Major depression is among the most common, challenging and disabling conditions. It is highly heterogeneous, affects patients throughout the lifespan and, in up to one-third of people affected, res...

While it was not a main focus of his work, Ernan McMullin contributed to reflection on being human in the context of human evolutionary history. His work developed multiple strands for the formation of a systematic Christian evolutionary theism regarding human beings. The first theme concerns St. Augustine’sexplorations of “seed-like” principles in developing the idea that God brought forth humans in part through a natural process. Secondly, the paper discussesMcMullin’s response to the claim that evolutionary theory suggests humans to be (...) the result of radical contingency, calling into question the Providential natureof human evolution. McMullin invokes Augustinian sensibilities about God’s eternality in his reply. Next, Fr. Ernan reflected on the concept of matter and howit can inform a response to dualistic conceptions of human being. Finally, in a characteristically even-handed tone, he defended emergentism as a viable optionto dualism, recognizing there to be serious philosophical and theological concerns about the emergentist picture. While McMullin did not solve the problems thatchallenge a synthesis of evolutionary theory and Christian anthropology, he offered a number of very helpful clues. (shrink)

Ethical issues in physician-industry and academia-industry relationships have focused largely on the financial nature of these relationships. It took very little time after solutions to transparenc...

Neurosurgery for psychiatric disorders, also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to (...) set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law, what types of regulations are required, and how to approach international harmonization given the potential migration of researchers and patients. (shrink)

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises (...) a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus. (shrink)

Electroencephalographic monitoring provides critical diagnostic and management information about patients with epilepsy and seizure mimics. Admission to an epilepsy monitoring unit (EMU) is the gold standard for such monitoring in major medical facilities worldwide. In many countries, access can be challenged by limited resources compared to need. Today, triaging admission to such units is generally approached by unwritten protocols that vary by institution. In the absence of explicit guidance, decisions can be ethically taxing and are easy to challenge. In an (...) effort to address this gap, we propose a two-component approach to EMU triage that takes into account the unique landscape of epilepsy monitoring informed by triage literature from other areas of medicine. Through the strategic component, we focus on the EMU wait list management infrastructure at the institutional level. Through the principled component, we apply a combination of the ethical principles of prioritarianism, utilitarianism and justice to triage; and we use individual case examples to illustrate how they apply. The effective implementation of this approach to specific epilepsy centres will need to be customised to the nuances of different settings, including diverse practice patterns, patient populations and constraints on resource distribution, but the conceptual consolidation of its components can alleviate some of the pressures imposed by the complex decisions involved in EMU triage. (shrink)

Review of Truth and Realism, edited by Patrick Greenough and Michael Lynch.

_"One of the most important political books of 2018."—Rod Dreher, ___American Conservative__ Of the three dominant ideologies of the twentieth century—fascism, communism, and liberalism—only the last remains. This has created a peculiar situation in which liberalism’s proponents tend to forget that it _is _an ideology and not the natural end-state of human political evolution. As Patrick Deneen argues in this provocative book, liberalism is built on a foundation of contradictions: it trumpets equal rights while fostering incomparable material inequality; its (...) legitimacy rests on consent, yet it discourages civic commitments in favor of privatism; and in its pursuit of individual autonomy, it has given rise to the most far-reaching, comprehensive state system in human history. Here, Deneen offers an astringent warning that the centripetal forces now at work on our political culture are not superficial flaws but inherent features of a system whose success is generating its own failure. (shrink)

How are we to make sense of madness and psychosis? For most of us the words conjure up images from television and newspapers of seemingly random, meaningless violence. It is something to be feared, something to be left to the experts. But is madness best thought of as a medical condition? Psychiatrists and the drug industry maintain that psychoses are brain disorders amenable to treatment with drugs, but is this actually so? There is no convincing evidence that the brain is (...) disordered in psychosis, yet governments across the world are investing huge sums of money on mental health services that take for granted the idea that psychosis is an illness to be treated with medication. Although some people who use mental health services find medication helpful, many do not, and resist the idea that their experiences are symptoms of illnesses like schizophrenia. Consequently they are forced into having treatment against their wishes. So, how do we make sense of this situation? Postpsychiatry addresses these questions. It involves an attempt to rethink some of the fundamental assumptions of mental health work, showing how recent developments in philosophy and ethics can help us to clarify some of the dilemmas and conflicts around different understandings of madness. Throughout, the authors examine the conflicting ways in which politicians, academics, and mental health professionals appear to understand madness, and contrast this with voices and experiences that are usually excluded - those of the people who use mental health services. They then examine the power of psychiatry to shape how we understand ourselves and our emotions, before considering some of the basic limitations of psychiatry as science to make madness meaningful. In the final section of the book they draw on evidence from service users and survivors, the humanities and anthropology, to point out a new direction for mental health practice. This new direction emphasises the importance of cultural contexts in understanding madness, placing ethics before technology in responding to madness, and minimising 'therapeutic' coercion. (shrink)

Social entrepreneurship activity continues to surge tremendously in market and economic systems around the world. Yet, social entrepreneurship theory and understanding lag far behind its practice. For instance, the nature of the entrepreneurial discovery phenomenon, a critical area of inquiry in general entrepreneurship theory, receives no attention in the specific context of social entrepreneurship. To address the gap, we conceptualize social entrepreneurial discovery based on an extension of corporate social responsibility into social entrepreneurship contexts. We develop a model that emphasizes (...) mobilization and timing as underpinnings of social entrepreneurial discovery and offer distinct conceptual aspects and theoretic propositions instrumental to future social entrepreneurship research. (shrink)

Tens of thousands of students have learned to be more discerning at constructing and evaluating arguments with the help of Patrick J. Hurley. Hurley’s lucid, friendly, yet thorough presentation has made A CONCISE INTRODUCTION TO LOGIC the most widely used logic text in North America. In addition, the book’s accompanying technological resources, such as CengageNOW and Learning Logic, include interactive exercises as well as video and audio clips to reinforce what you read in the book and hear in class. (...) In short, you’ll have all the assistance you need to become a more logical thinker and communicator. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

On the 4th of December 1967, Hans Kamp sent his UCLA seminar notes on the logic of ‘now’ to Arthur N. Prior. Kamp’s two-dimensional analysis stimulated Prior to an intense burst of creativity in which he sought to integrate Kamp’s work into tense logic using a one-dimensional approach. Prior’s search led him through the work of Castañeda, and back to his own work on hybrid logic: the first made temporal reference philosophically respectable, the second made it technically feasible in a (...) modal framework. With the aid of hybrid logic, Prior built a bridge from a two-dimensional UT calculus to a one-dimensional tense logic containing the ‘now’ operator J. Drawing on material from the Prior archive, and the paper “‘Now”’ that detailed Prior’s findings, we retell this story. We focus on Prior’s completeness conjecture for the hybrid system and the role played by temporal reference. (shrink)

In this paper we argue that Prior and Reichenbach are best viewed as allies, not antagonists. We do so by combining the central insights of Prior and Reichenbach in the framework of hybrid tense logic. This overcomes a well-known defect of Reichenbach’s tense schema, namely that it gives multiple representations to sentences in the future perfect and the future-in-the-past. It also makes it easy to define an iterative schema for tense that allows for multiple points of reference, a possibility noted (...) by Prior and demanded by Comrie, and we sketch how this schema can be generalized to a shift-and-restrict pattern in which special propositional symbols act as restrictors on the range of tense operators. (shrink)

This paper analyzes the metaphysical system developed in Cheyne’s Philosophical Principles of Religion. Cheyne was an early proponent of Newtonianism and tackled several philosophical questions raised by Newton’s work. The most pressing of these concerned the causal origin of gravitational attraction. Cheyne rejected the occasionalist explanations offered by several of his contemporaries in favor of a model on which God delegated special causal powers to bodies. Additionally, he developed an innovative approach to divine conservation. This allowed him to argue that (...) Newton’s findings provided evidence for God’s existence and providence without the need for continuous divine intervention in the universe. (shrink)

This paper explores the metaphysical system developed in Richard Bentley’s 1692 Boyle Lectures. The lectures are notable for their attempt to argue that developments in natural philosophy, including Newton’s Principia, could bolster natural theology. The paper explores Bentley’s matter theory focusing on his commitment to a particular form of mechanism and his rejection of occult qualities. It then examines his views on the nature of divine omnipotence. Finally, it turns to his understanding of gravitational attraction. While some recent commentators have (...) argued for a “superaddition” interpretation of gravitation in Bentley, this paper argues for an “occasionalist” interpretation. The argument proceeds on the basis of both textual considerations and considerations stemming from the systematic interpretation of Bentley’s metaphysics developed earlier in the paper. (shrink)

This article explores a previously neglected manuscript essay in which Thomas White offers an account of the metaphysics underpinning transubstantiation. White’s views are of particular interest because his explanation employs a broadly mechanist framework, rather than the hylomorphism traditionally associated with Roman Catholic discussions of the Eucharist. The manuscript helps to shed light on a number of topics of importance to early modern philosophy including the reception of Descartes’ views, the relationship between theology and natural philosophy, and mechanist accounts of (...) identity and individuation. (shrink)

This essay addresses a stream of thought manifested in some forms of social justice activism – namely, that members of marginalized groups have privileged insight into the nature of social reality which others cannot understand, much less critique. This position, which I call “epistemic isolationism,” seems to rest on the claim that the knowledge that is embedded in lived experience is incommunicable. The essay proceeds in three parts: first, there is a brief overview of standpoint epistemology, including a recent version (...) which seems to support epistemic isolationism. Second, there is an explication of the concept of “lived experience” as developed by Wilhelm Dilthey. Third, there is an argument against the claim that lived experience is incommunicable, drawing from the work of Dilthey, Hans-Georg Gadamer, and Paul Ricoeur. The payoff of the argument is that sharing lived experience through expressions like literature and narrative inspires mutual recognition and respect which can, in turn, support a robust form of solidarity and serve as a foundation for more effective social justice advocacy. (shrink)

In this paper I argue for an association between impurity and explanatory power in contemporary mathematics. This proposal is defended against the ancient and influential idea that purity and explanation go hand-in-hand (Aristotle, Bolzano) and recent suggestions that purity/impurity ascriptions and explanatory power are more or less distinct (Section 1). This is done by analyzing a central and deep result of additive number theory, Szemerédi’s theorem, and various of its proofs (Section 2). In particular, I focus upon the radically impure (...) (ergodic) proof due to Furstenberg (Section 3). Furstenberg’s ergodic proof is striking because it utilizes intuitively foreign and infinitary resources to prove a finitary combinatorial result and does so in a perspicuous fashion. I claim that Furstenberg’s proof is explanatory in light of its clear expression of a crucial structural result, which provides the “reason why” Szemerédi’s theorem is true. This is, however, rather surprising: how can such intuitively different conceptual resources “get a grip on” the theorem to be proved? I account for this phenomenon by articulating a new construal of the content of a mathematical statement, which I call structural content (Section 4). I argue that the availability of structural content saves intuitive epistemic distinctions made in mathematical practice and simultaneously explicates the intervention of surprising and explanatorily rich conceptual resources. Structural content also disarms general arguments for thinking that impurity and explanatory power might come apart. Finally, I sketch a proposal that, once structural content is in hand, impure resources lead to explanatory proofs via suitably understood varieties of simplification and unification (Section 5). (shrink)

This book examines the theory and practice of argument in primary, secondary and tertiary education. Several of its chapters offer theoretical discussion of the forms and functions of argument within social, philosophical, historical and rhetorical contexts.

This book offers a comprehensive overview of the arguments relating to the extent and manner to which social influences enable epistemic agents.

This book steers a middle course between two opposing conceptions that currently dominate the field of semantics, the logical and cognitive approaches. Patrick Duffley brings to light the inadequacies of both of these frameworks, arguing that linguistic semantics must be based on the linguistic sign itself and on the meaning that it conveys across the full range of its uses. The book offers 12 case studies that demonstrate the explanatory power of a sign-based semantics, dealing with topics such as (...) complementation with aspectual and causative verbs, control and raising, wh- words, full-verb inversion, and existential-there constructions. It calls for a radical revision of the semantics/pragmatics interface, proposing that the dividing line be drawn between content that is linguistically encoded and content that is not encoded but still communicated. While traditional linguistic analysis often places meaning at the level of the sentence or construction, this volume argues that meaning belongs at the lower level of linguistic items, where the linguistic sign is stored in a stable, permanent, and direct relation with its meaning outside of any particular context. Building linguistic analysis from the ground up in this way provides it with a more0solid foundation and increases its explanatory power. (shrink)

Commentators almost universally agree that Locke denies the possibility of thinking matter in Book IV Chapter 10 of the Essay. Further, they argue that Locke must do this in order for his proof of God’s existence in the chapter to be successful. This paper disputes these claims and develops an interpretation according to which Locke allows for the possibility that a system of matter could think (even prior to any act of superaddition on God’s part). In addition, the paper argues (...) that this does not destroy Locke’s argument in the chapter, instead it helps to illuminate the nature of it. The paper proceeds in two main stages. First, Locke denies that matter can produce thought. A distinction between two senses of “production” shows that this claim is compatible with the existence of thinking matter. Second, Locke denies that God could be a system of randomly moving particles. Most commentators take this to mean that such a system could not think. But Locke is better interpreted as denying that such a system could have the wisdom and knowledge of God. (shrink)

While the subjective experience of insight during problem solving is a common occurrence, an understanding of the processes leading to solution remains relatively uncertain. The goal of this study was to investigate the restructuring patterns underlying solution of a creative problem, and how providing cues to solution may alter the process. Results show that both providing cues to solution and analyzing problem solving performance on an aggregate level may result in restructuring patterns that appear incremental. Analysis of performance on an (...) individual level provides evidence for insight-like solution patterns. However, no evidence is found for a relationship between an individual’s restructuring pattern and their subjective experience of insight during problem solving. (shrink)

This chapter revisits three key disagreements between Locke and Berkeley. The disagreements relate to abstraction, the idea of substance, and the status of the primary/secondary quality distinction. The goal of the chapter is to show that these disagreements are rooted in a more fundamental disagreement over the nature of ideas. For Berkeley, ideas are tied very closely to perceptual content. Locke adopts a less restrictive account of the nature of ideas. On his view, ideas are responsible for both perceptual content (...) and non-perceptual mental content. Recognizing this allows for the following analysis of their disputes. Berkeley often appeals to introspection to suggest that we do not have some particular idea. But Locke’s arguments that we have a particular idea often appeal to the functional role the idea has in our cognitive economy rather than to facts about our immediate phenomenology. (shrink)

Sellars, Brandom, and McDowell (whom Maher aptly calls the “Pittsburgh School”) have tremendous influence on the current shape of the analytic tradition. Despite their differing views on philosophy of language, the philosophy of mind, philosophy of action, and epistemology, their shared application of ‘normative functionalism’ highlights important similarities in their approaches to the aforementioned disciplines. Normative functionalism interprets the ability to form judgments, possess concepts, rationally defend or be critical of judgments, and consequently act as an agent, as largely guided (...) by one’s responsiveness to norms. In this article, I argue for two related claims. First, I argue that the Pittsburgh School’s normative functionalism has germinated from the seed of Sellars’ ‘psychological nominalism’ and cannot be separated from it. Second, no philosophical question or approach can be free of competing claims as to the manner in which human beings think, communicate, act, and know. As a result, normative functionalism (insofar as it is a natural extension of psychological nominalism) is relevant to many philosophical disciplines, because it opposes nearly all the traditional views concerning how the human intellect comes into being and functionally operates. (shrink)

This paper provides a response to Hanna Pickard and Stephen Pearce’s paper ‘Balancing costs and benefits: a clinical perspective does not support a harm minimisation approach for self-injury outside of community settings.’ This paper responded to my article ‘Should healthcare professionals sometimes allow harm? The case of self-injury.’ There is much in the paper that I would agree with, but I feel it is important to respond to a number of the criticisms of my paper in order to clarify my (...) position and to facilitate ongoing debate in relation to this important issue. (shrink)

This paper examines the way in which Locke's deep and longstanding interest in the non-European world contributed to his views on species and their classification. The evidence for Locke's curiosity about the non-European world, especially his fascination with seventeenth-century travel literature, is presented and evaluated. I claim that this personal interest of Locke's almost certainly influenced the metaphysical and epistemological positions he develops in the Essay. I look to Locke's theory of species taxonomy for proof of this. I argue that (...) Locke uses evidence gathered from the non-European world to (1) show that in taxonomizing objects we rely on their sensible qualities rather than their real essences and to (2) undermine Scholastic Aristotelian views about a mind-independent species/genera structure to the world. (shrink)

An e-mail discussion can be rendered into print in several ways. Rather than trying to imitate a genuine conversation, this is a personal essay containing comments and replies by the other contributors. Most of the substantial points made in the e-mail discussion are contained here, although not always in the order they happened.

An e-mail discussion can be rendered into print in several ways. Rather than trying to imitate a genuine conversation, this is a personal essay containing comments and replies by the other contributors. Most of the substantial points made in the e-mail discussion are contained here, although not always in the order they happened.

Gerrit Lindeboom’s biography, Herman Boerhaave: The Man and His Work, presents a heroic account of Herman Boerhaave’s life and his many contributions to medicine and medical education. He is portrayed as an outstanding eighteenth century educator who introduced into Leiden’s Medical School a novel method of clinical teaching that was to be widely adopted and today remains at the centre of medical student instruction. Lindeboom’s historiography induced a resurgence of interest in Boerhaave, a renewal of the myth concerning Boerhaave’s innovative (...) teaching and the publication of many acclamatory articles and false epithets, and several critical analyses. Such varying responses prompted this critical examination of the extant Boerhaavian literature, an appraisal of Lindeboom’s objectivity and an assessment of his representations of Boerhaave’s clinical teaching. In doing so, the moral nature of his historiography and that of those who were to sustain his assertions will be established, and the myth that surrounds the novelty and excellence of Boerhaave’s clinical teaching will be evident. (shrink)

This paper offers a new approach to an old debate about superaddition in Locke. Did Locke claim that some objects have powers that are unrelated to their natures or real essences? The question has split commentators. Some (Wilson, Stuart, Langton) claim the answer is yes and others (Ayers, Downing, Ott) claim the answer is no. This paper argues that both of these positions may be mistaken. I show that Locke embraced a robust epistemic humility. This epistemic humility includes ignorance of (...) the real essences of bodies, of the causal processes underlying the production of natural phenomena, and of God’s method of creation. I show how this epistemic humility offers strong support for an agnostic response to the question of superaddition. Locke did not intend to claim that bodies either do or do not have properties unrelated to their real essences. Instead, his primary goal in discussing the topic was to emphasize the strict limits to human knowledge. (shrink)

As much a doubter as a believer, Emily Dickinson often expressed views about God in general—and God with respect to suffering in particular. In many of her poems, she contemplates the question posed by countless theologians and poets before her: how can one reconcile a benevolent deity with evil in the world? Examining Dickinson’s perspectives on the role played by a supposedly omnipotent and all-loving God in a world marked by violence and pain, Patrick Keane initially focuses on her (...) poem “Apparently with no surprise,” in which frost, a “blonde Assassin,” beheads a “happy Flower,” a spectacle presided over by “an Approving God.” This tiny lyric,Keane shows, epitomizes the poet’s embattled relationship with the deity of her Calvinist tradition. Although the problem of sufferingis usually couched in terms of natural disasters or human injustice, Dickinson found new ways of considering it. By choosing a flower as her innocent “victim,” she bypassed standard “answers” to the dilemma in order to focus on the problem in its purest symbolic form. Keane goes on toprovide close readings of many of Dickinson’s poems and letters engaging God, showing how she addressed the challenges posed—by her own experience and by an innate skepticism reinforced by a nascent Darwinism—to the argument from design and the concept of a benevolent deity. More than a dissection of a single poem, Keane’s book is a sweeping personal reflection on literature and religion, faith and skepticism, theology and science. He traces the evolving history of the Problem of Suffering from the Hebrew Scriptures, through the writings of Paul, Augustine, and Aquinas, to the most recent theological and philosophical studies of the problem. Keane is interested in _how_ readers today respond to Emily Dickinson’s often combative poems about God; at the same time, she is located as a poet whose creative life coincided with the momentous changes and challenges to religious faith associated with Darwin andNietzsche.Keane also considers Dickinson’s poems and letters in the context of the great Romantic tradition, as it runs fromMilton throughWordsworth, demonstrating how thework of these poets helps illuminate Dickinson’s poetry and thought. Because Dickinson the poet was also Emily the gardener, her love of flowers was an appropriate vehicle for her observations on mortality and her expressions of doubt. _Emily Dickinson’s Approving God _is a graceful study that reveals not only the audacity of Dickinson’s thought but also its relevance to modern readers. In light of ongoing confrontations between Darwinism and design, science and literal conceptions of a divine Creator, it is an equally provocative read for students of literature and students of life. (shrink)