Epigenetic control of gene expression by chromatin remodeling is critical for adult stem cell function. A decline in stem cell function is observed during aging, which is accompanied by changes in the chromatin structure that are currently unexplained. Here, we hypothesize that these epigenetic changes originate from the limited cellular capability to inherit epigenetic information. We suggest that spontaneous loss of histone modification, due to fluctuations over short time scales, gives rise to long‐term changes in DNA methylation and, accordingly, in (...) gene expression. These changes are assumed to impair stem cell function and, thus, to contribute to aging. We discuss cell replication as a major source of fluctuations in histone modification patterns. Gene silencing by our proposed mechanism can be interpreted as a manifestation of the conflict between the stem cell plasticity required for tissue regeneration and the permanent silencing of potentially deleterious genomic sequences. (shrink)

To what extent do aesthetic taste and our interest in the arts constitute who we are? In this paper, we present a series of empirical findings that suggest an Aesthetic Self Effect supporting the claim that our aesthetic engagements are a central component of our identity. Counterfactual changes in aesthetic preferences, for example, moving from liking classical music to liking pop, are perceived as altering us as a person. The Aesthetic Self Effect is as strong as the impact of moral (...) changes, such as altering political partisanship or religious orientation, and significantly stronger than for other categories of taste, such as food preferences. Using a multidimensional scaling technique to map perceived aesthetic similarities among musical genres, we determined that aesthetic distances between genres correlate highly with the perceived difference in identity. Further studies generalize the Aesthetic Self Effect beyond the musical domain: general changes in visual art preferences, for example from more traditional to abstract art, also elicited a strong Self Effect. Exploring the breadth of this effect we also found an Anaesthetic Self Effect. That is, hypothetical changes from aesthetic indifference to caring about music, art, or beauty are judged to have a significant impact on identity. This effect on identity is stronger for aesthetic fields compared to leisure activities, such as hiking or playing video games. Across our studies, the Anaesthetic Self Effect turns out to be stronger than the Aesthetic Self Effect. Taken together, we found evidence for a link between aesthetics and identity: we are aesthetic selves. When our tastes in music and the arts or our aesthetic interests change we take these to be transformative changes. (shrink)

Using the lens of positive organizational ethics, we theorized that empathy affects decisions in ethical dilemmas that concern the well-being of not only the organization but also other stakeholders. We hypothesized and found that empathetic managers were less likely to comply with requests by an authority figure to cut the wages of their employees than were non-empathetic managers. However, when an authority figure requested to hold wages constant, empathy did not affect wage cut decisions. These findings imply that empathy can (...) serve as a safeguard for ethical decision making in organizations during trying times without generally undermining organizational effectiveness. We conclude by discussing the implications of our research. (shrink)

An important part of friendships are the so-called special obligations generated by them. Friends owe things to each other that they do not owe to strangers. While such special obligations are an important part of our everyday practice, they raise several philosophical questions. These questions include the status of special obligations (are such obligations sui generis or is it possible to reduce them to general moral principles?), the source of such special obligations (what grounds special obligations of friendship?), and the (...) content of special obligations (what is the content of special obligations of friendship?). This chapter gives an overview of some of the most important positions in the literature with regard to these questions. (shrink)

This paper argues that the still-emerging paradigm of situated cognition requires a more systematic perspective on media to capture the enculturation of the human mind. By virtue of being media, cultural artifacts present central experiential models of the world for our embodied minds to latch onto. The paper identifies references to external media within embodied, extended, enactive, and predictive approaches to cognition, which remain underdeveloped in terms of the profound impact that media have on our mind. To grasp this impact, (...) I propose an enactive account of media that is based on expansive habits as media-structured, embodied ways of bringing forth meaning and new domains of values. We apply such habits, for instance, when seeing a picture or perceiving a movie. They become established through a process of reciprocal adaptation between media artifacts and organisms and define the range of viable actions within such a media ecology. Within an artifactual habit, we then become attuned to a specific media work that engages us. Both the plurality of habits and the dynamical adjustments within a habit require a more flexible neural architecture than is addressed by classical cognitive neuroscience. To detail how neural and media processes interlock, I will introduce the concept of neuromediality and discuss radical predictive processing accounts that could contribute to the externalization of the mind by treating media themselves as generative models of the world. After a short primer on general media theory, I discuss media examples in three domains: pictures and moving images; digital media; architecture and the built environment. This discussion demonstrates the need for a new cognitive media theory based on enactive artifactual habits—one that will help us gain perspective on the continuous re-mediation of our mind. (shrink)

Two kinds of membrane contacts in the vertebrate lens are described. Fiber gap junctions are domains where small molecules can pass between lens cells. Membrane structures of ball‐and‐socket type interlock adjacent lens fibers and thus contribute to the structural integrity of the lens. Both of these membrane contacts appear crucial for the maintenance of lens transparency.

We define aesthetic emotions as emotions that underlie the evaluative assessment of artworks. They are separated from the wider class of art-elicited emotions. Aesthetic emotions historically have been characterized as calm, as lacking specific patterns of embodiment, and as being a sui generis kind of pleasure. We reject those views and argue that there is a plurality of aesthetic emotions contributing to praise. After presenting a general account of the nature of emotions, we analyze twelve positive aesthetic emotions in four (...) different categories: emotions of pleasure, contemplation, amazement, and respect. The emotions that we identify in each category, including feelings of fluency, intrigue, wonder, and adoration, have been widely neglected both within aesthetics and in emotion research more broadly. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

This paper studies the causal interpretation of counterfactual sentences using a modifiable structural equation model. It is shown that two properties of counterfactuals, namely, composition and effectiveness, are sound and complete relative to this interpretation, when recursive (i.e., feedback-less) models are considered. Composition and effectiveness also hold in Lewis's closest-world semantics, which implies that for recursive models the causal interpretation imposes no restrictions beyond those embodied in Lewis's framework. A third property, called reversibility, holds in nonrecursive causal models but not (...) in Lewis's closest-world semantics, which implies that Lewis's axioms do not capture some properties of systems with feedback. Causal inferences based on counterfactual analysis are exemplified and compared to those based on graphical models. (shrink)

The Colombian-born photographer and artist Guadalupe Ruiz has undertaken a project to document the social and economic inequity in her native city of Bogotá. She explores six houses from the city's six different taxation classes whose residents range from extremely affluent to impoverished. By taking photographs of apartments and streetscapes, whole interiors and single pieces of furniture, Ruiz creates a cohesive and multilayered portrait of the city as a whole. She also examines personal and decorative objects, such as family portraits (...) and Catholic icons found in both slums and luxurious villas, and highlights the differences and some surprising cultural parallels between socioeconomic classes. Guadalupe Ruiz— Bogotá D. C. is a subtle, thought-provoking examination of urban life and includes over a hundred stunning images arranged by neighborhood. A map of the neighborhoods and a complementary essay are included to provide context for Ruiz's impressive photographs. Text in English, French, Spanish, and German. (shrink)

Europe's economic constitution is obviously affected in a very fundamental way. There is every reason to depart from an historical reconstruction of the origins of the economic constitution in the early 1920s, to consider its remarkable renaissance in postwar Germany, and to explore against this background its emigration to the European level of governance as well as its development and metamorphosis in the integration process. This chapter focuses on the Economic and Monetary Union (EMU), which, once hailed as the crowning (...) achievement of Europe's market building and the precursor of a more truly political Union, has become the epicenter of the present crisis. Ordoliberalism and the social‐market economy managed to coexist peacefully and dominated public opinion. The chapter also discusses the practices of Europe's crisis management and the specifics of the governance modes that they are generating. (shrink)

An important part of friendships are the so-called special obligations generated by them. Friends owe things to each other that they do not owe to strangers. While such special obligations are an important part of our everyday practice, they raise several philosophical questions. These questions include the status of special obligations (are such obligations sui generis or is it possible to reduce them to general moral principles?), the source of such special obligations (what grounds special obligations of friendship?), and the (...) content of special obligations (what is the content of special obligations of friendship?). This chapter gives an overview of some of the most important positions in the literature with regard to these questions. (shrink)

In this paper I suggest that the division between manas and atman in Nyaya philosophy can be interpreted in the light of Western discussions about irrationality. In Western philosophy irrationality has been explained by postulating a divided mind. This helps to account for a generally rational mind that is nevertheless sometimes prone to irrationality. I argue that the division of the mind bears similarities to the division between manas and tman. Looking at the arguments of the Naiy yikas Gautama and (...) V tsy yana for the existence of a permanent self, I do not find any of them convincing in the light of Buddhist criticism. However, by arguing for the division between manas and tman, the Naiy yikas have inadvertently provided their strongest argument for the existence of a self because they have managed to account for irrationality. (shrink)

"I cannot recommend this book highly enough!" Is this statement true or have I succeeded in lavishing enough praise on this book by writing this statement, making this statement in fact false? This is one way in which Adamson and Ganeri explain the view of the Buddhist philosopher Nāgārjuna that everything is empty. Nāgārjuna has to defend himself against the objection that if everything is "empty" then this surely also applies to his own view. He famously argues that he does (...) not have a thesis and provides the "silence" analogy, which I want to illustrate using my own example: if there is too much off-topic... (shrink)

Indian Epistemology and Metaphysics introduces the reader to new perspectives on Indian philosophy based on philological research within the last twenty years. Concentrating on topics such as perception, inference, skepticism, consciousness, self, mind, and universals, some of the most notable scholars working in classical Indian philosophy today examine core epistemological and metaphysical issues. Philosophical theories and arguments from a comprehensive range of Indian philosophical traditions (including the Nyaya, Mimamsa, Saiva, Vedanta, Samkhya, Jain, Buddhist, materialist and skeptical traditions, as well as (...) some 20th century thought) are covered. The contributors to this volume approach the topics from both a philosophical and a philological perspective. They demonstrate the importance of the subject matter for an understanding of Indian thought in general and they highlight its wider philosophical significance. By developing an appreciation of classical Indian philosophy in its own terms, set against the background of its unique assumptions and historical and cultural development, Indian Epistemology and Metaphysics is an invaluable guide to the current state of scholarship on Indian philosophy. It is a timely and much-needed reference resource, the first of its kind. (shrink)

This paper introduces pictures more generally into the discussion of cognition and mind. I will argue that pictures play a decisive role in shaping our mental lives because they have changed (and constantly keep changing) the ways we access the world. Focusing on pictures will therefore also shed new light on various claims within the field of embodied cognition. In the first half of this paper I address the question of whether, and in what possible ways, pictures might be considered (...) to be part of our extended mind. We will see however, that the explanatory means contingent upon the extended mind thesis – i.e. the claim that the vehicles of cognition are not confined to the boundaries of the individual organism – can only take us so far. Beyond such claims it will be pivotal to understand in what specific ways pictures might be regarded as being at the basis of certain perceptions of and interactions with the world. I will therefore address, in the second half of this paper, in what ways enactive and affective elements should inform our theory of the pictorial mind. In the course of this discussion it will become apparent that pictures are strange objects because they differ profoundly from other objects surrounding us. And it will also turn out that pictures – beyond the fact that they can be considered to be tools for our mind (in the sense that they facilitate our access to the world) – are rather strange or stubborn tools in that something in them resists full integration into our cognitive routines. (shrink)

According to an editor of The Economist, the world produced, in the years since World War II, seven times more goods than throughout all history. This is well appreciated by lay people, but has hardly affected social scientists. They do not have the conceptual apparatus for understanding accelerated material-technical change and its meaning for people's personal lives, for their ways of relating to them-selves and to the outside world. Of course, a great deal of speculation about emerging life forms in (...) industrialised societies exists and social scientists with a futuristic bend have projected their diverse visions upon public debates, ranging from thc Efficient Hedonism of "post-industrialist' society a la Daniel Bell to the “Responsible Convivialism” of 'post-materialist" critics such as Fritz Schumacher. Competing images of the coming "services society" or "self-service society" share a central concern: the ongoing relation between tile spheres of large organisations and personal lifestyles, between salaried work arid private consumption. They also share a eel-tau' implausibility: few people recognize themselves in either projection. And they sham ubiquitous reference to "technology", without accounting for it in real terms. A good diagnostic of what is actually happening seems to me to be Jonathan Gershuny, who sees a drift toward a particular type of self-service economy: a quite radical shift in the mode of provision of social services, as he calls it, based on new kinds of consumer technologies. Industrialization used to be partial, but is becoming total fast. This process obviously has many facets, the one I am interested in here is the intrusion of modern technology into spheres of life which in the past have been relatively little dependent on it. (shrink)

Across the globe, conditions of labour are worsening, providing both challenges and opportunities. As labour is one of the places where the intersectionality of race, ethnicity, gender, sexuality, and class is always at work, new models of resistance are created here as well. Deep solidarity describes what happens when the 99% who have to work for a living realise what they have in common, in order to employ their differences productively in the struggle. In this article, a theologian and a (...) labour and community organiser work together showing how the Abrahamic religious traditions and developments in the world of labour help us to shape deeper forms of solidarity. (shrink)

Friedrich Schleiermacher’s work appears in new perspective when examined in the context of his little-known studies of far-away countries such as Australia and its inhabitants as well as the “colonial phantasies” of his time. His views of the Jewish religion and its practitioners can also be reassessed in this light. As the connections between the flows of power and ideas are examined, a deeper understanding of Schleiermacher’s theology emerges both in terms of its limitations and its potential. This deeper understanding (...) also throws new light on more overarching matters in Schleiermacher research, such as the character of his philosophical method and his hermeneutic. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

Climate change poses a serious problem for established ethical theories. There is no dearth of literature on the subject of climate ethics that break down the complexity of the issue, thereby enabling one to arrive at partial conclusions such as: 'historical justice demands us to do this...' or 'intergenerational justice demands us to do that...'. In contrast, this article attempts to face up to this complexity, that is: to end with a synthesis of the arguments into what can be considered (...) to be the most reasonable and fairest approach to the politics of climate change on a global scale. A significant part of the paper is devoted to the questions whether or not a) historical emissions and b) population changes are relevant to how emissions rights should be distributed. I discuss the merits and drawbacks of each perspective and briefly outline the normative justifications. (shrink)

The condition of ‘genuine perceptual synaesthesia’ has been a focus of attention in research in psychology and neuroscience over the last decades. For subjects in this condition stimulation in one modality automatically and consistently over the subject’s lifespan triggers a percept in another modality. In hearing→colour synaesthesia, for example, a specific sound experience evokes a perception of a specific colour. In this paper, I discuss questions and challenges that the phenomenon of synaesthetic experience raises for theories of perceptual experience in (...) general, and for theories thatsee the content and modality of conscious experience as being constituted and determined by the active and skilful exploration of the environment in particular. The focus of my paper will be on the latter, ‘enactive’ view of perception and its theory of what determines the modality-specific ‘feel’ of a perceptual experience. (shrink)

Drawing upon the thought of Jacques Derrida and Martin Heidegger, the paper argues that contemporary discussions of religious experience and religious thought as two separate parts of religious practice and tradition--with religious experience as the "heart" of religion--is erroneous. Instead, it is argued, religious experience and religious thought are woven together in practice, the one implicating the other.

This article makes a contribution to debates in recognition theory by expanding the taxonomy of (mis-)recognition in the economic sphere. It argues that doing justice to the variety of ways in which recognition is engaged in economic relationships requires: (1) taking into consideration not just the recognition principle of esteem, but also (various aspects of) need and respect; (2) distinguishing a productive from a consumptive dimension with regards to each principle of recognition (need, esteem and respect); and (3) identifying the (...) specific economic relationship at stake (e.g. between consumers and producers, or between employers and employees). In this way, we can account for the diversity of demands for recognition made in the economic sphere, explain what underpins them, and bring structure into these diverse phenomena. What is more, this expanded taxonomy is a useful tool for social pathology theorists, who should appreciate the full range of variants of misrecognition when diagnosing pathologies of misrecognition in the economic sphere. (shrink)

In this article we review some of the main results of descriptive complexity theory in order to make the reader familiar with the nature of the investigations in this area. We start by presenting the characterization of automata recognizable languages by monadic second-order logic. Afterwards we explain the characterization of various logics by fIxed-point logics. We assume familiarity with logic but try to keep knowledge of complexity theory to aminimum.

In response to earlier papers in Informal Logic by Robert Fogelin and Andrew Lugg, this paper explores the issue of whether disagreement could ever be so deep that it defied rational resolution. Contra Lugg, I agree with Fogelin that such unresolvable disagreement is possible and, contra Fogelin, I suggest that the focus of such disagreement can be quite Iimited-a single proposition rather than a whole system of beliefs. I also suggest that emphasising arguing as a human practice rather than arguments (...) as a structure of propositions is unhelpful to consideration of these issues. (shrink)