In the October edition of the Journal of Medical Ethics, Akabayashi and colleagues state that ’to establish a heterogeneous [induced pluripotent stem cell] iPSC bank covering roughly 80% of Japan’s population…the Japanese government decided to invest JPY110 billion over 10 years in regenerative medicine research; a quarter of this was to be allocated to the iPSC stock project'. While they claim this amount of money to be an unfair distribution of state resources, we believe their assessment is based on a (...) misunderstanding of the facts. Similarly, other criticisms by them are based on mistaken interpretations. This article is a rebuttal to the arguments that form the basis of Akabayashi and colleagues’ five criticisms by explaining their misinterpretations. (shrink)

Sparrow highlights three potential applications of in vitro eugenics, that is, (a) research into the heredity of genetic disorders, (b) production of cell lines with specific genotypes, and (c) breeding better babies, and points to the need for researchers to discuss in advance the potential ethical problems that may emerge if the realization of this technology occurs in the near future. In this commentary, we pose a question for the sake of discussion. Is it, in fact, appropriate to label all (...) three applications raised by Sparrow as eugenics? By doing so, an unnecessary level of concern might be borne among the public, and as a result, the sound development of this specialized technology would be affected. If the label of eugenics is to be applied to all three of these applications, then Sparrow must justify how he perceives (a) and (b) as not inherently different from (c). (shrink)

BackgroundThe Act Regarding the Promotion of the Appropriate Supply of Hematopoietic Stem Cells for Transplant regulates only how public banks store and provide umbilical cord blood for research or transplantation. Japan had no laws to regulate how the private banks manage the procedures, harvesting, preparation, and storage of such blood. As a result, the status of UCB distribution remains unknown. We conducted a survey to investigate the current status of UCB storage and provision to private biobanks by Japanese institutions that (...) handle childbirth.MethodsQuestionnaire forms were mailed to 3,277 facilities handling childbirth that were registered in the Japan Council for Quality Health Care website.ResultsOf the 1,192 institutions handling childbirth that participated in the survey, 34.4% responded that they currently provide UCB to private biobanks, while 16.1% of facilities did so in the past. Moreover, some institutions currently provide or formerly provided UCB to medical treatment facilities, research institutions, companies, or overseas treatment facilities, research institutions, or companies. A certain number of institutions handling childbirth did not even provide explanations or obtain consent when the UCB was harvested from private bank users.ConclusionsThis is the first study to determine the status of UCB provision to private banks by Japanese institutions handling childbirth. Future studies will need to examine in detail how institutions handling childbirth provide explanations to private bank users and UCB providers as well as how these institutions obtain consent. (shrink)

In this article, we provide an ethical analysis of the first porcine cardiac xenotransplant, performed in Maryland, USA in early 2022. David Bennett was offered the experimental procedure after he was deemed ineligible for human heart transplantation and mechanical circulatory support, based on a history of non-compliance. It was reported that Mr Bennett’s previous instances of non-compliance were for medically non-life-threatening conditions years earlier, where the risks of non-compliance were not as high. We argue that, in Mr Bennett’s case, a (...) history of non-compliance in a different context, should not necessarily rule him ineligible for a potentially life-saving treatment now. Furthermore, using previous non-compliance to exclude individuals from donor organs may have the unintended effect of placing the burden of testing xenotransplantation on those who are already disadvantaged. We then argue that it is not enough to rely on patient consent to ethically justify xenotransplantation research. Taking a broad ethical perspective is crucial when mapping a clinical pathway for xenotransplantation. (shrink)

BackgroundPrevious studies have found that the decision-making process for stored unused frozen embryos involves much emotional burden influenced by socio-cultural factors. This study aims to ascertain how Japanese patients make a decision on the fate of their frozen embryos: whether to continue storage discard or donate to research.MethodsTen Japanese women who continued storage, 5 who discarded and 16 who donated to research were recruited from our infertility clinic. Tape-recorded interviews were transcribed and analyzed for emergent themes.ResultsA model of patients’ decision-making (...) processes for the fate of frozen embryos was developed, with a common emergent theme, “coming to terms with infertility” resulting in either acceptance or postponing acceptance of their infertility. The model consisted of 5 steps: 1) the embryo-transfer moratorium was sustained, 2) the “Mottainai”- embryo and having another child were considered; 3) cost reasonability was taken into account; 4) partner’s opinion was confirmed to finally decide whether to continue or discontinue storage. Those discontinuing, then contemplated 5): the effect of donation. Great emotional conflict was expressed in the theme, steps 2, 4, and 5.ConclusionsPatients’ 5 step decision-making process for the fate of frozen embryos was profoundly affected by various Japanese cultural values and moral standards. At the end of their decision, patients used culturally inherent values and standards to come to terms with their infertility. While there is much philosophical discussion on the moral status of the embryo worldwide, this study, with actual views of patients who own them, will make a significant contribution to empirical ethics from the practical viewpoint. (shrink)

BackgroundFew comparative studies of clinical ethics consultation practices have been reported. The objective of this study was to explore how American and Japanese experts analyze an Alzheimer's case regarding ethics consultation.MethodsWe presented the case to physicians and ethicists from the US and Japan (one expert from each field from both countries; total = 4) and obtained their responses through a questionnaire and in-depth interviews.ResultsEstablishing a consensus was a common goal among American and Japanese participants. In attempting to achieve consensus, the (...) most significant similarity between Japanese and American ethics consultants was that they both appeared to adopt an "ethics facilitation" approach. Differences were found in recommendation and assessment between the American and Japanese participants. In selecting a surrogate, the American participants chose to contact the grandson before designating the daughter-in-law as the surrogate decision-maker. Conversely the Japanese experts assumed that the daughter-in-law was the surrogate.ConclusionOur findings suggest that consensus building through an "ethics facilitation" approach may be a commonality to the practice of ethics consultation in the US and Japan, while differences emerged in terms of recommendations, surrogate assessment, and assessing treatments. Further research is needed to appreciate differences not only among different nations including, but not limited to, countries in Europe, Asia and the Americas, but also within each country. (shrink)

We define and investigate a uniformly locally o-minimal structure of the second kind in this paper. All uniformly locally o-minimal structures of the second kind have local monotonicity, which is a local version of monotonicity theorem of o-minimal structures. We also demonstrate a local definable cell decomposition theorem for definably complete uniformly locally o-minimal structures of the second kind. We define dimension of a definable set and investigate its basic properties when the given structure is a locally o-minimal structure which (...) admits local definable cell decomposition. (shrink)

Consider a definably complete uniformly locally o-minimal expansion of the second kind of a densely linearly ordered abelian group. Let $f:X \rightarrow R^n$ be a definable map, where X is a definable set and R is the universe of the structure. We demonstrate the inequality $\dim ) \leq \dim $ in this paper. As a corollary, we get that the set of the points at which f is discontinuous is of dimension smaller than $\dim $. We also show that the (...) structure is definably Baire in the course of the proof of the inequality. (shrink)

We consider locally o-minimal structures possessing tame topological properties shared by models of DCTC and uniformly locally o-minimal expansions of the second kind of densely linearly ordered abelian groups. We derive basic properties of dimension of a set definable in the structures including the addition property, which is the dimension equality for definable maps whose fibers are equi-dimensional. A decomposition theorem into quasi-special submanifolds is also demonstrated.

We first show that the projection image of a discrete definable set is again discrete for an arbitrary definably complete locally o‐minimal structure. This fact together with the results in a previous paper implies a tame dimension theory and a decomposition theorem into good‐shaped definable subsets called quasi‐special submanifolds. Using this fact, we investigate definably complete locally o‐minimal expansions of ordered groups when the restriction of multiplication to an arbitrary bounded open box is definable. Similarly to o‐minimal expansions of ordered (...) fields, Łojasiewicz's inequality, Tietze's extension theorem and affiness of pseudo‐definable spaces hold true for such structures under the extra assumption that the domains of definition and the pseudo‐definable spaces are definably compact. Here, a pseudo‐definable space is a topological space having finite definable atlases. We also demonstrate Michael's selection theorem for definable set‐valued functions with definably compact domains of definition. (shrink)

When I deliver an introductory lecture on Japanese Philosophy, I always raise the following question: Is it appropriate to modify the word philosophy with an adjective such as Japanese? Philosophy is, after all, a discipline that addresses universal problems, and so transcends the restrictions implied in geographical descriptors. However, as Kuki Shūzō argues in his essay “Tokyo and Kyoto,” I think that this is only part, and not the whole truth of the matter.One’s thinking takes place within the framework of (...) one’s cultural heritage, and the different nuances of each of the words one uses can influence how one thinks. It is for this reason that every philoso­phy has its own unique character. As Otto Pöggeler suggests, there is something about the thought of Japanese philosophers such as Nishida Kitarō and Nishitani Keiji that does not fit easily into the framework of “philosophy” in the Western tradition. This is a conse­quence of the fact that they did not simply passively adopt, but rather attempted to critically challenge Western philosophy. I suppose that their grounding in Japanese and other Eastern traditions contributed to their critical challenge of Western philosophy. And I submit that there is a strong tendency in traditional East Asian thought to not simply grasp things within a presupposed framework of “knowledge,” but rather, since “knowledge” itself is understood to be a certain kind of restriction, to return to its roots.Needless to say, neither Nishida’s nor Nishitani’s thought is merely a philosophical reiteration of such traditional East Asian teachings. Nevertheless, we can say that the East Asian idea that knowledge is at root something restrictive lives on in their thinking. The radical­ity of Nishida’s and Nishitani’s thought can be understood to lie in the manner in which they cast light on the limits of the “knowledge” pursued by Western philosophy, problematizing the basis on which this knowledge is established as well as the framework it sets up.I think that the “character” of this or that philosophy arises from such different ways of seeing things and different attitudes toward “knowledge.” It is crucial to point out, however, that the gaps resulting from these differences need not become hindrances for philosophical thinking. Indeed, I think that the existence of such gaps, rather than hindering “dialogues” between different philosophies, is precisely what enables them to be meaningful. This is also what I have in mind when I stress the importance of dialogue in my lectures on Japanese philoso­phy. It is, after all, the creative dialogue engendered in this manner that enables philosophy to progress along its path of radical inquiry. (shrink)

This paper presents a new correctness criterion for marked Danos-Reginer graphs (D-R graphs, for short) of Multiplicative Cyclic Linear Logic MCLL and Abrusci's non-commutative Linear Logic MNLL. As a corollary we obtain an affirmative answer to the open question whether a known quadratic-time algorithm for the correctness checking of proof nets for MCLL and MNLL can be improved to linear-time.

In this paper we consider properties, related to model-completeness, of the theory of integrally closed commutative regular rings. We obtain the main theorem claiming that in a Boolean algebra B, the truth of a prenex Σn-formula whose parameters ai partition B, can be determined by finitely many conditions built from the first entry of Tarski invariant T(ai)'s, n-characteristic D(n, ai)'s and the quantities S(ai, l) and S'(ai, l) for $l < n$. Then we derive two important theorems. One claims that (...) for any Boolean algebras A and B, an embedding of A into B preserving D(n, a) for all a ∈ A is a Σn-extension. The other claims that the theory of n-separable Boolean algebras admits elimination of quantifiers in a simple definitional extension of the language of Boolean algebras. Finally we translate these results into the language of commutative regular rings. (shrink)

A BCK-algebra is an algebra in which the terms are generated by a set of variables, 1, and an arrow. We mean by aBCK-identity an equation valid in all BCK-algebras. In this paper using a syntactic method we show that for two termss andt, if neithers=1 nort=1 is a BCK-identity, ands=t is a BCK-identity, then the rightmost variables of the two terms are identical.This theorem was conjectured firstly in [5], and then in [3]. As a corollary of this theorem, we (...) derive that the BCK-algebras do not form a variety, which was originally proved algebraically by Wroski ([4]). (shrink)

The third author gave a natural deduction style proof system called the \-calculus for implicational fragment of classical logic in. In -calculus, 2015, Post-proceedings of the RIMS Workshop “Proof Theory, Computability Theory and Related Issues”, to appear), the fourth author gave a natural subsystem “intuitionistic \-calculus” of the \-calculus, and showed the system corresponds to intuitionistic logic. The proof is given with tree sequent calculus, but is complicated. In this paper, we introduce some reduction rules for the \-calculus, and give (...) a simple and purely syntactical proof to the theorem by use of the reduction. In addition, we show that we can give a computation model with rich expressive power with our system. (shrink)

This paper presents a new correctness criterion for marked Danos-Reginer graphs of Multiplicative Cyclic Linear Logic MCLL and Abrusci's non-commutative Linear Logic MNLL. As a corollary we obtain an affirmative answer to the open question whether a known quadratic-time algorithm for the correctness checking of proof nets for MCLL and MNLL can be improved to linear-time.

膨大な資料をもとに魅力あふれる西田の素顔を描きだし、彼の言葉に豊かな広がりを与える決定的評伝。.