Schizophrenia is a serious mental disease whose pathogenesis has not been fully elucidated. Its clinical evaluation and diagnosis still highly depend on the clinical experience of doctors. It is of great scientific value and clinical significance to study the inducing factors and neuropathological mechanism of schizophrenia. Based on the four research problems of schizophrenia, this paper analyzes the data types that need to be stored in clinical trials and scientific research, including basic information, case report data, neuropsychological and cognitive function (...) evaluation, magnetic resonance data, electroencephalogram data, and intestinal flora data. Through the demand analysis of the system, including the data management part, data analysis part, the functional demand of the system management part, and the overall nonfunctional demand of the system, the overall architecture design, functional module division, and database table structure design of the system are completed. Adopting Browser/Server architecture and front-end and back-end separation mode and applying Java and Python programming language, based on spring framework and database, a multidimensional information management system for schizophrenia is designed and implemented, which includes four modules: data analysis, data management, system management, and security control. In addition, each functional module of the system is designed and implemented in detail, and the software operation flow of each module is illustrated with the sequence diagram. Finally, the multidimensional data of schizophrenia collected in our laboratory were used for system test to verify whether the system can meet the needs of clinical big data management of schizophrenia and the multidimensional information management system of schizophrenia can meet the needs of clinical big data management. The information management system helps schizophrenic researchers to carry out data management and data analysis. It also has advantages that are easy to use, safe, and efficient and has strong scalability in data management, data analysis, and scalability. It reflects the innovation of the system and provides a good platform for the management, research, and analysis of clinical big data of schizophrenia. (shrink)

Transcranial direct current stimulation has been widely utilized in research settings and modulates brain activity. The application of anodal tDCS on the prefrontal cortex has indicated improvement in cognitive functioning. The cingulate cortex, situated in the medial aspect of the prefrontal cortex, has been identified as a core region performing cognitive functions. Most of the previous studies investigating the impact of stimulation on the prefrontal cortex stimulated the dorsolateral prefrontal cortex, however, the impact of stimulation on cingulate has not been (...) explored. The current study investigates the effect of stimulation on the resting-state functional connectivity of the anterior cingulate cortex with other regions of the brain and changes in behavioral results in a color-word Stroop task, which has repeatedly elicited activation in different regions of the cingulate. Twenty subjects were randomly assigned to the experimental and sham group, and their medial prefrontal area was stimulated using MRI compatible tDCS. Resting-state functional magnetic resonance imaging and cognitive Stroop task were monitored before, during, and after the stimulation. Neuroimaging results indicated a significant decrease in resting-state functional connectivity in the experimental group during and after stimulation as compared to before stimulation in two clusters including right insular cortex, right central operculum cortex, right frontal operculum cortex and right planum polare with the left anterior cingulate cortex selected as the seed. The behavioral results indicated a significant decrease in reaction time following stimulation in the experimental group compared to the sham group. Moreover, the change in functional connectivity in subcortical regions with L-ACC as the seed and change in RT was positively correlated. The results demonstrated that ACC has a close functional relationship with the subcortical regions, and stimulation of ACC can modulate these connections, which subsequently improves behavioral performance, thus, providing another potential target of stimulation for cognitive enhancement.Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT04318522. (shrink)

The article is devoted to the functional-semantic category of inexpressible; its brief characteristics, the history of research in different countries and different sciences are given, the hierarchical organization of means of its expression is shown. The author of the article defines the specifics of the semantics of inexpressible in the story ‘The Seven Who Were Hanged‘ by L. Andreev. The semantics of inexpressible is described as the functional-semantic category. The description of the analytical and synthetic multi-level transmission means of semantics (...) of inexpressible is given: one-word, as part of indivisible combinations and in the word combinations that represent descriptive parts. Four significant results of studying the existence of elements of inexpressible in the analyzed novel have been defined. It was revealed that Andreev’s five of seven characters were marked with the markers of inexpressible. The following text function means of transmitting semantics of inexpressible were identified and characterized: characterological, actualization of content-conceptual information, actualization of means of expression, in particular, the antithesis; it was shown that this lexeme also actualizes the content-conceptual information and the antithesis of life and death in an art space story, is also a symbol of cross-cutting story. the interaction of semantics of inexpressible with the lexeme indicating the world of otherness - the unknown - was also revealed. The hypothesis is proved that the actualization of means of transmitting of semantics of inexpressible is due to the tasks posed in the story revealing the most important challenges of human’s life purpose, the interaction of life and death. (shrink)

GIS is important equipment in the substation system in a complex microgrid network. Due to the long-term service in harsh operation environments, the electrical performance of GIS equipment will be seriously affected. Therefore, the regular maintenance of GIS equipment in the substation system is a routine task so as to ensure the normal operation of the microgrid networks. The traditional method relies on manual labor, where not only with the low operation efficiency but also regarding some maintenance, labors cannot reach (...) the inside of the GIS equipment, which seriously restricted the completion of GIS equipment maintenance operation. Based on the above analysis, a basic configuration of a GIS equipment maintenance robot with smart structure, convenient control, and stable motion characteristic has been proposed in this paper. Through the optimization design of the chassis adsorption system, the GIS inspection robot can achieve hanging and vertical adsorption inside the GIS equipment and some special motion status. In this way, the entire GIS equipment can be inspected without blind spots. Through establishing the mechanical model of the GIS inspection robot under the hanging and vertical motion state, the robustness and stability of the GIS inspection robot in the special status have been analyzed, and the corresponding GIS inspection robot robust stability motion control method has also been proposed. Finally, through the integrated design of mechanical system and hardware and software control system, the GIS inspection robot physical prototype system has been developed and the maintenance operation experiment has been carried out in Hunan Electric Power Company Maintenance Company through simulating the internal GIS equipment. The physical prototype can realize the basic movement and special movement in internal GIS equipment without any blind spots and complete the inspection task of GIS equipment operation; the movement of GIS robot is dexterous and stable in the whole operation process, which has strong robust stability. The research of GIS inspection robot in the complex microgrid networks has important theoretical significance and practical application value for the intelligent operation and maintenance management of substation system in complex microgrid networks. (shrink)

Eudaimonia, Dao, and virtue -- Humanity : Xing and Ergon -- Virtue, mean, and disposition -- Habituation and ritualization -- Practical wisdom and appropriateness -- The highest good and the external goods -- The practical and the contemplative.

本书收录的文章按照四个主题进行了编排,分别是:世界历史与世界交往、马克思主义全球化理论建构、全球化与社会主义以及全球化理论的全球化等。.

本书从史学、文化学的角度对中国儒家伦理与商人精神进行探讨,文章有:《中国近世宗教伦理与商人精神》、《工业文明之精神基础》等。.

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

本书论文大多围绕对康德、黑格尔与马克思思想的反思而展开讨论,进行了“不应该把近代西方哲学与当代西方哲学简单地割裂开来,也不应该“将对西方哲学的研究和对马克思哲学的研究抽象地对立起来”的思考。.

Myelin oligodendrocyte glycoprotein antibody-associated disease is an immune-mediated demyelinating disease of the central nervous system that is present in both adults and children. The most common clinical manifestations are optic neuritis, myelitis, acute disseminated encephalomyelitis, and brainstem syndrome. Cerebral cortical encephalitis is a rare clinical phenotype of myelin oligodendrocyte glycoprotein antibody-associated disease, which usually begins with seizures, headaches, and fever, and may be misdiagnosed as viral encephalitis in the early stages. Herein, we report two typical MOG antibody -positive patients presenting (...) with CCE, both of whom presented with headache, fever, seizures, and who recovered completely after immunotherapy. In addition, we performed a systematic review of the present literature from the perspectives of population characteristics, clinical symptoms, MRI abnormalities, treatments, and prognosis. Among the patients reported in 25 articles, 33 met our inclusion criteria, with the age of onset ranging from 4 to 52 years. Most of the patients had seizures, headache, fever, and unilateral cortical lesions on brain MRI. For acute CCE, 30 patients were treated with high-dose intravenous methylprednisolone, and the symptoms of most patients were completely relieved after immunotherapy. This study reported our experience and lessons learned in the diagnosis and treatment of MOG-Ab-positive CCE and provides a systematic review of the literature to analyse this rare clinical phenotype. (shrink)

In _Xiong Shili’s Understanding of Reality and Function, 1920-1937_, SANG Yu presents a detailed examination and analysis of how Xiong Shili gradually established his philosophical system of Reality (_ti_) and Function (_yong_), a key conceptual polarity in traditional Chinese philosophy.

本书汇集了著名科学家、人文学者在中国科学院研究生院所做的有关科学前沿方面代表性的报告和讲座,内容涉及生物学、化学、农学、生态环境建设、可持续发展战略等。.

中国现代哲学是20世纪中国哲学变革和发展的重要时期,不少哲学家建立了自己独特的思想体系,对智慧问题予以高度重视。本书以中国现代哲学对形上智慧的追问和求索为主题,对中国现代哲学关于形而上学问题的理论发展 作了深入而清晰的梳理,并展示了其中的逻辑脉络。主要内容有科玄之争、知识和智慧、存在与天道、理智和直觉、名言之域与超名言之域、自由和境界等,着力对理气之辩、心物之辩、逻辑思维的辩证法、理性的直觉、可说的 和不可说的、思辩地说和诗意地说、天道和境界、自由和真善美等话题进行理性沉思。全书资料翔实、结构严谨、见解独特,是一部很有价值的学术专著,适合大学文科师生、哲学社会科学爱好者和研究者阅读使用。.

俞吾金(1948~ ),浙江萧山人,复旦大学哲学系教授、西方哲学学科点博士生导师.

本书详细追溯了方以智晚年的活动和他最后自沉于惶恐滩,通过他在明亡后的生活与思想,试图揭开当时遗民士大夫的精神世界的一角。.

本书分为九章,内容包括中西伦理思想概述,道德原则的分析与评价,几个重要的道德范畴,体现伦理价值的道德规范,完善人的道德等。.

本书作者通过对中国哲学史上的天、命、阴阳、五行、感应、时、经权、常变、新民、亲民等著名而重要的哲学概念、命题、观念的梳理,勾画出中国思维的基本品质。.

Antibiotic allergies are commonly reported among patients, but most do not experience reactions on rechallenge with the same agents. These reported allergies complicate management of infections in patients labelled as having penicillin allergy, including serious infections where penicillin-based antibiotics are the first-line (most effective and least toxic) treatment option. Allergy labels are rarely questioned in clinical practice, with many clinicians opting for inferior second-line antibiotics to avoid a perceived risk of allergy. Reported allergies thereby can have significant impacts on patients (...) and public health, and present major ethical challenges. Antibiotic allergy testing has been described as a strategy to circumvent this dilemma, but it carries limitations that often make it less feasible in patients with acute infections or in community settings that lack access to allergy testing. This article provides an empirically informed ethical analysis of key considerations in this clinical dilemma, usingStaphylococcus aureusbacteraemia in patients with penicillin allergies as a case study. We argue that prescribing first-line penicillin-based antibiotics to patients with reported allergies may often present a more favourable ratio of benefits to risks, and may therefore be more ethically appropriate than using second-line drugs. We recommend changes to policy-making, clinical research and medical education, in order to promote more ethically acceptable responses to antibiotic allergies than the status quo. (shrink)

This paper aims to explore the appropriation of Deleuzian literary theory in the Chinese context and its potential for mapping a new global poetics. The purpose of this treatment is thus twofold: first, it will redefine the East–West literary relationship, and second, it will seek a new ethics of life, as endorsed by Deleuze's philosophy of immanence. One finds an affinity between literature and life in Deleuze's philosophy: in short, literature appears as the passage of life and an enterprise of (...) health and thus seeks new possibilities of life, which consists in the invention of a new language and a new people. But what kind of health may such a view provide for a non-Western individual, people, literature and culture? This investigation further appeals to the medium of translation. This paper argues that the act of translation functions as a means of deterritorialisation that displays continuing variations of a language, and through translation, Deleuze's clinical and critical aspects of literature promote a transversal poetics that transcends the binary, oppositional conception of East–West and an immanent ethics of life that overcomes the sentiment of ressentiment. (shrink)

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...) stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli. (shrink)