The brains of higher mammals are extraordinary integrative devices. Signals from large numbers of functionally specialized groups of neurons distributed over many brain regions are integrated to generate a coherent, multimodal scene. Signals from the environment are integrated with ongoing, patterned neural activity that provides them with a meaningful context. We review recent advances in neurophysiology and neuroimaging that are beginning to reveal the neural mechanisms of integration. In addition, we discuss concepts and measures derived from information theory that lend (...) a theoretical basis to the notion of complexity as integration of information and suggest new experimental tests of these concepts. (shrink)

Integrated information theory (IIT) starts from the essential properties of experience and translates them into requirements that any physical system must satisfy to be conscious. It argues that the physical substrate of consciousness (PSC) must constitute a maximum of irreducible, internal cause‐effect power of a specific form, and provides a calculus to determine, in principle, both the quality and the quantity of an experience. Applied to the brain, IIT predicts that the spatio‐temporal grain of the neural units constituting the PSC, (...) and the relevant neural states, are those that maximize cause‐effect power. Moreover, the PSC can shrink, move, split and disintegrate depending on various anatomical and physiological parameters. These predictions are testable with brain stimulation and recording experiments. The theory can explain parsimoniously many known facts about the relationship between consciousness and the brain, including its association with certain cortical structures, its breakdown in deep sleep, anesthesia and seizures, and its return in dreams. (shrink)

Integrated information theory (IIT) starts from the essential properties of experience (axioms) and translates them into requirements that any physical system must satisfy to be conscious (postulates; see Integrated Information Theory of Consciousness: An Outline, this volume). The postulates of IIT can be seen as a list of requirements for something to exist ‘for itself’, as an intrinsic entity, and thus have relevance for ontology and metaphysics. Some implications of the theory include the divide between intrinsic and extrinsic entities, the (...) incoherence of ontological reductionism, and the intrinsic nature of meaning. (shrink)

A Nobel Prize-winning scientist and a leading brain researcher show how the brain creates conscious experience.

The target article misrepresents the foundations of integrated information theory and ignores many essential publications. It, thus, falls to this lead commentary to outline the axioms and postulates of IIT and correct major misconceptions. The commentary also explains why IIT starts from phenomenology and why it predicts that only select physical substrates can support consciousness. Finally, it highlights that IIT's account of experience – a cause–effect structure quantified by integrated information – has nothing to do with “information transfer.”.

We propose that sleep is linked to synaptic homeostasis. Specifically, we propose that: (1) Wakefulness is associated with synaptic potentiation in cortical circuits; (2) synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) slow wave activity is associated with synaptic downscaling; and (4) synaptic downscaling is tied to several beneficial effects of sleep, including performance enhancement.

Dreams are a remarkable experiment in psychology and neuroscience, conducted every night in every sleeping person. They show that the human brain, disconnected from the environment, can generate an entire world of conscious experiences by itself. Content analysis and developmental studies have promoted understanding of dream phenomenology. In parallel, brain lesion studies, functional imaging and neurophysiology have advanced current knowledge of the neural basis of dreaming. It is now possible to start integrating these two strands of research to address fundamental (...) questions that dreams pose for cognitive neuroscience: how conscious experiences in sleep relate to underlying brain activity; why the dreamer is largely disconnected from the environment; and whether dreaming is more closely related to mental imagery or to perception. (shrink)

This book explores how we can measure consciousness. It clarifies what consciousness is, how it can be generated from a physical system, and how it can be measured. It also shows how conscious states can be expressed mathematically and how precise predictions can be made using data from neurophysiological studies.

The distinction between receptive field and conceptual field is appealing and heuristically useful. Conceptually, it is more satisfactory to distinguish between information from the environment and from the brain. We emphasize here a selectionist view that considers information transmission within the brain as modulated by a stimulus, rather than information transmission from a stimulus as modulated by the context.

Many kinds of complex systems exhibit characteristic patterns of temporal correlations that emerge as the result of functional interactions within a structured network. One such complex system is the brain, composed of numerous neuronal units linked by synaptic connections. The activity of these neuronal units gives rise to dynamic states that are characterized by specific patterns of neuronal activation and co-activation. These patterns, called functional connectivity, are possible neural correlates of perceptual and cognitive processes. Which functional connectivity patterns arise depends (...) on the anatomical structure of the underlying network, which in turn is modified by a broad range of activity-dependent processes. Given this intricate relationship between structure and function, the question of how patterns of anatomical connectivity constrain or determine dynamical patterns is of considerable theoretical importance. The present study develops computational tools to analyze networks in terms of their structure and dynamics. We identify different classes of network, including networks that are characterized by high complexity. These highly complex networks have distinct structural characteristics such as clustered connectivity and short wiring length similar to those of large-scale networks of the cerebral cortex. (shrink)

A set of images can be considered as meaningfully different for an observer if they can be distinguished phenomenally from one another. Each phenomenal difference must be supported by some neurophysiological differences. Differentiation analysis aims to quantify neurophysiological differentiation evoked by a given set of stimuli to assess its meaningfulness to the individual observer. As a proof of concept using high-density EEG, we show increased neurophysiological differentiation for a set of natural, meaningfully different images in contrast to another set of (...) artificially generated, meaninglessly different images in nine participants. Stimulus-evoked neurophysiological differentiation (over 257 channels, 800 ms) was systematically greater for meaningful vs. meaningless stimulus categories both at the group level and for individual subjects. Spatial breakdown showed a central-posterior peak of differentiation, consistent with the visual nature of the stimulus sets. Temporal breakdown revealed an early peak of differentiation around 110 ms, prominent in the central-posterior region; and a later, longer-lasting peak at 300–500 ms that was spatially more distributed. The early peak of differentiation was not accompanied by changes in mean ERP amplitude, whereas the later peak was associated with a higher amplitude ERP for meaningful images. An ERP component similar to visual-awareness-negativity occurred during the nadir of differentiation across all image types. Control stimulus sets and further analysis indicate that changes in neurophysiological differentiation between meaningful and meaningless stimulus sets could not be accounted for by spatial properties of the stimuli or by stimulus novelty and predictability. (shrink)

Objective correlates—behavioral, functional, and neural—provide essential tools for the scientific study of consciousness. But reliance on these correlates should not lead to the ‘fallacy of misplaced objectivity’: the assumption that only objective properties should and can be accounted for objectively through science. Instead, what needs to be explained scientifically is what experience is intrinsically— its subjective properties—not just what we can do with it extrinsically. And it must be explained; otherwise the way experience feels would turn out to be magical (...) rather than physical. We argue that it is possible to account for subjective properties objectively once we move beyond cognitive functions and realize what experience is and how it is structured. Drawing on integrated information theory, we show how an objective science of the subjective can account, in strictly physical terms, for both the essential properties of every experience and the specific properties that make particular experiences feel the way they do. (shrink)

Causal reductionism is the widespread assumption that there is no room for additional causes once we have accounted for all elementary mechanisms within a system. Due to its intuitive appeal, causal reductionism is prevalent in neuroscience: once all neurons have been caused to fire or not to fire, it seems that causally there is nothing left to be accounted for. Here, we argue that these reductionist intuitions are based on an implicit, unexamined notion of causation that conflates causation with prediction. (...) By means of a simple model organism, we demonstrate that causal reductionism cannot provide a complete and coherent account of ‘what caused what’. To that end, we outline an explicit, operational approach to analyzing causal structures. (shrink)

This paper presents Integrated Information Theory (IIT) 4.0. IIT aims to account for the properties of experience in physical (operational) terms. It identifies the essential properties of experience (axioms), infers the necessary and sufficient properties that its substrate must satisfy (postulates), and expresses them in mathematical terms. In principle, the postulates can be applied to any system of units in a state to determine whether it is conscious, to what degree, and in what way. IIT offers a parsimonious explanation of (...) empirical evidence, makes testable predictions, and permits inferences and extrapolations. IIT 4.0 incorporates several developments of the past ten years, including a more accurate translation of axioms into postulates and mathematical expressions, the introduction of a unique measure of intrinsic information that is consistent with the postulates, and an explicit assessment of causal relations. By fully unfolding a system's irreducible cause-effect power, the distinctions and relations specified by a substrate can account for the quality of experience. (shrink)

This information-packed volume, without doubt a landmark event in the developing neuroscientific study of consciousness, deserves the attention of anyone interested in this subject. It is a sequel and companion to an earlier collection, The Boundaries of Consciousness: Neurobiology and Neuropathology, also edited by Steven Laureys (2005), which contains the proceedings of a 2004 conference sponsored by the Association for the Scientific Study of Consciousness (ASSC). Published initially as a special issue of Progress in Brain Research (volume 150), Boundaries has (...) been reissued in paperback and appears on the ASSC website as one of its official titles. Both volumes include many prominent figures in contemporary neuroscience, and the two volumes together constitute about as clear, comprehensive, and authoritative a picture as one can find anywhere of the current state of mainstream neuroscientific thinking about consciousness and the brain. Like classical physics of the late 19th century, it is a picture of great power and beauty; nevertheless, just as discordant phenomena such as black-body radiation and the photoelectric effect presaged the rise of quantum mechanics, this book, precisely because of its clarity, reveals signs of trouble ahead. (shrink)

Although there is little empirical doubt of the cerebral base of consciousness, it still has an unapproachable quality about it. Gerald Edelman and Giulio Tononi offer a hypothesis that should give us the tool to start disentangling the 'world knot', an image Arthur Schopenhauer used to describe the problem of the origin of consciousness. Their primary focus is not the richness in everyday experience, but the conditions that allow us that experiential richness -- a difficult enough task, as (...) most would admit reading the book. It shows how the cranial barrier can be overcome by new observation techniques, producing a plethora of experimental data in support of the concepts and theories described in the book. This material leads to the formulation of the dynamic-core hypothesis which describes the necessary biological conditions for consciousness. (shrink)

Two problems about rights have received so far little attention. One is the problem of identifying a general value in the practice of rights. The second is to see when, if at all, rights violations wrong the right-holder, in a morally significant sense. In the present essay, I address the first question by investigating the second. I first show that if we commit to the two ideas, common in the contemporary philosophy of rights, that claim-rights always correlate with directed duties (...) and that rights aspire to protect interests of the right-holder, we make it hard to explain why rights violations, in general, wrong right-holders. In the final section, I present what I see as a promising solution to the puzzle. I describe a particular social environment (the society of equals) where interacting with others through rights is indeed valuable because respecting rights communicates that one takes seriously others’ equal moral status. In such a society and only in such a society, I conclude, moral agents are required to treat all rights violations as wrongs perpetrated against the right-holder. (shrink)

There are two main meanings in Kant’s concept of moral certainty (moralische Gewissheit, certitudo moralis): first, it applies to the kind of certainty embodied in rational faith in the existence of God and a future life; second, it applies to the conscientiousness (Gewissenhaftigkeit) required of an agent in the practice of moral judgement. Despite the growing attention to Kant’s theory of conscience and his concept of conscientiousness, this article is the first to discuss ‘moral certainty’ as the aim of ‘conscientiousness’ (...) and to highlight the relevance of both notions in regard to moral education and the purposes of Kant’s ethical doctrines of method. (shrink)

In this paper, in line with the general framework of value-sensitive design, we aim to operationalize the general concept of “Meaningful Human Control” in order to pave the way for its translation into more specific design requirements. In particular, we focus on the operationalization of the first of the two conditions investigated: the so-called ‘tracking’ condition. Our investigation is led in relation to one specific subcase of automated system: dual-mode driving systems. First, we connect and compare meaningful human control with (...) a concept of control very popular in engineering and traffic psychology, and we explain to what extent tracking resembles and differs from it. This will help clarifying the extent to which the idea of meaningful human control is connected to, but also goes beyond, current notions of control in engineering and psychology. Second, we take the systematic analysis of practical reasoning as traditionally presented in the philosophy of human action and we adapt it to offer a general framework where different types of reasons and agents are identified according to their relation to an automated system’s behaviour. This framework is meant to help explaining what reasons and what agents play a role in controlling a given system, thereby enabling policy makers to produce usable guidelines and engineers to design systems that properly respond to selected human reasons. In the final part, we discuss a practical example of how our framework could be employed in designing automated driving systems. (shrink)

Contemporary brain reading technologies promise to provide the possibility to decode and interpret mental states and processes. Brain reading could have numerous societally relevant implications. In particular, the private character of mind might be affected, generating ethical and legal concerns. This paper aims at equipping ethicists and policy makers with conceptual tools to support an evaluation of the potential applicability and the implications of current and near future brain reading technology. We start with clarifying the concepts of mind reading and (...) brain reading, and the different kinds of mental states that could in principle be read. Subsequently, we devise an evaluative framework that is composed of five criteria-accuracy, reliability, informativity, concealability and enforceability-aimed at enabling a clearer estimation of the degree to which brain reading might be realistically deployed in contexts where mental privacy could be at stake. While accuracy and reliability capture how well a certain method can access mental content, informativity indicates the relevance the obtainable data have for practical purposes. Concealability and enforceability are particularly important for the evaluation of concerns about potential violations of mental privacy and civil rights. The former concerns the degree with which a brain reading method can be concealed from an individual’s perception or awareness. The latter regards the extent to which a method can be used against somebody’s will. With the help of these criteria, stakeholders can orient themselves in the rapidly developing field of brain reading. (shrink)

The term ‘recalcitrant emotions’ refers to those cases where we feel an emotion that apparently contradicts our better judgements. For instance, one may be afraid of flying while claiming not to believe that it is dangerous. This phenomenon is commonly conceived as an objection to cognitivism, according to which emotions are based on the subject's beliefs, insofar as it would force us to ascribe to the subject who feels them an excessive degree of irrationality, comparing recalcitrant emotions to contradictory beliefs. (...) For this reason, many philosophers have developed perceptual theories which describe emotions as forms of perception, allowing us to explain recalcitrant emotions without attributing to the subject contradictory beliefs, treating them as perceptual illusions. Facing the most compelling of these attempts, the article shows that perceptual accounts fail to explain in what sense recalcitrant emotions (and people who feel them) are irrational, keeping the comparison with optical illusions, which are not. Having rebutted three popular perceptual proposals, I conclude that the analogy between emotions and perceptions is flawed and that the appeal of these theories lies on a surreptitious shift in the meaning of the term ‘perceive’. (shrink)

It is argued that, of the three distinct approaches usually adhered to in discussions of this controversy, none will produce an adequate reconstruction of the episode. The philosophical-methodological type of approach leads to a glossing over of the intricacies of deductive and inductive procedures inhering in the writings of both antagonists (§ 1). The metaphysical approach leads to oversimplification as to the thinking of either scientist on the problem of the continuous or discontinuous character of Nature(§ 2). The epistemological (theory (...) of knowledge) type of approach, finally, leads authors to posit a Linnaean realism vs. a Buffonian nominalism, whereas the true position was much more complex than what transpires(§ 3). The paper proceeds, therefore, to provide a novel reconstruction of this wellknown controversy (§ 4-5), concentrating on the differing choices made by the two naturalists in their work of botanical or zoological classification : thus seeking to show that the clash came about because Buffon rejected the rigid principle of character subordination put forward by Linnaeus, and, on a more general level, because the two protagonists were proceeding from deeply diverging views of what natural history, and what the naturalist's function, should be. (shrink)

ABSTRACT This article analyses the abbé de Saint-Pierre as a mediator of ideas between France and England. The political proposal of the Projet pour rendre la paix perpétuelle en Europe circulated in Great Britain just before the signing of the peace treaties of Utrecht and Aachen, attesting the influence that Saint-Pierre’s proposal exerted on British thought and politics. The abbé was engaged in dialogue with Quaker pacifists and, in particular, with the projects put forward by William Penn and John Bellers, (...) both theorists of a ‘European State’. After examining the relationship between Penn’s Essay and Saint-Pierre’s ideas, the article will demonstrate how elements of Bellers’s Some Reasons found their way into the Projet with numerous convergences of lexicon and content suggesting that the abbé had drawn inspiration from Bellers. Quaker ideas on politics had a greater effect on Saint-Pierre’s conception of peace and international relations than is commonly recognized. In fact, there was a constant intellectual exchange between the abbé and British political, economic and philosophical thought. (shrink)

In the proem of the “Theogony” Hesiod describes the conception and birth of the Muses. At ll. 58-60 he specifies that Mnemosyne’s pregnancy lasted one entire year, ένιαντός. This unusual one-year pregnancy puzzles Hesiod’s commentators; West, for example, translates ένιαντός as ‘due time’ rather than ‘year’. The purpose of this article is to argue that Hesiod intended ένιαντός to mean ‘year’.

This paper argues that in Silvae 3.3, written to console Claudius Etruscus on the death of his beloved father, Statius reverses his own account of the contentious relationship between Tisiphone and Pietas in Thebaid Books 1 and 11 to present his patron's affectionate bond with his father as antithetical to Oedipus’ resentful relationship with his sons. In the Thebaid, Oedipus summons Tisiphone from the Underworld to punish his own children by stirring up civil war, and the Fury promptly obeys, banishing (...) Pietas from earth to prevent her from stopping the conflict. In Silvae 3.3, on the other hand, the poet asks Pietas to come back to earth, and urges the Furies to stay away from the deceased. The return of Pietas, also portrayed in Silvae 5.2, shows that in his collection of occasional poetry Statius rewrites his own epic to restore cosmos: while in the chaotic narrative universe of the Thebaid all fundamental values, including filial devotion, are turned upside down, the Silvae describe a more conventional and reassuring world, founded on virtue rather than vengeance. (shrink)

We study how to postpone the application of the reductio ad absurdum rule (RAA) in classical natural deduction. This technique is connected with two normalization strategies for classical logic, due to Prawitz and Seldin, respectively. We introduce a variant of Seldin’s strategy for the postponement of RAA, which induces a negative translation from classical to intuitionistic and minimal logic. Through this translation, Glivenko’s theorem from classical to intuitionistic and minimal logic is proven.