Decades of public investment in molecular technologies and data integration techniques have fueled promises of precision medicine (PM) as a novel, targeted, and data-driven approach that takes into...

By the start of the twenty-first century, the notion of ‘the sublime’ had come to seem incoherent. In the last ten years or so considerable light has been shed by empirical psychologists on a related notion of ‘awe’, and a fruitful dialogue between aestheticians and empirical psychologists has ensued. It is the aim of this paper to synthesize these advances and to offer what I call a ‘two-tiered’ theory of the sublime that shows it to be a coherent aesthetic category. (...) On this theory, sublime experiences begin in an ‘awe response’ (the ‘thin sublime’) and might, with the additional element of temporally-extended reflection, turn into a ‘thick sublime’ response. Building on accounts of the sublime as a species of ‘aesthetic awe’ (Clewis, 2019a and 2019b; Arcangeli, et al., 2020) I aim to show that this two-tiered theory helps to explain why sublime experiences seem to have a basic, primordial core, but also seem to be historically and culturally quite variable (as Nicolson, 1963 [1959]; Battersby, 2007; and McMahon, 2017 have stressed). On this model, the cultural and historical variability comes in largely at the point of the temporally-extended reflection characteristic of the thick sublime, due to the cognitive stock that the subject brings to the encounter. Thus, sublime experiences really lend themselves to being interpreted quite variously by the subject (as well as by the theorist) of these experiences, as, for example, affording insight into the Divine, our moral vocation, or our metaphysical unity with the entire universe, among other lofty thoughts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Annual Meeting of the Society for Buddhist-Christian StudiesSan Diego, California, USA November 21–23, 2014Sandra Costen Kunz, SBCS Secretary and Jonathan A. Seitz, Newsletter EditorThe annual meeting is an opportunity to meet, to reconnect, and to share our work. As a “Related Scholarly Organization” of the American Academy of Religion, the Society for Buddhist-Christian Studies holds its meetings concurrently with the AAR’s national conference. The SBCS normally organizes two (...) panels and holds board and members meetings. This year’s panels were “Liberation Theology and Engaged Buddhism: Challenging Each Other, Learning from Each Other,” and “Old Buddhist Texts: New Womanist Thought.” The papers from panels are often published in this journal.board meetings (officer and committee reports)The society’s annual board meeting was held on Friday, November 21, and its members meeting Sunday, Nov. 23. The board approved officer reports submitted by the treasurer, Denise Yarbrough, the interim journal editors, Terry Muck and Rita Gross, and the newsletter editor, Jonathan Seitz and the minutes submitted by secretary Sandra Kunz. An extended discussion treated the history of the relationship between the society, the journal, and the University of Hawai’i Press. The board voted to continue publishing with UHP while working out a new memorandum of understanding.We reviewed reports from the Nominating Committee, Streng Book Award Committee, Graduate Student Award Committee, Membership Committee, Social Media and Website Committee, and Program Committee.Nominating CommitteeThe Nominating Committee reported that the governing board terms of Yifa and John Makransky end with this board meeting. John remains on the board as vice president. We discussed nominees for these two board positions.Streng Book Award CommitteeThe Streng Book Award Committee noted that it would be helpful to receive nominations. Thomas Hastings joined the committee and J. Abraham Vélez de Cea was elected to another term. [End Page 207]Graduate Student Award CommitteeKaren Enriquez reported for the Graduate Student Award Committee, noting that although a good paper was selected this year, the problem of paper quality remains. Rita Gross suggested that members with students working in Buddhist-Christian studies should encourage them to present papers at regional AAR meetings and submit these to the award committee. Judith Simmer-Brown suggested we start a subsidiary online journal that would publish, among other things, commentaries on BCS articles, including grad student commentaries. John Makransky suggested that we also post important articles from past issues we see as classics in the field. In light of the board’s enthusiasm about this idea for publishing grad student papers online, and in light of the difficulties of scheduling graduate student award papers within our sessions, John moved that we discontinue the oral presentation of graduate student award papers. Judith seconded the motion, which passed unanimously. John later moved, and Judith seconded the motion, that the board charge Karen, Glenn Willis, and Sarah Swenson to develop a proposal by March for a website that would host a subsidiary peer-reviewed online journal, being sure to articulate how this could promote the society among younger scholars. It passed unanimously.Membership CommitteeReminding us of Jonathan Seitz’s list of past members, John Makransky suggested we send out a membership mailing to them. Sarah Swenson and Alice Keefe were charged with creating a comprehensive distribution list and sending out a mailing asking everyone to join, rejoin, or renew their membership.Social Media and Website CommitteeIn light of our proposal to start a subsidiary online journal, Judith Simmer-Brown was gratefully charged with chairing a new committee with David Gardiner and Glenn Willis, who has been handling Facebook publicity. They will get bids for hiring a professional website designer who can configure it in such a way that we could maintain it ourselves.Program CommitteeJohn Makransky reported briefly on the potential session topics suggested at the lunch meeting. We discussed pros and cons of forming panels of known experts and using AAR’s blind submission process. The discussion ended with general exhortation to scout out scholars with pertinent work to enlarge our pool of presenters.We briefly discussed the pros and cons of organizing an international conference and reviving and regularizing the... (shrink)

Thomas Hobbes has been hailed as the philosopher of power par excellence; however, I demonstrate that Hobbes’s conceptualization of political power is not stable across his texts. Once the distinction is made between the authorized and the effective power of the sovereign, it is no longer sufficient simply to defend a doctrine of the authorized power of the sovereign; such a doctrine must be robustly complemented by an account of how the effective power commensurate to this authority might be achieved. (...) Nor is this straightforward: for effective political power can fluctuate, sometimes severely. In this light, the prevalent juridical reading of Hobbes’s political philosophy is inadequate. (shrink)

This argument has emphasized the professional character of Darwin's early activities, largely in order to balance the usual portrayal of the amateurishness of his early training and field of study. Arguing this way has revealed the interplay between Darwin's personal interests and his professional obligations, the latter being particularly important for the period from October 1836 to July 1837. In several instances, notably the treatment of his collections, the progress of his thought followed the professional lead directly. In the absence (...) of such a lead Darwin did not pursue certain issues, if only for lack of time. Thus the subject of man did not figure in his initial formulation of a transmutationist position. Only after the commitment to the new point of view had been made did the issues emerge which will be treated in Part II of this article. However, we may close by noting Darwin's inherited disposition on the subject: in the summer of 1837 Darwin responded to Lyell's claim that the change from irrational animal to rational man represented “a phenomenon of a distinct kind from the passage from the more simple to the more perfect forms of animal organization and instinct” with a fanciful doodle in the margin.121 The thoughts behind the bemused scribbling were to occupy a good portion of Darwin's time for the next two years. (shrink)

The problem is pain. Patients and their families tell the story:He is your son. You love him. You want to help him in every way you can, but when he is in that kind of pain, you are helpless in a sense. Im his daddy. It was-what was I supposed to do for him? I felt, you know, helpless.It terrifies you. You want to run away from it. Pain is something you wish would kill you but does not. Agony results (...) from the pain that does not have the decency to knock you out.[W]e had a good family, but how much can you watch? How much suffering can you watch from your child, your 7-year-old child, and still keep your mind?I am a forty-six-year-old registered nurse who specializes in oncology care and education. I am also a patient who suffers from chronic nonmalignant pain, and this malady has been the most frightening, the most humiliating, and the most difficult ordeal of my life. (shrink)

Should journalists resist business constraints they perceive as a threat to their professional integrity? This article suggests that the answer, at least sometimes, is yes. But in choosing a resistance strategy, journalists should not consider the "take this job and shove it" stance as the only option with moral integrity-or even as the best ethical option. This article develops a model of resistance strategies using the experiences of journalists at one newspaper to illustrate the range of options available for resisting (...) business constraints within a news organization. The types of strategies identified vary along the ethical dimensions of (a) consideration of organizational, as well as professional, goals; and (b) openness with regard to journalists' preference for professional goals. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Balancing Depth and Breadth in Our Conversations:Denver 2022 SBCS Annual MeetingSandra Costen KunzIn 2020 and 2021, due to the corona virus pandemic, the Society for Buddhist-Christian Studies (SBCS) held its annual board meeting, members meeting, and paper sessions online. This year, in 2022, we were delighted to meet face-to-face again on November 18–19 in conjunction with the annual meeting of the American Academy of Religion (AAR). Because we are (...) an AAR "related scholarly organization," all of our events were scheduled through, and publicized by, AAR's staff. President Mark Unno not only presided at the board's table but also graciously ran a video conference, primarily to accommodate board and committee members who were outside the United States or dealing with travel-prohibiting health issues.The 2020 and 2021 fully online governance meetings, led by then-president Leo Lefebure, had been well organized, well run, highly effective, and a lot of fun. But as I watched the attentive eyes around the table this year and listened to the laughter, empathetic sighs, and plans for follow-up conversations, it seemed to me that meeting in person, in some ways, more powerfully supports the society's aim to foster in-depth Buddhist-Christian dialogue and comparative studies. Mark, then vice president, had organized the 2020 and 2021 online paper sessions carefully for online audiences. We were thrilled that these beautifully crafted and moderated presentations drew audiences that were amazingly broad in terms of both size and diversity. Planned as emergency extensions of the society's efforts to create, through our blog and Facebook page, safe online spaces for Buddhist-Christian dialogue and comparative studies, these sessions drew an international audience whose breadth astounded us! Conversations that had begun in these sessions could not, however, be quickly continued over a meal or coffee. In some ways, they did not appear to me to spark the same depth of ongoing conversation that the SBCS has prompted in our four decades of face-to-face meetings.As the board continues to discuss how to balance our desires for both depth and breadth of conversation among our board, our members, and nonmembers who attend our events, we sincerely welcome the wisdom of members and other readers. You can submit suggestions to: https://www.society-buddhist-christian-studies.org/contact. [End Page 263]board of governors meetingPresident's Opening RemarksCalling this year's board meeting to order a little past 9 a.m., Mark Unno said that he sensed that his father, Taitetsu Unno, "is with us, encouraging and congratulating the society on how far we've come in the past forty years." He recalled his father's participation in the Cobb–Abe dialogues and the network that evolved into the SBCS, and that these initial conversations were often highly theological—and testy—and often involved a translator. Mark is convinced, however, that this early debate was a necessary foundation for developing a more robust mutual learning community. Describing two significant ways the society is modeling collaborative learning, he said:1. We're providing a model of interreligious engagement for other people in our various traditions.2. Although we do have impacts on scholars and general audiences through our AAR sessions, journal, and online resources, our greatest impacts as board members have been on each other! Furthermore, any impact of lasting value will come through our embodiment of deep dialogue and mutual learning.Mark explained that we'd begin with the online European Network report, move to the Japan Society's report, and then to the treasurer's and secretary's reports, both of which would be presented online.International Advisor Report from EuropeElizabeth Harris, representing the European Network of Buddhist Christian Studies, explained that since its formation in the 1990s, its main work has been to hold a conference every other year and publish the papers. EOS Verlag has now published the papers that she and Perry Schmidt-Leukel edited from the 2020 conference titled "A Visionary Approach: Lynn A. de Silva and the Prospects for Buddhist-Christian Encounter." The 2022 conference titled "Euro-Buddhism and the Role of Christianity," whose papers are now being edited... (shrink)

Humans may be the only creatures conscious of having a future, but all too often we would rather not think about it. Likewise, our societies, unable to deal with radical uncertainty, do not make policies with a view to the long term. Instead, we suffer from a sense of powerlessness, collective irrationality, and perennial political discontent. In _The Future and Its Enemies_, Spanish philosopher Daniel Innerarity makes a plea for a new social contract that would commit us to moral and (...) political responsibility with respect to future generations. He urges us to become advocates for the future in the face of enemies who, oblivious to the costs of modernization, press for endless and unproductive acceleration. His accessible book proposes a new way of confronting the unknown—one grounded in the calculation of risk. Declaring the classical right-left divide to be redundant, Innerarity presents his hopes for a renewed democracy and a politics that would find convincing ways to mediate between the priorities of the present, the heritage of the past, and the challenges that lie ahead. (shrink)

Il testo analizza tre diverse declinazioni del concetto di illuminismo nella riflessione hegeliana e cerca di mostrare che l’intento di Hegel è quello di dispiegare un nuovo concetto di ragione, nei confronti del quale la ragione illuminista si presenta come istanza necessaria, ma al contempo incompleta. L’Illuminismo rappresenta un’esperienza storica di negazione dell’esistente che si diffonde come una malattia infettiva che distrugge il corpo collettivo che la ospita, ma che non può e non deve essere arrestata. Piuttosto, l’unico modo di (...) produrre gli anticorpi necessari per superare quel contagio dilagante è attraversare il baratro in cui esso fa sprofondare il legame tra io e mondo, tra particolare e universale. (shrink)

This volume portrays the Polish or Lvov-Warsaw School, one of the most influential schools in analytic philosophy, which, as discussed in the thorough introduction, presented an alternative working picture of the unity of science.

Precision medicine relies on data and biospecimens from participants who willingly offer their personal information on the promise that this act will ultimately result in knowledge that will improv...

Should journalists resist business constraints they perceive as a threat to their professional integrity? This article suggests that the answer, at least sometimes, is yes. But in choosing a resistance strategy, journalists should not consider the "take this job and shove it" stance as the only option with moral integrity-or even as the best ethical option. This article develops a model of resistance strategies using the experiences of journalists at one newspaper to illustrate the range of options available for resisting (...) business constraints within a news organization. The types of strategies identified vary along the ethical dimensions of consideration of organizational, as well as professional, goals; and openness with regard to journalists' preference for professional goals. (shrink)

Kant -- Decomposition -- Meaning and analysis -- A substitutional theory -- Analyticity -- Consequence -- Justification and proof -- A priori knowledge -- Things, collections and numbers -- Frege -- Husserl, logical psychologism, and the theory of knowledge.

Negri celebrates a conception of democracy in which the concrete powers of individual humans are not alienated away, but rather are added together: this is a democracy of the multitude. But how can the multitude act without alienating anyone’s power? To answer this difficulty, Negri explicitly appeals to Spinoza. Nonetheless, in this paper, I argue that Spinoza’s philosophy does not support Negri’s project. I argue that the Spinozist multitude avoids internal hierarchy through the mediation of political institutions and not in (...) spite of them; nor do these institutions merely emanate from the multitude as it is, but rather they structure, restrain and channel its passions. In particular, the required institutions are not those of a simple direct democracy. There may be other non-Spinozist arguments on which Negri can ground his theory, but he cannot legitimately defend his conception of the democratic multitude by appeal to Spinoza. (shrink)

The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethical considerations and debates, one of which centers on providing individual research results and incidental findings back to research participants taking part in genetic research efforts. In 2006 the Industry Pharmacogenomics Working Group offered some ‘Points-to-Consider’ on this topic within the context of the (...) drug development process from those who are affiliated to pharmaceutical companies. Today many of these points remain applicable to the discussion but will be expanded upon in this updated viewpoint from the I-PWG. The exploratory nature of pharmacogenomic work in the pharmaceutical industry is discussed to provide context for why these results typically are not best suited for return. Operational challenges unique to this industry which cause barriers to returning this information are also explained. (shrink)

This article examines the nature and structure of witness and defendant narrative accounts in the evidential portions of courtroom trials, using the O.J. Simpson, Oklahoma Bombers and Louise Woodward trials as a database. The article proposes a means of distinguishing narrative from non-narrative accounts, using Labov's definition of the `minimal narrative' as a starting point, and puts forward a modified model of narrative structure. A range of narrative structures are explored, and the model is used to analyse a series of (...) representative example narratives taken from the trial data. Different types of narrative fragmentation produced by multiple tellers of the same narrative are also examined, along with the frequent disjunction between `tellers' and `knowers'. Lastly, the article explores the relationship between narrative structures and narrative fragmentation and the discourse strategies used by lawyers in direct and cross-examination. (shrink)

Adaptation to novel visuomotor transformations for example when navigating a cursor on a computer monitor by using a computer mouse, can be explicit or implicit. Explicit adjustments are made when people are informed about the occurrence and the type of a novel visuomotor transformation and intentionally modify their movements. Implicit adjustments, in contrast, are made without reportable knowledge of a novel visuomotor transformation and without a change intention. The relation of implicit adjustments to explicit adjustments needs further clarification. Here we (...) show that these two types of adjustment occur at the same time and remain functionally independent. The size of total adjustment turned out to be the sum of explicit and implicit adjustments measured in isolation, even when both processes produce opposite outcomes. In perspective our results demonstrate that automatic, implicit processes of motor control are not superseded by intentional, explicit ones, but only superposed. (shrink)

The rise of genomic technologies has catalyzed shifts in the health care landscape through the commercialization of genome sequencing and testing services in the genomics marketplace. The development of consumer genomics into a growing array of information technologies aimed at collecting, curating, and broadly sharing personal data and biological materials reconstitutes the meaning of health and reframes patients into biocitizens. In this context, the good biocitizen is expected to assume personal responsibility for health through consumption of genomic information and acquiescence (...) to public and private efforts at data surveillance and aggregation. These shifts raise fundamental questions about how competing interests of the public, the state, and corporate entities will be reconciled and what trade‐offs are demanded for the promise of precision health. (shrink)

Scholarship has intrinsic value, of course; but when good scholarship can stimulate change for the better in an area as fundamental to human dignity as health care and the relief of suffering, there is a special satisfaction. This has been our experience since 1996, when the first of now four special issues of this journal focused on legal, regulatory, ethical, professional, and financial issues in medical treatment for pain.With the generous and steadfast support of the Mayday Fund, the American Society (...) of Law, Medicine & Ethics has generated a significant body of scholarship published in the Journal of Law, Medicine & Ethics. This research has proven absolutely essential in changing public policy to support better care for those who suffer pain.Over these years, the Mayday Project at ASLME has tackled many of the real and perceived barriers to effective pain relief. In pain management, both real and perceived obstacles can have a powerful negative effect. (shrink)

This groundbreaking text is the most complete and detailed book devoted to middle-range theories and their applications in clinical nursing research. The book thoroughly explains the process of selecting an appropriate theory for a particular nursing research study and sets forth criteria for critiquing theories. Each chapter includes examples of research using middle-range theories, definitions of key terms, analysis exercises, reference lists, and relevant Websites. Instruments are presented in appendices. New features of this edition include analysis questions for all theories; (...) new chapters on learning theory and physiologic middle-range theories; "Part" introductions to frame the selection process for each middle-range theory chosen; and a glossary of terms. (shrink)

Résumé L’article interroge l’approche familiale des adolescents nouvellement immigrés ayant subi de nombreux traumatismes de guerre. Il montre que la consultation familiale peut être une voie d’accès aux soins. Au travers de cas cliniques, la question du fraternel est interrogée dans cette période de reconstruction d’un passé difficile, pendant l’adolescence où confrontation au réel et à la loi symbolique du père et recherche identitaire peuvent s’exacerber. Les difficultés d’apprentissage, les problèmes identitaires, les symptômes multiples au sein de la même famille (...) sont étudiés. (shrink)

The nationally embedded and relatively broad-based economies characteristic of developed industrial countries are usually seen as the incarnation of a modern economy. These economies are largely internally oriented and are based, to a relatively great extent, on production and services based on local and national needs. Their provenance is generally assumed to have been processes of development that began in the sixteenth century and that, in the nineteenth century, accelerated with the expansion of industrial production and the growth of global (...) trade. This article challenges that assumption. It argues that today’s modern economies represent, not the culmination of long-term processes, but a recurring phenomenon within capitalism. It argues that, in the history of capitalism, there have been phases of nationally embedded and global free market capitalism – periods when capital is relatively more, and relatively less, free from the regulation of nation state. Today’s nationally embedded economies represent, not a further point along a unilinear developmental trajectory, but a return to features of the moral economies that characterized both European and non-European societies before the nineteenth century. (shrink)

This contribution argues, first, that pre-national forms of state were not displaced or supplanted by a new, national form. What we call the nation-state was not the successor to imperial or city-states but was itself a form of the European imperial city-states that had driven the expansion of capitalism in previous centuries. It argues, second, that national states emerged only after 1945 and only in a handful of states where, through welfare reforms and market and industry regulation, investment and production (...) were made to serve the expansion and integration of national markets. Third, with the dismantling of Keynesian policies in these states, pre-national (pre-Keynesian) structures are resurfacing. What scholars describe as the emergence of ‘post-national spatialities’ and of ‘global cities’ and city regions represents the resurgence of a durable and historically dominant form of state: the imperial city-state form. The ‘re-scaling’ of nation-states and growing prominence of ‘global cities’ and ‘city regions’ are heralding the end of the brief history of actually existing nation-states and the re-deployment of the imperial city-state model. (shrink)

John McCumber's Time in the Ditch: American Philosophy and the McCarthy Era provides a compelling account of a repressed part of philosophy's history and its tragic consequences for subsequent decades of philosophic practice in the U.S. Political values and interests originating in McCarthyism got encoded within abstract conceptual frameworks, propelling analytic philosophy to an undeserved position of authority while depriving it of critical self-understanding. This comment identifies residues of McCarthyism still playing out in the Science Wars, and the career of (...) critical philosophic projects in both other disciplines and philosophy's feminist and multicultural fringes. (shrink)

Thinking about Western sciences has always also meant making assumptions about modernity and about democratic social relations. Yet in recent decades the standard meanings and referents of all three of these terms—”Western sciences,” “modernity,” and “democratic social relations”—have come under skeptical scrutiny. This essay will look at three critics of modernity who also examine the political practices and consequences of Western sciences. All three also think postmodernisms to be valuable but merely symptomologies without useful prescriptions for change, and they all (...) propose specific strategies for transforming modern sciences into ones that are empirically more effective and politically more accountable. These are Bruno Latour, Ulrich Beck, and Ashis Nandy. Yet these otherwise valuable accounts each have serious shortcomings which create obstacles to the intellectual and political success of their projects. Here I focus on one such limitation: their blindness to the gendering of science and of modernity. (shrink)