In a town near mine, a small business owner used their changeable-letter sign to wage a public protest against a variety of restrictions implemented during the COVID-19 pandemic. Unlike a great man...

Abstract3′ untranslated regions (3′ UTRs) of mRNAs have many functions, including mRNA processing and transport, translational regulation, and mRNA degradation and stability. These different functions require cis‐elements in 3′ UTRs that can be either sequence motifs or RNA structures. Here we review the role of secondary structures in the functioning of 3′ UTRs and discuss some of the trans‐acting factors that interact with these secondary structures in eukaryotic organisms. We propose potential participation of 3′‐UTR secondary structures in cytoplasmic polyadenylation in (...) the model organism Drosophila melanogaster. Because the secondary structures of 3′ UTRs are essential for post‐transcriptional regulation of gene expression, their disruption leads to a wide range of disorders, including cancer and cardiovascular diseases. Trans‐acting factors, such as STAU1 and nucleolin, which interact with 3′‐UTR secondary structures of target transcripts, influence the pathogenesis of neurodegenerative diseases and tumor metastasis, suggesting that they are possible therapeutic targets. (shrink)

The authors investigated the ontological argument computationally. The premises and conclusion of the argument are represented in the syntax understood by the automated reasoning engine PROVER9. Using the logic of definite descriptions, the authors developed a valid representation of the argument that required three non-logical premises. PROVER9, however, discovered a simpler valid argument for God's existence from a single non-logical premise. Reducing the argument to one non-logical premise brings the investigation of the soundness of the argument into better focus. Also, (...) the simpler representation of the argument brings out clearly how the ontological argument constitutes an early example of a ?diagonal argument? and, moreover, one used to establish a positive conclusion rather than a paradox. (shrink)

This short, elegiac volume makes an impassioned case for the fundamental importance of the forgotten virtue of reverence, and how awe for things greater than oneself can - indeed must - be a touchstone for other virtues like respect, humility, and charity. Ranging widely over diverse cultural terrain - from Philip Larkin to ancient Greek poetry, from modern politics to Chinese philosphy - Woodruff shows how absolutely essential reverence is to a well-functioning society.

Includes a chapter on visual perception.

There is a classical paradox in education that also affects the epistemic virtues: the paradox inherent in the demand to develop general strategies for training persons to be free and creative individuals. This problem becomes particularly salient with respect to the epistemic virtue of creativity, the more so if we consider a radical form of creativity, namely, genius. This paper explores a historical constellation in which rigorous claims about the standards for knowledge and morality were developed, along with a highly (...) influential notion of genius: the philosophy of Kant and of immediate post‐Kantian philosophers. The paper shows how in this historical moment came together a new notion of “science,” a theory of “genius” and of virtues, and an analysis of the promises and difficulties inherent in educating a virtuous or creative individual. In this constellation of ideas, there also emerges a potentially fruitful account of how to teach intellectual creativity. (shrink)

Though Frege was interested primarily in reducing mathematics to logic, he succeeded in reducing an important part of logic to mathematics by defining relations in terms of functions. By contrast, Whitehead & Russell reduced an important part of mathematics to logic by defining functions in terms of relations (using the definite description operator). We argue that there is a reason to prefer Whitehead & Russell's reduction of functions to relations over Frege's reduction of relations to functions. There is an interesting (...) system having a logic that can be properly characterized in relational but not in functional type theory. This shows that relational type theory is more general than functional type theory. The simplification offered by Church in his functional type theory is an over-simplification: one can't assimilate predication to functional application.<br>. (shrink)

In this work, Paul Weithman offers a fresh, rigorous and compelling interpretation of John Rawls' reasons for taking his so-called 'political turn'.

Die Frage nach den grundsätzlichen Erkenntnisgrenzen der Physik wird hier verstanden als die Frage danach, welchen Status die Aussagen der Physik über unbeobachtbare Gegenstände haben, z.B. über den Urknall, über Quarks oder über dunkle Materie. Sind die diesbezüglichen Aussagen der besten physikalischen Theorien einfach wahr oder wenigstens annähernd wahr (realistische Interpretation)? Oder wenigstens wahrscheinlich? Oder handelt es sich um bloße Modellvorstellungen, die für Vorhersagen und ggf. technische Anwendungen praktisch sind, aber keinen Wahrheitsgehalt aufweisen (instrumentalistische Interpretation)? In diesem Aufsatz werden verschiedene (...) solcher Möglichkeiten genauer vorgestellt und die wichtigsten einschlägigen Argumente für und gegen solche Positionen diskutiert. (shrink)

The authors rightly critique existing social sciences approaches. However, they are too quick to dismiss the criticism that their proposed paradigm is atheoretical. Social and cognitive theories are indeed incommensurate, often due to the lack of a unifying framework. Without proper integration with theoretical frameworks, their proposal may merely produce a resource-intensive veneer of thoroughness without substantive improvements to understanding.

This article addresses the need to problematize “cases” in science and technology studies work, as a middle-range theory issue. The focus is not on any one case study per se, but on why case studies exist and endure in STS. Case studies are part of a specific problematization in the field. We therefore explore relations between motivation for the use of cases, their constitution, and ways they can be invoked to make particular kinds of arguments in STS. We set out (...) to examine the case as an object that links together research practices, intellectual debates, and programmatic concerns in our own work. Based on our experiences and on this reflection on the links between cases and questions in STS, we propose a number of casemaking strategies that shift and enrich the deployment of ethnographic cases as an epistemic tool in STS. (shrink)

This study examined the historical perspectives of eleven emergent bilingual and bilingual students at two middle schools. Data analysis revealed that the participants’ perspectives on U.S. history reflected three schematic narrative templates focused on nation-building, equality, and discrimination. The participants primarily employed the (in)equality narratives when discussing aspects of U.S. history directly linked to their identities. The findings add to the extant research on student historical perspectives and use of schematic narrative templates. The findings further suggest that engaging (emergent) bilingual (...) students in examining multiple perspectives and conducting critical history inquiry can contribute to notions of culturally and linguistically responsive social studies instruction. (shrink)

Quite remarkably, Friedrich Wilhelm Joseph Schelling uses the notion of “drive” in analysing important cognitive achievements: An important instance of this attitude can be found in his characterizing Kant as a philosopher who operates in the basis of instincts. His key argument in adopting “drives” as key to the cognitive faculties of humans derives from the conviction that cognitive endeavours need to be open and directed towards grasping reality not in individual items, but as a totality. He arrives, in employing (...) these terms, at an understanding of science, and of cognition in general, as an open, future-directed, and dynamic process. This chapter presents an overview of Schelling’s usage of “drive”-related terms, discusses his rather detailed description of the mechanics of drives within the structure of human faculties, and draws some conclusions as to Schelling’s understanding of “science” and the dynamics of science. (shrink)

Résumé L’envoûtement médiatique est un travail de l’imagination, effectué par le consommateur, qui occupe désormais la totalité, toujours croissante, de son temps de connexion. Cet hypertravail est au fondement de la nouvelle économie capitaliste, la chronophagie, en raison de sa rentabilité sans précédent, car le consommateur produit lui-même, par son imagination, un surcroît de valeur de la marchandise, qui lui fait accepter de la payer plus cher. L’hypertravail est le premier travail payant.

The value of biodiversity is usually confused with the value of biological resources, both actual and potential. A sharp distinction between biological resources and biodiversity offers a clearer insight into the value of biodiversity itself and therefore the need to preserve it. Biodiversity can be defined abstractly as the differences among biological entities. Using this definition, biodiversity can be seen more appropriately as: (a) a necessary precondition for the long term maintenance of biological resources, and therefore, (b) an essential environmental (...) condition. Three values of biodiversity are identified and arranged in a hierarchy: (1) the self-augmenting phenomenon of biodiversity maintains (2) the conditions necessary for the adaptive evolution of species and higher taxa, which in turn is necessary for providing humans with (3) a range of biological resources in the long term. Two broad policy implications emerge: increments of biodiversity should not be traded off against biological resources as if they were the same, and the conservation of biodiversity should be a constraint on the public interest, not a goal in service of the public interest. (shrink)

Like Plato, Protagoras held that young children learn virtue from fine examples in poetry. Unlike Plato, Protagoras taught adults by correcting the diction of poets. In this paper I ask what his standard of correctness might be, and what benefit he intended his students to take from exercises in correction. If his standard of correctness is truth, then he may intend his students to learn by questioning the content of poems; that would be suggestive of Plato’s program in Republic III. (...) But his standard is more likely to be the accurate use of language; in that case he would intend his students to learn to express their thoughts clearly enough that their audience would understand what they were saying. That standard would be independent of the truth of what they are saying; and that would be a precursor to modern techniques by which we try to teach speaking and writing. Truth is not so easy to escape, however, and we shall see that Protagoras’ exercise must assume that the poet is trying to tell the truth. (shrink)

Investigations of data-centered efforts in advocacy and activism are often cast in terms of a narrative of opposition between grassroots activists working through and with data, and corporations or institutions whose actions data might expose. The boundaries are, however, not so distinct in practice. Indeed, one outcome of successful advocacy efforts for opening big data to the public is that the activists may find themselves drawn into the institutions they critique or view as impediments in order to actualize those efforts (...) from the inside. Drawing on an ongoing ethnographic investigation of urban data initiatives inside city government, we explore the productive ambivalences of activism and advocacy that arise when those with data activist ideals find themselves operating within the government structure. (shrink)

Young traces the evolution of the term information from its general linguistic use into the mainstream of modern science, proposing an entirely new definition of information as a mass-energy phenomenon. He demonstrates that: information is in all cases a form phenomenon; both form and information are mass-energy rather than abstract phenomena; mind can be viewed as a mass-energy rather form-manipulating process; form constitutes a mechanism immanent in the physical universe via which mass-energy systems can communicate informationally and control their own (...) energetic activities. (shrink)

Science and the History of the Sciences. Conceptual Innovations Through Historicizing Science in the Eighteenth Century. The historical reconstruction of science is linked to philosophical discussions of the eighteenth century in many ways. The historiography of philosophy and the historiography of science share the conceptual problem to assemble the multitude of scientific and philosophical practices under general concepts. The historical analysis of scientific progress offers a clue by problematizing definitions of “science” and “sciences” as well as the system of sciences (...) as a whole. By analyzing these conceptual problems and the typology of historical enterprises of the eighteenth century, this paper will discuss the close interrelations which existed between philosophical and historical discourses of eighteenth‐century reflection on science. (shrink)

Trust is a temporary attachment between humans that pervades our daily lives. Recent research has shown that the affiliative hormone oxytocin rises with a social signal of interpersonal trust and is associated with trustworthy behavior (the reciprocation of trust). This commentary reports these results and relates them to the target article's findings for variations in affiliative-related behaviors.

In the Symposium of Plato, Socrates reports that Diotima once described to him a process of initiation by which a lover rises from desiring one beautiful body to catching sight of what seems to be the Platonic form of beauty. Scholars have debated whether the lover is to make this ascent by a rational process or a non-rational one, or by both working either in concert or independently. This paper argues that love leads and guides a process in this initiation (...) that necessarily involves rational activity. No teaching is necessary or appropriate, so that the process is an example of learning without being taught. The philosophical insight that results is life-changing, but it does not amount to the kind of knowledge that would fully satisfy a Socratic seeker after knowledge. (shrink)

This volume brings together Paul Williams's previously published papers on the Indian and Tibetan interpretations of selected verses from the eighth and ninth chapters of the Bodhicaryavatara. In addition, there is a much longer version of the paper 'Identifying the Object of Negation', and nearly half the book consists of a wholly new essay, 'The Absence of Self and the Removal of Pain', subtitled 'How Santideva Destroyed the Bodhisattva Path'. This book will be of interest to those concerned with (...) the history and interpretation of Indian and Tibetan philosophy. (shrink)

_Criticism and Conviction_ offers a rare opportunity to share personally in the intellectual life and journey of the eminent philosopher Paul Ricoeur. Internationally known for his influential works in hermeneutics, theology, psychoanalysis, and aesthetics, until now, Ricoeur has been conspicuously silent on the subject of himself. In this book--a conversation about his life and work with François Azouvi and Marc de Launay--Ricoeur reflects on a variety of philosophical, social, religious, and cultural topics, from the paradoxes of political power to (...) the relationship between life and art, and life and death. In the first of eight conversations, Ricoeur traces the trajectory of his life, recounting the origins of his convictions and the development of his intellect against the tragic events of the twentieth century. Declaring himself the "son of a victim of the First World War," Ricoeur, an orphan, sketches his early years in the house of stern but loving grandparents, and the molding of his intellect under the tutelage of Roland Dalbiez, Gabriel Marcel, and André Philip. Ricoeur tells the intriguing story of his capture and five-year imprisonment by the Germans during World War II, where he and his compatriots fashioned an intellectual life complete with a library and lectures, and where he, amazingly, was able to continue his dissertation research. Elegantly interweaving anecdotal with philosophical meditations, Ricoeur recounts his relationships with some of the twentieth century's greatest figures, such as Heidegger, Jaspers, and Eliade. He also shares his views on French philosophers and explains his tumultuous relationship with Jacques Lacan. And while expressing his deepest respect for the works of Claude Lévi-Strauss and Michel Foucault, Ricoeur reserves his greatest admiration for the narratologist Algirdas Julien Greimas. Ricoeur also explores the relationship between the philosophical and religious domains, attempting to reconcile the two poles in his thought. And readers who have struggled with Ricoeur's work will be grateful for these illuminating discussions that provide an invaluable key to his writings on language and narrative, especially those on metaphor and time. Spontaneous and lively, _Criticism and Conviction_ is a passionate confirmation of Ricoeur's eloquence, lucidity, and intellectual rigor, and affirms his position as one of this century's greatest thinkers. It is an essential book for anyone interested in philosophy and literary criticism. (shrink)

Are there disjunctive properties? This question is important for at least two reasons. First, disjunctive properties are invoked in defense of certain philosophical theories, especially in the philosophy of mind. Second, the question raises the prior issue of what counts as a genuine property, a central concern in the metaphysics of properties. I argue here, on the basis of general considerations in the metaphysics of properties, that there are no disjunctive properties. Specifically, I argue that genuine properties must guarantee similarity-in-a-respect (...) among their instances, and must inhere in their bearers (two notions to be clarified). Disjunctive properties would fail both requirements. I compare the case of disjunctive properties with “mere Cambridge properties,” determinable properties, and functional properties, and show how my conception of properties remains compatible with determinables and functional properties while ruling out disjunctive and mere Cambridge properties. (shrink)

Science can reveal or conceal the breathtaking wonders of creation. On one hand, knowledge of the natural world can open us up to greater love for the Creator, give us the means of more neighborly care, and fill us with ever-deepening astonishment. On the other hand, knowledge feeding an insatiable hunger for epistemic mastery can become a means of idolatry, hubris, and damage. Crucial to world-respecting science is the role of wonder: curiosity, perplexity, and astonishment. In this volume, philosopher William (...) Desmond explores the relation of the different modes of wonder to modern science. Responding to his thought are twelve thinkers across the domains of science, theology, philosophy, law, poetry, medicine, sociology, and art restoration. (shrink)

Réponses à Juliette Grange sur ses remises en cause peu argumentées d'une partie de la philosophie en France.

Governments of all nations presume they possess full discretionary policymaking powers over the lands and waters within their geopolitical boundaries. At least one global environmental issue—the rapid loss of the world’s biodiversity, the sixth major mass extinction event in geological time—challenges the legitimacy of this presumption. Increment by increment, the present generation is depleting the world’s biodiversity by way of altering species’ habitats for the sake of short term economic gain. When biodiversity is understood as an essential environmental condition—essential in (...) the long term because it is the source of the biological resources upon which humans depend—then the strongly differential distribution of benefits and burdens between generations raises an issue of intergenerational justice. We receive the short-term benefits of economic development; future generations will receive the resulting burden of a biosphere in which one of the life-support systems necessary for humanity will have been compromised. Using Ronald Dworkin’s conceptions of distributive justice, it can be demonstrated that constitutional constraints on the discretionary powers of governments, for the sake of intergenerational justice, are entirely consistent with central tenets of liberal democracy. As a result, we should abandon to some extent the presumption that governments have full jurisdiction over the lands and waters within their boundaries. (shrink)

This chapter contains sections titled: What Is Tragedy? Mimesis6 Understanding Katharsis17 Five Questions for Interpreters A Short History of Katharsis Interpretation The Nature of Our Question Notes Bibliography.