Despite the wide and daunting array of cross-cultural obstacles that the formulation of a global policy on advance directives will clearly pose, the need is equally evident. Specifically, the expansion of medical services driven by medical tourism, just to name one important example, makes this issue urgently relevant. While ensuring consistency across national borders, a global policy will have the additional and perhaps even more important effect of increasing the use of advance directives in clinical settings and enhancing their effectiveness (...) within each country, regardless of where that country's state of the law currently stands. One cross-cultural issue that may represent a major obstacle in formulating, let alone applying, a global policy is whether patient autonomy as the underlying principle for the use of advance directives is a universal norm or a construct of western traditions that must be reconciled with alternative value systems that may place lesser significance on individual choice. A global policy, at a minimum, must emphasize respect for patient autonomy, provision of medical information, limits to the obligations for physicians, and portability. And though the development of a global policy will be no easy task, active engagement in close collaboration with the World Health Organization can make it possible. (shrink)

Despite the wide and daunting array of cross-cultural obstacles that the formulation of a global policy on advance directives will clearly pose, the need is equally evident. Specifically, the expansion of medical services driven by medical tourism, just to name one important example, makes this issue urgently relevant. While ensuring consistency across national borders, a global policy will have the additional and perhaps even more important effect of increasing the use of advance directives in clinical settings and enhancing their effectiveness (...) within each country, regardless of where that country's state of the law currently stands. One cross-cultural issue that may represent a major obstacle in formulating, let alone applying, a global policy is whether patient autonomy as the underlying principle for the use of advance directives is a universal norm or a construct of western traditions that must be reconciled with alternative value systems that may place lesser significance on individual choice. A global policy, at a minimum, must emphasize respect for patient autonomy, provision of medical information, limits to the obligations for physicians, and portability. And though the development of a global policy will be no easy task, active engagement in close collaboration with the World Health Organization can make it possible. (shrink)

The contemporary age is approaching the downfall of human civilization due to the rapid collapse of the global ecology. As the popular obsession with industrial development, triggered by the Western modernization of the 18th century, expands across the entire world, minor regional environmental crises have merged intoan irremediable global ecological crisis. This suggests that human society has lost its ability to harmonize with nature and is driving itself to a crisis of survival, dangling on the brink of a fatal cliff. (...) The resolution of the global ecological crisis, which has been exacerbated primarily by Western civilization, requires an alternative thought paradigm that appeared in Korea over 100 years ago, one that can be characterized as ‘the ideology of Gaebyeok.’ This ideology proclaimsthat the global ecological crisis of our times is not simply a crisis of civilization sparked by energy over-consumption, but is rather an inevitable cyclical phenomenon stemming from a change in the universe’s natural order. The ideology of Gaebyeok, refined by a Korean Philosopher, Gim Il-Bu (1826-1898) in his work Jeongyeok (Right Change) and eventually brought to full blossom by Gang Jeung-San (1871-1909), suggests an excellent alternative way of thinking which offers a new hope to the citizens of the contemporary world who cannot ind an escape from their risky societies. My paper will discuss this enlightened vision of global hope. (shrink)

Scholars are becoming increasingly interested in whether and how government use of Big Data will affect public policy outcomes. Despite such growing scholarly interests, however, little evidence exists on the role Big Data can play in improving government service. We undertake one of the first quantitative studies revealing the potential utility and limitations of “Big Data-based policymaking” by exploring its recent use by the Seoul Metropolitan Government. In 2013, the government introduced the “Owl Bus”—a late-night bus system—the routes of which (...) were selected based on government analyses of Big Data relating to citizens’ late-night taxi and mobile phone use. The findings suggest that the average number of passengers utilizing the Owl Bus routes was significantly greater than that on other daytime bus routes with comparable characteristics. That said, we also present the potential limitations of evidence-based policymaking in general, especially when politics and equity considerations are factored in. (shrink)

The Canadian-American biologist Edmund Vincent Cowdry played an important role in the birth and development of the science of aging, gerontology. In particular, he contributed to the growth of gerontology as a multidisciplinary scientific field in the United States during the 1930s and 1940s. With the support of the Josiah Macy, Jr. Foundation, he organized the first scientific conference on aging at Woods Hole, Massachusetts, where scientists from various fields gathered to discuss aging as a scientific research topic. He also (...) edited Problems of Ageing (1939), the first handbook on the current state of aging research, to which specialists from diverse disciplines contributed. The authors of this book eventually formed the Gerontological Society in 1945 as a multidisciplinary scientific organization, and some of its members, under Cowdry's leadership, formed the International Association of Gerontology in 1950. This article historically traces this development by focusing on Cowdry's ideas and activities. I argue that the social and economic turmoil during the Great Depression along with Cowdry's training and experience as a biologist – cytologist in particular – and as a textbook editor became an important basis of his efforts to construct gerontology in this direction. (shrink)

Emmanuel Levinas’s doubts about the ethical value of artistic beauty have been widely acknowledged by the vast majority of Levinas’s commentators. However, though it is true that in “Reality and Its Shadow” Levinas persistently rebukes artistic beauty for its nonethicality, it is undeniable that he at least upholds the value of artistic criticism and modern literature. In this article I intend to relate Levinas’s exploration of the possibility of spiritual–ethical teaching in literature to Immanuel Kant’s reflections on the relation between (...) the feeling of beauty, that of sublimity, and sensible feeling in his third Critique. This up-close comparative examination fosters understanding of Levinas’s religious and philosophical approach to the sublime elements in some literary works, especially those of Fyodor Dostoevsky. (shrink)

SUMMARYBy examining the use of tissue culture in post-war American biomedicine, this paper investigates how scientists experience and manage failure. I study how Leonard Hayflick forged his new definition of failure and ways of managing it by refuting Alexis Carrel's definition of failure alongside his theory of the immortality of cultured cells. Unlike Carrel, Hayflick claimed that every vertebrate somatic cell should eventually die, unless it transformed into a tumour cell. This claim defined cell death, which had been a problem (...) leading to a laboratory failure, as a normal phenomenon. On the other hand, permanent life, which had been considered a normal cellular characteristic, became a major factor causing scientific failure, since it implied malignant transformation that scientists hoped to control. Hayflick then asserted that his cell strains and method would partly enable scientists to manage this factor—especially that occurred through viral infection—alongside other causes of failure in routine tasks, including bacterial contamination. I argue that the growing biomedical enterprise fostered this work of Hayflick's, which had repercussions in both his career and the uses of cells in diverse investigations. His redefinition of failure in the age of biomedicine resulted in the broad dissemination of his cells, medium, and method as well as his long struggle with the National Institutes of Health, which caused his temporarily failed career. (shrink)

This paper discusses how growth and aging became interrelated phenomena with the creation of gerontology in the United States. I first show that the relation of growth to senescence, which had hardly attracted scientific attention before the twentieth century, started to be investigated by several experimental scientists around the 1900s. Subsequently, research on the connection between the two phenomena entered a new domain through the birth of gerontology as a scientific field comprised of various disciplines, many of which addressed growth. (...) Due to gerontologists’ efforts, the association between aging and growth became stronger and more multifaceted within the discursive and organizational matrix constituting the new science, leading to a broader definition of senescence with an ambiguous connection to chronological age. Furthermore, as gerontologists borrowed the cultural agendas as well as research methods from studies of growth, aging began to be defined as a phenomenon that could be actively controlled and managed in both social arenas and laboratory environments. (shrink)

This paper presents an analysis of the birth and growth of scientific creationism in South Korea by focusing on the lives of four major contributors. After creationism arrived in Korea in 1980 through the global campaign of leading American creationists, including Henry Morris and Duane Gish, it steadily grew in the country, reflecting its historical and social conditions, and especially its developmental state with its structured mode of managing science and appropriating religion. We argue that while South Korea’s creationism started (...) with the state-centered conservative Christianity under the government that also vigilantly managed scientists, it subsequently constituted some technical experts’ efforts to move away from the state and its religion and science through their negotiation of a new identity as Christian intellectuals. Our historical study will thus explain why South Korea became what Ronald Numbers has called “the creationist capital of the world.”. (shrink)

The purpose of this study was to identify relationship between leisure constraint negotiations and leisure activity participation through meta-analysis within the Korean context. Through this study, the inconsistent research results of previous studies are explained by comprehensively clarifying the relationship between the two variables and identifying a third variable that controls the relationship. The efforts of this project are expected to provide useful data that can be used for future research and to seek ways of increasing participation in leisure activities. (...) In order to achieve the purpose of this study, the research questions set in this study are as follows. First, what is the magnitude of the effect of the correlation coefficient between leisure constraint negotiations and leisure participation? Second, what are the variables that control the relationship between leisure constraint negotiations and leisure participation? Materials were collected by utilizing Research Information Sharing Service, DBpia, Korean studies Information Service System, and Korea Citation Index. Finally, 20 pieces of research materials were selected with a total of 6,843 participants. The conclusions drawn from the research questions set in this study are as follows. First, leisure constraint negotiations and leisure participation are in a static relationship, and their level is considerable. In other words, efforts to overcome leisure constraints increase participation in leisure activities. Second, gender, age, and type of active leisure activities are major variables that control the relationship between leisure constraint negotiations and leisure participation. Finally, the limitation of this study and future research orientation were discussed. (shrink)

BackgroundAlthough the Life-Sustaining Treatment (LST) Decision Act was enforced in 2018 in Korea, data on whether it is well established in actual clinical settings are limited. Hospital-acquired pneumonia (HAP) is a common nosocomial infection with high mortality. However, there are limited data on the end-of-life (EOL) decision of patients with HAP. Therefore, we aimed to examine clinical characteristics and outcomes according to the EOL decision for patients with HAP.MethodsThis multicenter study enrolled patients with HAP at 16 referral hospitals retrospectively from (...) January to December 2019. EOL decisions included do-not-resuscitate (DNR), withholding of LST, and withdrawal of LST. Descriptive and Kaplan–Meier curve analyses for survival were performed.ResultsOf 1,131 patients with HAP, 283 deceased patients with EOL decisions (105 cases of DNR, 108 cases of withholding of LST, and 70 cases of withdrawal of LST) were analyzed. The median age was 74 (IQR 63–81) years. The prevalence of solid malignant tumors was high (32.4% vs. 46.3% vs. 54.3%, P = 0.011), and the ICU admission rate was lower (42.9% vs. 35.2% vs. 24.3%, P = 0.042) in the withdrawal group. The prevalence of multidrug-resistant pathogens, impaired consciousness, and cough was significantly lower in the withdrawal group. Kaplan–Meier curve analysis revealed that 30-day and 60-day survival rates were higher in the withdrawal group than in the DNR and withholding groups (log-rank P = 0.021 and 0.018). The survival of the withdrawal group was markedly decreased after 40 days; thus, the withdrawal decision was made around this time. Among patients aged below 80 years, the rates of EOL decisions were not different (P = 0.430); however, mong patients aged over 80 years, the rate of withdrawal was significantly lower than that of DNR and withholding (P = 0.001).ConclusionsAfter the LST Decision Act was enforced in Korea, a DNR order was still common in EOL decisions. Baseline characteristics and outcomes were similar between the DNR and withholding groups; however, differences were observed in the withdrawal group. Withdrawal decisions seemed to be made at the late stage of dying. Therefore, advance care planning for patients with HAP is needed. (shrink)

This paper examines vegetarianism in the eighth “no meat-eating” chapter of the Laṅkāvatāra with specific attention to how the sūtra confronts the previous dietary code and combats Buddhist resistance to the new doctrine. This study corroborates previous observations that vegetarianism in Indian Buddhism was a response to outsiders’ censure, rather than an expression of a specific Buddhist doctrine. It goes on to explore how the Laṅkāvatāra introduces a new dietary norm, one that was incompatible with the preexisting monastic code that (...) allowed monks to partake of meat pure in three aspects. The Laṅkāvatāra replaced the three conditions for meat to be pure with the three modes of killing, thereby rendering the old regulation into a rule that makes any form of meat-eating impossible. In an effort to suppress intra-Buddhist resistance to vegetarianism, the sūtra prophesized the future appearance of anti-vegetarian Buddhists and identified them as heretics. Eliminating the past and future possibility of meat-eating, the Laṅkāvatāra defines Buddhism as a meat-free tradition. (shrink)

Intense competition can compel lobbyists to exaggerate the benefits the government would see in tax returns and social welfare if agency officials allocate such resources to the lobbyist's members. This incentive to misrepresent grows when information asymmetry exists between lobbyists and government officials. A large body of literature has investigated how interest groups compete and interact, but it disregards the interdependency of interests between competing groups and associated strategic behaviors of other players. Our signaling model of lobbying reveals ways in (...) which agency officials can compel lobbyists for competing interests to lobby truthfully and what the policy implications of this compulsion can be. We also present case-study evidence of how this works in practice. (shrink)

The paper studies the nature of understanding in condensed matter physics (CMP), mediated by the successful employment of its models. I first consider two obvious candidates for the criteria of model-based understanding, Van Fraassen's sense of empirical adequacy and Hacking's instrumental utility , and conclude that both are unsatisfactory. Inspired by Hasok Chang's recent proposal to reformulate realism as the pursuit of ontological plausibility in our system of knowledge, we may require the model under consideration to be understood (or intelligible) (...) before claiming model-based understanding. Here the understanding of a model typically consists of the following: figuring out at least one plausible (preferably realistic) physical mechanism for the model, determining the theoretical consequences of the model by mathematically probing it and developing our physical intuitions about the model. I consider the q-state Potts model to illustrate. After having understood a model, we may employ the model to understand its target phenomena in the world. This is done by matching one of the interpretative models of the model with the central features of the phenomena. The matching should be motivated (ideally both theoretically and empirically) in the sense that we have good reason to believe that the central features of the phenomena can be thought of as having more or less the same structure as postulated by the interpretative model. In conclusion, I propose a two-stage account of model-based understanding in CMP: (1) understanding of a model and (2) matching a target phenomenon with a well-motivated interpretative model of the model. Empirical success and instrumental utility both play their roles in the evaluation of how successful the model is, but are not the essential part of model-based understanding. (shrink)

There is no consensus concerning how to understand the ‘two-step proof structure’ (§§15–20, 21–7) of the Transcendental Deduction in the B-edition of the Critique of Pure Reason. This disagreement invites a closer examination of what Kant might have meant by a ‘transcendental deduction’. I argue that the transcendental deduction consists of three tasks that parallel Kant’s broader project of a ‘critique’ of pure reason; first, an origin task to justify reason’s authority to use them; second, an analytical task that determines (...) the conditions under which this authority can be legitimately exercised; and third, a dialectical task to determine the conditions under which this authority cannot be legitimately exercised. So long as we continue to read the B-Deduction solely in terms of its two-step proof structure, we overlook how Kant’s notion of ‘critique’ constitutes the real grounds for his argumentative strategy there. (shrink)

Bird argues that scientific progress consists in increasing knowledge. Dellsén objects that increasing knowledge is neither necessary nor sufficient for scientific progress, and argues that scientific progress rather consists in increasing understanding. Dellsén also contends that unlike Bird’s view, his view can account for the scientific practices of using idealizations and of choosing simple theories over complex ones. I argue that Dellsén’s criticisms against Bird’s view fail, and that increasing understanding cannot account for scientific progress, if acceptance, as opposed to (...) belief, is required for scientific understanding. (shrink)

Drawing upon the dual status of the Eumenides as metics who were neither included in nor excluded from Athenian democratic politics, this essay attempts to bring the last scene of The Eumenides to contemporary political settings wherein we observe the duality of immigrants—that is, the tension between political citizenship and cultural foreignness—in our liberal society. The controversial bride kidnapping cases among Hmong immigrants show that the liberal regulative principles such as reciprocity and mutual respect cannot work in the context of (...) powerful and irreconcilable cultural and moral conflicts, which go beyond the line that we can tolerate in the name of cultural diversity. Instead, this essay focuses on the Athenian citizens’ and the Eumenides’ courageous decision to suffer together, not merely to live together, in an attempt to find a new possibility of democratic coexistence. (shrink)

Many realists argue that present scientific theories will not follow the fate of past scientific theories because the former are more successful than the latter. Critics object that realists need to show that present theories have reached the level of success that warrants their truth. I reply that the special theory of relativity has been repeatedly reinforced by unconceived scientific methods, so it will be reinforced by infinitely many unconceived scientific methods. This argument for the special theory of relativity overcomes (...) the critics’ objection, and has advantages over the no-miracle argument and the selective induction for it. (shrink)

Lawrence Sklar in his book, Physics and Chance (1993), proposes a sophisticated account of reduction of thermodynamics (TD) by statistical mechanics (SM). I argue that Sklar's analysis of the alleged reduction of TD by SM is problematic in several respects. I consider a few counterexamples to show that none of what Sklar takes to be the central features of successful reduction in science (unification and identification) holds in the case of TD and SM. I suggest the broader conclusion that a (...) more useful way of understanding the relationship between TD and SM is as collaboration and competition among alternative methodologies rather than reduction of one theory to another. (shrink)

Scientific realists argue that present theories are more successful than past theories, so present theories will not be superseded by alternatives, even though past theories were superseded by alternatives. Alai (2016) objects that although present theories are more successful than past theories, they will be replaced by future theories, just as past theories were replaced by present theories. He contends, however, that past theories were partly true, and that present theories are largely true. I argue that Alai’s discrimination between past (...) and present theories is subject to his own criticism against realists’ discriminations between past and present theories, and also subject to other criticisms that philosophers have raised against scientific realism and pessimism. (shrink)

In this paper we give a full account of the work of William Thomson on absolute temperature, which to this day provides the theoretical underpinnings for the most rigorous measurements of temperature. When Thomson fashioned his concepts of ‘absolute’ temperature, his main concern was to make the definition of temperature independent of the properties of particular thermometric substances . He tried out a succession of definitions based on the thermodynamics of ideal heat engines; most notably, in 1854 he gave the (...) ratio of two temperatures as the ratio of quantities of heat taken in and given out at those temperatures in a Carnot cycle. But there were difficulties with using such definitions for experimental work, since it was not possible even to approximate an ideal Carnot engine in reality. More generally, it is not trivial to connect an abstract concept with concrete operations in order to make physical measurements possible. In the end, Thomson argued that an ideal gas thermometer would indicate his absolute temperature, and that the deviation of actual gas thermometers from the ideal could be estimated by means of the Joule‐Thomson effect. However, the measurement of the Joule‐Thomson effect itself required measurements of temperature, so there was a problem of circularity. (shrink)

Metabolism is a set of chemical reactions, used by living organisms to process chemical compounds in order to take energy and eliminate toxic compounds, for example. Its processes are referred as metabolic pathways. Understanding metabolism is imperative to biology, toxicology and medicine, but the number and complexity of metabolic pathways makes this a difficult task. In our paper, we investigate the use of causal Bayesian networks to model the pathways of yeast saccharomyces cerevisiae metabolism: such a network can be used (...) to draw predictions about the levels of metabolites and enzymes in a particular specimen. We propose a two-stage methodology for causal networks, as follows. First construct a causal network from the network of metabolic pathways. The viability of this causal network depends on the validity of the causal Markov condition. If this condition fails, however, the principle of the common cause motivates the addition of a new causal arrow or a new `hidden' common cause to the network (stage 2 of the model formation process). Algorithms for adding arrows or hidden nodes have been developed separately in a number of papers, and in this paper we combine them, showing how the resulting procedure can be applied to the metabolic pathway problem. Our general approach was tested on neural cell morphology data and demonstrated noticeable improvements in both prediction and network accuracy. (shrink)

This paper aims: (1) to show that Lawrence Sklar`s recent attempt to reduce thermodynamics(TD) to statistical mechanics(SM) is fallacious in several respects; and (2) to suggest a broader conclusion that a more useful way of understanding the relationship between TD and SM is as collaboration and competition among alternative methodologies rather than reduction of one theory to another. To argue for (1), I discuss two cases (the distinction of intensive/extensive variables in TD and the existence of phase transitions) where TD (...) is more accurate than statistical mechnaics and thus corrects SM. I also discuss the case of temperature in order to argue for both (1) and (2). (shrink)

I raise the following six moral objections to the way God evaluates us. (i) He violates the human right to free thought. (ii) He makes the dubious assumption that it is praiseworthy and blameworthy, respectively, to believe and disbelieve that he exists. (iii) He excessively rewards believers and excessively punishes disbelievers. (iv) He only assigns to his evaluates the two extreme grades: eternal bliss and eternal damnation. (v) He overlooks diverse factors related to the belief of God. (vi) He is (...) silent on the issue of whether to evaluate animals. Therefore, God, who is allegedly omnipotent, omniscient, and omnibenevolent, does not exist. (shrink)

The generation of isometric force at the hand can be mediated by activating a few motor modules. Stroke induces alterations in motor modules underlying steady-state isometric force generation in the human upper extremity. However, how the altered motor modules impact task performance remains unclear as stroke survivors develop and converge to the three-dimensional target force. Thus, we tested whether stroke-specific motor modules would be activated from the onset of force generation and also examined how alterations in motor modules would induce (...) changes in force representation. During 3D isometric force development, electromyographic signals were recorded from eight major elbow and shoulder muscles in the paretic arm of 10 chronic hemispheric stroke survivors and both arms of six age-matched control participants. A non-negative matrix factorization algorithm identified motor modules in four different time windows: three “exploratory” force ramping phases and the stable force match phase. Motor module similarity and between-force coupling were examined by calculating the scalar product and Pearson correlation across the phases. To investigate the association between the end-point force representation and the activation of the motor modules, principal component analysis and multivariate multiple linear regression analyses were applied. In addition, the force components regressed on the activation profiles of motor modules were utilized to model the feasible force direction. Both stroke and control groups developed exploratory isometric forces with a non-linear relationship between EMG and force. During the force matching, only the stroke group showed abnormal between-force coupling in medial-lateral and backward-forward and medial-lateral and downward-upward directions. In each group, the same motor modules, including the abnormal deltoid module in stroke survivors, were expressed from the beginning of force development instead of emerging during the force exploration. The PCA and the multivariate multiple linear regression analyses showed that alterations in motor modules were associated with abnormal between-force coupling and limited feasible force direction after stroke. Overall, these results suggest that alterations in intermuscular coordination contribute to the abnormal end-point force control under isometric conditions in the UE after stroke. (shrink)

The emotion theory of concepts maintains that concepts may be in part constituted by sentiments and emotions. Very few works in the contemporary concepts literature discuss this possibility that concepts may be sentiments and emotions, and those that do discuss this possibility ultimately fail to establish the viability of this view. However, by in part relying on experimental evidence from psychology and neuroscience, I contend that some concrete and abstract concepts are in part constituted by sentiments and emotions.

In a recent number Mr. O. J. Todd has discussed the clumsy scansion of a line in a Delphic oracle, and has called fresh attention to the problem of the Pythia's prophesyings in verse. The chief difficulty consists in the differences between the indications on this subject as given by our various sources. The conventional phrases in most authors from Pindar and Herodotus until late periods describe the responses as uttered by the Pythia herself. This picture seems to imply that (...) the Pythia originated the verse form of the oracle. But this view would take no account of the existence of the official known as the προφήτης whose business was evidently to deliver the response to the inquirer. (shrink)