In lieu of an abstract, here is a brief excerpt of the content:The Courage To LiveAntonella ColaceI am not the patient. I have not received an organ. I am her mother; I am a shadow patient. My responsibility was to make decisions about a gift for my one-year-old daughter in the summer of 2007. A liver.Elisa had a hepatoblastoma. After chemotherapy, the tumor might have been removed, but in the final stages of the work-up a portal vein malformation necessitated a (...) transplant. The medical team at a hospital in northern Italy informed us of the intervention.So many words! Trying to understand what they were saying seemed like a lost cause to me, but I quickly realized that these were people I should trust blindly.These medical team members, by the end of the experience, would all become part of my family. They embraced us in their capacity as professionals and as human beings. I never felt alone or excluded.How many times late in the evening I heard a soft knock at the door of Elisa’s hospital room and behind that delicate touch, I found her doctor ready to leave for home, but not before one last [End Page 131] recommendation for his little patient and a wish of peaceful sleep.The relationship between health workers and the family has developed into an effective relationship of communion and understanding, which has often translated into affectionate terms in communicating with each other. They asked me: “Mom, how is Elisa?”..... Yes—mom!These highly trained medical experts have understood that a parent can sometimes somehow discern the danger behind the otherwise asymptomatic daughter’s subdued attitude; or a surreptitiously high fever, of little concern because Elisa was playing and laughing.I was made to feel an active part of every initiative and decision. My observation point on Elisa, who could not speak for herself, was fundamental for them.I never experienced the hospital as a hostile environment—quite the contrary!It comforted me to have people around us, ready to intervene, reason, and solve the physiological difficulties of my little girl. The hospital was a room in my house, a room whose door was always ajar and in need, I crossed its threshold full of trust, hope, and courage.Today some of those doctors and nurses are my friends. I have a lot of respect for them, gratitude, and admiration.Elisa being placed on the transplant list and waiting for a donor were the first obstacles to overcome.The “warrior” fought against two monsters, time and the tumor. The timing was everything because Elisa had to be in the period of non-toxicity after chemotherapy but could not wait too many weeks without active therapy in favor of a cancer that, lurking like a vulture, was only waiting for the ideal moment to start growing again.The most dramatic thing to overcome and accept was hoping for someone’s death. For Elisa to live, someone else had to die. I felt like an executioner. I didn’t think of anything else; I didn’t sleep at night.In the end, choosing to visualize death as a gift, I had to accept it.It was summer, on August 20th, and another hot and boring night in hospital awaited us. The nurse came into the room to tell me that our lottery ticket had won that night. There was a compatible liver for Elisa. The organ would come from a young woman who had died while swimming in the Sicilian Sea.If they had stabbed me at that moment, maybe not a drop of blood would have left my body. I was paralyzed, incredulous, terrified.My daughter had already been operated on, but it would be different this time. This time they would open her abdomen to remove her diseased liver and replace it with that of a dead young woman, by now sealed in a body bag in a Sicilian morgue. A cold body, deaf now, silent!A young woman for whom, while I was rejoicing, some other shadow patient was despairing, caught up in an unstoppable whirlwind of pain.I felt like throwing up while I cried tears of joyful hope. Guilt grew in my... (shrink)

_Treating Dissociative and Personality Disorders_ draws on major theorists and the very latest research to help formulate and introduce the Relational/Multi-Motivational Therapeutic Approach, a new model for treating such patients within a clinical psychoanalytic setting. Supported by her fellow contributors, Antonella Ivaldi provides an overview of existing theories and evidence for their effectiveness in practice, sets out her own theory in detail and provides rich clinical detail to demonstrate the advantages of the REMOTA model as applied in a clinical (...) setting. The narratives in this book show how it is possible to integrate different contributions within a multidimensional aetiopathogenic treatment model, which considers the mind as a manifestation of the relationship between body and world. From a conceptual perspective, according to which consciousness emerges and develops in the interpersonal dimension, this book shows how it becomes possible to understand, in the therapeutic space, what stands in the way of sound personal functioning, and how to create the conditions for improving this. Treating Dissociative and Personality Disorders will be highly useful in addressing the particular clusters of symptoms presented by patients, stimulating therapists of different backgrounds to explore the complexity of human nature. On reading this book, it will become clear that theories can truly become useful instruments, if approached with a critical mind and with humbleness, in order to venture into what we do not know and will never know completely: the relationship with the other, unique and irreplaceable. Treating Dissociative and Personality Disorders provides an integrative and comparative new approach that will be indispensable for combining relational clinical knowing and motivational theories. It_ _will appeal to psychoanalysts and psychotherapists, especially those in training, clinicians of different backgrounds interested in comparative psychotherapy, as well as social workers and graduate and postgraduate students. (shrink)

The chapter discusses the issue of how we may achieve knowledge of essence. It offers a critical survey of the main theories of knowledge of essence that have been proposed within contemporary debates, particularly by Lowe, Hale, Oderberg, Elder, and Kment.

This article aims to address challenges of translating emerging scientific technologies into legal terms and incorporate them into the existing North American regulatory regimes. A lack of full scientific knowledge about nanomedicine technologies results in the lack of development in legal discourse to describe products and to clearly set legal standards on their safety and efficacy. The increasing complexity and hybrid nature of technologies negatively impact the functionality of “law in action” leading to a legal uncertainty and ultimately to a (...) public distrust. Nanomedicine is an illustrative example of how law lags behind increasingly fast-paced scientific technologies making it difficult to find a balance between innovation and safety. This article argues that the boundary crossing nature of nanomedicine through different domains of science triggers a methodological and epistemological debate within science and law, suggesting that a critical revision is required in our traditional methods to learn, create, and categorize knowledge from breakthrough scientific advances. The highly disruptive nature of nanomedicine places stress on traditional conceptual frameworks, classifications of knowledge, and existing regulations. The legal challenge to identify definitions or to classify nanoapplications brings to light a conceptual vacuum surrounding nanomedicine. Moving away from confusing policies and obsolete classificatory models, this article suggests to undertake changes that are only the first steps of a more in-depth “epistemological transformation” that addresses knowledge as the process of not only gathering data, but also, as the process of elaborating new conceptual bases to better fulfill the legal language and facilitate the legal task of finding definitions and formulating criteria more adherent with scientific advances. This should compel regulators to explore new paradigms and develop new methodologies to evaluate data on nanomedicine applications in order to provide sustainable bases for a responsible development of nanomedicine. (shrink)

Temporal binding is the phenomenon in which events related as cause and effect are perceived by humans to be closer in time than they actually are). Despite the fact that temporal binding experiments with humans have relied on verbal instructions, we argue that they are adaptable to nonhuman animals, and that a finding of temporal binding from such experiments would provide evidence of causal reasoning that cannot be reduced to associative learning. Our argument depends on describing and theoretically motivating an (...) intermediate level of representations between the lower levels of associations of sensory features and higher symbolic representations. This intermediate level of representations makes it possible to challenge arguments given by some comparative psychologists that animals lack higher-level abstract and explicit forms of causal reasoning because their cognitive capacities are limited to learning and reasoning at the basic level of perceptual associations. Our multi-level account connects time perception with causal reasoning and provides a philosophically defensible framework for experimental investigations that have not yet been pursued. We describe the structure of some possible experiments and consider the implications that would follow from a positive finding of temporal binding in nonhuman animals. Such a finding would provide evidence of explicit awareness of causal relationships and would warrant attribution of intermediate representations that are more abstract and sophisticated than the associations allowed by the lower level of the two-level account. (shrink)

Is imagination a source of knowledge? Timothy Williamson has recently argued that our imaginative capacities can yield knowledge of a variety of matters, spanning from everyday practical matters to logic and set theory. Furthermore, imagination for Williamson plays a similar epistemic role in cognitive processes that we would traditionally classify as either a priori or a posteriori, which he takes to indicate that the distinction itself is shallow and epistemologically fruitless. In this chapter, I aim to defend the a priori-a (...) posteriori distinction from Williamson’s challenge by questioning his account of imagination. I distinguish two notions of imagination at play in Williamson’s account – sensory vs. belief-like imagination – and show that both face empirical and normative issues. Sensory imagination seems neither necessary nor sufficient for knowledge. Whereas, belief-like imagination isn’t adequately disentangled from inference. Additionally, Williamson’s examples are ad hoc and don’t generalize. I conclude that Williamson’s case against the a priori-a posteriori distinction is unconvincing, and so is the thesis that imagination is an epistemic source. (shrink)

I discuss several problems for Williamson’s counterfactual-theory of modal knowledge and argue that they have a common source, in that the theory neglects to elucidate the proper constraints on modal reasoning. Williamson puts forward an empirical hypothesis that rests on the role of counterfactual reasoning for modal knowledge. But he overlooks central questions of normative modal epistemology. In order for counterfactual reasoning to yield correct beliefs about modality, it needs to be suitably constrained. I argue that what is needed is, (...) specifically, information concerning the nature or essence of things. By integrating this information, essentialist deduction arguably provides a better account of our knowledge of modality. Furthermore, I argue that essences have distinctive causal and explanatory powers—indeed, essences are superexplanatory for how things are. Compared to Williamson’s counterfactual-theory, superexplanatory essentialism clarifies what the proper constraints on modal reasoning are, and why they have such a special status. (shrink)

Talk of metaphysical modality as “absolute” is ambiguous, as it appears to convey multiple ideas. Metaphysical possibility is supposedly completely unrestricted or unqualified; metaphysical necessity is unconditional and exceptionless. Moreover, metaphysical modality is thought to be absolute in the sense that it’s real or genuine and the most objective modality: metaphysical possibility and necessity capture ways things could and must have really been. As we disentangle these ideas, certain talk of metaphysical modality qua “absolute” turns out to be misguided. Metaphysical (...) possibility isn't completely unrestricted or most inclusive compared to the other modalities; metaphysical necessity, like all kinds of necessities, is relative to or conditional upon a specific framework of reference. Still, metaphysical modality captures how things could and must have really been most generally because it deals with reality and the nature of things or their essence. That’s the chief interest of metaphysics. Arguments against the alleged absoluteness of metaphysical modality may not thereby undermine its philosophical significance. (shrink)

I propose that we approach the epistemology of modality by putting modal metaphysics first and, specifically, by investigating the metaphysics of essence. Following a prominent Neo-Aristotelian view, I hold that metaphysical necessity depends on the nature of things, namely their essences. I further clarify that essences are core properties having distinctive superexplanatory powers. In the case of natural kinds, which is my focus in the paper, superexplanatoriness is due to the fact that the essence of a kind is what causes (...) all the many properties and behaviors that are typically shared by all the instances of the kind. Accordingly, we know what is necessarily true of kinds by knowing what is essential to them in the sense of actually playing such causal-explanatory roles. Modal reasoning aimed at discovering metaphysical necessity thus proceeds via essentialist deduction: we move from essentialist truths to reach necessary truths. (shrink)

The fourteen papers in this collection offer a variety of original contributions to the epistemology of modality. In seeking to explain how we might account for our knowledge of possibility and necessity, they raise some novel questions, develop some unfamiliar theoretical perspectives, and make some intriguing proposals. Collectively, they advance our understanding of the field. In Part I of this Introduction, I give some general background about the contemporary literature in the area, by sketching a timeline of the main tendencies (...) of the past twenty-five years or so, up to the present debates. Next, I focus on four features that largely characterize the latest literature, and the papers in the present collection in particular: (i) an endorsement of the importance of essentialism; (ii) a shift to a “metaphysics-first” approach to modal epistemology; (iii) a focus on metaphysical modality as opposed to other kinds of modality; and (iv) a preference for non-uniform modal epistemology. In Part II, I present the individual papers in the volume. These are organized around the following four chapters, based on their topic: (A) Skepticism & Deflationism; (B) Essentialism; (C) Non-Essentialist Accounts; (D) Applications. -/- LIST OF CONTRIBUTORS: Francesco Berto; Stephen Biggs & Jessica Wilson; Justin Clark-Doane; Philip Goff; Bob Hale; Frank Jackson; Mark Jago; Boris Kment; Antonella Mallozzi; Graham Priest; Gabriel Rabin; Amie Thomasson; Anand Vaidya & Michael Wallner; Jennifer Wang. -/- The volume is dedicated to the memory of Bob Hale. -/- . (shrink)

In this paper, we distinguish between a number of different phenomena that have been called imitation, and identify one form—a high fidelity mechanism for social learning—considered to be crucial for the development of language. Subsequently, we consider a common claim in the language evolution literature, which is that prior to the emergence of vocal language our ancestors communicated using a sophisticated gestural protolanguage, the learning of some parts of which required manual imitation. Drawing upon evidence from recent work in neuroscience, (...) primatology, and archeology, we argue that while gestural communication undoubtedly played a crucial role in language evolution, the grounds for thinking that manual imitation did are currently unconvincing. (shrink)

The paper explores the project of an ambitious modal epistemology that attempts to combine the a priori methods of Chalmers’ 2D semantics with Kripke’s modal metaphysics. I argue that such a project is not viable. The ambitious modal epistemology involves an inconsistent triad composed of (1) Modal Monism, (2) Two-Dimensionalism, and what I call (3) “Metaphysical Kripkeanism”. I present the three theses and show how only two of those can be true at a time. There is a fundamental incompatibility between (...) Chalmers’ Modal Rationalism and Kripke’s modal metaphysics. Specifically, Chalmers’ conceivability entails possibilities that a Kripkean rejects as genuinely metaphysical. However, three positive stances in modal epistemology emerge from the combinations that the triad allows. One of those offers a promising way forward for 2D modal epistemologies. But it comes with a cost, as it requires abandoning modal monism and reshaping the scope of what a priori conceivability can give us access to. (shrink)

In the current opinion paper, we provide a comparative perspective on specific aspects of primate empathic abilities, with particular emphasis on the mirror neuron system associated with mouth/face actions and expression. Mouth and faces can be very salient communicative classes of stimuli that allow an observer access to the emotional and physiological content of other individuals. We thus describe patterns of activations of neural populations related to observation and execution of specific mouth actions and emotional facial expressions in some species (...) of monkeys and in humans. Particular attention is given to dynamics of face-to-face interactions in the early phases of development and to the differences in the anatomy of facial muscles among different species of primates. We hypothesize that increased complexity in social environments and patterns of social development have promoted specializations of facial musculature, behavioral repertoires related to production and recognition of facial emotional expression, and their neural correlates. In several primates, mirror circuits involving parietal-frontal regions, insular regions, cingulate cortices, and amygdala seem to support automatic forms of embodied empathy, which probably contribute to facial mimicry and behavioural synchrony. In humans these circuits interact with specific prefrontal and temporo-parietal cortical regions, which facilitates higher order cognitive functions such as cognitive empathy and mental state attribution. Our analysis thus suggests that the evolution of higher forms of empathy, such as mentalizing, is also linked to the coupling between the perceptual and motor system related to face processing, which may have undergone a process of exaptation during primate phylogeny. (shrink)

This chapter offers a brief review of theories on mirror neuron development, highlighting different models. These models focus on either the role of genetic mechanisms or the contributions of experience and of learning processes in shaping the brain circuits involved in action–perception coupling. As an alternative, the chapter proposes an epigenetic model for mirror neuron development, explaining how such a model can help to elucidate, within a unifying explanatory framework, the emergence, diversity, and functional reuse of mirror neurons. Lastly, a (...) related evolutionary scenario is sketched in which epigenetic regulation, genetic assimilation/the Baldwin effect, and niche construction play crucial roles in mirror neuron evolution. (shrink)

According to Amie Thomasson's Modal Normativism (MN), knowledge of metaphysical modality is to be explained in terms of a speaker’s mastery of semantic rules, as opposed to one’s epistemic grasp of independent modal facts. In this chapter, I outline (MN)'s account of modal knowledge (§1) and argue that more than semantic mastery is needed for knowledge of metaphysical modality. Specifically (§2), in reasoning aimed at gaining such knowledge, a competent speaker needs to further deploy essentialist principles and information. In response, (...) normativists might contend that a competent speaker will only need to appeal to specific independence counterfactuals, on analogy with quasi-realism about morality. These conditionals fix the meaning of our terms at the actual world, independently of the particular context in which a statement is evaluated. However, I show that this strategy causes several problems for the account (§3). While those problems might perhaps be avoided by endorsing a certain picture of modal metaphysics (Modal Monism), such a picture involves notorious issues that normativists will have to address (§4). It is thus doubtful that (MN) can explain knowledge of metaphysical modality. Still, it may explain some modal knowledge without committing to Modal Monism. As I show (§5), semantic mastery may suffice for gaining knowledge of logical-conceptual modality or analyticity. (shrink)

The fourteen papers in this collection offer a variety of original contributions to the epistemology of modality. In seeking to explain our knowledge of possibility and necessity, they raise some novel questions, develop some unfamiliar theoretical perspectives, and make some intriguing proposals. In the Introduction (penultimate draft available for download), I give some general background about the contemporary literature in the area, by sketching a timeline of the main tendencies of the past twenty-five years or so, up to the present (...) debates. Next, I focus on four features that largely characterize the latest literature, and the papers in the present collection in particular: (i) an endorsement of the importance of essentialism; (ii) a shift to a “metaphysics-first” approach to modal epistemology; (iii) a focus on metaphysical modality as opposed to other kinds of modality; and (iv) a preference for non-uniform modal epistemology. Then I turn to present the individual papers in the volume, which are organized based on their topic around the following four chapters: (A) Skepticism & Deflationism; (B) Essentialism; (C) Non-Essentialist Accounts; (D) Applications. LIST OF CONTRIBUTORS: Francesco Berto; Stephen Biggs & Jessica Wilson; Justin Clark-Doane; Philip Goff; Bob Hale; Frank Jackson; Mark Jago; Boris Kment; Antonella Mallozzi; Graham Priest; Gabriel Rabin; Amie Thomasson; Anand Vaidya & Michael Wallner; Jennifer Wang. The volume is dedicated to the memory of Bob Hale. (shrink)

Epigenetics investigates the dynamics of gene expression in various cells, and the signals from the internal and external environment affecting these dynamics. Neuroepigenetics extends this research into neurons and glia cells. Environmental-induced changes in gene expression are not only associated with the emerging structure and function of the nervous system during ontogeny, but are also fundamental to the wiring of neural circuitries responsible for learning and memory. Yet philosophers of science and neuroscience have so far paid little attention to these (...) findings. In this article, we describe some recent experimental work on the neuroepigenetics of fear and stress responses in rodents, its ingenious experimental translation into humans, and how this work seems not to be accurately described by popular “mechanist” accounts. Our final goal is to motivate broader philosophical attention to neuroepigenetics practices and findings, especially for how it considers environmentally driven and developmental plasticity in psychological explanations. (shrink)

Songbirds possess mirror neurons (MNs) activating during the perception and execution of specific features of songs. These neurons are located in high vocal center (HVC), a premotor nucleus implicated in song perception, production and learning, making worth to inquire their properties and functions in vocal recognition and imitative learning. By integrating a body of brain and behavioral data, we discuss neurophysiology, anatomical, computational properties and possible functions of songbird MNs. -/- We state that the neurophysiological properties of songbird MNs depends (...) on sensorimotor regions that are outside the auditory neural system. Interestingly, songbirds MNs can be the result of the specific type of song representation possessed by some songbird species. At the functional level, we discuss whether songbird MNs are involved in others' song recognition, by dissecting the function of recognition in various different but possible overlapping processes: action-oriented perception, discriminative-oriented perception and identification of the signaler. We conclude that songbird MNs may be involved in recognizing other singer's vocalizations, while their role in imitative learning still require to solve how auditory feedback are used to correct own vocal performance to match the tutor song. Finally, we compare songbird and human mirror responses, hypothesizing a case of convergent evolution, and proposing new experimental directions. (shrink)

We understand interpersonal reality as consisting of those social facts that are informally created by people for themselves in everyday interactions, and involve the collective acceptance of positive and negative deontic powers. We submit that, in the case of interpersonal reality, Gilbert’s concept of a joint commitment is a suitable view of what collective acceptance amounts to. We then argue that creating interpersonal reality, even in common everyday-life situations, typically requires conversational exchanges involving several layers of joint commitments, and in (...) particular joint commitments to projects, joint meaning, and the joint commitments that are constitutive of conversations. (shrink)

In this essay I defend a kind of nonnaturalist normative supervenience, grounded in the essences of things. Essentialist theories, in fact, give us the tools to treat the nexus of normative supervenience as a nexus of metaphysical necessity, holding between the normative and the natural. In this context, essentialist grounding provides an explanation of normative supervenience that allows us to keep together both supervenience and nonnaturalism. Moreover, to achieve this significant result, I do not make use of hybrid properties, which (...) are both normative and natural. Rather, I endeavour to show that the notion of hybrid property is based on an erroneous notion of grounding. (shrink)

Language between God and the Poets: Maʿnā in the Eleventh Century. By Alexander Key. Berkeley Series in Postclassical Islamic Scholarship. Oakland: University of California Press, 2018. Pp. xvi + 267. $34.95.

The changes and general alarm of the current COVID-19 pandemic have amplified the sense of precariousness and vulnerability for family members who, in addition to the emotional trauma of the cancer diagnosis, add the distress and fear of the risks associated with infection. The primary objectives of the present study were to investigate the psychological impact of the COVID-19 pandemic on the parents of pediatric cancer patients, and the level of stress, anxiety, and the child’s quality of life perceived by (...) the parents during the COVID-19 epidemic. The parents of 45 consecutive children with solid and hematological tumors were enrolled. Four questionnaires were administered to the parents at the beginning of the pandemic lockdown. A 75% of parents exhibited remarkable levels of anxiety, with 60 subjects in state scale and 45 subjects in trait scale having scores that reached and exceeded the STAI-Y cut off. The bivariate matrix of correlation found a significant positive correlation between the IES-R and PSS scores. There was a positive correlation between the PSS and PedsQL scale and a negative correlation between IES-R and STAI-Y. The results confirm that parents of pediatric cancer patients have a high psychological risk for post-traumatic symptoms, high stress levels, and the presence of clinically significant levels of anxiety. (shrink)

In recent years numerous attempts have been made by analytic philosophers to _naturalize _various different domains of philosophical inquiry. All of these attempts have had the common goal of rendering these areas of philosophy amenable to empirical methods, with the intention of securing for them the supposedly objective status and broad intellectual appeal currently associated with such approaches. This volume brings together internationally recognised analytic philosophers, including Alvin Plantinga, Peter van Inwagen and Robert Audi, to question the project of naturalism. (...) The articles investigate what it means to _naturalize_ a domain of philosophical inquiry and look at how this applies to the various sub-disciplines of philosophy including epistemology, metaphysics and the philosophy of the mind. The issue of whether naturalism is desirable is raised and the contributors take seriously the possibility that excellent analytic philosophy can be undertaken without naturalization. Controversial and thought-provoking, _Analytic Philosophy Without Naturalism_ examines interesting and contentious methodological issues in analytic philosophy and explores the connections between philosophy and science. (shrink)