The gut microbiota is an important component of the human body and its immune‐modulating and metabolic activities are critical to maintain good health. Gut microbes, however, are sensitive to changes in diet, exposure to antibiotics, or infections, all of which cause transient disruptions in the microbial composition, a phenomenon known as dysbiosis. It is now recognized that microbial dysbiosis is at the root of many gastrointestinal disorders. However, the mechanisms through which bacterial dysbiosis initiates disease are not fully understood. Microbially‐derived (...) metabolites and their role in disease have also attracted significant attention. Identification of cancer‐associated bacteria and understanding the contributions of microbial metabolism in health and disease are exciting but challenging areas that will allow defining microbial biomarkers for predicting gastrointestinal disorders. Understanding the complex interactions between gut microbiota, diet, host immune system and host genetics will be critical to developing more personalized therapies and approaches to treat disease. (shrink)

While largely studied because of their harmful effects on human health, there is growing appreciation that bacteria are important partners for invertebrates and vertebrates, including man. Epithelia in metazoans do not only select their microbiota; a coevolved consortium of microbes enables both invertebrates and vertebrates to expand the range of diet supply, to shape the complex immune system and to control pathogenic bacteria. Microbes in zebrafish and mice regulate gut epithelial homeostasis. In a squid, microbes control the development (...) of the symbiotic light organ. These discoveries point to a key role for bacteria in any metazoan existence, and imply that beneficial bacteria‐host interactions should be considered an integral part of development and evolution. (shrink)

As it becomes increasingly plausible that the mind–brain is explicable in naturalistic terms, science‐and‐religion scholars have the opportunity to engage creatively and proactively with facets of brain‐related research that better inform our understanding of human well‐being. That is, once mental health is recognized as being a whole‐body phenomenon, exciting theological conversations can take place. One fascinating area of research involves the “gut–brain axis,” or the interactive relationship between the microbiome in the gastrointestinal tract (i.e., gut bacteria), the central nervous (...) system, and mental health. A growing body of literature explores the immensely significant interactions between the gut microbiome and mental health issues involving depression, anxiety, gene expression, and stress responses. One's mental health does not occur in a disembodied state, but in a complex physical environment that is strongly influenced by environmental factors, many of which we can control. This article argues that science‐and‐religion can welcome scientific research in this area, creatively incorporating such insights into a theology of mental health and physical well‐being. (shrink)

Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

How much bacterial evolution occurs in our intestines and which factors control it are currently burning questions. The formation of new ecotypes, some of which capable of coexisting for long periods of time, is highly likely in our guts. Horizontal gene transfer driven by temperate phages that can perform lysogeny is also widespread in mammalian intestines. Yet, the roles of mutation and especially lysogeny as key drivers of gut bacterial adaptation remain poorly understood. The mammalian gut contains hundreds of bacterial (...) species, each with many strains and ecotypes, whose abundance varies along the lifetime of a host. A continuous high input of mutations and horizontal gene transfer events mediated by temperate phages drives that diversity. Future experiments to study the interaction between mutations that cause adaptation in microbiomes and lysogenic events with different costs and benefits will be key to understand the dynamic microbiomes of mammals. Also see the video abstract here: https://youtu.be/Zjqsiyb5Pk0. (shrink)

Recent work in the philosophy of biology argues that we must rethink the biological individual beyond the boundary of the species, given that a key part of our essential functioning is carried out by the bacteria in our intestines in a way that challenges any strictly genetic account of what is involved for the biological human. The gut is a kind of ambiguous other within our understanding of ourselves, particularly when we also consider the status of gastro-intestinal disorders. Hegel (...) offers us theoretical tools to describe and understand our relationship to our gut. His description of our selves as continually mediated through otherness is strikingly compatible with the kind of structure contemporary biology presents us with. His accounts of digestion and habit, contextualized by his logic, help point toward an understanding of selfhood as porous and yet still capable of being sufficiently unified for us to make sense of ourselves, one which allows us to acknowledge otherness within us while still having enough unity for agency. (shrink)

It is necessary to complement next‐generation sequencing data on the soil resistome with theoretical knowledge provided by ecological studies regarding the spread of antibiotic resistant bacteria (ARB) in the abiotic and, especially, biotic fraction of the soil ecosystem. Particularly, when ARB enter agricultural soils as a consequence of the application of animal manure as fertilizer, from a microbial ecology perspective, it is important to know their fate along the soil food web, that is, throughout that complex network of feeding (...) interactions among members of the soil biota that has crucial effects on species richness and ecosystem productivity and stability. It is critical to study how the ARB that enter the soil through the application of manure can reach other taxonomical groups (e.g., fungi, protists, nematodes, arthropods, earthworms), paying special attention to their presence in the gut microbiomes of mesofauna‐macrofauna and to the possibilities for horizontal gene transfer of antibiotic resistant genes. (shrink)

We show how metagenomic analysis of the human gut antibiotic resistome, compared across large populations and against environmental or agricultural resistomes, suggests a strong anthropogenic cause behind increasing antibiotic resistance in bacteria. This area has been the subject of intense and polarized debate driven by economic and political concerns; therefore such recently available insights address an important need. We derive and compare antibiotic resistomes of human gut microbes from 832 individuals from ten different countries. We observe and describe significant (...) differences between samples from these countries in the gut resistance potential, in line with expectations from antibiotic usage and exposure in medical and food production contexts. Our results imply roles for both of these sources in increased resistance among pathogens in recent history. In contrast, other available metadata such as age, body mass index, sex, or health status have little effect on the antibiotic resistance potential of human gut microbes.Also watch the Video Abstract. (shrink)

The late 20th century saw a remarkable flourishing of philosophy in France. The work of French philosophers is wide ranging, historically informed, often reaching out beyond the boundaries of philosophy; they are public intellectuals, taken seriously as contributors to debates outside the academy. Gary Gutting tells the story of the development of a distinctively French philosophy in the last four decades of the 20th century. His aim is to arrive at an account of what it was to 'do philosophy' in (...) France, what this sort of philosophizing was able to achieve, and how it differs from the analytic philosophy dominant in Anglophone countries. -/- His initial focus is on the three most important philosophers who came to prominence in the 1960s: Michel Foucault, Gilles Deleuze, and Jacques Derrida. He sets out the educational and cultural context of their work, as a basis for a detailed treatment of how they formulated and began to carry out their philosophical projects in the 1960s and 1970s. He gives a fresh assessment of their responses to the key influences of Hegel and Heidegger, and the fraught relationship of the new generation to their father-figure Sartre. He concludes that Foucault, Derrida, and Deleuze can all be seen as developing their fundamental philosophical stances out of distinctive readings of Nietzsche. The second part of the book considers topics and philosophers that became prominent in the 1980s and 1990s, such as the revival of ethics in Levinas, Derrida, and Foucault, the return to phenomenology and its use to revive religious experience as a philosophical topic, and Alain Badiou's new ontology of the event. Finally Gutting brings to the fore the meta-philosophical theme of the book, that French philosophy since the 1960s has been primarily concerned with thinking the impossible. (shrink)

Richard Rorty was an analytic philosopher, in the sense that his work is an important moment in the historical development that began with Russell, Wittgenstein, and the Vienna circle; continued through Quine, Sellars, and Davidson. In his "Intellectual Autobiography" Rorty notes that his work depended particularly that of Wittgenstein, Sellars, Davidson, and Brandom, who in turn required an understanding of the analytic philosophers they reacted against: Russell, Carnap, and Ayer. According to Rorty, twentieth‐century philosophy that emphasized rigor and scientificity accepted (...) this modern view of philosophy. This included phenomenology as practiced by Husserl and, especially, analytic philosophy. Rorty's clearest and most detailed presentation of his metaphilosophy, the introduction to Consequences of Pragmatism. Rorty's response to both lines of realist criticism is that pragmatism does not hold any theory of truth and instead maintains that there is no useful purpose served by constructing such theories – as two millennia of philosophy amply illustrate. (shrink)

How to argue about politics -- Science: a consumer's guide -- The philosophical limits of science -- The new atheism -- Religious agnosticism -- Happiness, work, and capitalism -- Capitalism and education -- Thinking about art -- Can we stop arguing about abortion?

Notice that I’m not saying that observations we in fact have made are not relevant to our beliefs about what exists. But the mere fact that something is observable does not give us any reason to think that it ever has or will in fact be observed. The issue between us is whether mere observability—as distinct from actual observation—is relevant to our beliefs about what exists. I submit that it is not.

This book is an important introduction to the critical interpretation of the work of the major French thinker Michel Foucault. Through comprehensive and detailed analyses of such important texts as The History of Madness in the Age of Reason, The Birth of the Clinic, The Order of Things, and The Archaeology of Knowledge, Professor Gutting provides a lucid exposition of Foucault's 'archaeological' approach to the history of thought - a method for uncovering the 'unconscious' structures that set boundaries on the (...) thinking of a given epoch. The book also casts Foucault in a new light, relating his work to two major but neglected influences: Gaston Bachelard's philosophy of science and Georges Canguilhem's history of science. This perspective yields a new and valuable understanding of science, balancing and complementing the more common view that he was primarily a social critic and theorist. An excellent guide for those first approaching Foucault's work, the book will also be a challenging interpretation and evaluation for those already familiar with his writings. (shrink)

Philosophy has never delivered on its promise to settle the great moral and religious questions of human existence, and even most philosophers conclude that it does not offer an established body of disciplinary knowledge. Gary Gutting challenges this view by examining detailed case studies of recent achievements by analytic philosophers such as Quine, Kripke, Gettier, Lewis, Chalmers, Plantinga, Kuhn, Rawls, and Rorty. He shows that these philosophers have indeed produced a substantial body of disciplinary knowledge, but he challenges many common (...) views about what philosophers have achieved. Topics discussed include the role of argument in philosophy, naturalist and experimentalist challenges to the status of philosophical intuitions, the importance of pre-philosophical convictions, Rawls' method of reflective equilibrium, and Rorty's challenge to the idea of objective philosophical truth. The book offers a lucid survey of recent analytic work and presents a new understanding of philosophy as an important source of knowledge. (shrink)

This VSI highlights Foucault's life and thought, showing his impact on today's society. Beginning with a brief biography to set the social and political stage, Gary Gutting then tackles Foucault's thoughts on literature, in particular the avant-garde scene; his philosophical and historical work; and his treatment of knowledge and power in modern society, including his thoughts on sexuality.

In this book Gary Gutting tells, clearly and comprehensively, the story of French philosophy from 1890 to 1990. He examines the often neglected background of spiritualism, university idealism, and early philosophy of science, and also discusses the privileged role of philosophy in the French education system. Taking account of this background, together with the influences of avant-garde literature and German philosophy, he develops a rich account of existential phenomenology, which he argues is the central achievement of French thought during the (...) century, and of subsequent structuralist and poststructuralist developments. His discussion includes chapters on Bergson, Sartre, Beauvoir, Merleau-Ponty, Foucault, and Derrida, with sections on other major thinkers including Lyotard, Deleuze, Irigaray, Levinas, and Ricoeur. He offers challenging analyses of the often misunderstood relationship between existential phenomenology and structuralism and of the emergence of poststructuralism. Finally, he sketches the major current trends of French philosophy. (shrink)

In this book Gary Gutting offers a powerful account of the nature of human reason in modern times. The fundamental question addressed by the book is what authority human reason can still claim once it is acknowledged that our fundamental metaphysical and religious pictures of the world no longer command allegiance. If ethics and science remain sources of authority what is the basis of that authority? Gutting develops answers to these questions through critical analysis of the work of three dominant (...) philosophical voices in our time: Richard Rorty, Alasdair MacIntyre, and Charles Taylor. His own position is defined as 'pragmatic liberalism'. (shrink)

The present study addressed two related problems: The status of the concept of the soul in folk psychological conceptualizations across cultures, and the nature of mind-body dualism within Chinese folk psychology. We compared folk intuitions about three concepts – mind, body, and soul – among adults from China and Poland. The questionnaire study comprised of questions about the functional and ontological nature of the three entities. The results show that the mind and soul are conceptualized differently in the two countries: (...) The Chinese appear to think of the soul similarly to how they view the mind, while Poles differentiate it both in ontological and functional respects. The study provides important insights into cross-cultural differences in conceptualizing the soul as well as into the nature of Chinese mind-body dualism. (shrink)

THE GOAL OF THIS PAPER IS TO DEFEND SCIENTIFIC REALISM (OF\nTHE SORT PROPOSED BY WILFRID SELLARS) AGAINST THE ATTACK ON\nIT IMPLICIT IN HUSSERL'S "CRISIS". IN PARTICULAR, I DISCUSS\nTHREE ANTI-REALIST HUSSERLIAN THESES: (1) THAT THE METHOD\nOF SCIENCE IS IN ESSENCE ONE OF THE IDEALIZATION; (2) THAT\nALL SCIENTIFIC CONCEPTS CAN BE TRACED BACK TO OUR\nLIFE-WORLD EXPERIENCE; (3) THAT ANY SCIENTIFIC DESCRIPTION\nOF THE WORLD NECESSARILY OMITS MAJOR DIMENSIONS OF OUR\nLIFE-WORLD EXPERIENCES. I ARGUE THAT EACH OF THESE THESES\nIS INCONSISTENT WITH A CORRECT UNDERSTANDING OF (...) SCIENTIFIC\nMETHODOLOGY. I FURTHER ARGUE THAT THESE THESES DERIVE ONLY\nFROM HUSSERL'S FAULTY EXPLICATION OF SCIENTIFIC METHOD;\nTHERE IS NOTHING IN HUSSERL'S BASIC EPISTEMOLOGICAL\nPOSITION THAT IS INCONSISTENT WITH (A PROPERLY CONSTRUED)\nSCIENTIFIC REALISM. (shrink)

Contemporary research on mindreading or theory of mind has resulted in three major findings: There is a difference in the age of passing of the elicited-response false belief task and its spontaneous–response version; 15-month-olds pass the latter while the former is passed only by 4-year-olds. Linguistic and social factors influence the development of the ability to mindread in many ways. There are cultures with folk psychologies significantly different from the Western one, and children from such cultures tend to show different (...) timetables of mindreading development. The traditional accounts of the data are nativism, rational constructivism, and two-systems theory. In this paper, we offer criticism of these traditional cognitivist accounts and explore an alternative, action-based framework. We argue that even though they all seem to explain the above empirical data, there are other, theoretical reasons why their explanations are untenable. Specifically, we discuss the problem of foundationalism and the related problem of innateness. Finally, we explore an alternative, action-based framework that avoids these theoretical limitations and offer an interpretation of the empirical data from that perspective. (shrink)

This chapter contains section titled: Philosophy vs. Science, Continental vs. Analytic France: Neo‐Kantians and Bergson Germany: Neo‐Kantians and Phenomenology France: From Existentialism to Foucault Germany: Habermas and the Frankfurt School France: Poststructuralism and the Abuse of Science?

In this paper, we present a battery of empirical findings on the relationship between cultural context and theory of mind that show great variance in the onset and character of mindreading in different cultures; discuss problems that those findings cause for the largely-nativistic outlook on mindreading dominating in the literature; and point to an alternative framework that appears to better accommodate the evident cross-cultural variance in mindreading. We first outline the theoretical frameworks that dominate in mindreading research, then present the (...) relevant empirical findings, and finally we come back to the theoretical approaches in a discussion of their explanatory potential in the face of the data presented. The theoretical frameworks discussed are the two-systems approach; performance-based approach also known as modularity-nativist approach; and the social-communicative theory also known as the systems, relational-systems, dynamic systems and developmental systems theory. The former two, which both fall within the wider modular-computational paradigm, run into a challenge with the cross-cultural data presented, and the latter - the systemic framework - seems to offer an explanatorily potent alternative. The empirical data cited in this paper comes from research on cross-cultural differences in folk psychology and theory-of-mind development; the influence of parenting practices on the development of theory of mind; the development and character of theory of mind in deaf populations; and neuroimaging research of cultural differences in mindreading. (shrink)

Notice that I’m not saying that observations we in fact have made are not relevant to our beliefs about what exists. But the mere fact that something is observable does not give us any reason to think that it ever has or will in fact be observed. The issue between us is whether mere observability—as distinct from actual observation—is relevant to our beliefs about what exists. I submit that it is not.