Brandon ([1982] 1984, 1990) has argued that Salmon's (1971) concept of screening-off can be used to characterize (i) the idea that natural selection acts directly on an organism's phenotype, only indirectly on its genotype, and (ii) the biological problem of the levels of selection. Brandon also suggests (iii) that screening-off events in a causal chain are better explanations than the events they screen off. This paper critically evaluates Brandon's proposals.

We begin by considering two principles, each having the form causal completeness ergo screening-off. The first concerns a common cause of two or more effects; the second describes an intermediate link in a causal chain. They are logically independent of each other, each is independent of Reichenbach's principle of the common cause, and each is a consequence of the causal Markov condition. Simple examples show that causal incompleteness means that screening-off may fail to obtain. We derive a stronger (...) result: in a rather general setting, if the composite cause C1 & C2 & … & Cn screens-off one event from another, then each of the n component causes C1, C2, …, Cn must fail to screen-off. The idea that a cause may be ordinally invariant in its impact on different effects is defined; it plays an important role in establishing this no-go theorem. Along the way, we describe how composite and component causes can all screen-off when ordinal invariance fails. We argue that this theorem is relevant to assessing the plausibility of the two screening-off principles. The discovery of incomplete causes that screen-off is not evidence that causal completeness must engender screening-off. Formal and epistemic analogies between screening-off and determinism are discussed. (shrink)

Is evidential support transitive? The answer is negative when evidential support is understood as confirmation so that X evidentially supports Y if and only if p(Y | X) > p(Y). I call evidential support so understood “support” (for short) and set out three alternative ways of understanding evidential support: support-t (support plus a sufficiently high probability), support-t* (support plus a substantial degree of support), and support-tt* (support plus both a sufficiently high probability and a substantial degree of support). I also (...) set out two screening-off conditions (under which support is transitive): SOC1 and SOC2. It has already been shown that support-t is non-transitive in the general case (where it is not required that SOC1 holds and it is not required that SOC2 holds), in the special case where SOC1 holds, and in the special case where SOC2 holds. I introduce two rather weak adequacy conditions on support measures and argue that on any support measure meeting those conditions it follows that neither support-t* nor support-tt* is transitive in the general case, in the special case where SOC1 holds, or in the special case where SOC2 holds. I then relate some of the results to Douven’s evidential support theory of conditionals along with a few rival theories. (shrink)

Eells and Sober proved in 1983 that screening off is a sufficient condition for the transitivity of probabilistic causality, and in 2003 Shogenji noted that the same goes for probabilistic support. We start this paper by conjecturing that Hans Reichenbach may have been aware of this fact. Then we consider the work of Suppes and Roche, who demonstrated in 1986 and 2012 respectively that screening off can be generalized, while still being sufficient for transitivity. We point out an (...) interesting difference between Reichenbach’s screening off and the generalized version, which we illustrate with an example about haemophilia among the descendants of Queen Victoria. Finally, we embark on a further generalization: we develop a still weaker condition, one that can be made as weak as one wishes. (shrink)

Sober and Brandon et al. disagree about the role of screening-off in the appraisal of theories of natural selection. Some problems disregarded by them are unearthed in this discussion note.

The notion of probabilistic support is beset by well-known problems. In this paper we add a new one to the list: the problem of transitivity. Tomoji Shogenji has shown that positive probabilistic support, or confirmation, is transitive under the condition of screening off. However, under that same condition negative probabilistic support, or disconfirmation, is intransitive. Since there are many situations in which disconfirmation is transitive, this illustrates, but now in a different way, that the screening-off condition is too (...) restrictive. We therefore weaken this condition to what we call ‘partial’ screening off. We show that the domain defined by partial screening off comprises two mutually exclusive subdomains. In one subdomain disconfirmation is indeed transitive, but confirmation is then intransitive. In the other, confirmation is transitive, but here disconfirmation is once more intransitive. (shrink)

Sober and Brandon et al. disagree about the role of screening-off in the appraisal of theories of natural selection. Some problems disregarded by them are unearthed in this discussion note.

Sober and Brandon et al. disagree about the role of screening-off in the appraisal of theories of natural selection. Some problems disregarded by them are unearthed in this discussion note.

Sober and Brandon et al. disagree about the role of screening-off in the appraisal of theories of natural selection. Some problems disregarded by them are unearthed in this discussion note.

It is well known that the probabilistic relation of confirmation is not transitive in that even if E confirms H1 and H1 confirms H2, E may not confirm H2. In this paper we distinguish four senses of confirmation and examine additional conditions under which confirmation in different senses becomes transitive. We conduct this examination both in the general case where H1 confirms H2 and in the special case where H1 also logically entails H2. Based on these analyses, we argue that (...) the Screening-Off Condition is the most important condition for transitivity in confirmation because of its generality and ease of application. We illustrate our point with the example of Moore’s “proof” of the existence of a material world, where H1 logically entails H2, the Screening-Off Condition holds, and confirmation in all four senses turns out to be transitive. (shrink)

This chapter explains the screening‐off rule in the psychological laboratory. The Markov assumption states that any variable in a set is independent in probability of all its ancestors in the set conditional on its own parents. The screening‐off rule is also critical to allow Bayes nets to make an inference of the state of an unknown variable in a causal structure from the states of other variables in that structure. The chapter examines which causal representations people use to (...) make predictions and whether people conform to the screening‐off rule with respect to a causal model they have in mind. It analyzes what leads them to modify their causal model and whether or not people are causally oriented when making predictions. Making probability judgments is hard and requires careful deliberation. People are capable of such deliberation although they avoid it until they cannot, until the facts require more careful thought. (shrink)

In The Levels of Selection (Brandon, 1984), Robert Brandon provides a suggestive but ultimately unsuccessful attempt to use the probabilistic notion ofscreening off in providing a schema for dealing with an aspect of the units of selection question in the philosophy of biology. I characterize that failure, and suggest a revision and expansion of Brandon's account which addresses its key shortcoming.

Philosophers have used the probabilistic relation of ’screening-off‘ to explicate concepts in the theories of causation and explanation. Brandon has used screening-off relations in an attempt to reconstruct an argument of Mayr and Gould that natural selection acts at the level of the organism. I argue that Brandon‘s reconstruction is unsuccessful.

It is well known that the probabilistic relation of confirmation is not transitive in that even if E confirms H1 and H1 confirms H2, E may not confirm H2. In this paper we distinguish four senses of confirmation and examine additional conditions under which confirmation in different senses becomes transitive. We conduct this examination both in the general case where H1 confirms H2 and in the special case where H1 also logically entails H2. Based on these analyses, we argue that (...) the Screening-Off Condition is the most important condition for transitivity in confirmation because of its generality and ease of application. We illustrate our point with the example of Moore’s ‘‘proof’’ of the existence of a material world, where H1 logically entails H2, the Screening-Off Condition holds, and confirmation in all four senses turns out to be transitive. (shrink)

I present a puzzle about the epistemic role beliefs about experts' beliefs play in a rational agent's system of beliefs. It is shown that accepting the claim that an expert's degree of belief in a proposition, A, screens off the evidential support another proposition, B, gives to A in case the expert knows and is certain about whether B is true, leads in some cases to highly unintuitive conclusions. I suggest a solution to the puzzle according to which evidential (...) class='Hi'>screening off is rejected, but show that the price of this solution is either giving up on the mere idea of deferring to expert's opinion or giving up on Bayesian conditionalization. (shrink)

I argue elsewhere (Roche 2014) that evidence of evidence is evidence under screening-off. Tal and Comesaña (2017) argue that my appeal to screening-off is subject to two objections. They then propose an evidence of evidence thesis involving the notion of a defeater. There is much to learn from their very careful discussion. I argue, though, that their objections fail and that their evidence of evidence thesis is open to counterexample.

Sober (1992) has recently evaluated Brandon's (1982, 1990; see also 1985, 1988) use of Salmon's (1971) concept of screening-off in the philosophy of biology. He critiques three particular issues, each of which will be considered in this discussion.

We argue in Roche and Sober (2013) that explanatoriness is evidentially irrelevant in that Pr(H | O&EXPL) = Pr(H | O), where H is a hypothesis, O is an observation, and EXPL is the proposition that if H and O were true, then H would explain O. This is a “screening-off” thesis. Here we clarify that thesis, reply to criticisms advanced by Lange (2017), consider alternative formulations of Inference to the Best Explanation, discuss a strengthened screening-off thesis, and (...) consider how it bears on the claim that unification is evidentially relevant. (shrink)

This paper sets out a novel response to the ‘screening off problem’ for naïve realism. The aim is to resist the claim (which many naïve realists accept) that the kind of experience involved in hallucinating also occurs during perception, by arguing that there are causal constraints that must be met if an hallucinatory experience is to occur that are never met in perceptual cases. Notably, given this response, it turns out that, contra current orthodoxy, naïve realists need not adopt (...) any particular view about the psychological nature of hallucinatory experience to handle the screening off problem. Consequently, room opens up for naïve realists to endorse whatever theory of hallucinatory experience seems to best capture the distinctive nature of such episodes. (shrink)

This paper explains a flaw I find in Michael Martin's argument for the view that the phenomenal properties of a hallucination are its being indiscriminable from a certain sort of veridical perception. The argument relies, I argue, on the assumption that if a certain broad mental property sometimes has a certain narrow realizer, it never has any other narrow realizer. This assumption is false. Accordingly, the argumentation fails to rule out "positive multidisjunctivism": the fundamental kind of the veridical experience is (...) a broad property, while some matching hallucinations are subjective and others are intentional. (shrink)

Naïve realism is the view that veridical experiences are fundamentally relations of acquaintance to external objects and their features, and multidisjunctivism is the conjunction of naïve realism and the view that hallucinatory experiences don’t share a common fundamental kind. Multidisjunctivism allegedly removes the screening-off worry over naïve realism, and the relevant literature suggests that multidisjunctivism is one of the naïve realist responses to the worry. The present paper argues that the multidisjunctive solution is implicitly changing the subject, so the (...) impression that the multidisjunctivist is addressing the screening-off problem is illusory. (shrink)

My Ph.D. dissertation written under the supervision of Prof. Tomasz Placek at the Institute of Philosophy of the Jagiellonian University in Kraków. In one of its most basic and informal shapes, the principle of the common cause states that any surprising correlation between two factors which are believed not to directly influence one another is due to their common cause. Here we will be concerned with a version od this idea which possesses a purely probabilistic formulation. It was introduced, in (...) the form of a general principle, by Hans Reichenbach in his posthumously published book "The Direction of Time". The central notion of the principle in Reichenbach's formulation, and of the current essay, is that of screening off: two correlated events are screened off by a third event if conditioning on the third event makes them probabilistically independent. Reichenbach's principle marks also the beginning of a new field of philosophy: namely, that of ``probabilistic causality''. For the most part, the current essay can be seen as an effort at checking how far one can go with the purely statistical notions revolving around Reichenbach's idea of common cause. In short, the answer is ``surprisingly far''; in some classes of probability spaces all correlations between ``interesting'' events possess explanations of such sort. However, this fact lends itself to opposing interpretations; more on that in the conclusion. Chapters 6 and 7 contain mathematical results concerning these issues. The screening-off condition requires an equality of a probabilistic nature to hold; chapter 8 is a short discussion of slightly weakened versions of the condition, which hold if the sides of the above mentioned equality differ to a small degree. In chapter 2, after some mathematical preliminaries, we study the various formulations of the principle which might be said to stem from the original idea of Reichenbach. We also examine a few of the most salient counterarguments, which undermine at least some of the formulations. Chapter 3 is of a formal nature, dealing with various probabilistic notions which can be thought of as generalizations of Reichenbach's concept of common cause. The next chapter concerns the relationship between the idea of common causal explanation and the Bell inequalities. In chapter 5 we briefly present the form of Reichenbach's principle which can be found in the field of representing causal structures by means of directed acyclic graphs. (shrink)

In a pair of articles (1996, 1997) and in his recent book (1998), Miklos Redei has taken enormous strides toward characterizing the conditions under which relativistic quantum field theory is a safe setting for the deployment of causal talk. Here, we challenge the adequacy of the accounts of causal dependence and screening off on which rests the relevance of Redei's theorems to the question of causal good behavior in the theory.

We introduce a ``rarity of defeat'' principle, valid in cases of deference to an expert, to address intuitions involved in a puzzle of Nissan-Rozen concerning epistemic deference and evidential screening-off.

An important question in the current debate on the epistemic significance of peer disagreement is whether evidence of evidence is evidence. Fitelson argues that, at least on some renderings of the thesis that evidence of evidence is evidence, there are cases where evidence of evidence is not evidence. I introduce a condition and show that under this condition evidence of evidence is evidence.

In a pair of articles and in his recent book, Miklos Redei has taken enormous strides toward characterizing the conditions under which relativistic quantum field theory is a safe setting for the deployment of causal talk. Here, we challenge the adequacy of the accounts of causal dependence and screening off on which rests the relevance of Redei's theorems to the question of causal good behavior in the theory.

The Principle of common cause has its significance in providing explanations of phenomena in terms of causal theories. Though the principle has its own epistemological advantages, there can be certain situations where the principle might fail. In the first part of the paper, I offer a preliminary assessment of the PCC and then I turn to make an attempt to illustrate those scenarios where the PCC might misguide us in providing explanation of phenomena in terms of common cause.

The Principle of Common Cause (PCC) puts forward the idea that events which occur simultaneously and are correlated have a prior common cause which screens off the correlation. I endorse the view that the PCC does qualify as a principle that can be used as a tool in explaining improbable coincidences. However, though there are epistemological advantages in common cause explanations of correlated events, the PCC is not impeccable. This paper offers a preliminary assessment of the PCC advocated by Reichenbach, (...) and then attempts to illustrate three scenarios in which the principle might be inadequate in explaining correlated events. The paper also compares the Common Cause Principle and the Causal Markov Condition (CMC), and examines the advantages of CMC over the Common Cause Principle. (shrink)

On the origin of film and the resurrection of the people : D.W. Griffith's Intolerance -- The actor of the crowd : The great dictator -- Howard Hawks' idea of genre -- What is a cinema of Jewish vengeance? : Tarantino's Inglourious basterds.

This case describes the background of cigarette product placement in commercial movies and the emergence of the Smoke Free Movies Initiative. It draws onresearch by tobacco control activists on the impact of smoking in movies on youth smoking initiation. Voluntary and mandated restrictions on the use of cigarettes in film productions are discussed. Historic documents from tobacco industry archives reveal the explicit goals and intentions of tobacco companies to use films to market their products to unsuspecting observers.

In “Risk Based Passenger Screening in Aviation Security: Implications and Variants of a New Paradigm”, Sebastian Weydner-Volkmann describes the current paradigm shift from ‘traditional’ forms of screening to ‘risk based passenger screening’ (RBS) in aviation security. This paradigm shift is put in the context of the wider historical development of risk management approaches. Through a discussion of Michel Foucault, Herfried Münkler and Ulrich Beck, Weydner-Volkmann analyses the shortcomings of such approaches in public security policies, which become especially (...) evident in the aviation security context. As he shows, the turn towards methods of RBS can be seen as an attempt to address a trade-off ‘trilemma’ between the effective provision of security, the implied costs for industry and passengers, and the ethical, legal and societal implications of the screening procedures. In order to analyse foreseeable outcomes of embracing RBS, he differentiates three prototypical variants of the new paradigm on the basis of their main referent and rationale. For each variant, he then subsequently assesses the implications for the ‘trilemma’, after having unveiled the criteria of analysis that will necessarily have to be followed within a serious appraisal of RBS methods. (shrink)

Whether ethical screening affects portfolio performance is an important question that is yet to be settled in the literature. This paper aims to shed further light on this question by examining the performance of a large global sample of Islamic equity funds from 1984 to 2010. We find that IEFs underperform conventional funds by an average of 40 basis points per month, consistent with the underperformance hypothesis. In line with popular media claims that Islamic funds are a safer investment, (...) IEFs outperformed conventional funds during the recent banking crisis. However, we find no such outperformance for other crises or high volatility periods. Based on fund holdings-based data, we provide evidence of a negative curvilinear relation between fund performance and ethical screening intensity, consistent with a return trade-off to being more ethical. (shrink)

Studies of mediation practices typically focus on parental mediation, but during adolescence parents’ impact decreases relative to that of peers. This study compares perceived parental and peer mediation in the context of media portrayals of risk behavior and adolescents’ perceptions thereof. A cross-sectional survey was conducted among 278 adolescents aged 12 to 17 (M = 14.18, SD = 1.62, 51.4 % girls) using Hayes’s process macro (model 4) to investigate direct and indirect associations between mediation, media-related cognitions, and social norms. (...) Findings indicate that perceived parental and peer mediation are related to adolescents’ media-related cognitions and perceived social norms in equally important but different ways. (shrink)

Background: Poverty and social deprivation have adverse effects on health outcomes and place a significant burden on healthcare systems. There are some actions that can be taken to tackle them from within healthcare institutions, but clinicians who seek to make frontline services more responsive to the social determinants of health and the social context of people’s lives can face a range of ethical challenges. We summarise and consider a case in which clinicians introduced a poverty screening initiative into paediatric (...) practice using the discourse and methodology of healthcare quality improvement. -/- Discussion: Whilst suggesting that interventions like the PSI are a potentially valuable extension of clinical roles, which take advantage of the unique affordances of clinical settings, we argue that there is a tendency for such settings to continuously reproduce a narrower set of norms. We illustrate how the framing of an initiative as QI can help legitimate and secure funding for practical efforts to help address social ends from within clinical service, but also how it can constrain and disguise the value of this work. A combination of methodological emphases within QI and managerialism within healthcare institutions leads to the prioritisation, often implicitly, of a limited set of aims and governing values for healthcare. This can act as an obstacle to a genuine broadening of the clinical agenda, reinforcing norms of clinical practice that effectively push poverty ‘off limits.’ We set out the ethical dilemmas facing clinicians who seek to navigate this landscape in order to address poverty and the social determinants of health. -/- Conclusions: We suggest that reclaiming QI as a more deliberative tool that is sensitive to these ethical dilemmas can enable managers, clinicians and patients to pursue health-related values and ends, broadly conceived, as part of an expansive range of social and personal goods. (shrink)

November 2009’s announcement of the USPSTF’s recommendations for screening for breast cancer raised a firestorm of objections. Chief among them were that the panel had insufficiently valued patients’ lives or allowed cost considerations to influence recommendations. The publicity about the recommendations, however, often either simplified the actual content of the recommendations or bypassed significant methodological issues, which a philosophical examination of both the science behind screening recommendations and their import reveals. In this article, I discuss two of the (...) leading ethical considerations at issue in screening recommendations: respect for patient autonomy and beneficence and then turn to the most significant methodological issues raised by cancer screening: the potential biases that may infect a trial of screening effectiveness, the problem of base rates in communicating risk, and the trade-offs involved in a judgment of screening effectiveness. These issues reach more broadly, into the use of “evidence-based” medicine generally, and have important implications for informed consent. (shrink)

Cartwright (Synthese 121(1/2):3–27, 1999a; The dappled world, Cambridge University Press, Cambridge, 1999b) attacked the view that causal relations conform to the Markov condition by providing a counterexample in which a common cause does not screen off its effects: the prominent chemical factory. In this paper we suggest a new way to handle counterexamples to Markov causation such as the chemical factory. We argue that Cartwright’s as well as similar scenarios feature a certain kind of non-causal dependence that kicks in once (...) the common cause occurs. We then develop a representation of this specific kind of non-causal dependence that allows for modeling the problematic scenarios in such a way that the Markov condition is not violated anymore. (shrink)

Probably the main purpose of reproductive technologies is to enable people who choose to do so to avoid the birth of a baby with a disabling condition. However the conditions women want information about and the ‘price’ they are willing to pay for obtaining that information vary enormously. Individual women have to arrive at their own prenatal testing choices by ‘trading off’ means and ends in order to resolve the dilemmas facing them. We know very little about how individuals make (...) these trade-offs, so it is difficult to predict how new technologies will affect their choices and preferences. Uptake decisions can be expected to change, especially in the group of women who now are put off by some aspect of the current screening approach, where the avoidance of miscarriage risk may have provided a kind of ‘psychological shelter’, protecting a lot of people from having to make other decisions. Technologies such as Pre-implantation Genetic Diagnosis may remove a second ‘psychological shelter’ because they offer the means of avoiding the birth of an affected child without terminating a pregnancy. Even if new technologies will make some decisions easier in terms of their cognitive demands, they will also create new dilemmas and decision making will not necessarily become less stressful in emotional terms. Key challenges concern information and decision-making. (shrink)

We argued that explanatoriness is evidentially irrelevant in the following sense: Let H be a hypothesis, O an observation, and E the proposition that H would explain O if H and O were true. Then our claim is that Pr = Pr. We defended this screening-off thesis by discussing an example concerning smoking and cancer. Climenhaga argues that SOT is mistaken because it delivers the wrong verdict about a slightly different smoking-and-cancer case. He also considers a variant of SOT, (...) called “SOT*”, and contends that it too gives the wrong result. We here reply to Climenhaga’s arguments and suggest that SOT provides a criticism of the widely held theory of inference called “inference to the best explanation”. (shrink)

Relationalism is the view that perception is partly constituted by external objects (McDowell 1994; Campbell 2002; Martin 2004). Faced with the hallucination argument, and unsatisfied with the standard disjunctivist reply, some ‘new wave’ relationalists explain away the possibility of hallucinations as mere illusions (Alston 1999; Watzl 2010; Ali 2018; Masrour 2020). In this paper, I argue that some of these illusions (as in Chalmers 2005; Ali 2018) are perceptions of internal objects which appear as external ones. Then, in response to (...) the obvious screening-off objection, I argue for a novel reply called ‘intrameralism’: roughly, external objects are ordinarily perceived because they gain internal parts—they ‘grow into the head’. The preceding hallucinations are thus ultimately explained away as a kind of perceptual synecdoche, in which internal parts appear as their (ordinarily perceived) external wholes. The paper concludes by addressing some objections. (shrink)

This paper aims at offering a new disjunctivist solution – anomalous disjunctivism – to the screening-off problem. Anomalous disjunctivism focuses on the necessary causal conditions for perception and hallucination. It argues that the proximate cause is contingent on causing a particular kind of sensory experience that can either be perceptual or hallucinatory. It further shows that the perceived thing is a necessary causal condition for perceptual experience and the failure of perception is a necessary causal condition for the hallucinatory (...) counterpart. It is the case that any account of a hallucinatory experience relies on the nature of hallucination, and, therefore, the anti-naïve realist has to agree that the necessary causal condition matters. As a consequence, whatever account we take for a hallucination, it need not apply to its perceptual counterpart. The screening-off problem, thereby, is dissolved. (shrink)

Alzheimer's disease is characterized by formation of neuritic plaque primarily composed of a small filamentous protein called amyloid-beta peptide . The rate-limiting step in the production of Abeta is the processing of Abeta precursor protein by beta-site APP-cleaving enzyme . Hence, BACE1 activity plausibly plays a rate-limiting role in the generation of potentially toxic Abeta within brain and the development of AD, thereby making it an interesting drug target. A phase II trial of the promising LY2886721 inhibitor of BACE1 was (...) suspended in June 2013 by Eli Lilly and Co., due to possible liver toxicity. This outcome was apparently a surprise to the study's team, particularly since BACE1 knockout mice and mice treated with the drug did not show such liver toxicity. Lilly proposed that the problem was not due to LY2886721 anti-BACE1 activity. We offer an alternative hypothesis, whereby anti-BACE1 activity may induce apparent hepatotoxicity through inhibiting BACE1's processing of beta-galactoside alpha-2,6-sialyltransferase I . In knockout mice, paralogues, such as BACE2 or cathepsin D, could partially compensate. Furthermore, the short duration of animal studies and short lifespan of study animals could mask effects that would require several decades to accumulate in humans. Inhibition of hepatic BACE1 activity in middle-aged humans would produce effects not detectable in mice. We present a testable model to explain the off-target effects of LY2886721 and highlight more broadly that so-called off-target drug effects might actually represent off-site effects that are not necessarily off-target. Consideration of this concept in forthcoming drug design, screening, and testing programs may prevent such failures in the future. (shrink)

As is well known, implication is transitive but probabilistic support is not. Eells and Sober, followed by Shogenji, showed that screening off is a sufficient constraint for the transitivity of probabilistic support. Moreover, this screening off condition can be weakened without sacrificing transitivity, as was demonstrated by Suppes and later by Roche. In this paper we introduce an even weaker sufficient condition for the transitivity of probabilistic support, in fact one that can be made as weak as one (...) wishes. We explain that this condition has an interesting property: it shows that transitivity is retained even though the Simpson paradox reigns. We further show that by adding a certain restriction the condition can be turned into one that is both sufficient and necessary for transitivity. (shrink)

Atrial fibrillation is the most common cardiac arrhythmia in clinical practice. It often starts with asymptomatic and short episodes, which are difficult to detect without the assistance of automatic monitoring tools. The vast majority of methods proposed for this purpose are based on quantifying the irregular ventricular response during the arrhythmia. However, although AF totally alters the atrial activity reflected on the electrocardiogram, replacing stable P-waves by chaotic and time-variant fibrillatory waves, this information has still not been explored for automated (...) screening of AF. Hence, a pioneering AF detector based on quantifying the variability over time of the AA morphological pattern is here proposed. Results from two public reference databases have proven that the proposed method outperforms current state-of-the-art algorithms, reporting accuracy higher than 90%. A less false positive rate in the presence of other arrhythmias different from AF was also noticed. Finally, the combination of this algorithm with the classical analysis of RR series variability also yielded a promising trade-off between AF accuracy and detection delay. Indeed, this combination provided similar accuracy than RR-based methods, but with a significantly shorter delay of 10 beats. (shrink)

This paper makes explicit the basic problem perfect hallucinations pose for perceptual naive realists, more fundamental than the well‐trodden Screening‐off Problem. The deeper problem offers the basis for an overarching classification of the available naive‐ realist‐friendly approaches to perfect hallucinations. In the course of laying out the challenges to the different types of response, the paper makes a case for the superiority of a particular approach to perfect hallucinations, on which they would be understood as a special kind of (...) perceptual anomaly—arising from a secondary mode of perceptual processing. (shrink)

Generalized anxiety disorder can cause significant socioeconomic burden and daily life dysfunction; hence, therapeutic intervention through early detection is important. This study was the final stage of a 3-year anxiety screening tool development project that evaluated the psychometric properties and diagnostic screening utility of the Mental Health Screening Tool for Anxiety Disorders, which measures GAD. A total of 527 Koreans completed online and offline versions of the MHS: A, Beck Anxiety Inventory, Generalized Anxiety Disorder-7, and Penn State (...) Worry Questionnaire. The participants had an average age of 38.6 years and included 340 females. Participants were also administered the Mini-International Neuropsychiatric Interview. Internal consistency, convergent/criterion validity, item characteristics, and test information were assessed based on the item response theory, and a factor analysis and cut-off score analyses were conducted. The MHS: A had good internal consistency and good convergent validity with other anxiety scales. The two versions of the MHS: A were nearly identical. It had a one-factor structure and showed better diagnostic accuracy for GAD detection than the GAD-7 and BAI. The IRT analysis indicated that the MHS: A was most informative as a screening tool for GAD. The MHS: A can serve as a clinically useful screening tool for GAD in Korea. Furthermore, it can be administered both online and offline and can be flexibly used as a brief mental health screener, especially with the current rise in telehealth. (shrink)

How do human infants learn the causal dependencies between events? Evidence suggests that this remarkable feat can be achieved by observation of only a handful of examples. Many computational models have been produced to explain how infants perform causal inference without explicit teaching about statistics or the scientific method. Here, we propose a spiking neuronal network implementation that can be entrained to form a dynamical model of the temporal and causal relationships between events that it observes. The network uses spike-time (...) dependent plasticity, long-term depression, and heterosynaptic competition rules to implement Rescorla–Wagner-like learning. Transmission delays between neurons allow the network to learn a forward model of the temporal relationships between events. Within this framework, biologically realistic synaptic plasticity rules account for well-known behavioral data regarding cognitive causal assumptions such as backwards blocking and screening-off. These models can then be run as emulators for state inference. Furthermore, this mechanism is capable of copying synaptic connectivity patterns between neuronal networks by observing the spontaneous spike activity from the neuronal circuit that is to be copied, and it thereby provides a powerful method for transmission of circuit functionality between brain regions. (shrink)

The most serious candidates for common causes that fail to screen off and thus violate the causal Markov condition refer to quantum phenomena. In her seminal debate with Hausman and Woodward, Cartwright early on focussed on unfortunate non-quantum examples. Especially, Hausman and Woodward’s redescriptions of quantum cases saving the CMC remain unchallenged. This paper takes up this lose end of the discussion and aims to resolve the debate in favour of Cartwright’s position. It systematically considers redescriptions of ICC structures, including (...) those by Hausman and Woodward, and explains why these are inappropriate, when quantum mechanics is true. It first shows that all cases of purported quantum ICCs are cases of entanglement and then, using the tools of causal modelling, it provides an analysis of the quantum mechanical formalism for the case that the collapse of entangled systems is best described as a causal model with an ICC. (shrink)