"Viel ist über Medien geschrieben worden, und doch ist dem Medium aller Medien bislang keinerlei Abhandlung gewidmet. Die Rede ist vom Schleim. Nicht irgendein Schleim, sondern der Urschleim jeglichen Lebens, dem Rätsel der Wissenschaft, das bis heute als ungelöst gilt. Und noch ein Rätsel gilt es zu lösen, nämlich von der eigenartigen Koalition von Schleim und technischen Medien. Schleim, so die Wissenschaft, ist nicht nur Beginn der Menschwerdung sondern auch die Zukunft der Technologie. Much has been written about media, but (...) the medium of all media has not been studied so far: I am referring to slime. Not just any slime, but the protoplasm of all life, the scientific mystery, which is still regarded as unsolved. And another mystery remains be solved, namely the peculiar coalition of slime and technical media. According to science, slime is not only the origin of the human species, but also the future of technology. ". (shrink)

Although the emerging field of synthetic biology looks back on barely a decade of development, the stakes are high. It is a multidisciplinary research field that aims at integrating the life sciences with engineering and the physical/chemical sciences. The common goal is to design and construct novel biological components, functions and systems in order to implement, in a controlled way, biological devices and production systems not necessarily found in nature. Among the many potential applications are novel drugs and pesticides, cancer (...) treatments, biofuels, and new materials. According to the most optimistic visions, synthetic biology may thus lead to a biotechnological revolution by transforming microorganisms into ‘factories’ of sorts, which could eventually displace conventional industrial methods. (shrink)

Morphological engineering is an emerging research area in synthetic biology. In 2008 “synthetic morphology” was proposed as a prospective approach to engineering self-constructing anatomies by Jamie A. Davies of the University of Edinburgh. Synthetic morphology can establish a new paradigm, according to Davies, insofar as “cells can be programmed to organize themselves into specific, designed arrangements, structures and tissues.” It is obvious that this new approach will extrapolate morphology into a new realm beyond the traditional logic of morphological research. However, (...) synthetic morphology is a highly idealized vision of morphology which derives its visionary ideas from morphological engineering and mathematical idealizations in order to understand the principles of molecular morphology. Thus, the question is, if this approach will help to understand morphogenesis better or if it will just enable biologists to engineer morphogenesis. The paper investigates the development of synthetic morphology and its relation to synthetic biology as well as its epistemic gains. (shrink)

Re-Design des Lebens: Wissenschaft und Technik rekurrieren zunehmend auf das Prinzip des Synthetischen. Die Synthetische Chemie und seit Neuestem die Synthetische Biologie zielen auf ein Zusammensetzen von Bausteinen, um neue Entitäten zu designen - von Molekülen bis hin zu Stoffwechselnetzwerken in Organismen. Dieser Band unternimmt wissenschaftsphilosophische und -historische Annäherungen an das Prinzip der Syn-Thesis. Die Beiträge fragen: Welche Konstruktionsbedingungen realisieren die synthetischen Wissenschaften? Wie ist das Verhältnis zu analytischen Methoden? Und wo liegen die Grenzen technischer Synthesis?

Continuous culture techniques were developed in the early twentieth century to replace cumbersome studies of cell growth in batch cultures. In contrast to batch cultures, they constituted an open concept, as cells are forced to proliferate by adding new medium while cell suspension is constantly removed. During the 1940s and 1950s new devices have been designed—called “automatic syringe mechanism,” “turbidostat,” “chemostat,” “bactogen,” and “microbial auxanometer”—which allowed increasingly accurate quantitative measurements of bacterial growth. With these devices cell growth came under the (...) external control of the experimenters and thus accessible for developing a mathematical theory of growth kinetics—developed mainly by Jacques Monod, Aron Novick and Leo Szilard in the early 1950s and still in use today. The paper explores the development of continuous culture devices and claims that these devices are simulators for standard cells following specific requirements, in particular involving mathematical constraints in the design and setting of the devices as well as experiments. These requirements have led to contemporary designs of continuous culture techniques realizing a specific event-based flow algorithm able to simulate directed evolution and produce artificial cells and microorganisms. This current development is seen as an alternative approach to today’s synthetic biology. (shrink)

The modern program of operationalizing the mind, from Descartes to Kant, in the form of the externalization of human mind functions in logic and calculations, and its continuation in the program of formalization from the middle of the 19th century with Boole, Peirce and Turing, have led to the form of rationality that has become machine rationality: the digital computer as a logical-mathematical machine and algorithms as machine-rational interpretations of human thinking in the form of problem solving and decision making. (...) The modern program of the operationalization of the mind can be understood as the first program of an "artificial intelligence" on paper. With the advent of digital computers, it was transformed into the programs of "strong" and "weak" AI. As early as 2015, machine learning methods surpassed human competencies in image recognition and other fields, such turning AI increasingly into "superhuman AI." Thus, the philosophical question is, how to deal with this development as humans? (shrink)

The increasing digitalization of science particularly forgrounds the status of its visual objects. While more and more disciplines depend on methods of computer visualization, the respective transformation processes of knowledge on which the visualizations are based often remain unthematized. The article argues that an ontographic aisle between the abstraction and representation of knowledge lies in the visualization processes. This aisle is central to digitized scientific cultures. Therefore, two case studies from the history of computer graphics will be discussed.

ZusammenfassungGenomdaten, Kernstück der 2008 ausgerufenen Big Data-Revolution der Biologie, werden voll automatisiert sequenziert und analysiert. Der Wechsel von der manuellen Laborpraktik der Elektrophorese-Sequenzierung zu DNA-Sequenziermaschinen und softwarebasierten Analyseprogrammen vollzog sich zwischen 1982 und 1992. Erst dieser Wechsel ermöglichte die Flut an Daten, die mit der zweiten und dritten Generation der DNA-Sequenzierer erheblich zunimmt. Doch mit diesem Wechsel verändern sich auch die Validierungsstrategien der Genomdaten. Der Beitrag untersucht beides – die Automatisierung und die damit verbundene Validierungskultur – um ein Bild der (...) Komplexität der Datengenerierung und deren Datenpositivismus zu geben. Leitend ist dabei die Frage, ob dieser Datenpositivismus die Grundlage der aktuell angekündigten Big Data-Revolution der Molekularbiologie ist oder deren Datenhybris. (shrink)

ZusammenfassungGenomdaten, Kernstück der 2008 ausgerufenen Big Data-Revolution der Biologie, werden voll automatisiert sequenziert und analysiert. Der Wechsel von der manuellen Laborpraktik der Elektrophorese-Sequenzierung zu DNA-Sequenziermaschinen und softwarebasierten Analyseprogrammen vollzog sich zwischen 1982 und 1992. Erst dieser Wechsel ermöglichte die Flut an Daten, die mit der zweiten und dritten Generation der DNA-Sequenzierer erheblich zunimmt. Doch mit diesem Wechsel verändern sich auch die Validierungsstrategien der Genomdaten. Der Beitrag untersucht beides – die Automatisierung und die damit verbundene Validierungskultur – um ein Bild der (...) Komplexität der Datengenerierung und deren Datenpositivismus zu geben. Leitend ist dabei die Frage, ob dieser Datenpositivismus die Grundlage der aktuell angekündigten Big Data-Revolution der Molekularbiologie ist oder deren Datenhybris. (shrink)

Inspired by the success of synthesising organic substances by Friedrich Wöhler in 1828, the vision of creating life in the laboratory synthetically has become increasingly accessible for today’s synthetic biology and synthetic genomics, respectively. The engineering of biology – a contemporary version of the liaison of technology and organic form – creates cellular machines, biobricks, biomolecular ‘borgs’, and entire synthetic genomes of artificial organisms. Besides major ethical concerns, the shift in scientific epistemology is of interest. Unlike classical analytical science, synthetic (...) science understands by a process of generation, through which myriads of new things are created, dramatically changing the living environment. (shrink)

Bd. 1. A-B -- Bd. 2. C-F -- Bd. 3. G-Inn -- Bd. 4. Ins-Loc.

The Simple Counterfactual Analysis (SCA) was once considered the most promising analysis of disposition ascriptions. According to SCA, disposition ascriptions are to be analyzed in terms of counterfactual conditionals. In the last few decades, however, SCA has become the target of a battery of counterexamples. In all counterexamples, something seems to be interfering with a certain object’s having or not having a certain disposition thus making the truth-values of the disposition ascription and of its associated counterfactual come apart. Intuitively, however, (...) it would seem that, if all interferences were absent, the disposition ascription and its associated conditional would have the same truth-value. Although this idea may seem obvious, it is far from obvious how to implement it. In fact, it has become widely assumed that the content of qualifying ceteris paribus clauses (such as ‘if all interferences were absent’) cannot be specified in a clear and non-circular manner. In this paper, I will argue that this assumption is wrong. I will develop an analysis of disposition ascriptions, the Interference-Free Counterfactual Analysis, which relies on a clear and non-circular definition of the notion of interference and avoids the standard counterexamples to SCA while vindicating the intuition that disposition ascriptions and counterfactual conditionals are intimately related. (Please note that an erratum has been issued for the published version of this paper. It is recommended to read the self-archived version of the paper.). (shrink)

The volume deals with the history of logic, the question of the nature of logic, the relation of logic and mathematics, modal or alternative logics (many-valued, relevant, paraconsistent logics) and their relations, including translatability, to classical logic in the Fregean and Russellian sense, and, more generally, the aim or aims of philosophy of logic and mathematics. Also explored are several problems concerning the concept of definition, non-designating terms, the interdependence of quantifiers, and the idea of an assertion sign. The contributions (...) concerned with Wittgenstein's investigations into the philosophy of logic and mathematics pursue issues relating to logical necessity, the undeniability of the law of the excluded middle, and the source of self-evidence, often characterized in the literature as the "rule-following considerations". Additionally, they examine Wittgenstein's attitudes towards the very idea of set-theory as a possible foundation for arithmetic. The volume also includes a number of contributions on specific issues concerning Wittgenstein's views on moral and religious judgements. (shrink)

v. 1. Reflection & mystery -- v. 2. Faith & reality.

Public reason liberalism is defined by the idea that laws and policies should be justifiable to each person who is subject to them. But what does it mean for reasons to be public or, in other words, suitable for this process of justification? In response to this question, Kevin Vallier has recently developed the traditional distinction between consensus and convergence public reason into a classification distinguishing three main approaches: shareability, accessibility and intelligibility. The goal of this paper is to defend (...) the accessibility approach by demonstrating its ability to strike an appealing middle course in terms of inclusivity between shareability and intelligibility. We first argue against Vallier that accessibility can exclude religious reasons from public justification. Second, we use scientific reasons as a case study to show that accessibility excludes considerably fewer reasons than shareability. Throughout the paper, we connect our discussion of accessibility to John Rawls’s model of public reason, so as to give substance to the accessibility approach and to further our understanding of Rawls’s influential model. (shrink)

Famously, in the essay Inquiry Concerning the Distinctness of the Principles of Natural Theology and Morality (Prize Essay), Kant attempts to distance himself from the Wolffian model of philosophical inquiry. In this respect, Kant scholars have pointed out Kant’s claim that philosophy should not imitate the method of mathematics and his appeal to Newton’s “analytic method.” In this article, I argue that there is an aspect of Kant’s critique of the Wolffian model that has been neglected. Kant presents a powerful (...) attack of the idea that philosophy should proceed through the analysis of concepts and argues that we should give up the aim of arriving at “complete” concepts as one of its fundamental desiderata. Importantly, this attack of philosophy conceived as conceptual analysis is distinctive and original if one compares it with Kant’s critique of analysis in the Critique of Pure Reason, which rests on the idea that analysis is insufficient to ground substantial metaphysical truths. I also make an additional point: Scholars have debated whether the appeal to Newton’s analytic method involves a form of empiricism. I submit that this debate is ill-conceived because Kant uses a notion of “given concepts” that is indeterminate with respect to their a priori or a posteriori status. (shrink)

This edition of Marcel's inspiring Homo Viator has been updated to includle fifty-seven pages of new material available for the first time in English, making this the first English-language edition to conform to the standard French edition. Here, Christianity's foremost existentialist of the twentieth century gives us a prodigious personal insight on 'man on the way' that will reinforce and commend our own pilgrimages in hope. Book jacket.

This essay calls attention to a set of linguistic interactions between counterfactual conditionals, on one hand, and possibility modals like could have and might have, on the other. These data present a challenge to the popular variably strict semantics for counterfactual conditionals. Instead, they support a version of the strict conditional semantics in which counterfactuals and possibility modals share a unified quantificational domain. I’ll argue that pragmatic explanations of this evidence are not available to the variable analysis. And putative counterexamples (...) to the unified strict analysis, on careful inspection, in fact support it. Ultimately, the semantics of conditionals and modals must be linked together more closely than has sometimes been recognized, and a unified strict semantics for conditionals and modals is the only way to fully achieve this. (shrink)

This discussion of pride, shame, and guilt centers on the beliefs involved in the experience of any of these emotions. Through a detailed study, the author demonstrates how these beliefs are alike--in that they are all directed towards the self--and how they differ. The experience of these three emotions are illustrated by examples taken from English literature. These concrete cases supply a context for study and indicate the complexity of the situations in which these emotions usually occur.

The primary objective of this book is to open space for rethinking the relationship between art and politics. It seeks to combat one of the fundamental assumptions that has plagued many of the previous debates on this issue: that art and politics are distinct entities definable in terms of common properties, and that they have privileged points of intersection, which can be determined once and for all in terms of an established formula. This common sense assumption is rooted in a (...) transcendent illusion according to which there are more or less fixed characteristics that unify our terms, concepts, and practices in such a way as to guarantee their meaning. Against this substantialist approach, Radical History & the Politics of Art argues for a praxeological account that begins the other way around by analyzing specific cultural practices without presupposing a conceptual unity behind them. Such an orientation is radically historicist in the sense that it recognizes that all of our practices—be they linguistic, theoretical, aesthetic or political—are historically constituted and that they are necessarily part of a temporal dynamic. Hence the contingent nature of the labels used to classify various practices or even identify ‘practice’ as such. Radical history thereby proposes a significant departure from the extant debates on art and politics by maintaining that there is no ‘art’ or ‘politics’ in general, nor a singular relation between them. There are only historically constituted practices in various conjunctures, some of which have been labeled, through practical acts of denomination, as ‘artistic’ or ‘political.’ Instead of proposing one more response to the oft-repeated question ‘what is the relationship between Art and Politics?’ this book seeks to overcome the presuppositions that plague such a question. It thereby changes the very nature of the investigation by asking: ‘how do the diverse aspects of practices identified as ‘aesthetic’ and ‘political’ overlap, intertwine and sometimes merge in precise socio-historical force fields of action? (shrink)

From mass murder to genocide, slavery to colonial suppression, acts of atrocity have lives that extend far beyond the horrific moment. They engender trauma that echoes for generations, in the experiences of those on both sides of the act. Gabriele Schwab reads these legacies in a number of narratives, primarily through the writing of postwar Germans and the descendents of Holocaust survivors. She connects their work to earlier histories of slavery and colonialism and to more recent events, such as (...) South African Apartheid, the practice of torture after 9/11, and the "disappearances" that occurred during South American dictatorships. Schwab's texts include memoirs, such as Ruth Kluger's _Still Alive_ and Marguerite Duras's _La Douleur_; second-generation accounts by the children of Holocaust survivors, such as Georges Perec's _W_, Art Spiegelman's _Maus_, and Philippe Grimbert's _Secret_; and second-generation recollections by Germans, such as W. G. Sebald's _Austerlitz_, Sabine Reichel's _What Did You Do in the War, Daddy?_, and Ursula Duba's _Tales from a Child of the Enemy_. She also incorporates her own reminiscences of growing up in postwar Germany, mapping interlaced memories and histories as they interact in psychic life and cultural memory. Schwab concludes with a bracing look at issues of responsibility, reparation, and forgiveness across the victim/perpetrator divide. (shrink)

The idea that healthcare should become more person-centred is extremely influential. By using recent English policy developments as a case study, this article aims to critically analyse an important element of person-centred care, namely, the belief that to treat patients as persons is to think that care should be ‘co-produced’ by formal healthcare providers and patients together with unpaid carers and voluntary organizations. I draw on insights from political philosophy to highlight overlooked tensions between co-production and values like equality and (...) liberty. Regarding equality, I argue that co-production compounds both problems of gender inequality in the distribution of care labour and the challenges associated with securing equal access to care. Turning to liberty, I identify important commonalities between co-production and republicanism in political philosophy, given their shared insistence on common citizens’ civic virtue. Then, I use against co-production some liberal arguments against republicanism, to highlight a problem of over-demandingness. In bringing my argument to a close, however, I wish to caution against hastily rejecting co-production as a policy programme. (shrink)

The intellectual resistance to totalitarian regimes can take many forms. This remarkable volume portrays one such story of resistance in Romania during the reign of Ceausescu: that of Constantin Noica, one of the country's foremost intellectuals. The Paltinis Diary is a wonderful homage to an intellectual master and to the power of intellect and freedom. The book will be of interest to philosophers, non-philosophers alike, and to anyone who seeks to grasp the true meaning of survival under totalitarian conditions.