über Existenz’, and his ‘Logik’ are intimately connected.All of this indicates that these texts were written in roughly the same period, namely the early 1880s.Conclusive evidence for this is that the terms Vorstellung and Vorstellungsverbindung are used indiscriminately in both a psychological and a logical sense in the ‘Begriffsschrift’, a fact which contradicts the ‘Kernsätze’. (shrink)

My main concern in this paper is to develop and defend an account of why we ought to devote our lives to virtue—of the ground or reason for why we ought to do so—according to René Descartes. On my account, the answer is that we thereby, and indeed only thereby, do everything in our power to promote our own degree of intrinsic perfection or goodness. Descartes’s moral philosophy, as I understand it, thus constitutes a form of ethical perfectionism. While I (...) am not the first to interpret Descartes as an ethical perfectionist, there is as of yet no detailed account in the literature of what his particular form of ethical perfectionism would then entail. This is something that I hope to remedy here. (shrink)

The turn of the millennium has been marked by new developments in the study of early modern philosophy. In particular, the philosophy of René Descartes has been reinterpreted in a number of important and exciting ways, specifically concerning his work on the mind-body union, the connection between objective and formal reality, and his status as a moral philosopher. These fresh interpretations have coincided with a renewed interest in overlooked parts of the Cartesian corpus and a sustained focus on the similarities (...) between Descartes' thought and the philosophy of Baruch Spinoza. Mind, Body, and Moralityconsists of fifteen chapters written by scholars who have contributed significantly to the new turn in Descartes and Spinoza scholarship. The volume is divided into three parts. The first group of chapters examines different metaphysical and epistemological problems raised by the Cartesian mind-body union. Part II investigates Descartes' and Spinoza's understanding of the relations between ideas, knowledge, and reality. Special emphasis is put on Spinoza's conception of the relation between activity and passivity. Finally, the last part explores different aspects of Descartes' moral philosophy, connecting his views to important predecessors, Augustine and Abelard, and comparing them to Spinoza. nd Spinoza's understanding of the relations between ideas, knowledge, and reality. Special emphasis is put on Spinoza's conception of the relation between activity and passivity. Finally, the last part explores different aspects of Descartes' moral philosophy, connecting his views to important predecessors, Augustine and Abelard, and comparing them to Spinoza. (shrink)

Journal of Philosophy of Education, EarlyView.

Although there is a consensus among philosophers of mathematics and mathematicians that mathematical explanations exist, only a few authors have proposed accounts of explanation in mathematics. These accounts fit into the unificationist or top-down approach to explanation. We argue that these models can be complemented by a bottom-up approach to explanation in mathematics. We introduce the mechanistic model of explanation in science and discuss the possibility of using this model in mathematics, arguing that using it does not presuppose a Platonist (...) view of mathematics and allows one to gain insight into why a theorem is true by answering what-if-things-had-been-different questions. (shrink)

Differing accounts are conventionally given of the origins of medical sociology and its parent discipline of sociology. These distinct ‘histories’ are justified on the basis that the sociological founders were uninterested in medicine, mortality and disease. This article challenges these ‘constructions’ of the past, proposing the theorization of health not as a ‘late development of sociology’ but an integral part of its formation. Drawing on a selection of key sociological texts, it is argued that evidence of the founders’ sustained interest (...) in the infirmities of the individual, of mortality, and in medicine, have been expunged from the historical record through processes of ‘canonization’ and ‘medicalization’. (shrink)

The colors we perceive are the outcome of an attempt to meaningfully order the spectral information from the environment. These colors are not the result of a straightforward mapping of a physical property to a sensation, but arise from an interaction between our environment and our visual system. Thus, although one may infer from a surface’ reflectance characteristics that it will be perceived as “colored,” true colors only arise by virtue of the interaction of the reflected light with the eye (...) (and brain) of an observer. (shrink)

In one of the essays in his recent book on Christianity, La déclosion (2005), Nancy discusses the relationship between Judaism and Christianity. Nancy opens this discussion with a reference to Lyotard’s book on this relationship: Un trait d’union (1993). Both Lyotard and Nancy examine a very early figure in the emergence of Christianity from Judaism—whereas Lyotard focuses on the epistles of Paul, Nancy reads the epistle of James. Lyotard concludes that the hyphen in the expression ‘Judeo-Christian’ actually conceals ‘the most (...) impenetrable abyss within Western thought’. With this abyss, Lyotard refers to the point of departure of Judaism: the event in which a Voice has left behind letters, inaugurating an interminable work of interpretation. For Nancy, however, it is rather Christianity, and therefore, Western culture, which is deconstructive in nature. Its composition is co-original with a decomposition, and therefore, with an openness. In James, Nancy finds an emphasis on praxis, in such a way that existence is to be understood as transcendent within itself. With this reading of James, Nancy seems to deny that there is a fundamental difference between Judaism and Christianity. In order to clarify the differences between Lyotard and Nancy, it is shown that, in Lyotard’s view, an unsublatable alterity comes with aisthèsis, whereas in Nancy’s view, alterity comes with existence as such. (shrink)