Epigenetic control of gene expression by chromatin remodeling is critical for adult stem cell function. A decline in stem cell function is observed during aging, which is accompanied by changes in the chromatin structure that are currently unexplained. Here, we hypothesize that these epigenetic changes originate from the limited cellular capability to inherit epigenetic information. We suggest that spontaneous loss of histone modification, due to fluctuations over short time scales, gives rise to long‐term changes in DNA methylation and, accordingly, in (...) gene expression. These changes are assumed to impair stem cell function and, thus, to contribute to aging. We discuss cell replication as a major source of fluctuations in histone modification patterns. Gene silencing by our proposed mechanism can be interpreted as a manifestation of the conflict between the stem cell plasticity required for tissue regeneration and the permanent silencing of potentially deleterious genomic sequences. (shrink)

Possible-worlds accounts of mental or linguistic content are often criticized for being too coarse-grained. To make room for more fine-grained distinctions among contents, several authors have recently proposed extending the space of possible worlds by "impossible worlds". We argue that this strategy comes with serious costs: we would effectively have to abandon most of the features that make the possible-worlds framework attractive. More generally, we argue that while there are intuitive and theoretical considerations against overly coarse-grained notions of content, the (...) same kinds of considerations also prohibit an overly fine-grained individuation of content. An adequate notion of content, it seems, should have intermediate granularity. However, it is hard to construe a notion of content that meets these demands. Any notion of content, we suggest, must be either implausibly coarse-grained or implausibly fine-grained (or both). (shrink)

According to the standard version of the counterfactual comparative account of harm, an event is overall harmful for an individual if and only if she would have been on balance better off if it had not occurred. This view faces the “preemption problem.” In the recent literature, there are various ingenious attempts to deal with this problem, some of which involve slight additions to, or modifications of, the counterfactual comparative account. We argue, however, that none of these attempts work, and (...) that the preemption problem continues to haunt the counterfactual comparative account. (shrink)

In recent years CL diagrams inspired by Lange’s Cubus Logicus have been used in various contexts of diagrammatic reasoning. However, whether CL diagrams can also be used as a formal system seemed questionable. We present a CL diagram as a formal system, which is a fragment of propositional logic. Syntax and semantics are presented separately and a variant of bitstring semantics is applied to prove soundness and completeness of the system.

The Groundwork of the Metaphysics of Morals is Kant's central contribution to moral philosophy, and has inspired controversy ever since it was first published in 1785. Kant champions the insights of 'common human understanding' against what he sees as the dangerous perversions of ethical theory. Morality is revealed to be a matter of human autonomy: Kant locates the source of the 'categorical imperative' within each and every human will. However, he also portrays everyday morality in a way that many readers (...) find difficult to accept. The Groundwork is a short book, but its argument is dense, intricate and at times treacherous. This commentary explains Kant's arguments paragraph by paragraph, and also contains an introduction, a synopsis of the argument, six short interpretative essays on key topics of the Groundwork, and a glossary of key terms. It will be an indispensable tool for anyone wishing to study the Groundwork in detail. (shrink)

In a recent Utilitas article, Neil Feit argues that every person occupies a well-being level of zero at all times and possible worlds at which she fails to exist. Views like his face the problem of the subject': how can someone have a well-being level in a scenario where she lacks intrinsic properties? Feit argues that this problem can be solved by noting, among other things, that a proposition about a person can be true at a possible world in which (...) neither she nor the proposition exists. In this response, we argue that Feit has not solved the problem of the subject, and also raise various related problems for his approach. (shrink)

From the mid-1600s to the beginning of the eighteenth century, there were two main circles of German scholars which focused extensively on diagrammatic reasoning and representation in logic. The first circle was formed around Erhard Weigel in Jena and consists primarily of Johann Christoph Sturm and Gottfried Wilhelm Leibniz; the second circle developed around Christian Weise in Zittau, with the support of his students, particularly Samuel Grosser and Johann Christian Lange. Each of these scholars developed an original form of using (...) geometric diagrams in logic. In this paper, I will trace the historical notes of John Venn and other modern logicians back to the original works published in the Weigel and Weise circles and describe the development of using geometric figures for logical reasoning and representation in that period of time. (shrink)

The paper examines Schopenhauer’s complex diagrams from the Berlin Lectures of the 1820 s, which show certain partitions of classes. Drawing upon ideas and techniques from logical geometry, we show that Schopenhauer’s partition diagrams systematically give rise to a special type of Aristotelian diagrams, viz. (strong) α -structures.

IntroductionIf we were to identify the beginning of the study of visual argumentation, we would have to choose 1996 as the starting point. This was the year that Leo Groarke published “Logic, art and argument” in Informal logic, and it was the year that he and David Birdsell co-edited a special double issue of Argumentation and Advocacy on visual argumentation . Among other papers, the issue included Anthony Blair’s “The possibility and actuality of visual arguments”. It was also the year (...) that Gail J. Chryslee, Sonja K. Foss and Arthur L. Ranney published their short text on “The construction of claims in visual argumentation” , stating that even though theorists may know a great deal about the process of argumentation, “virtually none of this knowledge is applicable to visual argumentation […] because of the properties that distinguish visual imagery from discursive symbols” .Texts on visual rhetoric have been written as far back as the early 1980s, .. (shrink)

A prominent objection to the counterfactual comparative account of harm is that it classifies as harmful some events that are, intuitively, mere failures to benefit. In an attempt to solve this problem, Duncan Purves has recently proposed a novel version of the counterfactual comparative account, which relies on a distinction between making upshots happen and allowing upshots to happen. In this response, we argue that Purves’s account is unsuccessful. It fails in cases where an action makes the subject occupy a (...) high well-being level though one of the available alternatives would have made it even higher. In fact, it fails even in some cases where each of the available alternatives to the action that was actually performed would have made the subject’s well-being level lower. (shrink)

According to the “deprivation approach,” a person’s death is bad for her to the extent that it deprives her of goods. This approach faces the Lucretian problem that prenatal non-existence deprives us of goods just as much as death does, but does not seem bad at all. The two most prominent responses to this challenge—one of which is provided by Frederik Kaufman (inspired by Thomas Nagel) and the other by Anthony Brueckner and John Martin Fischer—claim that prenatal non-existence is relevantly (...) different from death. This paper criticizes these responses. (shrink)

In this paper, we critically examine Molly Gardner’s favored solution to what she calls “the problem of justified harm.” We argue that Gardner’s view is false and that her arguments in support of it are unconvincing. Finally, we briefly suggest an alternative solution to the problem which avoids the difficulties that beset Gardner’s proposal.

This paper discusses the relevance of models for cognitive science that integrate mechanistic and computational aspects. Its main hypothesis is that a model of a cognitive system is satisfactory and explanatory to the extent that it bridges phenomena at multiple mechanistic levels, such that at least several of these mechanistic levels are shown to implement computational processes. The relevant parts of the computation must be mapped onto distinguishable entities and activities of the mechanism. The ideal is contrasted with two other (...) accounts of modeling in cognitive science. The first has been presented by David Marr in combination with a distinction of “levels of computation”. The second builds on a hierarchy of “mechanistic levels” in the sense of Carl Craver. It is argued that neither of the two accounts secures satisfactory explanations of cognitive systems. The mechanistic-computational ideal can be thought of as resulting from a fusion of Marr’s and Craver’s ideals. It is defended as adequate and plausible in light of scientific practice, and certain metaphysical background assumptions are discussed. (shrink)

The paper presents the diagrammatic calculus CL, which combines features of tree, Euler-type, Venn-type diagrams and squares of opposition. In its basic form, `CL' (= Cubus Logicus) organizes terms in the form of a square or cube. By applying the arrows of the square of opposition to CL, judgments and inferences can be displayed. Thus CL offers on the one hand an intuitive method to display ontologies and on the other hand a diagrammatic tool to check inferences. The paper focuses (...) mainly on the adaptation of the square of opposition in CL and offers an algebraic notation, which corresponds to the diagrammatic representation. (shrink)

In the second preface to the Critique of Pure Reason, Kant claims that Galileo Galilei, Evangelista Torricelli and Georg Ernst Stahl caused a scientific revolution in experimental physics (B xii). In this paper, I advance the historical thesis that Kantʼs claim refers precisely to three passages from Discursus et demonstrationes mathematicae (Galilei), Lettera a Filaleti Di Timauro Antiate (Torricelli), and Beweiß von den Saltzen (Stahl). This historical thesis provides evidence for a newer systematic interpretation, which says that the topic of (...) the second preface is not epistemological, but rather methodological. (shrink)

In a recent article, I criticized Anthony L. Brueckner and John Martin Fischer’s influential argument—appealing to the rationality of our asymmetric attitudes towards past and future pleasures—against the Lucretian claim that death and prenatal non-existence are relevantly similar. Brueckner and Fischer have replied, however, that my critique involves an unjustified shift in temporal perspectives. In this paper, I respond to this charge and also argue that even if it were correct, it would fail to defend Brueckner and Fischer’s proposal against (...) my critique. (shrink)

Aufstieg zum Einen - das ist das Zentrum der Philosophie Plotins und des von ihm ausgehenden Neuplatonismus. Dass solcher Aufstieg zum Einen aber auch schon bei Platon eine zentrale Rolle spielt, gehört zu den wichtigsten Einsichten der neueren Platonforschung. Das vorliegende Buch zieht daraus die Konsequenz und bestimmt das Verhältnis zwischen Platon und dem Neuplatonismus neu. Es verbindet die erste umfassende Darstellung von Plotins Theorie des Absoluten mit einer Rekonstruktion von Platons Henologie. Dabei arbeitet es die enge Verbindung beider heraus (...) und macht zugleich die bleibende philosophische Relevanz des Themas deutlich. (shrink)

This paper considers Habermas’ model of a post‐secular political order in the light of the debate on male circumcision that arose in Germany after a court ruled that male circumcision was an unjustifiable act of bodily harm. Central to this model is the idea that religious reasons can only become effective in central legal institutions when they are translated into secular reasons. My paper demonstrates that there are two distinguishable readings of this proviso. On the one hand, there is a (...) broad reading according to which it is only necessary to reach a conclusion that is in line with the democratic principle stating that all citizens can be regarded as co‐legislators even if non‐generalizable value orientations might then shape the interpretation of fundamental rights (in the case of circumcision, the right to bodily integrity). On the other hand, a truly secular (narrow) reading would avoid the inclusion of non‐generalizable value orientations. The debate on circumcision demonstrates that these two interpretations lead to different and conflicting modes of justification. The broad reading allows for a justification of male circumcision, whereas the narrow reading makes such a justification unlikely. In addition, the filtering function of the proviso is weakened in a broad reading. (shrink)

According to the “deprivation approach,” a person’s death is bad for her to the extent that it deprives her of goods. This approach faces the Lucretian problem that prenatal non-existence deprives us of goods just as much as death does, but does not seem bad at all. The two most prominent responses to this challenge—one of which is provided by Frederik Kaufman and the other by Anthony Brueckner and John Martin Fischer—claim that prenatal non-existence is relevantly different from death. This (...) paper criticizes these responses. (shrink)

Some forms of argumentation are best performed through words. However, there are also some forms of argumentation that may be best presented visually. Thus, this paper examines the virtues of visual argumentation. What makes visual argumentation distinct from verbal argumentation? What aspects of visual argumentation may be considered especially beneficial?

As is well-known, David Lewis’ counterfactual theory of causation is subject to serious counterexamples in ‘exceptional’ cases. What has not received due attention in the literature so far is that Lewis’ theory fails to provide necessary and sufficient conditions for causation in ‘ordinary’ cases, too. In particular, the theory suffers from the ‘problem of large causes’. It is argued that this problem may be fixed by imposing a minimization constraint, whilst this solution brings along substantial costs as well. In particular, (...) a precise formulation of minimization requires defining an ‘essential part of an event’ and/or an ‘essential subevent’. Although the possibility of such a definition is ultimately left open, some doubts are raised on whether the counterfactualists’ resources are fit for this purpose, and whether the challenge can be met without substantially departing from Lewis’ intention, which was to provide a reductive account of causation. (shrink)

What is the primacy of logic? Concepts, judgments, or inferences? Whereas representationalists traditionally argue for a primacy of the conceptual, rationalists, referring to the context principle and the use theory of meaning, consider judgments and inferences to be primary. This dispute also seems to be applicable to logic diagrams: Whereas “Euler-type diagrams” are actually only for judgments and inferences, “concept diagrams” represent ontologies by using concepts. With reference to Schopenhauer, the paper develops a position called “rational representationalism.” According to this (...) point of view, the question of primacy is decided by analyzing the functions of the logic principles: For the explanation of logic and language, concepts are primary, but for understanding it is judgments. The mediation between intuitive representation and logical rationality is ensured by concept diagrams. (shrink)

Many have argued that there is something that is a priori about all necessary truths, including a posteriori necessities. According to a particularly popular claim of this kind, one can know a priori whether a sentence is G-necessary, i.e. whether it is either necessarily true or necessarily false. In this paper, I identify the most plausible version of this claim and I argue that it fails. My discussion also reveals, and depends upon, an important feature of putative natural kind terms (...) that has been widely overlooked. I conclude by outlining a proposal of what is really a priori about necessities. (shrink)

In this paper we present an overview of the current interpretations of the first volume of Arthur Schopenhauer’s main work The World as Will and Representation (W I) and discuss their problems. We discuss four issues, which in our opinion must clarify a current interpretation implicitly or explicitly, if it claims to be an interpretation of the whole book: (1) What does Schopenhauer mean by the fact that his work shares only one (single) thought? (2) How are the individual books (...) of W I related? (3) Do we have to read Schopenhauer’s W I as a normative guide to the denial of will-to-live or as a neutral description of the world? (4) Do the often discussed contradictions and aporias within the book follow a plan or are they errors of thought? (shrink)

Many philosophers maintain that artworks, such as statues, are constituted by other material objects, such as lumps of marble. I give an argument against this view, an argument which appeals to mereological simples.

John Martin Fischer and Anthony L. Brueckner have argued that a person’s death is, in many cases, bad for him, whereas a person’s prenatal non-existence is not bad for him. Their suggestion relies on the idea that death deprives the person of pleasant experiences that it is rational for him to care about, whereas prenatal non-existence only deprives him of pleasant experiences that it is not rational for him to care about. In two recent articles in The Journal of Ethics, (...) I have objected that it is irrelevant what it is in fact rational for the person to care about. Fischer and Brueckner have replied to my critique. In this paper I respond to their latest pair of replies. (shrink)

The ‘non-identity problem’ raises a well-known challenge to the person-affecting view, according to which an action can be wrong only if it affects someone for the worse. In a recent article, however, Thomas D. Bontly proposes a novel way to solve the non-identity problem in person-affecting terms. Bontly's argument is based on a contrastive causal account of harm. In this response, we argue that Bontly's argument fails even assuming that the contrastive causal account is correct.

Several attractive principles about prudential concern and moral responsibility seem to speak against animalism. I criticize some animalist responses to this kind of problem, and suggest another answer, which has similarites with the most important argument in favor of animalism: the “thinking animal” argument.

Predictive policing has become a new panacea for crime prevention. However, we still know too little about the performance of computational methods in the context of predictive policing. The paper provides a detailed analysis of existing approaches to algorithmic crime forecasting. First, it is explained how predictive policing makes use of predictive models to generate crime forecasts. Afterwards, three epistemologies of predictive policing are distinguished: mathematical social science, social physics and machine learning. Finally, it is shown that these epistemologies have (...) significant implications for the constitution of predictive knowledge in terms of its genesis, scope, intelligibility and accessibility. It is the different ways future crimes are rendered knowledgeable in order to act upon them that reaffirm or reconfigure the status of criminological knowledge within the criminal justice system, direct the attention of law enforcement agencies to particular types of crimes and criminals and blank out others, satisfy the claim for the meaningfulness of predictions or break with it and allow professionals to understand the algorithmic systems they shall rely on or turn them into a black box. By distinguishing epistemologies and analysing their implications, this analysis provides insight into the techno-scientific foundations of predictive policing and enables us to critically engage with the socio-technical practices of algorithmic crime forecasting. (shrink)

in recent years, the research on Schopenhauer has shown a change in the interpretation of his main work, «The World as Will and Presentation», from (1) a normative and linear instruction which guides the reader from idealism to mysticism, pessimism and nothingness to (2) value-free and independent descriptions of the world with all phenomena (like idealism, mysticism, nothingness etc.) in it. thus Schopenhauer’s main work has become an empirical or baconian approach—something like a «philosophical cosmography»—. this fundamental change of interpretation (...) radically puts into question what Schopenhauer means by characterizing his main work as an «organic system». the present paper attempts to give an answer to this question, reviewing the self-reflexive, methodological and metaphilosophical hints which Schopenhauer gives in the first volume of his «World» («as Will and presentation»). (shrink)

According to popular belief, big data and machine learning provide a wholly novel approach to science that has the potential to revolutionise scientific progress and will ultimately lead to the ‘end of theory’. Proponents of this view argue that advanced algorithms are able to mine vast amounts of data relating to a given problem without any prior knowledge and that we do not need to concern ourselves with causality, as correlation is sufficient for handling complex issues. Consequently, the human contribution (...) to scientific progress is deemed to be non-essential and replaceable. We, however, following the position most commonly represented in the philosophy of science, argue that the need for human expertise remains. Based on an analysis of big data and machine learning methods in two case studies—skin cancer detection and protein folding—we show that expert knowledge is essential and inherent in the application of these methods. Drawing on this analysis, we establish a classification of the different kinds of expert knowledge that are involved in the application of big data and machine learning in scientific contexts. We address the ramifications of a human-driven expert knowledge approach to big data and machine learning for scientific practice and the discussion about the role of theory. Finally, we show that the ways in which big data and machine learning both influence and are influenced by scientific methodology involve continuous conceptual shifts rather than a rigid paradigm change. (shrink)

Leibniz is often cited as an authority when it comes to the formulation and answer strategy of the question “Why is there something rather than nothing?” Yet much current research assumes that Leibniz advocates an unambiguous question and strategy for the answer. In this respect, one repeatedly finds the argument in the literature that alternative explanatory approaches to this question violate Leibniz’s intention, since he derives the question from the principle of sufficient reason and also demands a causal explanation to (...) the question. In particular, the new research on non-causal explanatory strategies to the Leibniz question seems to concern this counter-argument. In this paper, however, I will argue that while Leibniz raises the question by means of the principle of sufficient reason, he even favours a non-causal explanatory strategy to the question. Thus, a more accurate Leibniz interpretation seems not only to legitimise but also to support non-causal explanations to the Leibniz question. (shrink)

By formalizing the problem of mental causation, we first prove rigorously that the premises of the problem are jointly incompatible. Before the background of the formalizations, we clarify and assess the anti-physicalist argument by Scott Sturgeon and the supervenience argument by Jaegwon Kim. We demonstrate that, contrary to what has sometimes been contended, the negation of the non-identity premise of Kim's version of the supervenience argument is not tantamount to the claim that all mental events are identical to physical events, (...) that a premise implicitly invoked by Kim is actually required for the validity of the first stage of his supervenience argument, that precisely this premise makes an epiphenomenalism with respect to mental events an impossible position, and that there are good reasons to believe in the falsity of this implicit premise which in turn shows that Sturgeon's critique of the supervenience argument is substantive. (shrink)

Just as some illnesses and injuries are worse than others, so some deaths appear to be worse than others. This is so not only for the fairly trivial reason that those deaths that are bad are worse than those deaths that are not bad: less trivially, some bad deaths seem to be worse than other bad deaths. For instance, whereas it may well be bad for an eighty-year-old to die, it is likely to be even worse for a forty-year-old, and (...) still worse for a twenty-year-old. Supposing that the badness of death does indeed vary in this way, what factor or factors does it vary *with*? The example just given indicates that age is one such factor: in particular, the earlier one’s death occurs, the worse it is. For a number of reasons, however, things are more complicated—though not quite as complicated as some philosophers have suggested. (shrink)

The paper outlines the advantages and limits of the so-called ‘Calculus CL’ in the field of ontology engineering and automated theorem proving. CL is a diagram type that combines features of tree, Euler-type, Venn-type diagrams and squares of opposition. Due to the simple taxonomical structures and intuitive rules of CL, it is easy to edit ontologies and to prove inferences.

“Dialectic” has been a matter of growing interest in contemporary philosophy. The present article analyzes dialectical methods and positions them by reference to two paradigmatic texts of German idealism and analytic philosophy, i.e. J.G. Fichte’s Science of Knowing (1804) and J. McDowell’s Mind and World. Both dialectical approaches will be interpreted with regard to their contribution in the debate on reductionism and anti-reductionism: both Fichte and McDowell claim that philosophical positions and logical terms stand in a dualistic relationship to one (...) another, on the one hand, but are separated by a gulf, on the other. I will argue that for McDowell dialectic seems to be an alternative to one-sided reductionisms as well as to normal anti-reductionistic holism. Furthermore, for Fichte dialectic is an adequate method for describing the relationship of reductionism and anti-reductionism itself. Both see in dialectic a technique for bridging the gulf between binary opposite terms of logic as well as mutually exclusive positions, such as mind and world, subject and object, or idealism and realism. (shrink)

A pure time preference is a preference for something to occur at one point in time rather than another, merely because of when it occurs in time. Such preferences are widely regarded as paradigm examples of irrational preferences. However, Rosemary Lowry and Martin Peterson have recently argued that, for instance, a pure time preference to go to the opera tonight rather than next month may be rationally permissible, even if the amounts of intrinsic value realized in both cases are identical. (...) In this reply, we argue that Lowry and Peterson's argument is unsuccessful. (shrink)

The essay developes the principles of the antique resp. medieval ars memorativa, which was a skill of memorizing large amounts of varying informations. Then the parsonian theory of society is analysed and it is shown, that it is constructed according to the same principles. Hence it follows the thesis, that at least special kinds of sociological (and psychological) theories can be considered as modernized forms of the old ars memorativa. The author defends this thesis against a set of nearby objections. (...) It is not tried to prove the historical truth of thesis, i.e. to show, that the tradition of theoretical literature indeed roots in the tradition of antique resp. medieval ars memorativa. In any case an examination of this question might yield new insight in the prehistory of theoretical thought. (shrink)

In this paper, I identify and discuss the following feature of our judgments about hypothetical scenarios concerning the identity of persons: with respect to the vast majority of scenarios, both members of a pair of logically complementary propositions about personal identity are conceivable. I consider a number of explanations of this feature that draw on the metaphysics and the epistemology of personal identity, none of which prove to be satisfactory. I then argue that in order to give an adequate explanation, (...) one needs to recognize an important characteristic of our concept of personal identity: it is such that if there are mental substances (or the like), they constitute personal identity. At the same time, there can still be persons if there are no such substances. Since this finding casts doubts on the way that thought experiments about personal identity are usually set up, I end by outlining its potential consequences for the debate over the identity of persons. (shrink)