In addition to its well‐known role as a coenzyme in oxidation–reduction reactions, the distinct role of NAD as a precursor for molecules involved in cell regulation has been clearly established. The involvement of NAD in these regulatory processes is based on its ability to function as a donor of ADP‐ribose; NAD synthesis is therefore required to avoid depletion of the intracellular pool. The rising interest in the biosynthetic routes leading to NAD formation and the highly conserved nature of the enzymes (...) involved prompted us to reconstruct the NAD biosynthetic routes operating in distinct eukaryotic organisms. The evidence obtained from biochemical and computational analysis provides a good example of how complex metabolic pathways may evolve. In particular, it is proposed that the development of several NAD biosynthetic routes during evolution has led to partial functional redundancy, allowing a given pathway to freely acquire novel functions unrelated to NAD biosynthesis. BioEssays 25:683–690, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Political decisions have the potential to greatly impact our lives. Think of decisions in relation to abortion or climate change, for example. This makes political legitimacy an important normative concern. But what makes political decisions legitimate? Are they legitimate in virtue of having support from the citizens? Democratic conceptions of political legitimacy answer in the affirmative. Such conceptions righly highlight that legitimate political decision-making must be sensitive to disagreements among the citizens. But what if democratic decisions fail to track what (...) there is most reason to do? What if a democratically elected government fails to take measures necessary to protect its population from threats related to climate change? Peter argues that the legitimacy of political decisions doesn't just depend on respect for the citizens' will; and defends a novel hybrid conception of political legitimacy, called the Epistemic Accountability conception. According to this conception, political legitimacy also depends on how political decision-making responds to evidence for what there is most reason to do. Grounds for Political Legitmacy starts with an overview of the main ways in which philosophers have thought about political legitimacy, and identifies the epistemic accountability conception as an overlooked alternative. It then develops the epistemic accountability conception of political legitimacy and discusses its implications for legitimate political decision-making. Considering the norms that should govern political debate, it examines the role of experts in politics, and probes the responsibilities of democratically elected political leaders and as well as of citizens. (shrink)

A conception of legitimacy is at the core of normative theories of democracy. Many different conceptions of legitimacy have been put forward, either explicitly or implicitly. In this article, I shall first provide a taxonomy of conceptions of legitimacy that can be identified in contemporary democratic theory. The taxonomy covers both aggregative and deliberative democracy. I then argue for a conception of democratic legitimacy that takes the epistemic dimension of public deliberation seriously. In contrast to standard interpretations of epistemic democracy, (...) however, the conception I put forward avoids procedure-independent standards of correctness. Instead, it relies on a procedural social epistemology and defines legitimacy entirely in terms of the fairness of procedures. I call this conception of democratic legitimacy `Pure Epistemic Proceduralism'. I shall argue that it should be preferred over `Rational Epistemic Proceduralism', the conception of legitimacy that underlies the standard interpretation of epistemic democracy. Key Words: legitimacy • deliberative democracy • epistemic democracy • social epistemology. (shrink)

There is consistent and strong empirical evidence for social inequalities in health, as a vast and fast growing literature shows. In recent years, these findings have helped to move health equity high on international research and policy agendas. This paper examines how the empirical identification of social inequalities in health relates to a normative judgment about health inequities and puts forward an approach which embeds the pursuit of health equity within the general pursuit of social justice. It defends an indirect (...) approach to health equity, which views social inequalities in health as unjust in so far as they are the result of an unjust basic structure of society in Rawls’ sense. (shrink)

This paper reports on a manual monitoring of online representations of LGBT persons in the Republic of Cyprus for the period April 2015–February 2016. The article contextualizes the prevalence of “hate speech” in online Greek Cypriot comments against LGBT individuals, and, more generally, against non-heterosexuals. Adopting a Foucauldian position vis-à-vis the social and discursive construction of sexuality, we outline, first, the socio-historical context with a focus on LGBT rights in the Republic of Cyprus and the nationalistic project construing sexualities. We (...) then examine the different levels of discursive discrimination practices, providing a snapshot of the types of “hate speech” referring to this topic typically found in such an environment. The focus is on identification of the frames used to construct LGBT identities, and their perception.We use in our title the word subject as defined by post-modernists and by Butler in particular : subject refers to “a socially produced ‘agent’ and ‘deliberator’ whose agency and thought is made possible by a language that precedes that ‘I’. In this sense the ‘I’ is produced through power ”. This paper focuses on the socially produced definition of the LGBT community in the context under study. We thus address the way in which sexuality is constructed within a compulsory and hegemonic heterosexuality and heteronormativity. We analyze our data i.e. comments focused on the LGBT community, with corpus linguistic tools as well as through a qualitative examination of the identified frames. Our analysis confirms an interface between nationalism and compulsory hegemonic heteronormativity in the Republic as well as the influence of the Orthodox Church and its beliefs. (shrink)

This essay explores the role of the German expression Weltanschauung in the philosophy of Charles Sanders Peirce. Two philosophical contexts are distinguished in which the term occurs in his writings: a) the classical pragmatist’s discussion of what constitutes Pragmatism and b) the discussion of the systematic place of a »scientific philosophy«, both in terms of its relation to other sciences and in distinction from everyday beliefs. Thus, on the one hand, the essay compares Peirce’s version of pragmatism with the views (...) of other, more subjectivist pragmatists, who used the term »Weltanschauung« to denote their philosophical enterprises: William James and F. C. S. Schiller. On the other hand, Peirce’s ideal of scientific philosophy, particularly of scientific metaphysics, is contrasted with ›non-scientific metaphysics‹ – or how Peirce calls it: Weltanschauung. The essay also shows how his conception of scientific philosophy differs from Wilhelm Wundt’s idea that philosophy should provide a »Weltanschauung« based on the special sciences. (shrink)

Freivalds defined an acceptable programming system independent criterion for learning programs for functions in which the final programs were required to be both correct and "nearly" minimal size, i.e., within a computable function of being purely minimal size. Kinber showed that this parsimony requirement on final programs limits learning power. However, in scientific inference, parsimony is considered highly desirable. A lim-computablefunction is (by definition) one calculable by a total procedure allowed to change its mind finitely many times about its output. (...) Investigated is the possibility of assuaging somewhat the limitation on learning power resulting from requiring parsimonious final programs by use of criteria which require the final, correct programs to be "not-so-nearly" minimal size, e.g., to be within a lim-computable function of actual minimal size. It is shown that some parsimony in the final program is thereby retained, yet learning power strictly increases. Considered, then, are lim-computable functions as above but for which notations for constructive ordinals are used to bound the number of mind changes allowed regarding the output. This is a variant of an idea introduced by Freivalds and Smith. For this ordinal notation complexity bounded version of lim-computability, the power of the resultant learning criteria form finely graded, infinitely ramifying, infinite hierarchies intermediate between the computable and the lim-computable cases. Some of these hierarchies, for the natural notations determining them, are shown to be optimally tight. (shrink)

This paper discusses Freud's model of the psychical apparatus in the “Project”, and concludes that it is a remarkably sophisticated work which even today is still highly relevant to neuropsychological theorising. Freud rejects the notion that what happens in the brain can be clearly localised in space and time. This anticipates the notion of a distributed system found in recent developments in computing (“neural net works”) and in Derrida's conception of systems characterised by différance. Every part of such a system (...) is constituted by its relation to the rest of the system. Although such systems are spatio-temporal, processes occur ring in them can not be pinpointed in space and time. Against the common charge that Freud has a passive hydraulic-reflex model of the psychical apparatus, the authors argue that Freud presents it as an open, complex, self-organising system. Ricoeur's (1972) claim that the model of the psychical apparatus in the “Project” is essentially solipsistic, is accordingly rejected. In conclusion the authors explain why they prefer the model in the “Project” to the more linear model found in Ch. VII of the Traumdeutung. S. Afr. J. Philos. Vol.20(3) 2001: 1- 21. (shrink)

Dans son dialogue Sur le Bien (19 F = fr. 11 dP), Numénius écrit que le dieu qui est « deuxième et troisième est un ». Par là, il désigne un dieu considéré selon deux aspects qui correspondent à la double orientation de son attention. Dans le second, il est tourné vers le monde et joue le rôle de démiurge. Selon la plupart des chercheurs, ce démiurge serait à identifier à l’âme du monde que les fragments parvenus du dialogue ne (...) mentionnent pas. L’article montre que cette interprétation ne rend peut-être pas compte du propos de Numénius. Il indique les raisons théoriques et polémiques expliquant qu’en réalité, même si le démiurge a la fonction de l’âme du monde, Numénius ne l’identifie pas avec celle-ci. Il veut définir les principes qu’il identifie à l’être, conçu comme incorporel. Le mouvement intrinsèque à l’âme et l’immanence qui la caractérise, d’après la tradition platonicienne que suit Numénius et la tradition stoïcienne à laquelle il s’oppose, interdisent de donner à cette âme le statut de pur intelligible – le lui accorder serait précisément céder à l’immanentisme et au corporalisme stoïciens. Enfin, il n’est pas davantage utile de reconnaître dans le second aspect du deuxième dieu, un moment nommé « troisième dieu » dans le dialogue, le troisième dieu que Numénius aurait identifié au monde d’après le témoignage de Proclus (29 T = fr. 21 dP). Ce troisième dieu-là peut réellement correspondre au monde dont Platon fait un dieu, à condition que ce monde soit considéré comme le produit du seul intellect, ordre (κόσμος) qui comporte certes une âme, et même un intellect en elle, mais qui n’est réduit ni à l’une ni à l’autre. (shrink)

The exchange of ideas between nations during the Enlightenment was greatly facilitated by cultural ventures, commercial enterprise and scientific collaboration. But how were they exchanged? What were the effects of these exchanges on the idea or artefact being transferred? Focussing on contact between England, France and Ireland, a team of specialists explores the translation, appropriation and circulation of cultural products and scientific ideas during the Enlightenment. Through analysis of literary and artistic works, periodicals and official writings contributors uncover: the key (...) role played by literary translators and how they adapted, naturalized and sometimes distorted plays and novels to conform to new cultural norms; the effects of eighteenth-century anglomania, and how this was manifested in French art; how the vagaries of international politics and conflict affected both the cultural products themselves and the modes of dissemination; how religious censorship engendered new Irish Catholic and French Huguenot diasporas, with their particular intellectual pursuits and networks of exchan≥ the significance of newspapers and periodicals in disseminating new knowledge and often radical philosophical ideas. By exploring both broad areas of cultural activity and precise examples of cultural transfer, contributors to Intellectual journeys reveal the range and complexity of intellectual exchange and its role in the formation of a truly transnational Enlightenment. (shrink)

This paper gives a sketch for a reconstruction of the Freudian unconscious, and an argument for its existence. The strategy followed attempts to side-step the extended debates about the validity of Freud's methods and conclusions, by basing itself on the desire/belief schema for understanding and explaining human behaviour – a schema neither folk psychology nor scientific psychology can do without. People are argued to have, as ideal types, two fundamental modes of fulfilling their desires: engaging with reality, and wishful thinking. (...) The first mode tries to acknowledge the constraints reality imposes on the satisfaction of desires, while the second mode tries to ignore, deny or disguise these constraints, inasmuch as they threaten to make such satisfaction impossible or unfeasible. Crucially, wishful thinking can be used so as to ignore or deny any desire that is incompatible with other strong desires. Thus we end up unaware of the existence or nature of some of our desires, of the fact that they are in flu enc ing our thought and be hav iour, and of the process our own mind has used to thwart awareness of them. Once we acknowledge this possibility, we are already seriously entertaining the possibility of the Freudian unconscious, or something fairly close to it. The more aware the subject is that her wishful thinking is just that, the less effective it becomes. Wishful thinking thus requires an unconscious; it is inimical to a clear, complete and unambiguous acknowledgement of its own status. Next, various aspects of my account (and Freud's) that allow a conception of the unconscious in non-Cartesian terms are emphasised: the unconscious is largely constituted by semantic phenomena of a particular type: forms of representation which would conceal their meaning even if the full light of 'attention', Cartesian 'consciousness' or 'introspection' were cast upon them. If wishful thinking is an integral part of mental life, philosophers and others wishing to “educate humanity” will have to proceed differently from what would have been appropriate had rational thought and action been the only available option for satisfying desires. Mankind cannot bear too much reality – T.S. Eliot S. Afr. J. Philos. Vol.22(4) 2003: 361-377. (shrink)

« Les choses ont décidément changé en dix ans, les transformations du présent amènent à relire les textes passés, et la poésie française n’apparaît plus comme un grand désert de femmes. Il faut s’en réjouir » (p. 12). C’est avec ce commentaire enthousiaste que Christine Planté clôt l’avant-propos à la deuxième édition de l’anthologie qu’elle dirige, Femmes poètes du xixe siècle. Si l’édition de 1998 permit de faire découvrir une poésie de femmes que le lecteur ignorait, la nouvelle édition de...

Si l’homme est un être doté de raison et se distingue des autres animaux par sa capacité à réfléchir sur ses actes tant avant de les poser qu’après, il lui arrive cependant d’être irrationnel. Tandis que certains s’en désolent, considérant les différentes formes d’irrationalité comme autant d’expressions de notre inaptitude à atteindre la sagesse, d’autres semblent plutôt s’en réjouir, estimant que la possibilité de ne pas se conformer à ce que dicte ou suggère la raison est une preuve de notre (...) radicale liberté. Mais quel que soit le jugement moral, explicite ou implicite, porté sur ces phénomènes, la plupart des philosophes ne se contentent pas de les constater. Ils tentent de les cerner, d’en comprendre les mécanismes, parfois de les justifier. Comment et pour-quoi? Telles sont les questions auxquelles voudrait répondre ce numéro portant sur la délibération et l’irrationalité dans l’histoire. (shrink)

En 1965, H. Thesleff offrait le premier recueil des textes pseudopythagoriciens parvenus (The Pythagorean texts of the Hellenistic period, Abo Akademi, Abo). Certains d’entre eux ont depuis fait l’objet d’études spécifiques : le traité Sur la nature du monde et de l’âme du Pseudo-Timée de Locres par M. Baltes (Leiden, 1972), le traité Sur les catégories du Pseudo-Archytas par T. A. Szlezák (Berlin / New York, 1972) et les traités éthiques attribués à Archytas, Métopos, Théagès et Euriphamos p...

This paper reports on a manual monitoring of online representations of LGBT persons in the Republic of Cyprus for the period April 2015–February 2016. The article contextualizes the prevalence of “hate speech” in online Greek Cypriot comments against LGBT individuals, and, more generally, against non-heterosexuals. Adopting a Foucauldian position vis-à-vis the social and discursive construction of sexuality, we outline, first, the socio-historical context with a focus on LGBT rights in the Republic of Cyprus and the nationalistic project construing sexualities. We (...) then examine the different levels of discursive discrimination practices, providing a snapshot of the types of “hate speech” referring to this topic typically found in such an environment. The focus is on identification of the frames used to construct LGBT identities, and their perception.We use in our title the word subject as defined by post-modernists and by Butler in particular : subject refers to “a socially produced ‘agent’ and ‘deliberator’ whose agency and thought is made possible by a language that precedes that ‘I’. In this sense the ‘I’ is produced through power ”. This paper focuses on the socially produced definition of the LGBT community in the context under study. We thus address the way in which sexuality is constructed within a compulsory and hegemonic heterosexuality and heteronormativity. We analyze our data i.e. comments focused on the LGBT community, with corpus linguistic tools as well as through a qualitative examination of the identified frames. Our analysis confirms an interface between nationalism and compulsory hegemonic heteronormativity in the Republic as well as the influence of the Orthodox Church and its beliefs. (shrink)

In a poetic conversation with Thierry Zarcone, the painter and calligrapher Fabienne Verdier exposes her deep and harmonious connection to nature. She tells of her garden, her house and her osmosis with nature. Painting is to her an art of living and being that recalls the Tao masters as well as some Christan mystics.

The recent literature on the epistemology of disagreement focuses on the rational response question: how are you rationally required to respond to a doxastic disagreement with someone, especially with someone you take to be your epistemic peer? A doxastic disagreement with someone also confronts you with a slightly different question. This question, call it the epistemic trust question, is: how much should you trust our own epistemic faculties relative to the epistemic faculties of others? Answering the epistemic trust question is (...) important for the epistemology of disagreement because it sheds light on the rational response question. My main aim in this paper is to argue—against recent attempts to show otherwise—that epistemic self-trust does not provide a reason for remaining steadfast in doxastic disagreements with others. (shrink)

The contributions of this volume discuss the legacy of Emmanuel Levinas philosophy. Examining critically the limits of his thinking, they also bear witness to its influence, thus demonstrating the significance of his groundbreaking project of establishing ethics as first philosophy".

This qualitative study explored and described South African students’ experiences and perceptions regarding academic success. Focus group participants related academic success not only to achieveme...

The history of the phrase absolute music has been studied by many theorists of music and music historians, while historians of philosophy proved to be rather reluctant to such syncretic concept. However, absolute music is exactly the case of non-philosophical appropriation of a philosophical category, which fits theoretical framework of the studies in intellectual history. Initial exploration on the synthesis of history of philosophy and musicology and music history has shown that the conceptual field of intellectual history enables the transition (...) from abstract ideas to concrete social history of thought. It is proved that "absolute music" is not an authentic concept of music culture of the nineteenth century, but rather a good invention of new musical hermeneutics, which defined a period in the development of music and paradigm of concepts that characterized autonomy of musical form. The subject of historical and philosophical studies of the phrase "absolute music" lies in transformation of a philosophical term into a unit of aesthetic discourse, and later its reincarnation in the concept of musical historiosophy. Both philosophical and musicological approaches to the history of absolute music are based on the assumption that only theoretically relevant assertions and judgments appeal to the hermeneutic reconstruction and generalization, whereas political and social references of the discourse of absolute music can be left aside. So futher research shall focus on possibilities of how to reach the concrete social background of that form of thinking which employs the idiom absolute music. (shrink)

Name der Zeitschrift: Klio Jahrgang: 97 Heft: 1 Seiten: 389-391.

This commentary addresses three points. First, it is argued that the common coding principles, as developed in the target article, may supplement rather than replace stage views of human information processing. Second, the issue of the properties of an event code is briefly discussed. It is concluded that much remains to be specified so as to allow critical tests. Finally, the question of the limits of common coding is raised. It may be particularly relevant to direct perception and action coupling (...) but less useful for the analysis of cognitive skills. (shrink)

Classical ethology encourages a causal approach to animal behaviour, using Tinbergen's four questions concerning evolution, function, mechanism and development of behaviour. It sets aside the study of mental processes, which could otherwise help to unify our picture of the relationships between animal and environment. Here the steps in research focused on the psychological meaning of a peculiar behaviour in the mouse — carrying its tail — and what this implies regarding the mouse's cognitive world are given. Initial empirical observations suggested (...) epistemic choices concerning space and object notions in the mouse; this led us to go beyond the first stage in exploring the significance of this behaviour. Later experiments showed the limitations of an explanation based on a cause-effect relationship. An interpretative model integrating a phenomenological conceptual framework is proposed. (shrink)

This book offers a systematic treatment of the requirements of democratic legitimacy. It argues that democratic procedures are essential for political legitimacy because of the need to respect value pluralism and because of the learning process that democratic decision-making enables. It proposes a framework for distinguishing among the different ways in which the requirements of democratic legitimacy have been interpreted. Peter then uses this framework to identify and defend what appears as the most plausible conception of democratic legitimacy. According to (...) this conception, democratic legitimacy requires that the decision-making process satisfies certain conditions of political and epistemic fairness. (shrink)

In this paper we focus on the difficulty in judging what is called covert hate speech. We emphasize the need for a multidimensional framework when analysing covert hate speech in situ, and the need to consider the multifaceted dimension of such speech act to assess its performativity. To explain such need, we apply the test of the Rabat Plan of Action and adopt a pragmatic perspective to analyse a specific covert hate speech act, considering such speech act as both an (...) expressive and potentially performative act. We focus on the prosecution of hate speech against a woman holding a poster during an anti-safe pass demonstration. Her poster inferred a link between conspiracy theory, the government strategy addressing the Covid pandemic and many other collectives, primarily the Jewish community. Our analysis of the sign adopts a radically context-dependent methodology combining a pragmatic approach and the Rabat Plan of Action test. We then contrast our analysis with the legal and media perspective on the issue. We conclude by suggesting the benefit of integrating pragmatic analysis with application of normative set of rules such as the Rabat Plan of Action test, even though the fluidity of meaning always poses a challenge to any authority tasked with judging such communicative events. (shrink)

Dans son interprétation du Timée, Calcidius rapporte un exposé de Numénius sur la manière dont Pythagore, suivi par Platon, conçoit l’origine du monde. À cette occasion, Numénius identifie la matière à trois entités : la dyade indéterminée, la nécessité et l’âme mauvaise du monde évoquée dans les Lois (fr. 52 Des Places). L’article montre en quoi ces trois analogies permettent de comprendre le rôle qu’il attribue à la matière dans l’origine du mal, et ce même avant l’incarna­tion de l’âme, d’après (...) les témoignages sur sa pensée fournis par Jamblique (fr. 43 Des Places) et Énée de Gaza (fr. 49 Des Places). Il analyse le contexte philo­sophique et exégétique de ces analogies, montrant combien la pensée de Numénius est profondément ancrée dans les cadres fournis par l’école platonicienne, tant pour ses choix herméneutiques que pour ses débats avec les autres écoles (le stoïcisme essentiellement ici). (shrink)