Neste estudo abordaremos algumas etapas da concepção holística que caracteriza as relações entre o homem, o cosmo e a sociedade na época das Antiguidades Arcaica e Clássica; a transformação da visão holística como consequência da alteração da concepção antropológica ao longo da época moderna; para terminar com uma reflexão que destaque a necessidade de voltar à humanização. Na introdução, nossa atenção estará direcionada, especificamente, para a perspectiva holística com a qual a filosofia e a medicina inauguraram o estudo propriamente antropológico. (...) Em seguida, será examinado o momento de passagem da visão holística para uma concepção mecanicista do homem e das práticas sociais que o veem como objeto de estudo e de cuidado. Por fim, gostaríamos de destacar os esforços que estão sendo efetuados para voltar a uma visão global na qual o homem, a sociedade e a natureza fazem parte de um único e mesmo sistema orgânico. (shrink)

This project seeks to highlight the benefits of the implementation and management of the teaching digital portfolio. In today's world full of technology and tools that facilitate daily activities, education and its various processes must also embrace the digital tools available and make them the basis for any innovation and improvement process. The teaching portfolio in physics has long been the means by which teachers have organized the processes, evidence, and other results of educational work. Nowadays, all that range of (...) evidence and productions, which signify the achievement and advances in each group of students, has been able to be integrated into technology. (shrink)

Niniejszy tekst stanowi w pewnym sensie streszczenie książki Panajotisa Kondylisa Die Aufklärung im Rahmen des neuzeitlichen Rationalismus, wydanej po raz pierwszy w 1981 r. w wydawnictwie Klett-Cotta. W roku 1987 pojawiło się na rynku pierwsze wydanie greckie. Niemieckie wydania szybko zniknęły z rynku, a książka stała się jednym ze standardowych dzieł poświęconych oświeceniu w Niemczech i Grecji. Jej pozycję podkreślają kolejne wydania już po śmierci Kondylisa, chociażby przez wydawnictwo Felixa Meinera w 2002 r. Tekst będący przedmiotem niniejszego przekładu ukazał (...) się jako posłowie na końcu trzeciego tomu książki Karla Vorländera Geschichte der Philosophie. Neuzeit bis Kant wydanej w 1990 r.. Wprowadzenie, tytuł oraz przypisy wersji polskiej pochodzą od tłumacza. (shrink)

We systematically study the completion of choice problems in the Weihrauch lattice. Choice problems play a pivotal rôle in Weihrauch complexity. For one, they can be used as landmarks that characterize important equivalences classes in the Weihrauch lattice. On the other hand, choice problems also characterize several natural classes of computable problems, such as finite mind change computable problems, non-deterministically computable problems, Las Vegas computable problems and effectively Borel measurable functions. The closure operator of completion generates the concept of total (...) Weihrauch reducibility, which is a variant of Weihrauch reducibility with total realizers. Logically speaking, the completion of a problem is a version of the problem that is independent of its premise. Hence, studying the completion of choice problems allows us to study simultaneously choice problems in the total Weihrauch lattice, as well as the question which choice problems can be made independent of their premises in the usual Weihrauch lattice. The outcome shows that many important choice problems that are related to compact spaces are complete, whereas choice problems for unbounded spaces or closed sets of positive measure are typically not complete. (shrink)

We welcome Blumenthal-Barby’s et al. (2022) plaidoyer for the integration of philosophy in bioethics because of a perceived mutual benefit. Drawing on experience from a collaborative project, funde...

Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

In this article I argue that most biases in argumentation and decision-making can and should be counteracted. Although biases can prove beneficial in certain contexts, I contend that they are generally maladaptive and need correction. Yet critical thinking alone seems insufficient to mitigate biases in everyday contexts. I develop a contextualist approach, according to which cognitive debiasing strategies need to be supplemented by extra-psychic devices that rely on social and environmental constraints in order to promote rational reasoning. Finally, I examine (...) several examples of contextual debiasing strategies and show how they can contribute to enhance critical thinking at a cognitive level. (shrink)

Neste trabalho abordamos a obra de Francis Bacon e as suas contribuições para a Filosofia da Ciência, incluindo a sua proposta de método científico e o seu posicionamento crítico face à anterior versão aristotélica e a influência que o pensamento baconiano exerceu na promoção de um novo quadro filosófico para o desenvolvimento científico na modernidade. Este trabalho foi realizado no âmbito da disciplina de Filosofia das Ciências I, parte do curso de Filosofia da Faculdade de Letras da Universidade do Porto, (...) Portugal. (shrink)

La ira interior, la tristeza, el disgusto, el nerviosismo, la impotencia, más que conceptos, son en realidad sentimientos que por carne propia podemos experimentar, además de ser constantes dentro de nuestra vida anímica, incluso más que el sentido de gozo y placer, que tanto buscamos dentro de nuestras actividades ordinarias. Sin embargo, al experimentar estas emociones en sí mismas parecen no generar algún problema mayor. El problema mismo viene en la acción para poder colmar estas intensas emociones que muchas veces (...) se presentan dentro de nosotros mismos “como criterio el dolor es inmutable, variable es, en cambio, el modo y manera como el ser humano se enfrenta a él”. (shrink)

Normative theories of argumentation tend to assume that logical and dialectical rules suffice to ensure the rationality of argumentative discourse. Yet, in everyday debates people use arguments that seem valid in light of such rules but nonetheless biased and tendentious. This article seeks to show that the rationality of argumentation can only be fully promoted if we take into account its ethical dimension. To substantiate this claim, I review some of the empirical evidence indicating that people’s inferential reasoning is systematically (...) affected by a variety of biases and heuristics. Insofar as these cognitive illusions are typically unintentional, it appears that arguers may be biased despite their well-intended efforts to follow the rules of critical argumentation. Nevertheless, I argue that people remain responsible for the rationality of their arguments, given that there are a number of measures that they can (and ought to) take to avoid such distortions. I highlight the importance of argumentational virtues and critical thinking to rational debates, and describe a set of indirect strategies of “argumentative self-control”. (shrink)

Neste breve ensaio, exploramos alguns caminhos de uma controvérsia milenar em torno do estatuto dos entes matemáticos e apresentamos alguns argumentos a favor de uma posição platonista, aproximadamente clássica, sobre o tema. Este trabalho foi realizado no âmbito da disciplina de Filosofia das Ciências II, parte do curso de Filosofia da Faculdade de Letras da Universidade do Porto, Portugal.

Resumo: Abordo, neste artigo, a forma pela qual o representacionismo perceptual compreende a tese da transparência, comprometendo-a, principalmente, com uma concepção indireta da experiência perceptual. Defendo, a partir de uma análise das perspectivas de Fred Dretske e Michael Tye, que é possível vincular-se representacionismo e a tese da transparência com uma concepção direta da experiência perceptual, cujo conteúdo é singular.Abstract: In this paper, I intend to review the way in which perceptive representationalism understands the thesis of transparency and its commitment (...) to an indirect conception of perception. From an analysis of the perspectives of Fred Dretske and Michael Tye, I argue for the possibility of relating representationism and the thesis of transparency to a direct conception of perception. (shrink)

O presente artigo trata da concepção evolucionista da moral, considerando, primeiramente, duas análises que diferem quanto à maior ou menor importância atribuída à evolução. Discutimos, também, dois problemas filosóficos relacionados com a atribuição da origem evolutiva para moral: o determinismo e objetivismo moral. Defendemos que a vinculação entre evolução e moral não implica necessariamente o determinismo nem a exclusão de justificação e crítica. A perspectiva evolucionista pode, a nosso ver, cooperar para a ultrapassagem da oposição racionalismo e empirismo frente à (...) moralidade, ao levar em conta a influência dos sentimentos, mas sem desconsiderar a especificidade das normas morais. This article discusses the evolutionist conception of moral, considering two approaches, which differ in relation to the importance of evolution in understanding moral behavior. Moreover, it discusses two philosophical problems related to the association between moral and evolution: the determinism, and the problem of objectivity of morality. Evolutionist perspective does not always implicate in determinism. Indeed, it can overcome the opposition between rationalism and empiricism, because it considers the nature of the feelings, without denying the specificity of moral norms. (shrink)

Sex has become to-day a sort of secular religion, i.e. a mass-belief in a new world entirely redeemed from its evils by revolution. Hope in revolution presupposes the ideas of man's original innocence and of society'sresponsibility for evil. As no political or economical revolution can entirely liberate man from his aggressiveness, the sexual revolution isproposed as the basic step towards the new world. But a totally free sexuality, breaking the dialectics between Eros and Thanatos, gives way to the deathinstinct and (...) therefore to a world of struggle for domination, not of liberty. (shrink)

This article focuses on emergency medical care in black urban populations, suggesting that the classification of a “community” within clinical trial language is problematic. The article references a cultural history of black Americans with pre-hospital emergency medical treatment as relevant to contemporary emergency medicine paradigms. Part I explores a relationship between “autonomy” and “community.” The idea of community emerges as a displacement for the ethical principle of autonomy precisely at the moment that institutionalized medicine focuses on diversity. Part II examines (...) a clinical trial for the blood substitute PolyHeme® (Northfield Laboratories, Inc., Evanston, IL). It illustrates the ways in which bias in research paradigms and Institutional Review Board decisions attach to the notion and utility of the language of “community.” The conclusion's contemporary anecdote makes apparent the vitality of the issues of prehospital emergency medical care and the ways in which decisions and practices fall too easily into a narrative of culturally biased treatment. (shrink)

O foco deste trabalho repousa sobre um certo caminho histórico percorrido pela ciência, como um todo, no sentido desta se despir de qualquer revestimento metafísico e que teve como marco incontornável a criação, em 1929, do Círculo de Viena. Abordamos algumas tendências e limitações desse movimento e argumentamos que o metafísico terá sempre um espaço no seio mais íntimo da reflexão científica. Este trabalho foi realizado no âmbito da disciplina de Filosofia das Ciências I, parte do curso de Filosofia da (...) Faculdade de Letras da Universidade do Porto, Portugal. (shrink)

We study the uniform computational content of different versions of the Baire category theorem in the Weihrauch lattice. The Baire category theorem can be seen as a pigeonhole principle that states that a complete metric space cannot be decomposed into countably many nowhere dense pieces. The Baire category theorem is an illuminating example of a theorem that can be used to demonstrate that one classical theorem can have several different computational interpretations. For one, we distinguish two different logical versions of (...) the theorem, where one can be seen as the contrapositive form of the other one. The first version aims to find an uncovered point in the space, given a sequence of nowhere dense closed sets. The second version aims to find the index of a closed set that is somewhere dense, given a sequence of closed sets that cover the space. Even though the two statements behind these versions are equivalent to each other in classical logic, they are not equivalent in intuitionistic logic, and likewise, they exhibit different computational behavior in the Weihrauch lattice. Besides this logical distinction, we also consider different ways in which the sequence of closed sets is “given.” Essentially, we can distinguish between positive and negative information on closed sets. We discuss all four resulting versions of the Baire category theorem. Somewhat surprisingly, it turns out that the difference in providing the input information can also be expressed with the jump operation. Finally, we also relate the Baire category theorem to notions of genericity and computably comeager sets. (shrink)

Neste trabalho abordamos as contribuições de Larry Laudan para a questão do progresso científico. O modelo proposto, baseado na eficácia das teorias na resolução de problemas, serve de ponto de partida para uma breve reflexão sobre a influência contemporânea que as dificuldades de visão do mundo exercem sobre o desenvolvimento das ciências. Este trabalho foi realizado no âmbito da disciplina de Filosofia das Ciências II, parte do curso de Filosofia da Faculdade de Letras da Universidade do Porto, Portugal.

We prove that the Weihrauch lattice can be transformed into a Brouwer algebra by the consecutive application of two closure operators in the appropriate order: first completion and then parallelization. The closure operator of completion is a new closure operator that we introduce. It transforms any problem into a total problem on the completion of the respective types, where we allow any value outside of the original domain of the problem. This closure operator is of interest by itself, as it (...) generates a total version of Weihrauch reducibility that is defined like the usual version of Weihrauch reducibility, but in terms of total realizers. From a logical perspective completion can be seen as a way to make problems independent of their premises. Alongside with the completion operator and total Weihrauch reducibility we need to study precomplete representations that are required to describe these concepts. In order to show that the parallelized total Weihrauch lattice forms a Brouwer algebra, we introduce a new multiplicative version of an implication. While the parallelized total Weihrauch lattice forms a Brouwer algebra with this implication, the total Weihrauch lattice fails to be a model of intuitionistic linear logic in two different ways. In order to pinpoint the algebraic reasons for this failure, we introduce the concept of a Weihrauch algebra that allows us to formulate the failure in precise and neat terms. Finally, we show that the Medvedev Brouwer algebra can be embedded into our Brouwer algebra, which also implies that the theory of our Brouwer algebra is Jankov logic. (shrink)

This article presents an impact assessment framework that allows for the evaluation of positive and negative local-level impacts that have resulted from "responsible trade" interventions such as fair trade and ethical trade. The framework investigates impact relating to (1) livelihood impacts on primary stakeholders; (2) socio-economic impacts on communities; (3) organizational impacts; (4) environmental impacts; (5) policies and institutional impacts; and (6) future prospects. It identifies relevant local-level stakeholders and facilitates the analysis of conflicting interests. The framework was developed in (...) the context of, and is applied in this article to, the fair trade coffee industry in northern Nicaragua. It was designed, however, so that it can be applied across commodity sectors and responsible trade initiatives. It is able to do this by accommodating for differences in the social, environmental, political and institutional contexts of different areas, and by taking into account the distinct nature of an initiative's overall objectives, different levels of intervention, and the full range of stakeholders involved. (shrink)

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

Children with developmental language disorder (DLD) served as a test case for determining the role of extant vocabulary knowledge, endogenous attention, and phonological working memory abilities in cross-situational word learning. First-graders (Mage = 7 years; 3 months), 44 with typical development (TD) and 28 with DLD, completed a cross-situational word-learning task comprised six cycles, followed by retention tests and independent assessments of attention, memory, and vocabulary. Children with DLD scored lower than those with TD on all measures of learning and (...) retention, a performance gap that emerged in the first cycle of the cross-situational protocol and that we attribute to weaknesses in initial encoding. Over cycles, children with DLD learned words at a similar rate as their TD peers but they were less flexible in their strategy use, demonstrating a propose-but-verify approach but never a statistical aggregation approach. Also, they drew upon different mechanisms to support their learning. Attention played a greater role for the children with DLD, whereas extant vocabulary size played a greater role for the children with TD. Children navigate the problem space of cross-situational learning via varied routes. This conclusion is offered as motivation for theorists to capture all learners, not just the most typical ones. (shrink)

We study the computational content of the Brouwer Fixed Point Theorem in the Weihrauch lattice. Connected choice is the operation that finds a point in a non-empty connected closed set given by negative information. One of our main results is that for any fixed dimension the Brouwer Fixed Point Theorem of that dimension is computably equivalent to connected choice of the Euclidean unit cube of the same dimension. Another main result is that connected choice is complete for dimension greater than (...) or equal to two in the sense that it is computably equivalent to Weak Kőnig’s Lemma. While we can present two independent proofs for dimension three and upward that are either based on a simple geometric construction or a combinatorial argument, the proof for dimension two is based on a more involved inverse limit construction. The connected choice operation in dimension one is known to be equivalent to the Intermediate Value Theorem; we prove that this problem is not idempotent in contrast to the case of dimension two and upward. We also prove that Lipschitz continuity with Lipschitz constants strictly larger than one does not simplify finding fixed points. Finally, we prove that finding a connectedness component of a closed subset of the Euclidean unit cube of any dimension greater than or equal to one is equivalent to Weak Kőnig’s Lemma. In order to describe these results, we introduce a representation of closed subsets of the unit cube by trees of rational complexes. (shrink)

En el siguiente trabajo expondré las características principales del materialismo de Alfred Schmidt, el cual, debe ser entendido en su vertiente: no dogmática, crítica y dialéctica. Me refiero a la primera característica, en el sentido de que Schmidt, deja de lado la lectura marxista ortodoxa de la ..

Este artigo é uma pesquisa bibliográfica centrada na análise de cinco textos do marxista húngaro György Lukács cujo objetivo era compreender melhor como esse autor caracteriza o complexo da educação em sua teoria. As obras selecionadas para o estudo foram o capítulo A reprodução do livro Para uma ontologia do ser social 2, além de quatro ensaios dispersos em outras obras: O Poema pedagógico de Makarenko, Os anos de aprendizado de Wilhelm Meister, Lenin e os problemas de transição e Gottfried (...) Keller. Expõe-se que Lukács não compreende a educação em sentido estrito como limitada à sociedade capitalista, mas como universal, por se caracterizar como uma práxis intencional que pode ocorrer em diversos âmbitos da sociedade. Tal resultado aponta para uma interpretação da educação em Lukács menos limitada à crítica de função reprodutora e, portanto, abrindo maiores possibilidades de conexão entre a teoria lukacsiana e a luta revolucionária. (shrink)

Until recently, economics conceived of poverty solely as a lack of material resources. This view likely captures the reality of poverty experienced by many people around the globe. However, two waves of behavioral economics demonstrate that the narrowing of people’s external environments may change people themselves: poverty lowers the quality of decision-making and poverty and oppression may depress the capacity to aspire. Poverty and a history of oppression also change how individuals are perceived. To overcome these effects may require helping (...) people acquire new mental models. This essay discusses key findings from behavioral economics, the implications for agency, and some interventions with promising outcomes. We hope to inspire scholars and policymakers to think more deeply about the nature of poverty and oppression and to consider policies that target the psychological and sociological factors that create cycles of poverty. (shrink)

Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...

In this paper we study a new approach to classify mathematical theorems according to their computational content. Basically, we are asking the question which theorems can be continuously or computably transferred into each other? For this purpose theorems are considered via their realizers which are operations with certain input and output data. The technical tool to express continuous or computable relations between such operations is Weihrauch reducibility and the partially ordered degree structure induced by it. We have identified certain choice (...) principles such as co-finite choice, discrete choice, interval choice, compact choice and closed choice, which are cornerstones among Weihrauch degrees and it turns out that certain core theorems in analysis can be classified naturally in this structure. In particular, we study theorems such as the Intermediate Value Theorem, the Baire Category Theorem, the Banach Inverse Mapping Theorem, the Closed Graph Theorem and the Uniform Boundedness Theorem. We also explore how existing classifications of the Hahn—Banach Theorem and Weak Kőnig's Lemma fit into this picture. Well-known omniscience principles from constructive mathematics such as LPO and LLPO can also naturally be considered as Weihrauch degrees and they play an important role in our classification. Based on this we compare the results of our classification with existing classifications in constructive and reverse mathematics and we claim that in a certain sense our classification is finer and sheds some new light on the computational content of the respective theorems. Our classification scheme does not require any particular logical framework or axiomatic setting, but it can be carried out in the framework of classical mathematics using tools of topology, computability theory and computable analysis. We develop a number of separation techniques based on a new parallelization principle, on certain invariance properties of Weihrauch reducibility, on the Low Basis Theorem of Jockusch and Soare and based on the Baire Category Theorem. Finally, we present a number of metatheorems that allow to derive upper bounds for the classification of the Weihrauch degree of many theorems and we discuss the Brouwer Fixed Point Theorem as an example. (shrink)

Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

El objetivo de este artículo consiste en abordar algunos argumentos de la filosofía de J. Rancière relacionados con la necesidad de repensar el comunismo. La hipótesis de trabajo insiste en señalar que Rancière no defiende ningún proyecto comunista. Esto al menos por tres razones: no hay igualdad de las inteligencias, el comunista funge como profesor explicador en aras de concientizar a los embrutecidos, el comunismo pertenece a una temporalidad histórica teleológica, lo que a su vez supone un aplazamiento de la (...) emancipación. Finalmente, cerramos este diálogo con las posibilidades presentes de esta otra forma de concebir la igualdad y la emancipación. (shrink)

In this paper we study a reducibility that has been introduced by Klaus Weihrauch or, more precisely, a natural extension for multi-valued functions on represented spaces. We call the corresponding equivalence classes Weihrauch degrees and we show that the corresponding partial order induces a lower semi-lattice. It turns out that parallelization is a closure operator for this semi-lattice and that the parallelized Weihrauch degrees even form a lattice into which the Medvedev lattice and the Turing degrees can be embedded. The (...) importance of Weihrauch degrees is based on the fact that multi-valued functions on represented spaces can be considered as realizers of mathematical theorems in a very natural way and studying the Weihrauch reductions between theorems in this sense means to ask which theorems can be transformed continuously or computably into each other. As crucial corner points of this classification scheme the limited principle of omniscience LPO, the lesser limited principle of omniscience LLPO and their parallelizations are studied. It is proved that parallelized LLPO is equivalent to Weak Kőnig's Lemma and hence to the Hahn—Banach Theorem in this new and very strong sense. We call a multi-valued function weakly computable if it is reducible to the Weihrauch degree of parallelized LLPO and we present a new proof, based on a computational version of Kleene's ternary logic, that the class of weakly computable operations is closed under composition. Moreover, weakly computable operations on computable metric spaces are characterized as operations that admit upper semi-computable compact-valued selectors and it is proved that any single-valued weakly computable operation is already computable in the ordinary sense. (shrink)

The investigation of computational properties of discontinuous functions is an important concern in computable analysis. One method to deal with this subject is to consider effective variants of Borel measurable functions. We introduce such a notion of Borel computability for single-valued as well as for multi-valued functions by a direct effectivization of the classical definition. On Baire space the finite levels of the resulting hierarchy of functions can be characterized using a notion of reducibility for functions and corresponding complete functions. (...) We use this classification and an effective version of a Selection Theorem of Bhattacharya-Srivastava in order to prove a generalization of the Representation Theorem of Kreitz-Weihrauch for Borel measurable functions on computable metric spaces: such functions are Borel measurable on a certain finite level, if and only if they admit a realizer on Baire space of the same quality. This Representation Theorem enables us to introduce a realizer reducibility for functions on metric spaces and we can extend the completeness result to this reducibility. Besides being very useful by itself, this reducibility leads to a new and effective proof of the Banach-Hausdorff-Lebesgue Theorem which connects Borel measurable functions with the Baire functions. Hence, for certain metric spaces the class of Borel computable functions on a certain level is exactly the class of functions which can be expressed as a limit of a pointwise convergent and computable sequence of functions of the next lower level. (shrink)

Matthias Schröder has asked the question whether there is a weakest discontinuous problem in the topological version of the Weihrauch lattice. Such a problem can be considered as the weakest unsolvable problem. We introduce the discontinuity problem, and we show that it is reducible exactly to the effectively discontinuous problems, defined in a suitable way. However, in which sense this answers Schröder’s question sensitively depends on the axiomatic framework that is chosen, and it is a positive answer if we work (...) in Zermelo–Fraenkel set theory with dependent choice and the axiom of determinacy $\mathsf {AD}$. On the other hand, using the full axiom of choice, one can construct problems which are discontinuous, but not effectively so. Hence, the exact situation at the bottom of the Weihrauch lattice sensitively depends on the axiomatic setting that we choose. We prove our result using a variant of Wadge games for mathematical problems. While the existence of a winning strategy for Player II characterizes continuity of the problem (as already shown by Nobrega and Pauly), the existence of a winning strategy for Player I characterizes effective discontinuity of the problem. By Weihrauch determinacy we understand the condition that every problem is either continuous or effectively discontinuous. This notion of determinacy is a fairly strong notion, as it is not only implied by the axiom of determinacy $\mathsf {AD}$, but it also implies Wadge determinacy. We close with a brief discussion of generalized notions of productivity. (shrink)

Este artículo tiene como objetivo revisar el concepto de emancipación en la obra de J. Rancière, particularmente como aparece desarrollado en El maestro ignorante y El espectador emancipado. De esta forma, se muestra que la emancipación no es el fin de un proyecto histórico sino un punto de partida a través de la igualdad de las inteligencias, y por lo tanto, cualquiera puede tener acceso a esta experiencia sin un proceso de concientización o un maestro explicador. Por último, reflexionamos sobre (...) los posibles retos y posibilidades del método de la igualdad. (shrink)