The sites of tightest adhesion that form between cells and substrate surfaces in tissue culture are termed focal contacts. The external faces of focal contacts include specific receptors, belonging to the integrin family of proteins, for fibronectin and vitronectin, two common components of extracellular matrices. On the internal (cytoplasmic) side of focal contacts, several proteins, including talin and vinculin, mediate interactions with the actin filament bundles of the cytoskeleton. The changes that occur in focal contacts as a result of viral (...) transformation are discussed. (shrink)

I. THE TASK OF DOGMATICS As a theological discipline dogmatics is the scientific self- examination of the Christian Church with respect to the content of ...

In his preface to the English edition, Apel (identified with critical theory) explains that the title of his two-volume German collection connotes both a reconstruction of the process of hermeneutic transformation in recent philosophy and the author's semiotical transformation of transcendental logic. The emphasis here is on the latter with discussions of the a priori nature of language per Wittgenstein, Peirce, and Chomsky, and its implications for a rational foundation for ethics in modern science. Includes a new foreword. Name index (...) only. Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

Errol Lord’s The Importance of Being Rational is a beautiful presentation of how one might defend a reasons-first approach to rationality. I’m going to focus these comments on some of the larger systematic ambitions of the book. In doing so, my hope is to draw Lord out concerning the larger project of which the book is a part and to raise some more general questions about the project of defining rationality in terms of reasons. In doing so, my focus with (...) be on the relationship between the reasons-first program and a more traditional view, which we might call the reason-first program. (shrink)

Excerpt from Charles Renouvier's Philosophie der Praktischen Vernunft Kritisch Beleuchtet Als die notwendigen und ausreichenden Grundlagen der Sittlichkeit gibt R. Im 1. Kapitel seiner "reinen rationalen Moral die zwei Tatsachen an: I. Der Mensch ist mit Vernunft begabt, 2. Der Mensch hält sich für frei. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct (...) the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

The intent of Jaspers' philosophizing then is simply to recall us to our authentic situation. This recall is not itself a doctrine; it is only the stimulus to an inward action each must perform for himself in communication with others. Jaspers' Existenz-philosophy is thus an attempt to consider and enact human honesty; it is philosophy, not as wisdom, but as the love of wisdom.

The explanation versus understanding debate was important to the philosophy of thesocial sciences from the time of Dilthey and Weber through the work of Popper and Hempel.

Die zukunft der philosophie.--Das ethische zeitalter.--Die frauen in der philosophie.--Philosophenehen.--Die sphinx des pessimismus.--Stirner.--Philosophie und dichtung.

v. 1. Philosophical world orientation.--v. 2. Existential elucidation.--v. 3. Metaphysics.

With the publication of Reason and Existenz, originally delivered as a series of five lectures at the University of Groningen in 1935, one of the most important of Jaspers's philosophic works is made available to the English-speaking world. It concerns itself with a general statement of the principal philosophic categories which have given uniqueness to Jaspers's thinking: existence, freedom, and history, and the limit-situations of death, suffering, and sin. Written shortly after Jaspers's major systematic work and before his analysis of (...) the problem of truth, Reason and Existenz occupies a primary position in the development of his thought. (shrink)

A 2016 article in the Journal of Consumer Research argues that busyness has become a status symbol. In earlier societies, such as the 19th century Thorstein Veblen describes in his Theory of the Leisure Class, the wealthy conspicuously avoided work. They saw idleness as an ideal. By contrast, contemporary Americans praise being overworked. They see busy individuals as possessing rare and desirable characteristics, such as competence and ambition. -/- To respond philosophically to our new overworked overlords and status icons, we (...) need only return to the 19th century Danish philosopher Søren Kierkegaard. Kierkegaard is known for his philosophical account of boredom, which is often associated with idleness. If busyness is the opposite of idleness, perhaps he can diagnose busyness also. (shrink)

This paper is a response to Justin Bell's “Depression Applied to Moral Imagination: Deweyan Tools for Moral Inquiry." The author first contextualizes Bell’s use of evolutionary psychology in the context of two influential philosophical engagements with medicine: Alasdair MacIntyre’s concept of the therapeutic and the recent turn towards person-centered medicine over disease-centered medicine. He then raises two concerns about the accounts of depression used in the sources Bell draws on: the way they identify depression as oriented towards social problems and (...) the way they view depression as intentional. (shrink)

The introduction (pp. 7-29) discusses Nazi denigration of "Jewish philosophy, " from Spinoza to Bergson and Husserl, and the elevation of "German" philosophers, particularly Eckhart and Nietzsche, to the role of forerunners of Nazism. The chapters on the work of the four Jewish philosophers mention briefly their murder by the Nazis (in the case of Benjamin, his death while fleeing the Nazis).

Recently, much discussion of Hegel has focused on the nature of his idealism, and especially on its relation to Kant’s transcendental idealism—a doctrine whose meaning is itself still much in dispute. It is clear enough that Hegel calls himself an “absolute idealist,” and that he is a major figure in the “German idealist” tradition, but the precise meaning and value of falling under the idealist label is not so clear. Moreover, some recent interpretations have suggested ways in which Hegel can (...) be termed a realist, and for all interpreters it is conceded that there is a peculiarly “objective” nature to Hegel’s idealism that serves to set it apart from most other versions. (shrink)

Provides a thorough background study of the postmodern assault on the standpoint of the subject as a foundation for philosophy, and assesses what remains today of the philosophy of subjectivity.

This book grapples with these perennial questions, primarily through a dialogue with Cornelius Castoriadis and Charles Taylor, using an interdisciplinary ...

Der Wissenschaftskonzeption der "kritischen Theorie" der zu verändernden Gesellschaft wird im wesentlichen zugestimmt. Sie wird verteidigt insbesondere gegen ein Selbstverständnis der Geistes- und Sozialwissenschaften, das sich im Namen der "Freiheit von Forschung und Lehre" auf einen Begriff "der" interesse- bzw. wertfreien Wissenschaft zurückzieht. Andererseits will der Autor die genannte Konzeption ergänzen bzw. präzisieren: Zwar stellt die Einheit von Theorie und Praxis ein Postulat philosophischer Reflexion dar, letztere erweist aber auf ihrer höchsten Stufe das politisch interessierte Engagement und das wissenschaftliche Interesse (...) an entdogmatisierender Reflexion jedes Engagements unter den Bedingungen menschlicher Endlichkeit als polar-entgegengesetzte, auseinandertretende Momente. (shrink)